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Volumn 2, Issue 3, 2016, Pages 138-153

High-throughput automated scoring of Ki67 in breast cancer tissue microarrays from the Breast Cancer Association Consortium

(43)  Abubakar, Mustapha a   Howat, William J b   Daley, Frances a   Zabaglo, Lila c   McDuffus, Leigh Anne b   Blows, Fiona b   Coulson, Penny a   Raza Ali, H b   Benitez, Javier d,e   Milne, Roger f,g   Brenner, Herman h   Stegmaier, Christa i   Mannermaa, Arto j,k   Chang Claude, Jenny h,l   Rudolph, Anja h   Sinn, Peter m   Couch, Fergus J n   Tollenaar, Rob A E M o   Devilee, Peter o   Figueroa, Jonine p   more..


Author keywords

automated algorithm; breast cancer; immunohistochemistry; Ki67; tissue microarrays

Indexed keywords

KI 67 ANTIGEN;

EID: 85056746527     PISSN: None     EISSN: 20564538     Source Type: Journal    
DOI: 10.1002/cjp2.42     Document Type: Article
Times cited : (20)

References (56)
  • 1
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sørlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000; 406 (6797):747–752.
    • (2000) Nature , vol.406 , Issue.6797 , pp. 747-752
    • Perou, C.M.1    Sørlie, T.2    Eisen, M.B.3
  • 2
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sørlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Nat Acad Sci 2001; 98(19):10869–10874.
    • (2001) Proc Nat Acad Sci , vol.98 , Issue.19 , pp. 10869-10874
    • Sørlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 3
    • 77953248475 scopus 로고    scopus 로고
    • Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies
    • Blows FM, Driver KE, Schmidt MK, et al. Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies. PLoS Med 2010; 7(5):e1000279.
    • (2010) PLoS Med , vol.7 , Issue.5
    • Blows, F.M.1    Driver, K.E.2    Schmidt, M.K.3
  • 4
    • 62449131093 scopus 로고    scopus 로고
    • Supervised risk predictor of breast cancer based on intrinsic subtypes
    • Parker JS, Mullins M, Cheang MC, et al. Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol 2009; 27(8):1160–1167.
    • (2009) J Clin Oncol , vol.27 , Issue.8 , pp. 1160-1167
    • Parker, J.S.1    Mullins, M.2    Cheang, M.C.3
  • 5
    • 79551694006 scopus 로고    scopus 로고
    • Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium Studies
    • Yang XR, Chang-Claude J, Goode EL, et al. Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium Studies. J Nat Cancer Institute 2011; 103(3):250–263.
    • (2011) J Nat Cancer Institute , vol.103 , Issue.3 , pp. 250-263
    • Yang, X.R.1    Chang-Claude, J.2    Goode, E.L.3
  • 6
    • 4944226962 scopus 로고    scopus 로고
    • Etiology of hormone receptor–defined breast cancer: a systematic review of the literature
    • Althuis MD, Fergenbaum JH, Garcia-Closas M, et al. Etiology of hormone receptor–defined breast cancer: a systematic review of the literature. Cancer Epidemiol Biomark Prevent 2004; 13(10):1558–1568.
    • (2004) Cancer Epidemiol Biomark Prevent , vol.13 , Issue.10 , pp. 1558-1568
    • Althuis, M.D.1    Fergenbaum, J.H.2    Garcia-Closas, M.3
  • 7
    • 84883325272 scopus 로고    scopus 로고
    • Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013
    • Goldhirsch A, Winer EP, Coates AS, et al. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol 2013; 24(9):2206–2223.
    • (2013) Ann Oncol , vol.24 , Issue.9 , pp. 2206-2223
    • Goldhirsch, A.1    Winer, E.P.2    Coates, A.S.3
  • 8
    • 80052764314 scopus 로고    scopus 로고
    • Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Aebi S, Davidson T, Gruber G, et al. Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2011; 22(suppl 6):vi12–vi24.
    • (2011) Ann Oncol , vol.22 , pp. vi12-vi24
    • Aebi, S.1    Davidson, T.2    Gruber, G.3
  • 9
    • 77950795113 scopus 로고    scopus 로고
    • Molecular pathology in epidemiologic studies: a primer on key considerations
    • Sherman ME, Howatt W, Blows FM, et al. Molecular pathology in epidemiologic studies: a primer on key considerations. Cancer Epidemiol Biomark Prevent 2010; 19(4):966–972.
    • (2010) Cancer Epidemiol Biomark Prevent , vol.19 , Issue.4 , pp. 966-972
    • Sherman, M.E.1    Howatt, W.2    Blows, F.M.3
  • 10
    • 84951573783 scopus 로고    scopus 로고
    • Crowdsourcing the general public for large scale molecular pathology studies in cancer
    • do Reis FJC, Lynn S, Ali HR, et al. Crowdsourcing the general public for large scale molecular pathology studies in cancer. EBioMedicine 2015; 2(7):679–687.
    • (2015) EBioMedicine , vol.2 , Issue.7 , pp. 679-687
    • do Reis, F.J.C.1    Lynn, S.2    Ali, H.R.3
  • 12
    • 84886793148 scopus 로고    scopus 로고
    • Interobserver concordance of Ki67 labeling index in breast cancer: Japan Breast Cancer Research Group Ki67 Ring Study
    • Mikami Y, Ueno T, Yoshimura K, et al. Interobserver concordance of Ki67 labeling index in breast cancer: Japan Breast Cancer Research Group Ki67 Ring Study. Cancer Sci 2013; 104(11):1539–1543.
    • (2013) Cancer Sci , vol.104 , Issue.11 , pp. 1539-1543
    • Mikami, Y.1    Ueno, T.2    Yoshimura, K.3
  • 13
    • 84870388235 scopus 로고    scopus 로고
    • Comparison of the effect of different techniques for measurement of Ki67 proliferation on reproducibility and prognosis prediction accuracy in breast cancer
    • Gudlaugsson E, Skaland I, Janssen EAM, et al. Comparison of the effect of different techniques for measurement of Ki67 proliferation on reproducibility and prognosis prediction accuracy in breast cancer. Histopathology 2012; 61(6):1134–1144.
    • (2012) Histopathology , vol.61 , Issue.6 , pp. 1134-1144
    • Gudlaugsson, E.1    Skaland, I.2    Janssen, E.A.M.3
  • 14
    • 77950854530 scopus 로고    scopus 로고
    • Assessment of automated image analysis of breast cancer tissue microarrays for epidemiologic studies
    • Bolton KL, Garcia-Closas M, Pfeiffer RM, et al. Assessment of automated image analysis of breast cancer tissue microarrays for epidemiologic studies. Cancer Epidemiol Biomark Prevent 2010; 19(4):992–999.
    • (2010) Cancer Epidemiol Biomark Prevent , vol.19 , Issue.4 , pp. 992-999
    • Bolton, K.L.1    Garcia-Closas, M.2    Pfeiffer, R.M.3
  • 15
    • 71049183065 scopus 로고    scopus 로고
    • Automated image analysis for high-throughput quantitative detection of ER and PR expression levels in large-scale clinical studies: The TEAM trial experience
    • Faratian D, Kay C, Robson T, et al. Automated image analysis for high-throughput quantitative detection of ER and PR expression levels in large-scale clinical studies: The TEAM trial experience. Histopathology 2009; 55(5):587–593.
    • (2009) Histopathology , vol.55 , Issue.5 , pp. 587-593
    • Faratian, D.1    Kay, C.2    Robson, T.3
  • 16
    • 46949097718 scopus 로고    scopus 로고
    • Automated quantitative analysis of estrogen receptor expression in breast carcinoma does not differ from expert pathologist scoring: a tissue microarray study of 3,484 cases
    • English
    • Turbin D, Leung S, Cheang MU, et al. Automated quantitative analysis of estrogen receptor expression in breast carcinoma does not differ from expert pathologist scoring: a tissue microarray study of 3,484 cases. Breast Cancer Res Treat 2008; 110(3):417–426. English.
    • (2008) Breast Cancer Res Treat , vol.110 , Issue.3 , pp. 417-426
    • Turbin, D.1    Leung, S.2    Cheang, M.U.3
  • 17
    • 84875215136 scopus 로고    scopus 로고
    • Astronomical algorithms for automated analysis of tissue protein expression in breast cancer
    • Ali HR, Irwin M, Morris L, et al. Astronomical algorithms for automated analysis of tissue protein expression in breast cancer. Br J Cancer 2013; 108(3):602–612.
    • (2013) Br J Cancer , vol.108 , Issue.3 , pp. 602-612
    • Ali, H.R.1    Irwin, M.2    Morris, L.3
  • 18
    • 85013759699 scopus 로고    scopus 로고
    • Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium
    • Howat WJ, Blows FM, Provenzano E, et al. Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium. J Pathol: Clin Res 2015; 1(1):18–32.
    • (2015) J Pathol: Clin Res , vol.1 , Issue.1 , pp. 18-32
    • Howat, W.J.1    Blows, F.M.2    Provenzano, E.3
  • 19
    • 59449103707 scopus 로고    scopus 로고
    • Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer
    • Rexhepaj E, Brennan DJ, Holloway P, et al. Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer. Breast Cancer Res 2008; 10(5):R89.
    • (2008) Breast Cancer Res , vol.10 , Issue.5 , pp. R89
    • Rexhepaj, E.1    Brennan, D.J.2    Holloway, P.3
  • 20
    • 9244229046 scopus 로고    scopus 로고
    • Automated quantitative analysis of tissue microarrays reveals an association between high Bcl-2 expression and improved outcome in Melanoma
    • DiVito KA, Berger AJ, Camp RL, et al. Automated quantitative analysis of tissue microarrays reveals an association between high Bcl-2 expression and improved outcome in Melanoma. Cancer Res 2004; 64(23): 8773–8777.
    • (2004) Cancer Res , vol.64 , Issue.23 , pp. 8773-8777
    • DiVito, K.A.1    Berger, A.J.2    Camp, R.L.3
  • 21
    • 23844442173 scopus 로고    scopus 로고
    • Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis
    • Psyrri A, Yu Z, Weinberger PM, et al. Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis. Clin Cancer Res 2005; 11(16): 5856–5862.
    • (2005) Clin Cancer Res , vol.11 , Issue.16 , pp. 5856-5862
    • Psyrri, A.1    Yu, Z.2    Weinberger, P.M.3
  • 22
    • 1842477822 scopus 로고    scopus 로고
    • Expression of HER2neu (c-erbB-2) and epidermal growth factor receptor in cervical cancer: prognostic correlation with clinical characteristics, and comparison of manual and automated imaging analysis
    • Lee CM, Lee RJ, Hammond E, et al. Expression of HER2neu (c-erbB-2) and epidermal growth factor receptor in cervical cancer: prognostic correlation with clinical characteristics, and comparison of manual and automated imaging analysis. Gynecol Oncol 2004; 93(1): 209–214.
    • (2004) Gynecol Oncol , vol.93 , Issue.1 , pp. 209-214
    • Lee, C.M.1    Lee, R.J.2    Hammond, E.3
  • 23
    • 0028797073 scopus 로고
    • Assessment of the new proliferation marker MIB1 in breast carcinoma using image analysis: associations with other prognostic factors and survival
    • Pinder S, Wencyk P, Sibbering D, et al. Assessment of the new proliferation marker MIB1 in breast carcinoma using image analysis: associations with other prognostic factors and survival. Br J Cancer 1995; 71(1): 146.
    • (1995) Br J Cancer , vol.71 , Issue.1 , pp. 146
    • Pinder, S.1    Wencyk, P.2    Sibbering, D.3
  • 24
    • 0029861983 scopus 로고    scopus 로고
    • The important prognostic value of Ki-67 expression as determined by image analysis in breast cancer
    • Pietiläinen T, Lipponen P, Aaltomaa S, et al. The important prognostic value of Ki-67 expression as determined by image analysis in breast cancer. J Cancer Res Clin Oncol 1996; 122(11): 687–692.
    • (1996) J Cancer Res Clin Oncol , vol.122 , Issue.11 , pp. 687-692
    • Pietiläinen, T.1    Lipponen, P.2    Aaltomaa, S.3
  • 25
    • 79953143904 scopus 로고    scopus 로고
    • Proliferative activity in human breast cancer: Ki-67 automated evaluation and the influence of different Ki-67 equivalent antibodies
    • Fasanella S, Leonardi E, Cantaloni C, et al. Proliferative activity in human breast cancer: Ki-67 automated evaluation and the influence of different Ki-67 equivalent antibodies. Diagnost Pathol 2011; 6(Suppl 1): S7.
    • (2011) Diagnost Pathol , vol.6 , pp. S7
    • Fasanella, S.1    Leonardi, E.2    Cantaloni, C.3
  • 26
    • 78951470719 scopus 로고    scopus 로고
    • Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer
    • Konsti J, Lundin M, Joensuu H, et al. Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer. BMC Clin Pathol 2011; 11(1): 3.
    • (2011) BMC Clin Pathol , vol.11 , Issue.1 , pp. 3
    • Konsti, J.1    Lundin, M.2    Joensuu, H.3
  • 27
    • 84856432316 scopus 로고    scopus 로고
    • Comparison of visual and automated assessment of Ki-67 proliferative activity and their impact on outcome in primary operable invasive ductal breast cancer
    • Mohammed ZMA, McMillan DC, Elsberger B, et al. Comparison of visual and automated assessment of Ki-67 proliferative activity and their impact on outcome in primary operable invasive ductal breast cancer. Br J Cancer 2012; 106(2): 383–388.
    • (2012) Br J Cancer , vol.106 , Issue.2 , pp. 383-388
    • Mohammed, Z.M.A.1    McMillan, D.C.2    Elsberger, B.3
  • 28
    • 84940463741 scopus 로고    scopus 로고
    • Standardized Ki67 diagnostics using automated scoring – clinical validation in the GeparTrio Breast Cancer Study
    • Klauschen F, Wienert S, Schmitt WD, et al. Standardized Ki67 diagnostics using automated scoring – clinical validation in the GeparTrio Breast Cancer Study. Clin Cancer Res 2015; 21(16): 3651–3657.
    • (2015) Clin Cancer Res , vol.21 , Issue.16 , pp. 3651-3657
    • Klauschen, F.1    Wienert, S.2    Schmitt, W.D.3
  • 29
    • 78650900647 scopus 로고    scopus 로고
    • ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67
    • Tuominen VJ, Ruotoistenmaki S, Viitanen A, et al. ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67. Breast Cancer Res 2010; 12(4): R56.
    • (2010) Breast Cancer Res , vol.12 , Issue.4 , pp. R56
    • Tuominen, V.J.1    Ruotoistenmaki, S.2    Viitanen, A.3
  • 30
    • 85063926104 scopus 로고    scopus 로고
    • Breast Cancer Association Consortium [cited 2015 19/08/,]. Available fro
    • BCAC. Breast Cancer Association Consortium [cited 2015 19/08/ 2015]. Available from: http://apps.ccge.medschl.cam.ac.uk/consortia/bcac//index.html.
    • (2015)
  • 31
    • 84899491271 scopus 로고    scopus 로고
    • A methodology to ensure and improve accuracy of Ki67 labelling index estimation by automated digital image analysis in breast cancer tissue
    • Laurinavicius A, Plancoulaine B, Laurinaviciene A, et al. A methodology to ensure and improve accuracy of Ki67 labelling index estimation by automated digital image analysis in breast cancer tissue. Breast Cancer Res 2014; 16 : R35.
    • (2014) Breast Cancer Res , vol.16 , pp. R35
    • Laurinavicius, A.1    Plancoulaine, B.2    Laurinaviciene, A.3
  • 32
    • 81555208345 scopus 로고    scopus 로고
    • Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group
    • Dowsett M, Nielsen TO, A'Hern R, et al. Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group. J Nat Cancer Institute 2011; 103(22): 1656–1664.
    • (2011) J Nat Cancer Institute , vol.103 , Issue.22 , pp. 1656-1664
    • Dowsett, M.1    Nielsen, T.O.2    A'Hern, R.3
  • 33
    • 48849096940 scopus 로고    scopus 로고
    • Proliferation markers and survival in early breast cancer: a systematic review and meta-analysis of 85 studies in 32,825 patients
    • Stuart-Harris R, Caldas C, Pinder S, et al. Proliferation markers and survival in early breast cancer: a systematic review and meta-analysis of 85 studies in 32,825 patients. Breast 2008; 17(4): 323–334.
    • (2008) Breast , vol.17 , Issue.4 , pp. 323-334
    • Stuart-Harris, R.1    Caldas, C.2    Pinder, S.3
  • 34
    • 58149412516 scopus 로고
    • Weighted kappa: nominal scale agreement provision for scaled disagreement or partial credit
    • Cohen J. Weighted kappa: nominal scale agreement provision for scaled disagreement or partial credit. Psychol Bull 1968; 70(4): 213.
    • (1968) Psychol Bull , vol.70 , Issue.4 , pp. 213
    • Cohen, J.1
  • 35
    • 0024369033 scopus 로고
    • Ki67 immunostaining in primary breast cancer: pathological and clinical associations
    • Bouzubar N, Walker KJ, Griffiths K, et al. Ki67 immunostaining in primary breast cancer: pathological and clinical associations. Br J Cancer 1989; 59(6): 943–947.
    • (1989) Br J Cancer , vol.59 , Issue.6 , pp. 943-947
    • Bouzubar, N.1    Walker, K.J.2    Griffiths, K.3
  • 36
    • 0023183168 scopus 로고
    • Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variables
    • Barnard NJ, Hall PA, Lemoine NR, et al. Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variables. J Pathol 1987; 152(4): 287–295.
    • (1987) J Pathol , vol.152 , Issue.4 , pp. 287-295
    • Barnard, N.J.1    Hall, P.A.2    Lemoine, N.R.3
  • 37
    • 20244374922 scopus 로고    scopus 로고
    • International Breast Cancer Study Group: Ki-67 expression in breast carcinoma: its association with grading systems, clinical parameters, and other prognostic factors-a surrogate marker
    • Trihia H, Murray S, Price K, et al. International Breast Cancer Study Group: Ki-67 expression in breast carcinoma: its association with grading systems, clinical parameters, and other prognostic factors-a surrogate marker. Cancer 2003; 97(5): 1321–1331.
    • (2003) Cancer , vol.97 , Issue.5 , pp. 1321-1331
    • Trihia, H.1    Murray, S.2    Price, K.3
  • 38
    • 0035914249 scopus 로고    scopus 로고
    • Relationship between tumour shrinkage and reduction in Ki67 expression after primary chemotherapy in human breast cancer
    • Bottini A, Berruti A, Bersiga A, et al. Relationship between tumour shrinkage and reduction in Ki67 expression after primary chemotherapy in human breast cancer. Br J Cancer 2001; 85(8): 1106–1112.
    • (2001) Br J Cancer , vol.85 , Issue.8 , pp. 1106-1112
    • Bottini, A.1    Berruti, A.2    Bersiga, A.3
  • 39
    • 0032904256 scopus 로고    scopus 로고
    • Correlation between p53, c-erbB-2, and topoisomerase II alpha expression, DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications
    • Rudolph P, Olsson H, Bonatz G, et al. Correlation between p53, c-erbB-2, and topoisomerase II alpha expression, DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications. J Pathol 1999; 187(2): 207–276.
    • (1999) J Pathol , vol.187 , Issue.2 , pp. 207-276
    • Rudolph, P.1    Olsson, H.2    Bonatz, G.3
  • 40
    • 0030010161 scopus 로고    scopus 로고
    • Prognostic value of Ki-67 compared to S-phase fraction in axillary node-negative breast cancer
    • Brown RW, Allred CD, Clark GM, et al. Prognostic value of Ki-67 compared to S-phase fraction in axillary node-negative breast cancer. Clin Cancer Res 1996; 2(3): 585–592.
    • (1996) Clin Cancer Res , vol.2 , Issue.3 , pp. 585-592
    • Brown, R.W.1    Allred, C.D.2    Clark, G.M.3
  • 41
    • 0037089663 scopus 로고    scopus 로고
    • Correlation between MIB-1 and other proliferation markers
    • Spyratos F, Ferrero-Poüs M, Trassard M, et al. Correlation between MIB-1 and other proliferation markers. Cancer 2002; 94(8): 2151–2159.
    • (2002) Cancer , vol.94 , Issue.8 , pp. 2151-2159
    • Spyratos, F.1    Ferrero-Poüs, M.2    Trassard, M.3
  • 42
    • 0030462119 scopus 로고    scopus 로고
    • Proliferation marker MIB-1 correlates well with proliferative activity evaluated by BrdU in breast cancer: an immunohistochemical study including correlation with PCNA, p53, c-erbB-2 and estrogen receptor status
    • Moriki T, Takahashi T, Kataoka H, et al. Proliferation marker MIB-1 correlates well with proliferative activity evaluated by BrdU in breast cancer: an immunohistochemical study including correlation with PCNA, p53, c-erbB-2 and estrogen receptor status. Pathol Int 1996; 46(12): 953–961.
    • (1996) Pathol Int , vol.46 , Issue.12 , pp. 953-961
    • Moriki, T.1    Takahashi, T.2    Kataoka, H.3
  • 43
    • 0030069047 scopus 로고    scopus 로고
    • Long term prognostic value of growth fraction determination by Ki-67 immunostaining in primary operable breast cancer
    • English
    • Pierga JY, Leroyer A, Viehl P, et al. Long term prognostic value of growth fraction determination by Ki-67 immunostaining in primary operable breast cancer. Breast Cancer Res Treat 1996; 37(1): 57–64. English.
    • (1996) Breast Cancer Res Treat , vol.37 , Issue.1 , pp. 57-64
    • Pierga, J.Y.1    Leroyer, A.2    Viehl, P.3
  • 44
    • 78649825336 scopus 로고    scopus 로고
    • Current and emerging biomarkers in breast cancer: prognosis and prediction
    • Weigel MT, Dowsett M. Current and emerging biomarkers in breast cancer: prognosis and prediction. Endocrine Relat Cancer 2010; 17(4): R245–R262.
    • (2010) Endocrine Relat Cancer , vol.17 , Issue.4 , pp. R245-R262
    • Weigel, M.T.1    Dowsett, M.2
  • 45
    • 27244443082 scopus 로고    scopus 로고
    • Proliferation marker Ki-67 in early breast cancer
    • Urruticoechea A, Smith IE, Dowsett M. Proliferation marker Ki-67 in early breast cancer. J Clin Oncol 2005; 23(28): 7212–7220.
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 7212-7220
    • Urruticoechea, A.1    Smith, I.E.2    Dowsett, M.3
  • 46
    • 84924246744 scopus 로고    scopus 로고
    • Invasive lobular carcinoma of the breast: morphology, biomarkers and ‘omics
    • Reed A, Kutasovic J, Lakhani S, et al. Invasive lobular carcinoma of the breast: morphology, biomarkers and ‘omics. Breast Cancer Res 2015; 17(1): 12. doi:10.1186/s13058-015-0519-x.
    • (2015) Breast Cancer Res , vol.17 , Issue.1 , pp. 12
    • Reed, A.1    Kutasovic, J.2    Lakhani, S.3
  • 47
    • 0033172879 scopus 로고    scopus 로고
    • Proliferative and apoptotic activity in lobular breast carcinoma
    • Krüger S, Fahrenkrog T, Müller H. Proliferative and apoptotic activity in lobular breast carcinoma. Int J Mol Med 1999; 4(2): 171–174.
    • (1999) Int J Mol Med , vol.4 , Issue.2 , pp. 171-174
    • Krüger, S.1    Fahrenkrog, T.2    Müller, H.3
  • 48
    • 3142765936 scopus 로고    scopus 로고
    • Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome
    • Arpino G, Bardou V, Clark G, et al. Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome. Breast Cancer Res 2004; 6(3): R149–R156.
    • (2004) Breast Cancer Res , vol.6 , Issue.3 , pp. R149-R156
    • Arpino, G.1    Bardou, V.2    Clark, G.3
  • 49
    • 0026320061 scopus 로고
    • Breast cancer cell kinetics: immunocytochemical determination of growth fractions by monoclonal antibody Ki-67 and correlation with flow cytometric S-phase and with some features of tumor aggressiveness
    • Gasparini G, Pozza F, Meli S, et al. Breast cancer cell kinetics: immunocytochemical determination of growth fractions by monoclonal antibody Ki-67 and correlation with flow cytometric S-phase and with some features of tumor aggressiveness. Anticancer Res 1991; 11(6): 2015–2021.
    • (1991) Anticancer Res , vol.11 , Issue.6 , pp. 2015-2021
    • Gasparini, G.1    Pozza, F.2    Meli, S.3
  • 50
    • 0026461059 scopus 로고
    • Value of epidermal growth factor receptor status compared with growth fraction and other factors for prognosis in early breast cancer
    • Gasparini G, Bevilacqua P, Pozza F, et al. Value of epidermal growth factor receptor status compared with growth fraction and other factors for prognosis in early breast cancer. Br J Cancer 1992; 66(5): 970–976.
    • (1992) Br J Cancer , vol.66 , Issue.5 , pp. 970-976
    • Gasparini, G.1    Bevilacqua, P.2    Pozza, F.3
  • 51
    • 0027309375 scopus 로고
    • Relationship between EGF-R, c-erbB-2 protein expression and Ki67 immunostaining in breast cancer and hormone sensitivity
    • Nicholson RI, McClelland RA, Finlay P, et al. Relationship between EGF-R, c-erbB-2 protein expression and Ki67 immunostaining in breast cancer and hormone sensitivity. Europ J Cancer 1993; 29(7): 1018–1023.
    • (1993) Europ J Cancer , vol.29 , Issue.7 , pp. 1018-1023
    • Nicholson, R.I.1    McClelland, R.A.2    Finlay, P.3
  • 52
    • 0029844506 scopus 로고    scopus 로고
    • The prognostic significance of epidermal growth factor receptor (EGFR), C-erbB-2, Ki-67 and PCNA expression in breast cancer
    • Ioachim E, Kamina S, Athanassiadou S, et al. The prognostic significance of epidermal growth factor receptor (EGFR), C-erbB-2, Ki-67 and PCNA expression in breast cancer. Anticancer Res 1996; 16(5B): 3141–3147.
    • (1996) Anticancer Res , vol.16 , Issue.5B , pp. 3141-3147
    • Ioachim, E.1    Kamina, S.2    Athanassiadou, S.3
  • 53
    • 0034896073 scopus 로고    scopus 로고
    • Measures of cell turnover (proliferation and apoptosis) and their association with survival in breast cancer
    • Liu S, Edgerton SM, Moore DH, et al. Measures of cell turnover (proliferation and apoptosis) and their association with survival in breast cancer. Clin Cancer Res 2001; 7(6): 1716–1723.
    • (2001) Clin Cancer Res , vol.7 , Issue.6 , pp. 1716-1723
    • Liu, S.1    Edgerton, S.M.2    Moore, D.H.3
  • 54
    • 0030758884 scopus 로고    scopus 로고
    • Ki-67 immunostaining in 322 primary breast cancers: associations with clinical and pathological variables and prognosis
    • Molino A, Micciolo R, Turazza M, et al. Ki-67 immunostaining in 322 primary breast cancers: associations with clinical and pathological variables and prognosis. Int J Cancer 1997; 74(4): 433–437.
    • (1997) Int J Cancer , vol.74 , Issue.4 , pp. 433-437
    • Molino, A.1    Micciolo, R.2    Turazza, M.3
  • 55
    • 0026099714 scopus 로고
    • Ki-67 immunostaining in human breast tumors and its relationship to prognosis
    • Wintzer HO, Zipfel I, Schulte-Mönting J, et al. Ki-67 immunostaining in human breast tumors and its relationship to prognosis. Cancer 1991; 67(2): 421–428.
    • (1991) Cancer , vol.67 , Issue.2 , pp. 421-428
    • Wintzer, H.O.1    Zipfel, I.2    Schulte-Mönting, J.3
  • 56
    • 84863205849 scopus 로고    scopus 로고
    • NIH Image to ImageJ: 25 years of image analysis
    • Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Method 2012; 9(7): 671–675.
    • (2012) Nat Method , vol.9 , Issue.7 , pp. 671-675
    • Schneider, C.A.1    Rasband, W.S.2    Eliceiri, K.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.