Enzyme inhibitor examples for the treatment of breast cancer

Enzymes and their Inhibitors: Drug Development

Volumn , Issue , 2004, Pages 221-241

  Lawrence Woo, L W ^a  

^a University of Bath   (United Kingdom)

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EID: 85056681734     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (12)

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4. Akhtar, M., Njar, V.C., and Wright, J.N. (1993). Mechanistic studies on aromatase and related C-C bond cleavage P450 enzymes. Journal of Steroid Biochemistry and Molecular Biology, 44, 375-387.
5. Kao, Y.C., Korzekwa, K.R., Laughton, C.A. et al. (2001). Evaluation of the mechanism of aromatase cytochrome P450. A site-directed mutagenesis study. European Journal of Biochemistry, 268, 243-251.
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7. Poirier, D., Ciobanu, L.C. and Maltais, R. (1999). Steroid sulfatase inhibitors. Expert Opinion on Therapeutic Patents, 9, 1083-1099.
8. Nussbaumer, P. and Billich, A. (2003). Steroid sulfatase inhibitors. Expert Opinion on Therapeutic Patents, 13, 605-625.
9. Smith, H.J., Nichols, P.J., Simons, C., and Le Lain, R. (2001). Inhibitors of steroidogenesis as agents for the treatment of hormone-dependent cancers. Expert Opinion on Therapeutic Patents, 11, 789-824.
10. Hernandez-Guzman, F.G., Higashiyama, T., Pangborn, W. et al. (2003). Structure of human estrone sulfatase suggests functional roles of membrane association. Journal of Biological Chemistry, 278, 22989-22997.
11. Woo, L.W.L., Purohit, A., Malini, B. et al. (2000). Potent active site-directed inhibition of steroid sulfatase by tricyclic coumarin-based sulfamates. Chemistry & Biology, 7, 773-791.
12. Woo, L.W.L., Sutcliffe, O.B., Bubert, C. et al. (2003). First dual aromatase-steroid sulfatase inhibitors. Journal of Medicinal Chemistry, 46, 3193-3196.