An emerging epigenetic framework of systemic and central mechanisms underlying stress-related disorders

Neuropsychopharmacology

Volumn 44, Issue 1, 2019, Pages 235-236

  Nasca, Carla ^a   Rasgon, Natalie ^a,b   McEwen, Bruce ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEVACECARNINE;

ALLOSTASIS; ARTICLE; BRAIN REGION; CENTRAL NERVOUS SYSTEM DISEASE; COGNITION; DISEASE SEVERITY; EMOTION; EPIGENETICS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HYPERCORTISOLISM; PRIORITY JOURNAL; STRESS; ANIMAL; GENETIC EPIGENESIS; GENETICS; PATHOPHYSIOLOGY; POSTTRAUMATIC STRESS DISORDER;

ANIMALS; EPIGENESIS, GENETIC; HUMANS; STRESS DISORDERS, TRAUMATIC;

EID: 85056671912     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/s41386-018-0227-1     Document Type: Article

References (6)

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2. Nasca C, Bigio B, Lee FS, Young SP, Kautz MM, Albright A, et al. Acetyl-l-carnitine deficiency in patients with major depressive disorder. Proceedings of the National Academy of Sciences. 2018;115:8627–32.
3. Nasca C, Xenos D, Barone Y, Caruso A, Scaccianoce S, Matrisciano F, et al. L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. Proc Natl Acad Sci USA. 2013;110:4804–9.
4. Bigio B, Mathe AA, Sousa VC, Zelli D, Svenningsson P, McEwen BS, et al. Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance. Proc Natl Acad Sci USA. 2016;113:7906–11.
5. Nasca C, Bigio B, Zelli D, de Angelis P, Lau T, Okamoto M, et al. Role of the astroglial glutamate exchanger xCT in ventral hippocampus in resilience to stress. Neuron. 2017;96:402–13. e405
6. Akil H, Gordon J, Hen R, Javitch J, Mayberg H, McEwen B, et al. Treatment resistant depression: a multi-scale, systems biology approach. Neurosci Biobehav Rev. 2017;84:272–88.