Monthly High-Dose Vitamin D Supplementation and Cancer Risk: A Post Hoc Analysis of the Vitamin D Assessment Randomized Clinical Trial

JAMA Oncology

Volumn 4, Issue 11, 2018, Pages

  Scragg, Robert ^a   Khaw, Kay Tee ^b   Toop, Les ^c   Sluyter, John ^a   Lawes, Carlene M M ^a   Waayer, Debbie ^a   Giovannucci, Edward ^d   Camargo, Carlos A ^e  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; COLECALCIFEROL; PLACEBO; 25-HYDROXYVITAMIN D; VITAMIN D;

ADULT; AGED; ARTICLE; CANCER INCIDENCE; CANCER MORTALITY; CANCER PREVENTION; CANCER RISK; COMMUNITY CARE; CONTROLLED STUDY; DATA ANALYSIS; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; ETHNICITY; EUROPEAN; FEMALE; FOLLOW UP; GENERAL PRACTICE; HAZARD RATIO; HUMAN; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASM; NEW ZEALAND; NUTRITIONAL ASSESSMENT; PATIENT COMPLIANCE; POLYNESIAN; POST HOC ANALYSIS; RACE DIFFERENCE; RANDOMIZED CONTROLLED TRIAL; SOUTH ASIAN; TREATMENT OUTCOME; VERY ELDERLY; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; DIETARY SUPPLEMENT; INCIDENCE; MIDDLE AGED; NEOPLASM; TIME FACTOR;

AGED; AGED, 80 AND OVER; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; NEOPLASMS; TIME FACTORS; VITAMIN D;

EID: 85056379649     PISSN: 23742437     EISSN: 23742445     Source Type: Journal    
DOI: 10.1001/jamaoncol.2018.2178     Document Type: Article

References (36)

1. Garland CF, Garland FC. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol. 1980; 9 (3): 227-231. doi: 10.1093/ije/9.3.227 7440046
2. Garland FC, Garland CF, Gorham ED, Young JF. Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prev Med. 1990; 19 (6): 614-622. doi: 10.1016/0091-7435(90)90058-R 2263572
3. Schwartz GG, Hulka BS. Is vitamin D deficiency a risk factor for prostate cancer? (Hypothesis). Anticancer Res. 1990; 10 (5A): 1307-1311. 2241107
4. Lefkowitz ES, Garland CF. Sunlight, vitamin D, and ovarian cancer mortality rates in US women. Int J Epidemiol. 1994; 23 (6): 1133-1136. doi: 10.1093/ije/23.6.1133 7721513
5. Gandini S, Boniol M, Haukka J, Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma. Int J Cancer. 2011; 128 (6): 1414-1424. doi: 10.1002/ijc.25439 20473927
6. Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H. Meta-analysis: serum vitamin D and breast cancer risk. Eur J Cancer. 2010; 46 (12): 2196-2205. doi: 10.1016/j.ejca.2010.03.037 20456946
7. Lee JE, Li H, Chan AT, Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studies. Cancer Prev Res (Phila). 2011; 4 (5): 735-743. doi: 10.1158/1940-6207.CAPR-10-0289 21430073
8. Afzal S, Brøndum-Jacobsen P, Bojesen SE, Nordestgaard BG. Genetically low vitamin D concentrations and increased mortality: mendelian randomisation analysis in three large cohorts. BMJ. 2014; 349: g6330. doi: 10.1136/bmj.g6330 25406188
9. Ong JS, Cuellar-Partida G, Lu Y,; Australian Ovarian Cancer Study. Association of vitamin D levels and risk of ovarian cancer: a mendelian randomization study. Int J Epidemiol. 2016; 45 (5): 1619-1630. doi: 10.1093/ije/dyw207 27594614
10. Dimitrakopoulou VI, Tsilidis KK, Haycock PC,; GECCO Consortium; PRACTICAL Consortium; GAME-ON Network (CORECT, DRIVE, ELLIPSE, FOCI-OCAC, TRICL-ILCCO). Circulating vitamin D concentration and risk of seven cancers: mendelian randomisation study. BMJ. 2017; 359: j4761. doi: 10.1136/bmj.j4761 29089348
11. Wactawski-Wende J, Kotchen JM, Anderson GL,; Women's Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med. 2006; 354 (7): 684-696. doi: 10.1056/NEJMoa055222 16481636
12. Chlebowski RT, Johnson KC, Kooperberg C,; Women's Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of breast cancer. J Natl Cancer Inst. 2008; 100 (22): 1581-1591. doi: 10.1093/jnci/djn360 19001601
13. Brunner RL, Wactawski-Wende J, Caan BJ, The effect of calcium plus vitamin D on risk for invasive cancer: results of the Women's Health Initiative (WHI) calcium plus vitamin D randomized clinical trial. Nutr Cancer. 2011; 63 (6): 827-841. doi: 10.1080/01635581.2011.594208 21774589
14. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 2007; 85 (6): 1586-1591. doi: 10.1093/ajcn/85.6.1586 17556697
15. Lappe J, Watson P, Travers-Gustafson D, Effect of vitamin D and calcium supplementation on cancer incidence in older women: a randomized clinical trial. JAMA. 2017; 317 (12): 1234-1243. doi: 10.1001/jama.2017.2115 28350929
16. Scragg R, Stewart AW, Waayer D, Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the Vitamin D Assessment Study: a randomized clinical trial. JAMA Cardiol. 2017; 2 (6): 608-616. doi: 10.1001/jamacardio.2017.0175 28384800
17. Keum N, Giovannucci E. Vitamin D supplements and cancer incidence and mortality: a meta-analysis. Br J Cancer. 2014; 111 (5): 976-980. doi: 10.1038/bjc.2014.294 24918818
18. Scragg R, Waayer D, Stewart AW, The Vitamin D Assessment (ViDA) Study: design of a randomized controlled trial of vitamin D supplementation for the prevention of cardiovascular disease, acute respiratory infection, falls and non-vertebral fractures. J Steroid Biochem Mol Biol. 2016; 164: 318-325. doi: 10.1016/j.jsbmb.2015.09.010 26365555
19. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, Del Valle HB, eds. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academies Press; 2011.
20. Ministry of Health New Zealand. Enrolment in a primary health organisation. https://www.health.govt.nz/our-work/primary-health-care/about-primary-health-organisations/enrolment-primary-health-organisation. Accessed February 05, 2018.
21. Wareham NJ, Jakes RW, Rennie KL, Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation Into Cancer and Nutrition (EPIC) study. Public Health Nutr. 2003; 6 (4): 407-413. doi: 10.1079/PHN2002439 12795830
22. Scragg R, Jackson R, Holdaway IM, Lim T, Beaglehole R. Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: a community-based study. Int J Epidemiol. 1990; 19 (3): 559-563. doi: 10.1093/ije/19.3.559 2262248
23. Ilahi M, Armas LA, Heaney RP. Pharmacokinetics of a single, large dose of cholecalciferol. Am J Clin Nutr. 2008; 87 (3): 688-691. doi: 10.1093/ajcn/87.3.688 18326608
24. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes [published corrections appear in Am J Clin Nutr. 2006;84(5):1253 and Am J Clin Nutr. 2007;86(3):809]. Am J Clin Nutr. 2006; 84 (1): 18-28. doi: 10.1093/ajcn/84.1.18 16825677
25. Scragg R, Sowers M, Bell C; Third National Health and Nutrition Examination Survey. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care. 2004; 27 (12): 2813-2818. doi: 10.2337/diacare.27.12.2813 15562190
26. Black PN, Scragg R. Relationship between serum 25-hydroxyvitamin D and pulmonary function in the Third National Health and Nutrition Examination Survey. Chest. 2005; 128 (6): 3792-3798. doi: 10.1378/chest.128.6.3792 16354847
27. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens. 2007; 20 (7): 713-719. doi: 10.1016/j.amjhyper.2007.01.017 17586404
28. Vitamin D External Quality Assessment Scheme program. http://www.deqas.org. Accessed March 28, 2018.
29. Sachs MC, Shoben A, Levin GP, Estimating mean annual 25-hydroxyvitamin D concentrations from single measurements: the Multi-ethnic Study of Atherosclerosis. Am J Clin Nutr. 2013; 97 (6): 1243-1251. doi: 10.3945/ajcn.112.054502 23615830
30. Ministry of Health New Zealand. New Zealand Cancer Registry-table of available data. https://www.health.govt.nz/nz-health-statistics/national-collections-and-surveys/collections/new-zealand-cancer-registry-nzcr/new-zealand-cancer-registry-table-available-data. Accessed February 05, 2018.
31. Cunningham R, Sarfati D, Hill S, Kenwright D. An audit of colon cancer data on the New Zealand Cancer Registry. N Z Med J. 2008; 121 (1279): 46-56. 18709047
32. Martinaityte I, Kamycheva E, Didriksen A, Jakobsen J, Jorde R. Vitamin D stored in fat tissue during a 5-year intervention affects serum 25-hydroxyvitamin D levels the following year. J Clin Endocrinol Metab. 2017; 102 (10): 3731-3738. doi: 10.1210/jc.2017-01187 28973683
33. OpenEpi-Toolkit Shell for Developing New Applications. http://www.openepi.com/Power/PowerRCT.htm. Accessed February 5, 2018.
34. Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ. 2003; 326 (7387): 469. doi: 10.1136/bmj.326.7387.469 12609940
35. Hollis BW, Wagner CL. Clinical review: the role of the parent compound vitamin D with respect to metabolism and function: why clinical dose intervals can affect clinical outcomes. J Clin Endocrinol Metab. 2013; 98 (12): 4619-4628. doi: 10.1210/jc.2013-2653 24106283
36. Heaney RP, Armas LA. Quantifying the vitamin D economy. Nutr Rev. 2015; 73 (1): 51-67. doi: 10.1093/nutrit/nuu004 26024057