Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis of the MAL-ED cohort study

The Lancet Global Health

Volumn 6, Issue 12, 2018, Pages e1309-e1318

  Platts Mills, James A ^a   Liu, Jie ^a   Rogawski, Elizabeth T ^a   Kabir, Furqan ^b   Lertsethtakarn, Paphavee ^c   Siguas, Mery ^d   Khan, Shaila S ^e   Praharaj, Ira ^f   Murei, Arinao ^g   Nshama, Rosemary ^h   Mujaga, Buliga ⁱ   Havt, Alexandre ^j   Maciel, Irene A ^k   McMurry, Timothy L ^a   Operario, Darwin J ^a   Taniuchi, Mami ^a   Gratz, Jean ^a   Stroup, Suzanne E ^a   Roberts, James H ^a   Kalam, Adil ^b   Aziz, Fatima ^b   Qureshi, Shahida ^b   Islam, M Ohedul ^e   Sakpaisal, Pimmada ^c   Silapong, Sasikorn ^c   Yori, Pablo P ^d,l   Rajendiran, Revathi ^f   Benny, Blossom ^f   McGrath, Monica ^l,m   McCormick, Benjamin J J ^m   Seidman, Jessica C ^m   Lang, Dennis ^m   Gottlieb, Michael ^m   Guerrant, Richard L ^a   Lima, Aldo A M ^j   Leite, Jose Paulo ^k   Samie, Amidou ^g   Bessong, Pascal O ^g   Page, Nicola ⁿ   Bodhidatta, Ladaporn ^c   Mason, Carl ^c   Shrestha, Sanjaya ^o,p   Kiwelu, Ireen ⁱ   Mduma, Estomih R ^h   Iqbal, Najeeha T ^b   Bhutta, Zulfiqar A ^b   Ahmed, Tahmeed ^e   Haque, Rashidul ^e   Kang, Gagandeep ^f   Kosek, Margaret N ^d,l   Houpt, Eric R ^a   Acosta, Angel Mendez ^q   Rios de Burga, Rosa ^q   Chavez, Cesar Banda ^q   Flores, Julian Torres ^q   Olotegui, Maribel Paredes ^q   Pinedo, Silvia Rengifo ^q   Trigoso, Dixner Rengifo ^q   Vasquez, Angel Orbe ^q   Ahmed, Imran ^q   Alam, Didar ^q   Ali, Asad ^q   Rasheed, Muneera ^q   Soofi, Sajid ^q   Turab, Ali ^q   Yousafzai, Aisha ^q   Zaidi, Anita KM ^q   Shrestha, Binob ^q   Rayamajhi, Bishnu Bahadur ^q   Strand, Tor ^q   Ammu, Geetha ^q   Babji, Sudhir ^q   Bose, Anuradha ^q   George, Ajila T ^q   Hariraju, Dinesh ^q   Jennifer, M Steffi ^q   John, Sushil ^q   Kaki, Shiny ^q   Karunakaran, Priyadarshani ^q   Koshy, Beena ^q   Lazarus, Robin P ^q   Muliyil, Jayaprakash ^q   Ragasudha, Preethi ^q   Raghava, Mohan Venkata ^q   Raju, Sophy ^q   Ramachandran, Anup ^q   Ramadas, Rakhi ^q   Ramanujam, Karthikeyan ^q   Rose, Anuradha ^q   Roshan, Reeba ^q   Sharma, Srujan L ^q   Sundaram, Shanmuga ^q   Thomas, Rahul J ^q   Pan, William K ^q   Ambikapathi, Ramya ^q   Carreon, J Daniel ^q   Doan, Viyada ^q   Hoest, Christel ^q   Knobler, Stacey ^q   Miller, Mark A ^q   Psaki, Stephanie ^q   Rasmussen, Zeba ^q   Richard, Stephanie A ^q   Tountas, Karen H ^q   Svensen, Erling ^q   Amour, Caroline ^q   Bayyo, Eliwaza ^q   Mvungi, Regisiana ^q   Pascal, John ^q   Yarrot, Ladislaus ^q   Barrett, Leah ^q   Dillingham, Rebecca ^q   Petri, William A ^q   Scharf, Rebecca ^q   Ahmed, AM Shamsir ^q   Alam, Md Ashraful ^q   Haque, Umma ^q   Hossain, Md Iqbal ^q   Islam, Munirul ^q   Mahfuz, Mustafa ^q   Mondal, Dinesh ^q   Nahar, Baitun ^q   Tofail, Fahmida ^q   Chandyo, Ram Krishna ^q   Shrestha, Prakash Sunder ^q   Shrestha, Rita ^q   Ulak, Manjeswori ^q   Bauck, Aubrey ^q   Black, Robert ^q   Caulfield, Laura ^q   Checkley, William ^q   Lee, Gwenyth ^q   Schulze, Kerry ^q   Scott, Samuel ^q   Murray Kolb, Laura E ^q   Ross, A Catharine ^q   Schaefer, Barbara ^q   Simons, Suzanne ^q   Pendergast, Laura ^q   Abreu, Cláudia B ^q   Costa, Hilda ^q   Di Moura, Alessandra ^q   Filho, José Quirino ^q   Leite, Álvaro M ^q   Lima, Noélia L ^q   Lima, Ila F ^q   Maciel, Bruna LL ^q   Medeiros, Pedro HQS ^q   Moraes, Milena ^q   Mota, Francisco S ^q   Oriá, Reinaldo B ^q   Quetz, Josiane ^q   Soares, Alberto M ^q   Mota, Rosa MS ^q   Patil, Crystal L ^q   Mahopo, Cloupas ^q   Maphula, Angelina ^q   Nyathi, Emanuel ^q   more..

^a UNIVERSITY OF VIRGINIA   (United States)

^b AGA KHAN UNIVERSITY   (Pakistan)

^c ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

^d ASOCIACIÓN BENÉFICA PRISMA   (Peru)

^e INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH   (Bangladesh)

^f CHRISTIAN MEDICAL COLLEGE   (India)

^g UNIVERSITY OF VENDA   (South Africa)

^h Haydom Global Health Institute   (Tanzania)

ⁱ KILIMANJARO CLINICAL RESEARCH INSTITUTE   (Tanzania)

^j FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^k INSTITUTO OSWALDO CRUZ   (Brazil)

^l JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^m NATIONAL INSTITUTES OF HEALTH   (United States)

ⁿ NATIONAL INSTITUTE FOR COMMUNICABLE DISEASES   (South Africa)

^o Walter Reed/AFRIMS Research Unit   (Nepal)

^p UNIVERSITY OF BERGEN   (Norway)

^q University of Bergen ^*

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRIDAE; ARTICLE; ASTROVIRIDAE; BLOODY DIARRHEA; CAMPYLOBACTER JEJUNI; CHILD; COHORT ANALYSIS; CRYPTOSPORIDIUM; DIARRHEA; DISEASE BURDEN; DISEASE SURVEILLANCE; ENTEROPATHOGEN; ESCHERICHIA COLI; FECES ANALYSIS; HUMAN; INFANT; MAJOR CLINICAL STUDY; NEWBORN; NOROVIRUS; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; ROTAVIRUS; SAPOVIRUS; SCORING SYSTEM; SHIGELLA; ASIA; BRAZIL; HEALTH CARE PLANNING; INCIDENCE; MOLECULAR DIAGNOSIS; PERU; REAL TIME POLYMERASE CHAIN REACTION; SOUTH AFRICA; SUPPLY AND DISTRIBUTION; TANZANIA;

ASIA, WESTERN; BRAZIL; CHILD, PRESCHOOL; COHORT STUDIES; DIARRHEA; HEALTH RESOURCES; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; MOLECULAR DIAGNOSTIC TECHNIQUES; PERU; REAL-TIME POLYMERASE CHAIN REACTION; SOUTH AFRICA; TANZANIA;

EID: 85056358756     PISSN: None     EISSN: 2214109X     Source Type: Journal    
DOI: 10.1016/S2214-109X(18)30349-8     Document Type: Article

References (31)

1. GBD Diarrhoeal Diseases Collaborators. Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Infect Dis 17 (2017), 909–948.
2. Guerrant, RL, Oria, RB, Moore, SR, Oria, MOB, Lima, AAM, Malnutrition as an enteric infectious disease with long-term effects on child development. Nutr Rev 66 (2008), 487–505.
3. Lorntz, B, Soares, AM, Moore, SR, et al. Early childhood diarrhea predicts impaired school performance. Pediatr Infect Dis J 25 (2006), 513–520.
4. Sreeramareddy, CT, Low, Y-P, Forsberg, BC, Slow progress in diarrhea case management in low and middle income countries: evidence from cross-sectional national surveys, 1985–2012. BMC Pediatr, 17, 2017, 83.
5. Operario, DJ, Platts-Mills, JA, Nadan, S, et al. Etiology of severe acute watery diarrhea in children in the Global Rotavirus Surveillance Network using quantitative polymerase chain reaction. J Infect Dis 216 (2017), 220–227.
6. Liu, J, Platts-Mills, JA, Juma, J, et al. Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study. Lancet 388 (2016), 1291–1301.
7. WHO. The treatment of diarrhoea. A manual for physicians and other senior health workers. 2005, World Health Organization, Geneva, 44.
8. Rogawski, ET, Platts-Mills, JA, Seidman, JC, et al. Use of antibiotics in children younger than two years in eight countries: a prospective cohort study. Bull World Health Organ 95 (2017), 49–61.
9. Pavlinac, PB, Denno, DM, John-Stewart, GC, et al. Failure of syndrome-based diarrhea management guidelines to detect shigella infections in Kenyan children. J Pediatric Infect Dis Soc 5 (2016), 366–374.
10. Tickell, KD, Brander, RL, Atlas, HE, Pernica, JM, Walson, JL, Pavlinac, PB, Identification and management of Shigella infection in children with diarrhoea: a systematic review and meta-analysis. Lancet Glob Health 5 (2017), e1235–e1248.
11. The Lancet Infectious Diseases. Time for global political action on antimicrobial resistance. Lancet Infect Dis, 16, 2016, 1085.
12. Laxminarayan, R, Bhutta, ZA, Antimicrobial resistance–a threat to neonate survival. Lancet Glob Health 4 (2016), e676–e677.
13. MAL-ED Network Investigators. The MAL-ED study: a multinational and multidisciplinary approach to understand the relationship between enteric pathogens, malnutrition, gut physiology, physical growth, cognitive development, and immune responses in infants and children up to 2 years of age in resource-poor environments. Clin Infect Dis 59:suppl 4 (2014), S193–S206.
14. Platts-Mills, JA, Babji, S, Bodhidatta, L, et al. Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED). Lancet Glob Health 3 (2015), e564–e575.
15. Das, SK, Ahmed, S, Ferdous, F, et al. Etiological diversity of diarrhoeal disease in Bangladesh. J Infect Dev Ctries 7 (2013), 900–909.
16. Lluque, A, Mosquito, S, Gomes, C, et al. Virulence factors and mechanisms of antimicrobial resistance in Shigella strains from periurban areas of Lima (Peru). Int J Med Microbiol 305 (2015), 480–490.
17. Temu, MM, Kaatano, GM, Miyaye, ND, et al. Antimicrobial susceptibility of Shigella flexneri and S. dysenteriae isolated from stool specimens of patients with bloody diarrhoea in Mwanza, Tanzania. Tanzan Health Res Bull 9 (2007), 186–189.
18. Davey, PG, Marwick, C, Appropriate vs. inappropriate antimicrobial therapy. Clin Microbiol Infect 14:suppl 3 (2008), 15–21.
19. Houpt, ER, Gratz, J, Kosek, M, et al. Microbiologic methods utilized in the MAL-ED cohort study. Clin Infect Dis 59:suppl 4 (2014), S225–S232.
20. Liu, J, Gratz, J, Amour, C, et al. Optimization of quantitative PCR methods for enteropathogen detection. PLoS One, 11, 2016, e0158199.
21. Liu, J, Kabir, F, Manneh, J, et al. Development and assessment of molecular diagnostic tests for 15 enteropathogens causing childhood diarrhoea: a multicentre study. Lancet Infect Dis 14 (2014), 716–724.
22. Liu, J, Almeida, M, Kabir, F, et al. Direct detection of shigella in stool specimens by use of a metagenomic approach. J Clin Microbiol 56 (2018), e01374–e01417.
23. Bruzzi, P, Green, SB, Byar, DP, Brinton, LA, Schairer, C, Estimating the population attributable risk for multiple risk factors using case-control data. Am J Epidemiol 122 (1985), 904–914.
24. Youden, WJ, Index for rating diagnostic tests. Cancer 3 (1950), 32–35.
25. Sanchez, GJ, Mayta, H, Pajuelo, MJ, et al. Epidemiology of sapovirus infections in a birth cohort in Peru. Clin Infect Dis 66 (2018), 1858–1863.
26. Levine, GA, Walson, JL, Atlas, HE, Lamberti, LM, Pavlinac, PB, Defining pediatric diarrhea in low-resource settings. J Pediatric Infect Dis Soc 6 (2017), 289–293.
27. Wierzba, TF, Bourgis, A, Defining cases of severe pediatric diarrhea for an efficacy trial of an enterotoxigenic Escherichia coli (ETEC) vaccine: report on an international workshop, Washington DC, March 2016. Vaccine 35 (2017), 503–507.
28. Rogawski, ET, Liu, J, Platts-Mills, JA, et al. Use of quantitative molecular diagnostic methods to investigate the effect of enteropathogen infections on linear growth in children in low-resource settings: longitudinal analysis of results from the MAL-ED cohort study. Lancet Glob Health, 2018 published online Oct 1. http://dx.doi.org/10.1016/S2214-109X(18)30351-6.
29. Martin, JM, Pitetti, R, Maffei, F, Tritt, J, Smail, K, Wald, ER, Treatment of shigellosis with cefixime: two days vs. five days. Pediatr Infect Dis J 19 (2000), 522–526.
30. Fleming-Dutra, KE, Hersh, AL, Shapiro, DJ, et al. Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010–2011. JAMA 315 (2016), 1864–1873.
31. Elias, C, Moja, L, Mertz, D, Loeb, M, Forte, G, Magrini, N, Guideline recommendations and antimicrobial resistance: the need for a change. BMJ Open, 7, 2017, e016264.