Can the UNAIDS 90-90-90 target be achieved? A systematic analysis of national HIV treatment cascades

BMJ Global Health

Volumn 1, Issue 2, 2016, Pages

  Levi, Jacob ^a   Raymond, Alice ^a   Pozniak, Anton ^b   Vernazza, Pietro ^c   Kohler, Philipp ^c   Hill, Andrew ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^c CANTONAL HOSPITAL ST GALLEN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85055634102     PISSN: None     EISSN: 20597908     Source Type: Journal    
DOI: 10.1136/bmjgh-2015-000010     Document Type: Article

References (49)

1. The Joint United Nations Programme on HIV/AIDS. 90-90-90 An ambitious treatment target to help end the AIDS epidemic. 2014; JC2684. http://www.unaids.org/sites/default/files/media_asset/90-90-90_en_0.pdf
2. Lundgren JD, Babiker AG, Gordin F, et al., The INSIGHT START Study Group. Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection. N Engl J Med 2015;373:795-807.
3. Cohen MS, Chen YQ, McCauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 2011;365:493-505.
4. Gruskin S, Tarantola D. Universal Access to HIV prevention, treatment and care: assessing the inclusion of human rights in international and national strategic plans. AIDS 2008;22(Suppl 2): S123-32.
5. Gardner EM, McLees MP, Steiner JF, et al. The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infection. Clin Infect Dis 2011;52:793-800.
6. Danel C, Moh R, Gabillard D, TEMPRANO ANRS 12136 Study Group. A trial of early antiretrovirals and isoniazid preventive therapy in Africa. N Engl J Med 2015;373:808-22.
7. Doherty M. New directions in the 2015 WHO Consolidated ARV Guidelines.presentation SUSA0608, 2. Eighth International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015); Vancouver, Canada
8. Hull MW, Wu Z, Montaner JS. Optimizing the engagement of care cascade: a critical step to maximize the impact of HIV treatment as prevention. Curr Opin HIV AIDS 2012;7:579-86.
9. Kranzer K, Ford N. Unstructured treatment interruption of antiretroviral therapy in clinical practice: a systematic review. Trop Med Int Health 2011;16:1297-313.
10. Lourenço L, Hull M, Nosyk B, et al. The need for standardisation of the HIV continuum of care. Lancet HIV 2015;2:e225-6.
11. Joint United Nations Programme on HIV/AIDS. How AIDS changed everything. MDG6: 15 years, 15 lessons of hope from the AIDS response 2015;UNAIDS. http://www.unaids.org/sites/default/files/media_asset/MDG6Report_en.pdf
12. Boender TS, Sigaloff KC, McMahon JH, et al. Long-term Virological Outcomes of First-Line Antiretroviral Therapy for HIV-1 in Low- and Middle-Income Countries: a Systematic Review and Meta-analysis. Clin Infect Dis 2015;61:1453-61.
13. Nosyk B, Montaner JS, Colley G, et al., STOP HIV/AIDS Study Group. The cascade of HIV care in British Columbia, Canada, 1996-2011: a population-based retrospective cohort study. Lancet Infect Dis 2014;14:40-9.
14. Chamie G, Clark TD, Kabami J, et al. A hybrid mobile approach for population-wide HIV testing in rural east Africa: an observational study. The Lancet HIV 2016;3:e111-9.
15. Maman, David, et al. "Closer to 90-90-90. The cascade of care after 10 years of ART scale-up in rural Malawi: a population study." Journal of the International AIDS Society 19.1, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26894388
16. Baral S, Grosso A, Mnisi Z, et al. Examining prevalence of HIV infection and risk factors among female sex workers (FSW) and men who have sex with men (MSM) in Swaziland. Baltimore, MD: Research to Prevention, 2013.
17. Joint United Nations Programme on HIV/AIDS (UNAIDS). UNGASS Country level reports (GARPR). GLOBAL AIDS RESPONSE PROGRESS REPORTING 2015 2015;JC2702E. http://www.unaids. org/sites/default/files/media_asset/JC2702_GARPR2015 guidelines_en.pdf
18. Bradley H, Hall I, Wolitski RJ, et al. Vital Signs: HIV Diagnosis, Care, and Treatment Among Persons Living with HIV - United States, 2011 Weekly November 28, 2014. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6347a5.htm
19. Public Health England. HIV in the United Kingdom: 2014 Report. London: Public Health England, 2014.
20. Supervie V. The spectrum of engagement in HIV care in France: strengths and gaps. Abstract: 1030. ed. Atlanta, USA: 20th Conference on Retroviruses and Opportunistic Infections; March 2013.
21. The Kirby Institute. HIV, viral hepatitis and sexually transmissible infections. Australia Annual Surveillance Report 2014 HIV Supplement. UNSW Sydney: The Kirby Institute for infection and immunity in society 2014. Report number: UNSW, NSW 2052; September 2014.
22. Van Sighem A, Gras L, Kesselring A, et al. Monitoring Programme report 2014: Human Immunodefificeny Virus (HIV) infection in the Netherland. 2014. http://www.hiv-monitoring.nl/files/8914/1527/1076/SHM_Monitoring_report_2014.pdf
23. Pokrovskaya A, Popova A, Ladnaya N, et al. The Cascade of HIV Care in Russia, 2011-2013. J Int AIDS Soc 2014;17(Suppl 3): 19506.
24. Nsanzimana S. Rwanda HIV cascade - towards 90-90-90 targets. International AIDS Society Conference TUSY0403 2015; Rwanda: Rwanda Biomedical Centre, (New directions in ARV guidelines: programmatic updates) Rwanda HIV cascade - towards 90-90-90 targets, 2015.
25. Barth RE, van der Loeff MF, Schuurman R, et al. Virological follow-up of adult patients in antiretroviral treatment programmes in sub-Saharan Africa: a systematic review. Lancet Infect Dis 2010;10:155-66.
26. Camoni L, Raimondo M, Dorrucci M, et al. Estimating minimum adult HIV prevalence: a cross-sectional study to assess the characteristics of people living with HIV in Italy. AIDS Res Hum Retroviruses 2015;31:282-7.
27. Kelly SL, Wilson DP. HIV cascade monitoring and simple modeling reveal potential for reductions in HIV incidence. J Acquir Immune Defic Syndr 2015;69:257-63.
28. Hayes R, Ayles H, Beyers N, et al., HPTN 071 (PopART) Study Team. HPTN 071 (PopART): rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment - a study protocol for a cluster randomised trial. Trials 2014;15:57.
29. Bolsewicz K, Vallely A, Debattista J, et al. Factors impacting HIV testing: a review - perspectives from Australia, Canada, and the UK. AIDS Care 2015;27:570-80.
30. Underwood C, Hendrickson Z, Van Lith LM, et al. Role of community-level factors across the treatment cascade: a critical review. J Acquir Immune Defic Syndr 2014;66(Suppl 3): S311-18.
31. Musheke M, Ntalasha H, Gari S, et al. A systematic review of qualitative findings on factors enabling and deterring uptake of HIV testing in Sub-Saharan Africa. BMC Public Health 2013;13:220.
32. Mayer K, Gazzard B, Zuniga JM, et al, International Association of Physicians in AIDS Care. Controlling the HIV epidemic with antiretrovirals: IAPAC consensus statement on treatment as prevention and preexposure prophylaxis. J Int Assoc Provid AIDS Care 2013;12:208-16.
33. Granich R, Crowley S, Vitoria M, et al. Highly active antiretroviral treatment as prevention of HIV transmission: review of scientific evidence and update. Curr Opin HIV AIDS 2010;5:298-304.
34. Medley A, Bachanas P, Grillo M, et al. Integrating prevention interventions for people living with HIV into care and treatment programs: a systematic review of the evidence. J Acquir Immune Defic Syndr 2015;68(Suppl 3):S286-96.
35. Napierala Mavedzenge S, Baggaley R, Corbett EL, et al. A review of self-testing for HIV: research and policy priorities in a new era of HIV prevention. Clin Infect Dis 2013;57:126-38.
36. Sabapathy K, Van den Bergh R, Fidler S, et al. Uptake of home-based voluntary HIV testing in sub-Saharan Africa: a systematic review and meta-analysis. PLoS Med 2012;9:e1001351.
37. Olney J, Braitstein P, Eaton JW, et al. Optimal Timing of Home- Based HIV Testing in Western Kenya Abstract number 51, Boston CROI.
38. Gari S, Doig-Acuña C, Smail T, et al. Access to HIV/AIDS care: a systematic review of socio-cultural determinants in low and high income countries. BMC Health Serv Res 2013;13:198.
39. Posse M, Meheus F, van Asten H, et al. Barriers to access to antiretroviral treatment in developing countries: a review. Trop Med Int Health 2008;13:904-13.
40. Rosen S. Maskew M, Fox MP, et al. Viral reservoirs/antiretroviral therapy randomized clinical trials, initiating ART at a patient's first clinic visit: the RapIT randomized trial abstract 28 session O-2: CROI Boston 23-26 Feburary 2016.
41. Liau A, Crepaz N, Lyles CM, et al, HIV/AIDS Prevention Research Synthesis (PRS) Team. Interventions to promote linkage to and utilization of HIV medical care among HIV-diagnosed persons: a qualitative systematic review, 1996-2011. AIDS Behav 2013;17:1941-62.
42. Quinn TC, Wawer MJ, Sewankambo N, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med 2000;342:921-9.
43. Heymer KJ, Wentzlaff-Eggebert M, Mortimer E, et al. An economic case for providing free access to antiretroviral therapy for HIV-positive people in South Australia. Sex Health 2012;9:220-6.
44. Crowley T, Mayers P. Trends in task shifting in HIV treatment in Africa: effectiveness, challenges and acceptability to the health professions. Afr J Prim Health Care Fam Med 2015;7 (1), Art. #807, 9 pages. http://dx.doi.org/10.4102/phcfm.v7i1.807 http://www.phcfm.org/index.php/phcfm/article/viewFile/807/pdf_1
45. Cameron D, Gerber A, Mbatha M, et al. Nurse initiation and maintenance of patients on antiretroviral therapy: Are nurses in primary care clinics initiating ART after attending NIMART training? S Afr Med J 2012;102:98-100.
46. Marco Antonio De Avila. Brazilian Ministry of Health, STD/AIDS epidemiological report, Ano III, numero 1, October 2014, Brasilia, Brazil. HIV epidemiology report, Brazilian Ministry of Health; October 2014.
47. Beer L, Skarbinski J. Adherence to antiretroviral therapy among HIV-infected adults in the United States. AIDS Educ Prev 2014;26:521-37.
48. Vitoria M, Ford N, Doherty M, et al. Simplification of antiretroviral therapy: a necessary step in the public health response to HIV/AIDS in resource-limited settings. Antivir Ther 2014;19(Suppl 3):31-7.
49. Achara T, Sorakij B. The system's status, access to antiretroviral therapy among people infected with HIV are expected to live in Thailand at the end of 2014. GARP (Reported from NAP-Plus, Thai GPO, AEM and NAPHA-Extension), as of 2014.