Comparison of time-to-first event and recurrent-event methods in randomized clinical trials

Circulation

Volumn 138, Issue 6, 2018, Pages 570-577

  Claggett, Brian ^a   Pocock, Stuart ^b   Wei, L J ^c   Pfeffer, Marc A ^a   McMurray, John J V ^d   Solomon, Scott D ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Clinical trial; Cox model; Heart failure; Recurrent events; Statistical methodology; Survival analysis

Indexed keywords

ARTICLE; CLINICAL OUTCOME; COMPARATIVE STUDY; DISEASE BURDEN; GENETIC HETEROGENEITY; HEART FAILURE; HOSPITALIZATION; HUMAN; MORTALITY; PATIENT RISK; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECURRENT DISEASE; RISK FACTOR; RISK REDUCTION; SIMULATION; BIOASSAY; COMPUTER SIMULATION; METHODOLOGY; PATHOPHYSIOLOGY; PHASE 3 CLINICAL TRIAL (TOPIC); PROCEDURES; STATISTICAL ANALYSIS; STATISTICAL MODEL; TIME FACTOR; TREATMENT OUTCOME;

CARDIOVASCULAR AGENT;

CARDIOVASCULAR AGENTS; CLINICAL TRIALS, PHASE III AS TOPIC; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; ENDPOINT DETERMINATION; HEART FAILURE; HOSPITALIZATION; HUMANS; MODELS, STATISTICAL; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECURRENCE; RESEARCH DESIGN; TIME FACTORS; TREATMENT OUTCOME;

EID: 85055605673     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.117.033065     Document Type: Article

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