Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats

BMC Pulmonary Medicine

Volumn 18, Issue 1, 2018, Pages

  Cheng, Yusheng ^a,b   Yu, Min ^b   Xu, Jian ^b   He, Mengyu ^b   Wang, Hong ^b   Kong, Hui ^b   Xie, Weiping ^b  

^a WANNAN MEDICAL COLLEGE   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Pulmonary hypertension; Pulmonary vascular remodeling; Shp2

Indexed keywords

COMPOUND PHPS 1; MONOCROTALINE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE SHP 2; STAT3 PROTEIN; UNCLASSIFIED DRUG; PTPN11 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTERY MEDIA; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; HEART HYPERTROPHY; HEART MUSCLE FIBROSIS; HEART RIGHT VENTRICLE HYPERTROPHY; HEMODYNAMIC PARAMETERS; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LUNG ARTERY PRESSURE; MALE; MIGRATION INHIBITION; MONOCROTALINE-INDUCED PULMONARY HYPERTENSION; NONHUMAN; PATHOGENESIS; PULMONARY ARTERIOLE; PULMONARY ARTERY SMOOTH MUSCLE CELL; RAT; RAT MODEL; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; VASCULAR REMODELING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECT; LUNG; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PULMONARY ARTERY; PULMONARY HYPERTENSION; SMOOTH MUSCLE CELL;

ANIMALS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; LUNG; MALE; MONOCROTALINE; MYOCYTES, SMOOTH MUSCLE; PLATELET-DERIVED GROWTH FACTOR; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 85054931852     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/s12890-018-0700-y     Document Type: Article

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