Targeting PDGF pathway in pulmonary arterial hypertension

Expert Opinion on Therapeutic Targets

Volumn 16, Issue 11, 2012, Pages 1055-1063

  Antoniu, Sabina Antonela ^a  

^a GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Imatinib; Platelet derived growth factor; Pulmonary arterial hypertension; Tyrosin kinases; Vascular remodeling

Indexed keywords

AIX 102; AMBRISENTAN; ANTIBODY; ANTIBODY IM 3G3; APTAMER; BOSENTAN; CORTICOSTEROID; CRENOLANIB; DASATINIB; E 10030; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ILOPROST; IMATINIB; NILOTINIB; ORANTINIB; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PREDNISOLONE; PROSTACYCLIN; SILDENAFIL; SIMVASTATIN; TADALAFIL; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; DOSE RESPONSE; DRUG TARGETING; ENZYME INHIBITION; GASTROINTESTINAL STROMAL TUMOR; HEART VENTRICLE REMODELING; HUMAN; HYPEREOSINOPHILIC SYNDROME; MYELODYSPLASTIC SYNDROME; NEOPLASM; NONHUMAN; PATHOGENESIS; PROLIFERATIVE GLOMERULONEPHRITIS; PULMONARY HYPERTENSION; REVIEW; SMOOTH MUSCLE FIBER; VASODILATATION;

ANIMALS; HUMANS; HYPERTENSION, PULMONARY; PLATELET-DERIVED GROWTH FACTOR; PROTEIN KINASE INHIBITORS;

EID: 84867490166     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2012.719500     Document Type: Review

References (58)

1. Humbert M, Deng Z, Simonneau G, et al. Bmpr2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives. Eur Respir J 2002;20:518-23
2. Humbert M, McLaughlin VV. The 4th world symposium on pulmonary hypertension. Introduction. J Am College Cardiol 2009. 54:S1-2
3. Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med 2004;351:1425-36
4. Barst RJ. Pdgf signaling in pulmonary arterial hypertension. J Clin Invest 2005;115:2691-4
5. Schermuly RT, Dony E, Ghofrani HA, et al. Reversal of experimental pulmonary hypertension by pdgf inhibition. J Clin Invest 2005;115:2811-21
6. Graves LM, Bornfeldt KE, Sidhu JS, et al. Platelet-derived growth factor stimulates protein kinase a through a mitogen-activated protein kinase-dependent pathway in human arterial smooth muscle cells. J Biol Chem 1996;271:505-11
7. Raines EW. Pdgf and cardiovascular disease. Cytokine Growth Factor Rev 2004;15:237-54
8. Tuder RM, Abman SH, Braun T, et al. Development and pathology of pulmonary hypertension. J Am Coll Cardiol 2009;54:S3-9
9. Ross R, Vogel A. The platelet-derived growth factor. Cell 1978;14:203-10
10. Kohler N, Lipton A. Platelets as a source of fibroblast growth-promoting activity. Exp Cell Res 1974;87:297-301
11. Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 2008;22:1276-312
12. Bergsten E, Uutela M, Li X, et al. Pdgf-d is a specific, protease-activated ligand for the pdgf beta-receptor. Nat Cell Biol 2001;3:512-16
13. Li X, Ponten A, Aase K, et al. Pdgf-c is a new protease-activated ligand for the pdgf alpha-receptor. Nat Cell Biol 2000;2:302-9
14. Fredriksson L, Li H, Eriksson U. The pdgf family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev 2004;15:197-204
15. Betsholtz C, Lindblom P, Bjarnegard M, et al. Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice. Curr Opin Nephrol Hypertens 2004;13:45-52
16. Heidaran MA, Pierce JH, Jensen RA, et al. Chimeric alpha- and beta-platelet-derived growth factor (pdgf) receptors define three immunoglobulin-like domains of the alpha-pdgf receptor that determine pdgf-aa binding specificity. J Biol Chem 1990;265:18741-4
17. Heidaran MA, Pierce JH, Yu JC, et al. Role of alpha beta receptor heterodimer formation in beta platelet-derived growth factor (pdgf) receptor activation by pdgf-ab. J Biol Chem 1991;266:20232-7
18. Allam M, Martinet N, Gallati H, et al. Platelet-derived growth factor aa and ab dimers are present in normal human epithelial lining fluid. Eur Respir J 1993;6:1162-8
19. Humbert M. Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: pathophysiology. Eur Respir Rev 2010;19:59-63
20. Morrell NW, Adnot S, Archer SL, et al. Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol 2009;54:S20-31
21. Hassoun PM, Mouthon L, Barbera JA, et al. Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol 2009;54:S10-19
22. Zhao Y, Biswas SK, McNulty PH, et al. Pdgf-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates. Am J Physiol Cell Physiol 2011;300:C1375-85
23. Bongalon S, Dai YP, Singer CA, Yamboliev IA. Pdgf and il-1beta upregulate cofilin and limk2 in canine cultured pulmonary artery smooth muscle cells. J Vasc Res 2004;41:412-21
24. Yu Y, Sweeney M, Zhang S, et al. Pdgf stimulates pulmonary vascular smooth muscle cell proliferation by upregulating trpc6 expression. Am J Physiol Cell Physiol 2003;284:C316-30
25. Malabanan KP, Sheahan AV, Khachigian LM. Platelet-derived growth factor-bb mediates cell migration through induction of activating transcription factor 4 and tenascin-c. Am J Pathol 2012;180(6):2590-7
26. Humbert M, Monti G, Fartoukh M, et al. Platelet-derived growth factor expression in primary pulmonary hypertension: Comparison of hiv seropositive and hiv seronegative patients. Eur Respir J 1998;11:554-9
27. Perros F, Montani D, Dorfmuller P, et al. Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 2008;178:81-8
28. Katayose D, Ohe M, Yamauchi K, et al. Increased expression of pdgf a- and b-chain genes in rat lungs with hypoxic pulmonary hypertension. Am J Physiol 1993;264:L100-6
29. Jones R, Capen D, Jacobson M. Pdgf and microvessel wall remodeling in adult lung: Imaging pdgf-rbeta and pdgf-bb molecules in progenitor smooth muscle cells developing in pulmonary hypertension. Ultrastruct Pathol 2006;30:267-81
30. Freyhaus HT, Dagnell M, Leuchs M, et al. Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases. Am J Respir Crit Care Med 2011;183:1092-102
31. Berg JT, Breen EC, Fu Z, et al. Alveolar hypoxia increases gene expression of extracellular matrix proteins and platelet-derived growth factor-b in lung parenchyma. Am J Respir Crit Care Med 1998;158:1920-8
32. Schultz K, Fanburg BL, Beasley D. Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2006;290:H2528-34
33. Ren W, Watts SW, Fanburg BL. Serotonin transporter interacts with the pdgfbeta receptor in pdgf-bb-induced signaling and mitogenesis in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2011;300:L486-97
34. Kida T, Chuma H, Murata T, et al. Chronic treatment with pdgf-bb and endothelin-1 synergistically induces vascular hyperplasia and loss of contractility in organ-cultured rat tail artery. Atherosclerosis 2011;214:288-94
35. Yahiaoui L, Villeneuve A, Valderrama-Carvajal H, et al. Endothelin-1 regulates proliferative responses, both alone and synergistically with pdgf, in rat tracheal smooth muscle cells. Cell Physiol Biochem 2006;17:37-46
36. Dahal BK, Heuchel R, Pullamsetti SS, et al. Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-beta. Pulm Circ 2011;1:259-68
37. Jankov RP, Kantores C, Belcastro R, et al. A role for platelet-derived growth factor beta-receptor in a newborn rat model of endothelin-mediated pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol 2005;288:L1162-70
38. Yi ES, Remick DG, Lim Y, et al. The intratracheal administration of endotoxin: X. Dexamethasone downregulates neutrophil emigration and cytokine expression in vivo. Inflammation 1996;20:165-75
39. Agency EM. Glivec: Epar-product information 2009, 2012 update
40. Pullamsetti SS, Berghausen EM, Dabral S, et al. Role of src tyrosine kinases in experimental pulmonary hypertension. Arterioscler Thromb Vasc Biol 2012;32(6):1354-65
41. Nakamura K, Akagi S, Ogawa A, et al. Pro-apoptotic effects of imatinib on pdgf-stimulated pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Int J Cardiol 2011
42. Gambaryan N, Perros F, Montani D, et al. Imatinib inhibits bone marrow-derived c-kit+ cell mobilisation in hypoxic pulmonary hypertension. Eur Respir J 2010;36:1209-11
43. Maurer B, Reich N, Juengel A, et al. Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis. Ann Rheum Dis 2012;71(8):1382-7
44. Chen Z, Lee FY, Bhalla KN, Wu J. Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by bms-354825 (dasatinib). Mol Pharmacol 2006;69:1527-33
45. Abe K, Toba M, Alzoubi A, et al. Tyrosine kinase inhibitors are potent acute pulmonary vasodilators in rats. Am J Respir Cell Mol Biol 2011;45:804-8
46. Montani D, Bergot E, Gunther S, et al. Pulmonary arterial hypertension in patients treated by dasatinib/ clinical perspective. Circulation 2012;125:2128-37
47. Orlandi EM, Rocca B, Pazzano AS, Ghio S. Reversible pulmonary arterial hypertension likely related to long-term, low-dose dasatinib treatment for chronic myeloid leukaemia. Leuk Res 2012;36:e4-6
48. Hennigs J, Keller G, Baumann H, et al. Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-capillary pulmonary hypertension? BMC Pulm Med 2011;11:30
49. Ghofrani HA, Morrell NW, Hoeper MM, et al. Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy. Am J Respir Crit Care Med 2010;182:1171-7
50. Hoeper M, Barst RJ, Galie N, et al. Imatinib in pulmonary arterial hypertension,a randomized,efficacy study (impres). Eur Respir J 2011;38:50s
51. Johnson RJ, Raines EW, Floege J, et al. Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor. J Exp Med 1992;175:1413-16
52. Vassbotn FS, Langeland N, Hagen I, Holmsen H. A monoclonal antibody against pdgf b-chain inhibits pdgf-induced DNA synthesis in c3h fibroblasts and prevents binding of pdgf to its receptor. Biochim Biophys Acta BBA Mol Cell Res 1990;1054:246-9
53. Floege J, Ostendorf T, Janssen U, et al. Novel approach to specific growth factor inhibition in vivo: Antagonism of platelet-derived growth factor in glomerulonephritis by aptamers. Am J Pathol 1999;154:169-79
54. Lu C, Shahzad MMK, Moreno-Smith M, et al. Targeting pericytes with a pdgf-b aptamer in human ovarian carcinoma models. Cancer Biol Ther 2010;9:176-82
55. Duan DS, Pazin MJ, Fretto LJ, Williams LT. A functional soluble extracellular region of the platelet-derived growth factor (pdgf) beta-receptor antagonizes pdgf-stimulated responses. J Biol Chem 1991;266:413-18
56. Ogawa A, Nakamura K, Matsubara H, et al. Prednisolone inhibits proliferation of cultured pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension. Circulation 2005;112:1806-12
57. Ogawa A, Firth AL, Yao W, et al. Prednisolone inhibits pdgf-induced nuclear translocation of nf-kappab in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2008;295:L648-57
58. Ikeda T, Nakamura K, Akagi S, et al. Inhibitory effects of simvastatin on platelet-derived growth factor signaling in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. J Cardiovasc Pharmacol 2010;55:39-48