Frailty is associated with worse outcomes in non-ST-segment elevation acute coronary syndromes: Insights from the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial

European Heart Journal: Acute Cardiovascular Care

Volumn 5, Issue 3, 2016, Pages 231-242

  White, Harvey D ^a   Westerhout, Cynthia M ^b   Alexander, Karen P ^c,d   Roe, Matthew T ^c,d   Winters, Kenneth J ^e   Cyr, Derek D ^c   Fox, Keith A A ^f   Prabhakaran, Dorairaj ^g   Hochman, Judith S ^h   Armstrong, Paul W ^b,i   Ohman, E Magnus ^c,d  

^a AUCKLAND CITY HOSPITAL   (New Zealand)

^b UNIVERSITY OF ALBERTA   (Canada)

^c DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e ELI LILLY AND COMPANY   (United States)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

^g PUBLIC HEALTH FOUNDATION OF INDIA   (India)

^h NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

ⁱ UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Acute coronary syndrome; Clinical trial; Elderly; Frailty; Outcome assessment

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE; PRASUGREL; PROTON PUMP INHIBITOR; ANTITHROMBOCYTIC AGENT; TICLOPIDINE;

AGED; ANGIOGRAPHY; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DIABETES MELLITUS; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; ENDURANCE; FATIGUE; FEMALE; FOLLOW UP; FRAIL ELDERLY; FRAILTY; HEART INFARCTION; HEART MUSCLE REVASCULARIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NON ST SEGMENT ELEVATION ACUTE CORONARY SYNDROME; PERCUTANEOUS CORONARY INTERVENTION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; THROMBOCYTE AGGREGATION INHIBITION; TRANSIENT ISCHEMIC ATTACK; TREATMENT OUTCOME; WEAKNESS; WEIGHT REDUCTION; ACUTE CORONARY SYNDROME; AGE; ANALOGS AND DERIVATIVES; HEALTH SURVEY; MORTALITY; PROGNOSIS; VERY ELDERLY;

ACUTE CORONARY SYNDROME; AGE FACTORS; AGED; AGED, 80 AND OVER; DOUBLE-BLIND METHOD; FEMALE; FRAIL ELDERLY; HEALTH SURVEYS; HUMANS; MALE; PLATELET AGGREGATION INHIBITORS; PRASUGREL HYDROCHLORIDE; PROGNOSIS; TICLOPIDINE; TREATMENT OUTCOME;

EID: 85054757096     PISSN: 20488726     EISSN: 20488734     Source Type: Journal    
DOI: 10.1177/2048872615581502     Document Type: Article

References (38)

1. Alexander KP, Newby LK, Cannon CP, et al.; American Heart Association Council on Clinical Cardiology; Society of Geriatric Cardiology. Acute coronary care in the elderly, part I: Non-ST-segment-elevation acute coronary syndromes: A scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: In collaboration with the Society of Geriatric Cardiology. Circulation 2007; 115: 2549-2569.
2. Singh M, Stewart R and White H. Importance of frailty in patients with cardiovascular disease. Eur Heart J 2014; 35: 1726-1731.
3. Afilalo J, Alexander KP, Mack MJ, et al. Frailty assessment in the cardiovascular care of older adults. J Am Coll Cardiol 2014; 63: 747-762.
4. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56: M146-M156.
5. Chikwe J and Adams DH. Frailty: The missing element in predicting operative mortality. Semin Thorac Cardiovasc Surg 2010; 22: 109-110.
6. Ewe SH, Ajmone Marsan N, Pepi M, et al. Impact of left ventricular systolic function on clinical and echocardiographic outcomes following transcatheter aortic valve implantation for severe aortic stenosis. Am Heart J 2010; 160: 1113-1120.
7. Green P, Woglom AE, Genereux P, et al. The impact of frailty status on survival after transcatheter aortic valve replacement in older adults with severe aortic stenosis: A single-center experience. JACC Cardiovasc Interv 2012; 5: 974-981.
8. Green P, Woglom AE, Genereux P, et al. Gait speed and dependence in activities of daily living in older adults with severe aortic stenosis. Clin Cardiol 2012; 35: 307-314.
9. Rodes-Cabau J, Webb JG, Cheung A, et al. Transcatheter aortic valve implantation for the treatment of severe symptomatic aortic stenosis in patients at very high or prohibitive surgical risk: Acute and late outcomes of the multicenter Canadian experience. J Am Coll Cardiol 2010; 55: 1080-1090.
10. Schoenenberger AW, Stortecky S, Neumann S, et al. Predictors of functional decline in elderly patients undergoing transcatheter aortic valve implantation (TAVI). Eur Heart J 2013; 34: 684-692.
11. Stortecky S, Schoenenberger AW, Moser A, et al. Evaluation of multidimensional geriatric assessment as a predictor of mortality and cardiovascular events after transcatheter aortic valve implantation. JACC Cardiovasc Interv 2012; 5: 489-496.
12. Purser JL, Kuchibhatla MN, Fillenbaum GG, et al. Identifying frailty in hospitalized older adults with significant coronary artery disease. J Am Geriatr Soc 2006; 54: 1674-1681.
13. Afilalo J, Karunananthan S, Eisenberg MJ, et al. Role of frailty in patients with cardiovascular disease. Am J Cardiol 2009; 103: 1616-1621.
14. Dasgupta M, Rolfson DB, Stolee P, et al. Frailty is associated with postoperative complications in older adults with medical problems. Arch Gerontol Geriatr 2009; 48: 78-83.
15. Forman DE, Rich MW, Alexander KP, et al. Cardiac care for older adults. Time for a new paradigm. J Am Coll Cardiol 2011; 57: 1801-1810.
16. Gharacholou SM, Roger VL, Lennon RJ, et al. Comparison of frail patients versus nonfrail patients ≥65 years of age undergoing percutaneous coronary intervention. Am J Cardiol 2012; 109: 1569-1575.
17. Sundermann S, Dademasch A, Praetorius J, et al. Comprehensive assessment of frailty for elderly high-risk patients undergoing cardiac surgery. Eur J Cardiothorac Surg 2011; 39: 33-37.
18. McNulty EJ, Ng W, Spertus JA, et al. Surgical candidacy and selection biases in nonemergent left main stenting: Implications for observational studies. JACC Cardiovasc Interv 2011; 4: 1020-1027.
19. Singh M, Rihal CS, Lennon RJ, et al. Influence of frailty and health status on outcomes in patients with coronary disease undergoing percutaneous revascularization. Circ Cardiovasc Qual Outcomes 2011; 4: 496-502.
20. Matsuzawa Y, Konishi M, Akiyama E, et al. Association between gait speed as a measure of frailty and risk of cardiovascular events after myocardial infarction. J Am Coll Cardiol 2013; 61: 1964-1972.
21. Ekerstad N, Swahn E, Janzon M, et al. Frailty is independently associated with 1-year mortality for elderly patients with non-ST-segment elevation myocardial infarction. Eur J Prev Cardiol 2014; 21: 1216-1224.
22. Sanchis J, Bonanad C, Ruiz V, et al. Frailty and other geriatric conditions for risk stratification of older patients with acute coronary syndrome. Am Heart J 2014; 168: 784-791.
23. Roe MT, Armstrong PW, Fox KA, et al.; TRILOGY ACS investigators. Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. N Engl J Med 2012; 367: 1297-1309.
24. Chin CT, Roe MT, Fox KA, et al.; TRILOGY ACS Steering Committee. Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non-ST-segment elevation myocardial infarction: The TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) Trial. Am Heart J 2010; 160: 16-22e1.
25. Eagle KA, Lim MJ, Dabbous OH, et al.; GRACE investigators. A validated prediction model for all forms of acute coronary syndrome: Estimating the risk of 6-month postdischarge death in an international registry. JAMA 2004; 291: 2727-2733.
26. Hamm CW, Bassand JP, Agewall S, et al.; ESC Committee for Practice Guidelines. ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the Management of Acute Coronary Syndromes (ACS) in Patients Presenting Without Persistent ST-segment Elevation of the European Society of Cardiology (ESC). Eur Heart J 2011; 32: 2999-3054.
27. Wright RS, Anderson JL, Adams CD, et al. 2011 ACCF/ AHA focused update of the guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction (Updating the 2007 Guideline): A report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines developed in collaboration with the American College of Emergency Physicians, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol 2011; 57: 1920-1959.
28. National Institute for Health and Care Excellence. Clinical guidelines. Unstable angina and NSTEMI (CG94), available at: http://guidance.nice.org.uk/CG94 (accessed 13 May 2014).
29. De Araujo Goncalves P, Ferreira J, Aguiar C, et al. TIMI, PURSUIT, and GRACE risk scores: Sustained prognostic value and interaction with revascularization in NSTE-ACS. Eur Heart J 2005; 26: 865-872.
30. Aragam KG, Tamhane UU, Kline-Rogers E, et al. Does simplicity compromise accuracy in ACS risk prediction? A retrospective analysis of the TIMI and GRACE risk scores. PLoS One 2009; 4: e7947.
31. Roe MT, Goodman SG, Ohman EM, et al. Elderly patients with acute coronary syndromes managed without revascularization: Insights into the safety of long-term dual antiplatelet therapy with reduced-dose prasugrel versus standard-dose clopidogrel. Circulation 2013; 128: 823-833.
32. Bandeen-Roche K, Xue QL, Ferrucci L, et al. Phenotype of frailty: Characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci 2006; 61: 262-266.
33. Chaves PH, Semba RD, Leng SX, et al. Impact of anemia and cardiovascular disease on frailty status of communitydwelling older women: The Women's Health and Aging Studies I and II. J Gerontol A Biol Sci Med Sci 2005; 60: 729-735.
34. Collard RM, Boter H, Schoevers RA, et al. Prevalence of frailty in community-dwelling older persons: A systematic review. J Am Geriatr Soc 2012; 60: 1487-1492.
35. Chew DP, Junbo G, Parsonage W, et al.; Perceived Risk of Ischemic and Bleeding Events in Acute Coronary Syndrome Patients (PREDICT) Study investigators. Perceived risk of ischemic and bleeding events in acute coronary syndromes. Circ Cardiovasc Qual Outcomes 2013; 6: 299-308.
36. Barreto Pde S, Greig C and Ferrandez AM. Detecting and categorizing frailty status in older adults using a self-report screening instrument. Arch Gerontol Geriatr 2012; 54: e249-e254.
37. Johansen KL, Dalrymple LS, Delgado C, et al. Comparison of self-report-based and physical performance-based frailty definitions among patients receiving maintenance hemodialysis. Am J Kidney Dis 2014; 64: 600-607.
38. Rippon I and Steptoe A. Feeling old vs being old: Associations between self-perceived age and mortality. JAMA Intern Med 2015; 175: 307-309.