Importance of frailty in patients with cardiovascular disease

European Heart Journal

Volumn 35, Issue 26, 2014, Pages

  Singh, Mandeep ^a   Stewart, Ralph ^b   White, Harvey ^b  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Assessment; Cardiovascular disease; Frailty; Prognosis

Indexed keywords

AGING; CARDIOVASCULAR DISEASE; EXERCISE; FRAILTY; HUMAN; PHYSICAL DISEASE; PRIORITY JOURNAL; REVIEW; ROCKWOOD CLINICAL FRAILTY SCALE; AGED; CARDIOVASCULAR DISEASES; ELDERLY CARE; FITNESS; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HEALTH STATUS; KINESIOTHERAPY; PATIENT REFERRAL; PROCEDURES; PROGNOSIS; QUESTIONNAIRE; RISK ASSESSMENT; STANDARDS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CARDIOVASCULAR DISEASES; EXERCISE THERAPY; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HEALTH SERVICES FOR THE AGED; HEALTH STATUS; HUMANS; PHYSICAL FITNESS; PROGNOSIS; QUESTIONNAIRES; REFERRAL AND CONSULTATION; RISK ASSESSMENT;

EID: 84906820853     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehu197     Document Type: Review

References (101)

1. Heart disease and stroke: The nation's leading killers. http://www.cdc.gov 2005
2. Roger VL, Jacobsen SJ,Weston SA, Bailey KR, Kottke TE, Frye RL. Trends in heart disease deaths in Olmsted County, Minnesota, 1979-1994. Mayo Clin Proc 1999;74: 651-657
3. Roger VL, Weston SA, Killian JM, Pfeifer EA, Belau PG, Kottke TE, Frye RL, Bailey KR, Jacobsen SJ. Time trends in the prevalence of atherosclerosis: A population-based autopsy study. Am J Med 2001;110:267-273
4. Roger VL, Weston SA, Redfield MM, Hellermann-Homan JP, Killian J, Yawn BP, Jacobsen SJ. Trends in heart failure incidence and survival in a community-based population. JAMA 2004;292:344-350
5. Alexander KP, Newby LK, ArmstrongPW, Cannon CP, Gibler WB, RichMW, Van de Werf F, White HD, Weaver WD, Naylor MD, Gore JM, Krumholz HM, Ohman EM. Acute coronary care in the elderly, part II: ST-segment-elevation myocardial infarction: A scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology. Circulation 2007;115:2570-2589
6. Alexander KP, Newby LK, Cannon CP, ArmstrongPW, Gibler WB, RichMW, Van de Werf F, White HD, Weaver WD, Naylor MD, Gore JM, Krumholz HM, Ohman EM. Acute coronary care in the elderly, part I: Non-ST-segment-elevation acute coronary syndromes: A scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology. Circulation 2007;115:2549-2569
7. Nichols M, Townsend N, Scarborough P, Rayner M. Cardiovascular disease in Europe: epidemiological update. Eur Heart J 2013;34:3028-3034
8. Nichols M,Townsend N, Scarborough P, Rayner M. Trends in age-specific coronary heart disease mortality in the European Union over three decades: 1980-2009. Eur Heart J 2013;34:3017-3027
9. https://www.census.gov/compendia//statab/2012/tables/12s0105. 2012.
10. Spoon DB PP, Singh M, Holmes Jr DR, Gersh BJ, Rihal CS, Lennon RJ, Moussa ID, Simari RD, Gulati R. Trends in causes of long-term death after percutaneous coronary intervention. Circulation 2013;128:A16049
11. Holmes DR Jr, Mack MJ, Kaul S, Agnihotri A, Alexander KP, Bailey SR, Calhoon JH, Carabello BA, Desai MY, Edwards FH, Francis GS, Gardner TJ, Kappetein AP, Linderbaum JA, Mukherjee C, Mukherjee D, Otto CM, Ruiz CE, Sacco RL, Smith D, Thomas JD. 2012 ACCF/AATS/SCAI/STS expert consensus document on transcatheter aortic valve replacement. J Am Coll Cardiol 2012;59:1200-1254
12. Strandberg TE, Pitkala KH. Frailty in elderly people. Lancet 2007;369:1328-1329
13. PutsMT, Lips P, Deeg DJ. Sex differences in the risk of frailty for mortality independent of disability and chronic diseases. J Am Geriatr Soc 2005;53:40-47
14. Rockwood K, Mitnitski A. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin Geriatr Med 2011;27:17-26
15. Ferrucci L, Cavazzini C, Corsi A, Bartali B, Russo CR, Lauretani F, Corsi AM, Bandinelli S, Guralnik JM. Biomarkers of frailty in older persons. J Endocrinol Invest 2002;25(10 Suppl):10-15
16. Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger WH Jr, Heimovitz H, Cohen HJ, Wallace R. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med 1999;106: 506-512
17. Leng SX, Cappola AR, Andersen RE, Blackman MR, Koenig K, Blair M,Walston JD. Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty. Aging Clin Exp Res 2004;16:153-157
18. Taaffe DR, Harris TB, Ferrucci L,RoweJ, Seeman TE. Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. J Gerontol A Biol Sci Med Sci 2000;55:M709-M715
19. Visser M, Pahor M, Taaffe DR, Goodpaster BH, Simonsick EM, Newman AB, Nevitt M, Harris TB. Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: The Health ABC Study. J Gerontol A Biol Sci Med Sci 2002;57:M326-M332
20. Walston J, Arking DE, Fallin D, Li T, Beamer B, Xue Q, Ferrucci L, Fried LP, Chakravarti A. IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women. Exp Gerontol 2005;40: 344-352
21. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 2004;59:255-263
22. Davison KK, Ford ES, Cogswell ME, Dietz WH. Percentage of body fat and body mass index are associated with mobility limitations in people aged 70 and older from NHANES III. J Am Geriatr Soc 2002;50:1802-1809
23. Landi F, Liperoti R, Fusco D, Mastropaolo S, Quattrociocchi D, Proia A, Tosato M, Bernabei R, Onder G. Sarcopenia and mortality among older nursing home residents. J Am Med Direct Assoc 2012;13:121-126
24. de Vries NM, Staal JB, van Ravensberg CD, Hobbelen JS, Olde RikkertMG, Nijhuisvan der Sanden MW. Outcome instruments to measure frailty: A systematic review. Ageing Res Rev 2011;10:104-114
25. Studenski S, Perera S, Patel K, Rosano C, Faulkner K, Inzitari M, Brach J, Chandler J, Cawthon P, Connor EB, Nevitt M, Visser M, Kritchevsky S, Badinelli S, Harris T, Newman AB, Cauley J, Ferrucci L, Guralnik J. Gait speed and survival in older adults. JAMA 2011;305:50-58
26. Dumurgier J, Elbaz A, Ducimetiere P, Tavernier B, Alperovitch A, Tzourio C. Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study. BMJ 2009;339:b4460
27. Ling CH, Taekema D, de Craen AJ, Gussekloo J,Westendorp RG, Maier AB. Handgrip strength and mortality in the oldest old population: The Leiden 85-plus study. CMAJ 2010;182:429-435
28. van Iersel MB, Munneke M, Esselink RA, Benraad CE, Olde Rikkert MG. Gait velocity and the Timed-Up-and-Go test were sensitive to changes in mobility in frail elderly patients. J Clin Epidemiol 2008;61:186-191
29. Fried LP, Tangen CM,Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56:M146-M156
30. Ensrud KE, Ewing SK, Cawthon PM, Fink HA, Taylor BC, Cauley JA, Dam TT, Marshall LM, Orwoll ES, Cummings SR.Acomparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. JAmGeriatr Soc 2009; 57:492-498
31. Purser JL, Kuchibhatla MN, Fillenbaum GG, Harding T, Peterson ED, Alexander KP. Identifying frailty in hospitalized older adults with significant coronary artery disease. J Am Geriatr Soc 2006;54:1674-1681
32. Hilmer SN, Perera V, Mitchell S, Murnion BP, Dent J, Bajorek B, Matthews S, Rolfson DB. The assessment of frailty in older people in acute care. Aus J Ageing 2009;28:182-188
33. Rockwood K, Stadnyk K, MacKnight C, McDowell I, Hebert R, Hogan DB. A brief clinical instrument to classify frailty in elderly people. Lancet 1999;353:205-206
34. Kulminski AM, Ukraintseva SV, Kulminskaya IV, Arbeev KG, Land K, Yashin AI. Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study. J Am Geriatr Soc 2008;56:898-903
35. Abellan van Kan G, Rolland Y, Bergman H, Morley JE, Kritchevsky SB, Vellas B. The I.A.N.A Task Force on frailty assessment of older people in clinical practice. J Nutr Health Aging 2008;12:29-37
36. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitnitski A. A global clinical measure of fitness and frailty in elderly people. CMAJ 2005;173:489-495
37. Vellas B, Balardy L, Gillette-Guyonnet S, Abellan Van Kan G, Ghisolfi-Marque A, Subra J, Bismuth S, Oustric S, Cesari M. Looking for frailty in community-dwelling older persons: The Gerontopole Frailty Screening Tool (GFST). J Nutr Health Aging 2013;17:629-631
38. Rolfson DB, Majumdar SR, Tsuyuki RT, Tahir A, Rockwood K. Validity and reliability of the Edmonton Frail Scale. Age Ageing 2006;35:526-529
39. Ensrud KE, Ewing SK, Taylor BC, Fink HA, Cawthon PM, Stone KL, Hillier TA, Cauley JA, Hochberg MC, Rodondi N, Tracy JK, Cummings SR. Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Inter Med 2008;168:382-389
40. Morley JE, Vellas B, van Kan GA, Anker SD, Bauer JM, Bernabei R, Cesari M, Chumlea WC, Doehner W, Evans J, Fried LP, Guralnik JM, Katz PR, Malmstrom TK, McCarter RJ, Gutierrez Robledo LM, Rockwood K, von Haehling S, Vandewoude MF, Walston J. Frailty consensus: A call to action. J Am Med Direct Assoc 2013;14:392-397
41. CigolleCT, Ofstedal MB, Tian Z, Blaum CS. Comparing models of frailty: The Health and Retirement Study. J Am Geriatr Soc 2009;57:830-839
42. Singh M, Alexander K, Roger VL, Rihal CS, Whitson HE, Lerman A, Jahangir A, Nair KS. Frailty and its potential relevance to cardiovascular care. Mayo Clin Proc 2008;83:1146-1153
43. Collard RM, Boter H, Schoevers RA, Oude Voshaar RC. Prevalence of frailty in community-dwelling older persons: A systematic review. J Am Geriatr Soc 2012; 60:1487-1492
44. Kanwar A, Singh M, Lennon R, Ghanta K, McNallan SM, Roger VL. Frailty and health-related quality of life among residents of long-term care facilities. J Aging Health 2013;25:792-802
45. vonHaehling S, Anker SD, DoehnerW, Morley JE, Vellas B. Frailty and heart disease. Int J Cardiol 2013;168:1745-1747
46. Newman AB, Gottdiener JS, McBurnie MA, Hirsch CH, Kop WJ, Tracy R, Walston JD, Fried LP. Associations of subclinical cardiovascular disease with frailty. J Gerontol A Biol Sci Med Sci 2001;56:M158-M166
47. Newman AB, Arnold AM, Naydeck BL, Fried LP, Burke GL, Enright P, Gottdiener J, Hirsch C, O'Leary D, Tracy R. 'Successful aging': effect of subclinical cardiovascular disease. Arch Intern Med 2003;163:2315-2322
48. Singh M, Rihal CS, Lennon RJ, Spertus JA, Nair KS, Roger VL. Influence of frailty and health status on outcomes in patients with coronary disease undergoing percutaneous revascularization. Circulation 2011;4:496-502
49. Singh MRV, Rihal C, Lennon R, Jahangir A, Lerman A, Sloan J, Spertus J. Correlates of frailty in patients with coronary heart disease undergoing percutaneous coronary interventions. Circulation 2007;115:E556
50. GerberY, Melton LJ III, McNallan SM, Jiang R,Weston SA, Roger VL.Cardiovascular and noncardiovascular disease associations with hip fractures. Am J Med 2013;126: 169 e19-26
51. Hubbard RE, O'Mahony MS, Calver BL,WoodhouseKW. Nutrition, inflammation, and leptin levels in aging and frailty. J Am Geriatr Soc 2008;56:279-284
52. Cohen MB, Mather PJ.Areviewof the association between congestive heart failure and cognitive impairment. Am J Geriatr Cardiol 2007;16:171-174
53. Woods NF, LaCroix AZ, Gray SL, Aragaki A, Cochrane BB, Brunner RL, Masaki K, Murray A, Newman AB. Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc 2005;53:1321-1330
54. Chaves PH, Semba RD, Leng SX,Woodman RC, Ferrucci L, Guralnik JM, Fried LP. Impact of anemia and cardiovascular disease on frailty status of community-dwelling older women: TheWomen's Health and Aging Studies I and II. J Gerontol A, Biol Sci Med Sci 2005;60:729-735
55. Cacciatore F, Abete P, Mazzella F, Viati L, Della Morte D, D'Ambrosio D, Gargiulo G, Testa G, Santis D, Galizia G, Ferrara N, Rengo F. Frailty predicts longterm mortality in elderly subjects with chronic heart failure. Eur J Clin Invest 2005;35: 723-730
56. Boxer RS,Wang Z,Walsh SJ, Hager D, Kenny AM. The utility of the 6-minute walk test as a measure of frailty in older adults with heart failure.AmJ Geriatr Cardiol 2008; 17:7-12
57. Boxer R, Kleppinger A, Ahmad A, Annis K, Hager D, Kenny A. The 6-minute walk is associated with frailty and predicts mortality in older adults with heart failure. Cong Heart Fail 2010;16:208-213
58. Sanchez E, VidanMT, Serra JA, Fernandez-Aviles F, Bueno H. Prevalence of geriatric syndromes and impact on clinical and functional outcomes in older patients with acute cardiac diseases. Heart 2011;97:1602-1606
59. Roe MT, Armstrong PW, Fox KA, White HD, Prabhakaran D, Goodman SG, Cornel JH, Bhatt DL, Clemmensen P, Martinez F, Ardissino D, Nicolau JC, Boden WE, Gurbel PA, Ruzyllo W, Dalby AJ, McGuire DK, Leiva-Pons JL, Parkhomenko A, Gottlieb S, Topacio GO, Hamm C, Pavlides G, Goudev AR, Oto A, Tseng CD, Merkely B, Gasparovic V, Corbalan R, Cinteza M, McLendon RC, Winters KJ, Brown EB, Lokhnygina Y, Aylward PE, Huber K, Hochman JS, Ohman EM. Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. N Engl J Med 2012;367:1297-1309
60. Volpato S, Cavalieri M, Sioulis F, Guerra G, Maraldi C, Zuliani G, Fellin R, Guralnik JM. Predictive value of the Short Physical Performance Battery following hospitalization in older patients. J Gerontol A Biol Sci Med Sci 2011;66:89-96
61. McNallan SM, Singh M, Chamberlain AM, Kane RL, Dunlay SM, Redfield MM, Weston SA, Roger VL. Frailty and healthcare utilization among patients with heart failure in the community. JACC 2013;1:135-141
62. Lee DH, Buth KJ, Martin BJ, Yip AM, Hirsch GM. Frail patients are at increased risk for mortality and prolonged institutional care after cardiac surgery. Circulation 2010; 121:973-978
63. Sundermann S, Dademasch A, Rastan A, Praetorius J, Rodriguez H, Walther T, Mohr FW, Falk V. One-year follow-up of patients undergoing elective cardiac surgery assessed with the Comprehensive Assessment of Frailty test and its simplified form. Interact Cardiovasc Thorac Surg 2011;13:119-123; discussion 123
64. Green P,Woglom AE, Genereux P, Daneault B, Paradis JM, Schnell S, Hawkey M, Maurer MS, Kirtane AJ, Kodali S, Moses JW, Leon MB, Smith CR, Williams M. The impact of frailty status on survival after transcatheter aortic valve replacement in older adults with severe aortic stenosis: A single-center experience. JACC Cardiovasc Interv 2012;5:974-981
65. Schoenenberger AW, Stortecky S, Neumann S, Moser A, Juni P, Carrel T, Huber C, Gandon M, Bischoff S, Schoenenberger CM, Stuck AE, Windecker S,Wenaweser P. Predictors of functional decline in elderly patients undergoing transcatheter aortic valve implantation (TAVI). Eur Heart J 2013;34:684-692
66. Stortecky S, Schoenenberger AW, Moser A, Kalesan B, Juni P, Carrel T, Bischoff S, Schoenenberger CM, Stuck AE, Windecker S,Wenaweser P. Evaluation of multidimensional geriatric assessment as a predictor of mortality and cardiovascular events after transcatheter aortic valve implantation. JACC Cardiovasc Interv 2012;5: 489-496
67. Rumsfeld JS, MaWhinney S, McCarthyMJr, Shroyer AL, VillaNueva CB, O'Brien M, Moritz TE, Henderson WG, Grover FL, Sethi GK, Hammermeister KE. Health-related quality of life as a predictor of mortality following coronary artery bypass graft surgery. Participants of the Department of Veterans Affairs Cooperative Study Group on Processes, Structures, and Outcomes of Care in Cardiac Surgery. JAMA 1999;281:1298-1303
68. Singh M, Rihal C, Roger VL, Lennon R, Spertus J, Jahangir A, HolmesDJr. Comorbid conditions and outcomes after percutaneous coronary intervention. Heart 2008; 94:1424-1428
69. Ekerstad N, Swahn E, Janzon M, Alfredsson J, Lofmark R, Lindenberger M, Carlsson P. Frailty is independently associated with short-term outcomes for elderly patients with non-ST-segment elevation myocardial infarction. Circulation 2011;124:2397-2404
70. Stewart RA ZD, She L, Lee K, Drazner M, Lubiszewska B, Hebeler R, Kosevic D, Ruengsakulrach P, Nicolau J, Coutu B, Choudhary S, Mark D, Cleland J, Pina I, Velazquez E, Rynkiewicz A, White H. Exercise capacity and mortality in patients with ischemic left ventricular dysfunction randomized to coronary artery bypass surgery or medical therapy: An analysis from the Surgical Treatment for Ischemic Heart Failure (STICH) trial. JACC Heart Fail 2014;in press
71. Ory MG, Schechtman KB, Miller JP, Hadley EC, Fiatarone MA, Province MA, Arfken CL, Morgan D, Weiss S, Kaplan M. Frailty and injuries in later life: The FICSIT trials. J Am Geriatr Soc 1993;41:283-296
72. Fiatarone MA, O'Neill EF, Ryan ND, Clements KM, Solares GR, Nelson ME, Roberts SB, Kehayias JJ, Lipsitz LA, Evans WJ. Exercise training and nutritional supplementation for physical frailty in very elderly people. The N Engl J Med 1994;330: 1769-1775
73. Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, Napoli N, Qualls C, Shah K. Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med 2011;364:1218-1229
74. Singh NA, Quine S, Clemson LM, Williams EJ, Williamson DA, Stavrinos TM, Grady JN, Perry TJ, Lloyd BD, Smith EU, Singh MA. Effects of high-intensity progressive resistance training and targeted multidisciplinary treatment of frailty on mortality and nursing home admissions after hip fracture: A randomized controlled trial. J Am Med Direct Assoc 2012;13:24-30
75. Goel K, Lennon RJ, Tilbury RT, SquiresRW, Thomas RJ. Impact of cardiac rehabilitation on mortality and cardiovascular events after percutaneous coronary intervention in the community. Circulation 2011;123:2344-2352
76. Sierra-Johnson J, Romero-Corral A, Somers VK, Lopez-Jimenez F, Thomas RJ, SquiresRW, Allison TG. Prognostic importance of weight loss in patients with coronary heart disease regardless of initial body mass index. Eur J Cardiovasc Prev Rehabil 2008;15:336-340
77. Suaya JA, Stason WB, Ades PA, Normand SL, Shepard DS. Cardiac rehabilitation and survival in older coronary patients. J Am Coll Cardiol 2009;54:25-33
78. Pack QR, Goel K, Lahr BD, Greason KL, Squires RW, Lopez-Jimenez F, Zhang Z, Thomas RJ. Participation in cardiac rehabilitation and survival after coronary artery bypass graft surgery: A community-based study. Circulation 2013;128:590-597
79. Paddon-Jones D, Rasmussen BB. Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care 2009;12:86-90
80. Tieland M, van de Rest O, Dirks ML, van der Zwaluw N, Mensink M, van Loon LJ, de Groot LC. Protein supplementation improves physical performance in frail elderly people: A randomized, double-blind, placebo-controlled trial. J Am Med Direct Assoc 2012;13:720-726
81. Tieland M, Dirks ML, van der Zwaluw N, Verdijk LB, van de Rest O, de Groot LC, van Loon LJ. Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: A randomized, double-blind, placebo-controlled trial. J Am Med Direct Assoc 2012;13:713-719
82. Tieland M, Borgonjen-Van den Berg KJ, van Loon LJ, de Groot LC. Dietary protein intake in community-dwelling, frail, and institutionalized elderly people: scope for improvement. Eur J Nutr 2012;51:173-179
83. Paddon-Jones D. Perspective: exercise and protein supplementation in frail elders. J Am Med Direct Assoc 2013;14:73-74
84. Malafarina V, Uriz-Otano F, Iniesta R, Gil-Guerrero L. Effectiveness of nutritional supplementation on muscle mass in treatment of sarcopenia in old age: A systematic review. J Am Med Direct Assoc 2013;14:10-17
85. Murad MH, Elamin KB, Abu Elnour NO, Elamin MB, Alkatib AA, Fatourechi MM, Almandoz JP, Mullan RJ, Lane MA, Liu H, Erwin PJ, Hensrud DD, Montori VM. Clinical review: The effect of vitamin D on falls: A systematic review and meta-analysis. J Clin Endocrinol Metab 2011;96:2997-3006
86. Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, Flicker L, Wark J, Jackson RD, Cauley JA, Meyer HE, Pfeifer M, Sanders KM, Stahelin HB, Theiler R, Dawson-Hughes B. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 2012;367:40-49
87. Rejnmark L, Avenell A, Masud T, Anderson F, Meyer HE, Sanders KM, Salovaara K, Cooper C, Smith HE, Jacobs ET, Torgerson D, Jackson RD, Manson JE, Brixen K, Mosekilde L, Robbins JA, Francis RM, Abrahamsen B. Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials. J Clin Endocrinol Metab 2012;97:2670-2681
88. Rosen CJ. Clinical practice. Vitamin D insufficiency. N Engl J Med 2011;364: 248-254
89. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ 2011;342:d2040
90. Manson JE, Bassuk SS, Lee IM, Cook NR, Albert MA, Gordon D, Zaharris E, Macfadyen JG, Danielson E, Lin J, Zhang SM, Buring JE. The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials 2012;33:159-171
91. Flaherty JH, PerryHMIII, Lynchard GS, Morley JE. Polypharmacyand hospitalization among older home care patients. J Gerontol A Biol Sci Med Sci 2000;55:M554-M559
92. Gnjidic D, Hilmer SN, Blyth FM, Naganathan V,Waite L, Seibel MJ, McLachlan AJ, Cumming RG, Handelsman DJ, Le Couteur DG. Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol 2012;65:989-995
93. Jano E, Aparasu RR. Healthcare outcomes associated with beers' criteria: A systematic review. Ann Pharmacother 2007;41:438-447
94. Alexander KP, Chen AY, Roe MT, Newby LK, Gibson CM, Allen-LaPointe NM, Pollack C, Gibler WB, Ohman EM, Peterson ED. Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes. JAMA 2005;294:3108-3116
95. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2012;60:616-631
96. Barry PJ, Gallagher P, Ryan C, O'Mahony D. START (screening tool to alert doctors to the right treatment)-an evidence-based screening tool to detect prescribing omissions in elderly patients. Age Ageing 2007;36:632-638
97. Gallagher P, O'Mahony D. STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions): Application to acutely ill elderly patients and comparison with Beers' criteria. Age Ageing 2008;37:673-679
98. Xue QL, Bandeen-Roche K, Varadhan R, Zhou J, Fried LP. Initial manifestations of frailty criteria and the development of frailty phenotype in theWomen's Health and Aging Study II. J Gerontol A Biol Sci Med Sci 2008;63:984-990
99. Cameron ID, Fairhall N, Langron C, Lockwood K, Monaghan N, Aggar C, Sherrington C, Lord SR, Kurrle SE. A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial. BMC Med 2013;11:65
100. Fairhall N, Aggar C, Kurrle SE, Sherrington C, Lord S, Lockwood K, Monaghan N, Cameron ID. Frailty intervention trial (FIT). BMC Geriatr 2008;8:27
101. Abellan van Kan G, Rolland YM, Morley JE, Vellas B. Frailty: Toward a clinical definition. J Am Med Dir Assoc 2008;9:71-72