메뉴 건너뛰기




Volumn 45, Issue 2, 2019, Pages 102-109

Comparing once-weekly semaglutide to incretin-based therapies in patients with type 2 diabetes: a systematic review and meta-analysis

Author keywords

Dipeptidyl peptidase 4 inhibitors; Glucagon like peptide 1 receptor agonist; Meta analysis; Semaglutide; Type 2 diabetes

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR; DULAGLUTIDE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOSE; HEMOGLOBIN A1C; LIRAGLUTIDE; SEMAGLUTIDE; SITAGLIPTIN; ANTIDIABETIC AGENT; GLUCAGON LIKE PEPTIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLYCOSYLATED HEMOGLOBIN; INCRETIN;

EID: 85054531184     PISSN: 12623636     EISSN: 18781780     Source Type: Journal    
DOI: 10.1016/j.diabet.2018.09.002     Document Type: Review
Times cited : (18)

References (36)
  • 1
    • 75549091061 scopus 로고    scopus 로고
    • Incretin-based therapies: viewpoints on the way to consensus
    • Nauck, MA, Vilsboll, T, Gallwitz, B, Garber, A, Madsbad, S, Incretin-based therapies: viewpoints on the way to consensus. Diabetes Care 32:2 (2009), S223–S331.
    • (2009) Diabetes Care , vol.32 , Issue.2 , pp. S223-S331
    • Nauck, M.A.1    Vilsboll, T.2    Gallwitz, B.3    Garber, A.4    Madsbad, S.5
  • 2
    • 84898540957 scopus 로고    scopus 로고
    • Global guideline for type 2 diabetes
    • Global guideline for type 2 diabetes. Diabetes Res Clin Pract 104 (2014), 1–52.
    • (2014) Diabetes Res Clin Pract , vol.104 , pp. 1-52
  • 3
    • 85039705599 scopus 로고    scopus 로고
    • 8 pharmacologic approaches to glycemic treatment: standards of medical care in diabetes-2018
    • American Diabetes Association. 8 pharmacologic approaches to glycemic treatment: standards of medical care in diabetes-2018. Diabetes Care 41:Suppl 1 (2018), S73–S85.
    • (2018) Diabetes Care , vol.41 , pp. S73-S85
  • 4
    • 85044526898 scopus 로고    scopus 로고
    • Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm – 2018 executive summary.
    • Garber, AJ, Abrahamson, MJ, Barzilay, JI, Blonde, L, Bloomgarden, ZT, Bush, MA, et al. Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm – 2018 executive summary. Endocr Pract 24 (2018), 91–120.
    • (2018) Endocr Pract , vol.24 , pp. 91-120
    • Garber, A.J.1    Abrahamson, M.J.2    Barzilay, J.I.3    Blonde, L.4    Bloomgarden, Z.T.5    Bush, M.A.6
  • 5
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker, DJ, Nauck, MA, The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368 (2006), 1696–1705.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 6
    • 84870054636 scopus 로고    scopus 로고
    • GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus
    • Meier, JJ, GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus. Nat Rev Endocrinol 8 (2012), 728–742.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 728-742
    • Meier, J.J.1
  • 7
    • 68049137869 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration
    • Liberati, A, Altman, DG, Tetzlaff, J, Mulrow, C, Gotzsche, PC, Ioannidis, JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med, 6, 2009, e1000100.
    • (2009) PLoS Med , vol.6 , pp. e1000100
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3    Mulrow, C.4    Gotzsche, P.C.5    Ioannidis, J.P.6
  • 8
    • 85063071089 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [update March 2011]. London, UK: The Cochrane Collaboration Available from
    • Higgins J, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [update March 2011]. London, UK: The Cochrane Collaboration; 2011. Available from http://handbook.cochrane.org.
    • (2011)
    • Higgins, J.1    Green, S.2
  • 10
    • 85042212837 scopus 로고    scopus 로고
    • Comparing SGLT-2 inhibitors to DPP-4 inhibitors as an add-on therapy to metformin in patients with type 2 diabetes: a systematic review and meta-analysis
    • Mishriky, BM, Tanenberg, RJ, Sewell, KA, Cummings, DM, Comparing SGLT-2 inhibitors to DPP-4 inhibitors as an add-on therapy to metformin in patients with type 2 diabetes: a systematic review and meta-analysis. Diabetes Metab 44 (2018), 112–120.
    • (2018) Diabetes Metab , vol.44 , pp. 112-120
    • Mishriky, B.M.1    Tanenberg, R.J.2    Sewell, K.A.3    Cummings, D.M.4
  • 11
    • 84937971687 scopus 로고    scopus 로고
    • The efficacy and safety of DPP-4 inhibitors compared to sulfonylureas as add-on therapy to metformin in patients with type 2 diabetes: a systematic review and meta-analysis
    • Mishriky, BM, Cummings, DM, Tanenberg, RJ, The efficacy and safety of DPP-4 inhibitors compared to sulfonylureas as add-on therapy to metformin in patients with type 2 diabetes: a systematic review and meta-analysis. Diabetes Res Clin Pract 109 (2015), 378–388.
    • (2015) Diabetes Res Clin Pract , vol.109 , pp. 378-388
    • Mishriky, B.M.1    Cummings, D.M.2    Tanenberg, R.J.3
  • 12
    • 84957878858 scopus 로고    scopus 로고
    • Incretin therapies: highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors
    • Nauck, M, Incretin therapies: highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Diabetes Obes Metab 18 (2016), 203–216.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 203-216
    • Nauck, M.1
  • 13
    • 85029679644 scopus 로고    scopus 로고
    • Cardiovascular Actions and Clinical Outcomes With Glucagon-Like Peptide-1 Receptor Agonists and Dipeptidyl Peptidase-4 Inhibitors
    • Nauck, MA, Meier, JJ, Cavender, MA, Abd El Aziz, M, Drucker, DJ, Cardiovascular Actions and Clinical Outcomes With Glucagon-Like Peptide-1 Receptor Agonists and Dipeptidyl Peptidase-4 Inhibitors. Circulation 136 (2017), 849–870.
    • (2017) Circulation , vol.136 , pp. 849-870
    • Nauck, M.A.1    Meier, J.J.2    Cavender, M.A.3    Abd El Aziz, M.4    Drucker, D.J.5
  • 14
    • 85041220578 scopus 로고    scopus 로고
    • Efficacy and safety of once-weekly semaglutide versus exenatide ER in subjects with type 2 diabetes (SUSTAIN 3): a 56-week, open-label, randomized clinical trial
    • Ahmann, AJ, Capehorn, M, Charpentier, G, Dotta, F, Henkel, E, Lingvay, I, et al. Efficacy and safety of once-weekly semaglutide versus exenatide ER in subjects with type 2 diabetes (SUSTAIN 3): a 56-week, open-label, randomized clinical trial. Diabetes Care 41 (2018), 258–266.
    • (2018) Diabetes Care , vol.41 , pp. 258-266
    • Ahmann, A.J.1    Capehorn, M.2    Charpentier, G.3    Dotta, F.4    Henkel, E.5    Lingvay, I.6
  • 15
    • 85017351452 scopus 로고    scopus 로고
    • Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial
    • Ahren, B, Masmiquel, L, Kumar, H, Sargin, M, Karsbol, JD, Jacobsen, SH, et al. Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial. Lancet Diabetes Endocrinol 5 (2017), 341–354.
    • (2017) Lancet Diabetes Endocrinol , vol.5 , pp. 341-354
    • Ahren, B.1    Masmiquel, L.2    Kumar, H.3    Sargin, M.4    Karsbol, J.D.5    Jacobsen, S.H.6
  • 16
    • 84962052845 scopus 로고    scopus 로고
    • A phase 2, randomized, dose-finding study of the novel once-weekly human GLP-1 analog, semaglutide, compared with placebo and open-label liraglutide in patients with type 2 diabetes
    • Nauck, MA, Petrie, JR, Sesti, G, Mannucci, E, Courreges, JP, Lindegaard, ML, et al. A phase 2, randomized, dose-finding study of the novel once-weekly human GLP-1 analog, semaglutide, compared with placebo and open-label liraglutide in patients with type 2 diabetes. Diabetes Care 39 (2016), 231–241.
    • (2016) Diabetes Care , vol.39 , pp. 231-241
    • Nauck, M.A.1    Petrie, J.R.2    Sesti, G.3    Mannucci, E.4    Courreges, J.P.5    Lindegaard, M.L.6
  • 17
    • 85041567004 scopus 로고    scopus 로고
    • Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial
    • Pratley, RE, Aroda, VR, Lingvay, I, Ludemann, J, Andreassen, C, Navarria, A, et al. Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial. Lancet Diabetes Endocrinol 6 (2018), 275–286.
    • (2018) Lancet Diabetes Endocrinol , vol.6 , pp. 275-286
    • Pratley, R.E.1    Aroda, V.R.2    Lingvay, I.3    Ludemann, J.4    Andreassen, C.5    Navarria, A.6
  • 18
    • 85040743855 scopus 로고    scopus 로고
    • Safety and efficacy of semaglutide once weekly vs sitagliptin once-daily, both as monotherapy in Japanese people with type 2 diabetes
    • Seino, Y, Terauchi, Y, Osonoi, T, Yabe, D, Abe, N, Nishida, T, et al. Safety and efficacy of semaglutide once weekly vs sitagliptin once-daily, both as monotherapy in Japanese people with type 2 diabetes. Diabetes Obes Metab 20 (2018), 378–388.
    • (2018) Diabetes Obes Metab , vol.20 , pp. 378-388
    • Seino, Y.1    Terauchi, Y.2    Osonoi, T.3    Yabe, D.4    Abe, N.5    Nishida, T.6
  • 19
    • 84892408228 scopus 로고    scopus 로고
    • The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview
    • Nathan, DM, The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview. Diabetes Care 37 (2014), 9–16.
    • (2014) Diabetes Care , vol.37 , pp. 9-16
    • Nathan, D.M.1
  • 20
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • Nathan, DM, Genuth, S, Lachin, J, Cleary, P, Crofford, O, Davis, M, et al. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. New Engl J Med 329 (1993), 977–986.
    • (1993) New Engl J Med , vol.329 , pp. 977-986
    • Nathan, D.M.1    Genuth, S.2    Lachin, J.3    Cleary, P.4    Crofford, O.5    Davis, M.6
  • 21
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352 (1998), 854–865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 23
    • 85017574447 scopus 로고    scopus 로고
    • GLP-1 receptor agonist confer target organ protection in type 2 diabetes
    • Bonnet, F, GLP-1 receptor agonist confer target organ protection in type 2 diabetes. Diabetes Metab 43:1 (2017), s1–s2.
    • (2017) Diabetes Metab , vol.43 , Issue.1 , pp. s1-s2
    • Bonnet, F.1
  • 24
    • 84963966467 scopus 로고    scopus 로고
    • Clinical implications of cardiovascular outcome trials in type 2 diabetes: from DCCT to EMPA-REG
    • Ryden, L, Shahim, B, Mellbin, L, Clinical implications of cardiovascular outcome trials in type 2 diabetes: from DCCT to EMPA-REG. Clin Ther 38 (2016), 1279–1287.
    • (2016) Clin Ther , vol.38 , pp. 1279-1287
    • Ryden, L.1    Shahim, B.2    Mellbin, L.3
  • 29
    • 84917723836 scopus 로고    scopus 로고
    • Heart failure, saxagliptin, and diabetes mellitus: observations from the SAVOR-TIMI 53 randomized trial
    • Scirica, BM, Braunwald, E, Raz, I, Cavender, MA, Morrow, DA, Jarolim, P, et al. Heart failure, saxagliptin, and diabetes mellitus: observations from the SAVOR-TIMI 53 randomized trial. Circulation 130 (2014), 1579–1588.
    • (2014) Circulation , vol.130 , pp. 1579-1588
    • Scirica, B.M.1    Braunwald, E.2    Raz, I.3    Cavender, M.A.4    Morrow, D.A.5    Jarolim, P.6
  • 30
    • 84930085787 scopus 로고    scopus 로고
    • Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial
    • Zannad, F, Cannon, CP, Cushman, WC, Bakris, GL, Menon, V, Perez, AT, et al. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial. Lancet 385 (2015), 2067–2076.
    • (2015) Lancet , vol.385 , pp. 2067-2076
    • Zannad, F.1    Cannon, C.P.2    Cushman, W.C.3    Bakris, G.L.4    Menon, V.5    Perez, A.T.6
  • 31
    • 85021438535 scopus 로고    scopus 로고
    • Association between sitagliptin use and heart failure hospitalization and related outcomes in type 2 diabetes mellitus: secondary analysis of a randomized clinical trial
    • McGuire, DK, Van de Werf, F, Armstrong, PW, Standl, E, Koglin, J, Green, JB, et al. Association between sitagliptin use and heart failure hospitalization and related outcomes in type 2 diabetes mellitus: secondary analysis of a randomized clinical trial. JAMA Cardiol 1 (2016), 126–135.
    • (2016) JAMA Cardiol , vol.1 , pp. 126-135
    • McGuire, D.K.1    Van de Werf, F.2    Armstrong, P.W.3    Standl, E.4    Koglin, J.5    Green, J.B.6
  • 32
    • 85043762831 scopus 로고    scopus 로고
    • GLP-1 receptor agonists and cardiovascular protection: a class effect or not?
    • Scheen, AJ, GLP-1 receptor agonists and cardiovascular protection: a class effect or not?. Diabetes Metab 44 (2018), 193–196.
    • (2018) Diabetes Metab , vol.44 , pp. 193-196
    • Scheen, A.J.1
  • 33
    • 23644457189 scopus 로고    scopus 로고
    • In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias
    • Terrin, N, Schmid, CH, Lau, J, In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias. J Clin Epidemiol 58 (2005), 894–901.
    • (2005) J Clin Epidemiol , vol.58 , pp. 894-901
    • Terrin, N.1    Schmid, C.H.2    Lau, J.3
  • 34
    • 0038726233 scopus 로고    scopus 로고
    • Adjusting for publication bias in the presence of heterogeneity
    • Terrin, N, Schmid, CH, Lau, J, Olkin, I, Adjusting for publication bias in the presence of heterogeneity. Stat Med 22 (2003), 2113–2126.
    • (2003) Stat Med , vol.22 , pp. 2113-2126
    • Terrin, N.1    Schmid, C.H.2    Lau, J.3    Olkin, I.4
  • 35
    • 0034112926 scopus 로고    scopus 로고
    • Publication bias in meta-analysis: its causes and consequences
    • Thornton, A, Lee, P, Publication bias in meta-analysis: its causes and consequences. J Clin Epidemiol 53 (2000), 207–216.
    • (2000) J Clin Epidemiol , vol.53 , pp. 207-216
    • Thornton, A.1    Lee, P.2
  • 36
    • 85042911235 scopus 로고    scopus 로고
    • Durability of protective effect of dulaglutide on pancreatic beta-cells in diabetic mice: GLP-1 receptor expression is not reduced despite long-term dulaglutide exposure
    • Kimura, T, Obata, A, Shimoda, M, Hirukawa, H, Kanda-Kimura, Y, Nogami, Y, et al. Durability of protective effect of dulaglutide on pancreatic beta-cells in diabetic mice: GLP-1 receptor expression is not reduced despite long-term dulaglutide exposure. Diabetes Metab 44 (2018), 250–260.
    • (2018) Diabetes Metab , vol.44 , pp. 250-260
    • Kimura, T.1    Obata, A.2    Shimoda, M.3    Hirukawa, H.4    Kanda-Kimura, Y.5    Nogami, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.