Efficacy of low-dose daily versus alternate-day prednisolone in frequently relapsing nephrotic syndrome: an open-label randomized controlled trial

Pediatric Nephrology

Volumn 34, Issue 5, 2019, Pages 829-835

  Yadav, Menka ^a   Sinha, Aditi ^a   Khandelwal, Priyanka ^a   Hari, Pankaj ^a   Bagga, Arvind ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Glucocorticoids; Minimal change disease; Steroid dependence

Indexed keywords

PREDNISOLONE; GLUCOCORTICOID; IMMUNOSUPPRESSIVE AGENT;

ARTICLE; CATARACT; CHILD; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; DRUG EFFICACY; DRUG SAFETY; DRUG USE; FEMALE; FREQUENTLY RELAPSING NEPHROTIC SYNDROME; HUMAN; INFECTION; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; NEPHROTIC SYNDROME; PERITONITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RELAPSE; REMISSION; SIDE EFFECT; TREATMENT FAILURE; ADOLESCENT; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ADMINISTRATION; FOLLOW UP; IMMUNOLOGY; PRESCHOOL CHILD; PROCEDURES; PROSPECTIVE STUDY; RECURRENT DISEASE; SECONDARY PREVENTION; TREATMENT OUTCOME;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; GLUCOCORTICOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; NEPHROTIC SYNDROME; PREDNISOLONE; PROSPECTIVE STUDIES; RECURRENCE; SECONDARY PREVENTION; TREATMENT OUTCOME;

EID: 85053449905     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-018-4071-7     Document Type: Article

References (27)

1. International Study of Kidney Disease in Children (1979) Nephrotic syndrome in children: a randomized trial comparing two prednisone regimens in steroid-responsive patients who relapse early. Report of the international study of kidney disease in children. J Pediatr 95:239–243
2. Emma F, Sesto A, Rizzoni G (2003) Long-term linear growth of children with severe steroid-responsive nephrotic syndrome. Pediatr Nephrol 18:783–788
3. Kyrieleis HA, Lowik MM, Pronk I, Cruysberg HR, Kremer JA, Oyen WJ, van den Heuvel BL, Wetzels JF, Levtchenko EN (2009) Long-term outcome of biopsy-proven, frequently relapsing minimal-change nephrotic syndrome in children. Clin J Am Soc Nephrol 4:1593–1600
4. Kidney Disease: Improving Global Outcomes (KDIGO) Glomerulonephritis Work Group (2012) Steroid-sensitive nephrotic syndrome in children. Kidney Int Suppl 2(2011):163–171
5. Indian Pediatric Nephrology Group, Indian Academy of Pediatrics, Bagga A, Ali U, Banerjee S, Kanitkar M, Phadke KD, Senguttuvan P, Sethi S, Shah M (2008) Management of steroid sensitive nephrotic syndrome: revised guidelines. Indian Pediatr 45:203–214
6. Consensus statement on management and audit potential for steroid responsive nephrotic syndrome (1994) Workshop by the British Association for Paediatric Nephrology and Research Unit, Royal College of Physicians. Arch Dis Child 70:151–157
7. Hahn D, Hodson EM, Willis NS, Craig JC (2015) Corticosteroid therapy for nephrotic syndrome in children. Cochrane Database Syst Rev: CD001533
8. Sinha A, Hari P, Sharma PK, Gulati A, Kalaivani M, Mantan M, Dinda AK, Srivastava RN, Bagga A (2012) Disease course in steroid sensitive nephrotic syndrome. Indian Pediatr 49:881–887
9. Uwaezuoke SN (2015) Steroid-sensitive nephrotic syndrome in children: triggers of relapse and evolving hypotheses on pathogenesis. Ital J Pediatr 41:19
10. Gulati A, Sinha A, Sreenivas V, Math A, Hari P, Bagga A (2011) Daily corticosteroids reduce infection-associated relapses in frequently relapsing nephrotic syndrome: a randomized controlled trial. Clin J Am Soc Nephrol 6:63–69
11. Abeyagunawardena AS, Trompeter RS (2008) Increasing the dose of prednisolone during viral infections reduces the risk of relapse in nephrotic syndrome: a randomised controlled trial. Arch Dis Child 93:226–228
12. Mattoo TK, Mahmoud MA (2000) Increased maintenance corticosteroids during upper respiratory infection decrease the risk of relapse in nephrotic syndrome. Nephron 85:343–345
13. Leisti S, Hallman N, Koskimies O, Perheentupa J, Rapola J, Vilska J (1977) Association of postmedication hypocortisolism with early first relapse of idiopathic nephrotic syndrome. Lancet 2:795–796
14. Leisti S, Koskimies O (1983) Risk of relapse in steroid-sensitive nephrotic syndrome: effect of stage of post-prednisone adrenocortical suppression. J Pediatr 103:553–557
15. Leisti S, Vilska J, Hallman N (1977) Adrenocortical insufficiency and relapsing in the idiopathic nephrotic syndrome of childhood. Pediatrics 60:334–342
16. Leisti S, Koskimies O, Perheentupa J, Vilska J, Hallman N (1978) Idiopathic nephrotic syndrome: prevention of early relapse. Br Med J 1:892
17. Srivastava RN, Vasudev AS, Bagga A, Sunderam KR (1992) Long-term, low-dose prednisolone therapy in frequently relapsing nephrotic syndrome. Pediatr Nephrol 6:247–250
18. Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20:629–637
19. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114:555–576
20. de Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J (2007) Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 85:660–667
21. Schoeneman MJ (1983) Minimal change nephrotic syndrome: treatment with low doses of hydrocortisone. J Pediatr 102:791–793
22. Wingen AM, Muller-Wiefel DE, Scharer K (1990) Comparison of different regimens of prednisone therapy in frequently relapsing nephrotic syndrome. Acta Paediatr Scand 79:305–310
23. Elzouki AY, Jaiswal OP (1988) Long-term, small dose prednisone therapy in frequently relapsing nephrotic syndrome of childhood. Effect on remission, statural growth, obesity, and infection rate. Clin Pediatr (Phila) 27:387–392
24. Arbeitsgemeinschaft fur Padiatrische Nephrologie (1981) Alternate day prednisone is more effective than intermittent prednisone in frequently relapsing nephrotic syndrome. Eur J Pediatr 135:229–237
25. Moel DI, Kwun YA, Teitcher J (1980) Hypothalamic-pituitary-adrenal function in adrenocortical steroid treated minimal change nephrotic syndrome. Clin Nephrol 14:36–41
26. Abeyagunawardena AS, Hindmarsh P, Trompeter RS (2007) Adrenocortical suppression increases the risk of relapse in nephrotic syndrome. Arch Dis Child 92:585–588
27. Ribeiro D, Zawadynski S, Pittet LF, Chevalley T, Girardin E, Parvex P (2015) Effect of glucocorticoids on growth and bone mineral density in children with nephrotic syndrome. Eur J Pediatr 174:911–917