Effect of Excess Iodine Intake from Iodized Salt and/or Groundwater Iodine on Thyroid Function in Nonpregnant and Pregnant Women, Infants, and Children: A Multicenter Study in East Africa

Thyroid

Volumn 28, Issue 9, 2018, Pages 1198-1210

  Farebrother, Jessica ^a   Zimmermann, Michael B ^a,b   Abdallah, Fatma ^c   Assey, Vincent ^d,e   Fingerhut, Ralph ^f   Gichohi Wainaina, Wanjiku N ^g,h   Hussein, Izzeldin ⁱ   Makokha, Anselimo ^h   Sagno, Kalil ^j   Untoro, Juliawati ^k   Watts, Michael ^l   Andersson, Maria ^a,b,f  

^a ETH ZURICH   (Switzerland)

^b Iodine Network   (Canada)

^c Tanzania Food and Nutrition Centre   (Tanzania)

^d Elderly and Children   (Tanzania)

^e Regional Coordinator East and Southern Africa   (Canada)

^f UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^g International Crops Research Institute for the Semi Arid Tropics (ICRISAT)   (Malawi)

^h JOMO KENYATTA UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Kenya)

ⁱ Regional Coordinator Middle East and North Africa   (Canada)

^j Djibouti Country Office   (Djibouti)

^k UNITED NATIONS CHILDREN'S FUND   (Kenya)

^l BRITISH GEOLOGICAL SURVEY   (United Kingdom)

more..

Author keywords

groundwater; iodine excess; salt iodization; thyroglobulin; thyroid function; urinary iodine concentration

Indexed keywords

DRINKING WATER; GROUND WATER; GROUNDWATER IODINE; IODINE; IODIZED SALT; SODIUM CHLORIDE; THYROGLOBULIN; THYROTROPIN; THYROXINE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; BREAST FEEDING; BREAST MILK; CHILD; CROSS-SECTIONAL STUDY; DIETARY INTAKE; DIETARY SUPPLEMENT; DJIBOUTI; FEMALE; GESTATIONAL AGE; HEAD CIRCUMFERENCE; HUMAN; INFANT; IODINATION; IODINE INTAKE; KENYA; KIDNEY CONCENTRATING CAPACITY; LABORATORY TEST; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PREGNANT WOMAN; PREVALENCE; PRIORITY JOURNAL; RURAL AREA; SUBCLINICAL HYPERTHYROIDISM; TANZANIA; THYROID FUNCTION; URBAN AREA; URINE SAMPLING; URINE VOLUME; WEANING; WORLD HEALTH ORGANIZATION; AFRICA; CHEMISTRY; DIET; DRUG EFFECT; NEWBORN; PHYSIOLOGY; PREGNANCY; SALT INTAKE; THYROID GLAND; YOUNG ADULT;

ADOLESCENT; ADULT; AFRICA, EASTERN; CHILD; CROSS-SECTIONAL STUDIES; DIET; FEMALE; GROUNDWATER; HUMANS; INFANT; INFANT, NEWBORN; IODINE; PREGNANCY; SODIUM CHLORIDE, DIETARY; THYROID GLAND; YOUNG ADULT;

EID: 85053389525     PISSN: 10507256     EISSN: 15579077     Source Type: Journal    
DOI: 10.1089/thy.2018.0234     Document Type: Article

References (75)

1. Stinca S, Andersson M, Weibel S, Herter-Aeberli I, Fingerhut R, Gowachirapant S, Hess SY, Jaiswal N, Jukic T, Kusic Z, Mabapa NS, Nepal AK, San Luis TO, Zhen JQ, Zimmermann MB 2017 Dried blood spot thyroglobulin as a biomarker of iodine status in pregnant women. J Clin Endocrinol Metab 102:23-32.
2. Zimmermann MB, Aeberli I, Andersson M, Assey V, Yorg JA, Jooste P, Jukic T, Kartono D, Kusic Z, Pretell E, San Luis TO Jr, Untoro J, Timmer A 2013 Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100-299 lg/L: A UNICEF/ICCIDD study group report. J Clin Endocrinol Metab 98:1271-1280.
3. Shi X, Han C, Li C, Mao J, Wang W, Xie X, Li C, Xu B, Meng T, Du J, Zhang S, Gao Z, Zhang X, Fan C, Shan Z, Teng W 2015 Optimal and safe upper limits of iodine intake for early pregnancy in iodine-sufficient regions: A cross-sectional study of 7190 pregnant women in China. J Clin Endocrinol Metab 100:1630-1638.
4. World Health Organization, United Nations Children's Fund, International Council for the Control of Iodine Deficiency Disorders 2007 Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination. A Guide for Programme Managers. Third edition. World Health Organization, Geneva, Switzerland.
5. Iodine Global Network. Global Scorecard. Available at: www. ign. org/cm-data/IGN-Global-Scorecard-AllPop-and- PW-May2017. pdf (accessed August 28, 2017).
6. Barikmo I, Henjum S, Dahl L, Oshaug A, Torheim LE 2011 Environmental implication of iodine in water, milk and other foods used in Saharawi refugees camps in Tindouf, Algeria. J Food Compost Anal 24:637-641.
7. Chung HR, Shin CH, Yang SW, Choi CW, Kim BI 2009 Subclinical hypothyroidism in Korean preterm infants associated with high levels of iodine in breast milk. J Clin Endocrinol Metab 94:4444-4447.
8. Kassim IA, Moloney G, Busili A, Nur AY, Paron P, Jooste P, Gadain H, Seal AJ 2014 Iodine intake in Somalia is excessive and associated with the source of household drinking water. J Nutr 144:375-381.
9. Katagiri R, Yuan X, Kobayashi S, Sasaki S 2017 Effect of excess iodine intake on thyroid diseases in different populations: A systematic review and meta-analyses including observational studies. PLoS One 12:e0173722.
10. Nepal AK, Suwal R, Gautam S, Shah GS, Baral N, Andersson M, Zimmermann MB 2015 Subclinical hypothyroidism and elevated thyroglobulin in infants with chronic excess iodine intake. Thyroid 25:851-859.
11. Watts MJ, O'Reilly J, Maricelli A, Coleman A, Ander EL, Ward NI 2010A snapshot of environmental iodine and selenium in La Pampa and San Juan provinces of Argentina. J Geochem Explor 107:87-93.
12. Voutchkova DD, Ernstsen V, Hansen B, Sorensen BL, Zhang C, Kristiansen SM 2014 Assessment of spatial variation in drinking water iodine and its implications for dietary intake: A new conceptual model for Denmark. Sci Total Environ 493:432-444.
13. Watts MJ, Joy EJ, Young SD, Broadley MR, Chilimba AD, Gibson RS, Siyame EW, Kalimbira AA, Chilima B, Ander EL 2015 Iodine source apportionment in the Malawian diet. Sci Rep 5:15251.
14. Chen W, Li X, Wu Y, Bian J, Shen J, Jiang W, Tan L, Wang X, Wang W, Pearce EN, Zimmermann MB, Carriquiry AL, Zhang W 2017 Associations between iodine intake, thyroid volume, and goiter rate in school-aged Chinese children from areas with high iodine drinking water concentrations. Am J Clin Nutr 105:228-233.
15. Leung AM, Braverman LE 2014 Consequences of excess iodine. Nat Rev Endocrinol 10:136-142.
16. Laurberg P, Cerqueira C, Ovesen L, Rasmussen LB, Perrild H, Andersen S, Pedersen IB, Carle A 2010 Iodine intake as a determinant of thyroid disorders in populations. Best Pract Res Clin Endocrinol Metab 24:13-27.
17. Krejbjerg A, Bjergved L, Bulow Pedersen I, Carle A, Knudsen N, Perrild H, Ovesen L, Banke Rasmussen L, Laurberg P 2016 Serum thyroglobulin as a biomarker of iodine deficiency in adult populations. Clin Endocrinol 85:475-482.
18. Vejbjerg P, Knudsen N, Perrild H, Laurberg P, Carle A, Pedersen IB, Rasmussen LB, Ovesen L, Jorgensen T 2009 Thyroglobulin as a marker of iodine nutrition status in the general population. Eur J Endocrinol 161:475-481.
19. Ma ZF, Skeaff SA 2014 Thyroglobulin as a biomarker of iodine deficiency: A review. Thyroid 24:1195-1209.
20. Zimmermann MB, de Benoist B, Corigliano S, Jooste PL, Molinari L, Moosa K, Pretell EA, Al-Dallal ZS, Wei Y, Zu-Pei C, Torresani T 2006 Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient children. J Clin Endocrinol Metab 91:4881-4887.
21. Talsma E 2014 Yellow Cassava: Efficacy of Pprovitamin A Rich Cassava on Improvement of Vitamin A Status in Kenyan Schoolchildren. VLAG, Wageningen University, The Netherlands.
22. Kenya Ministry of Health 2014 Demographic and Health Survey. Kenya National Bureau of Statistics, Ministry of Health, National AIDS Cntrol Council, Kenya Medical Research Institute, National Council for Population and Development, The DHS Program, ICF International, Nairobi, Kenya.
23. Kenya Ministry of Health, Kenya Medical Research Institute, UNICEF, University of Nairobi 2006 Iodine nutrition situation in Kenya and trends in the control of iodine deficiency. Ministry of Health, Nairobi, Kenya.
24. Kenya Ministry of Health 2011 The Kenya National Micronutrient Survey 2011. Nutrition and Dietetics Unit, Ministry of Health, Nairobi, Kenya.
25. Arusei MK 1991 Hydrochemistry of Olkaria and Eburru Geothermal Fields, Kenyan Rift Valley. Olkaria Geothermal Project, Naivasha, Kenya.
26. Watts MJ, Middleton DRS, Humphrey O, Hamilton EM, McCormack V, Osano O, Menya D 2018 Measurements to apportion micronutrient status in Western Kenya, Poster presentation, 34th International Conference ''Geochemistry for sustainable development, '' Livingstone, Zambia.
27. The United Republic of Tanzania 2010 The United Republic of Tanzania. Salt Acts: The Mining Act 1979: The mining (salt production and iodation) regulations 1994 and The Food (Control of Quality) Act 1978. Regulations made under section 16 (1) and (2). The Food (Iodated salt) regulation. Salt Acts. Dar es Salaam, Tanzania 1994. Government gazette. 1994.
28. 2010 Tanzania Food, Drugs and Cosmetics Act 2003, Iodated Salt Regulations 2010.
29. National Bureau of Statistics, ICF Macro 2011 Tanzania Demographic and Health Survey 2010. NBS and ICF Macro, Dar es Salaam, Tanzania.
30. National Bureau of Statistics, ICF Macro 2011 Micronutrients: Results of the 2010 Tanzania Demographic andHealth Survey. NBS, Dar es Salaam, Tanzania. ICF Macro, Dar es Salaam, Tanzania.
31. UNICEF, World Health Organization 2009 WHO Child Growth Standards and the Identification of Severe Acute Malnutrition in Infants and Children. World Health Organization, Geneva, Switzerland.
32. Lemeshow S, Hosmer DW, Klar J, Lwanga SK 1990 Adequacy of Sample Size in Health Studies. John Wiley, Chichester, United Kingdom.
33. Naing L, Winn T, Rusli B 2006 Practical issues in calculating the sample size for prevalence studies. Arch Orofacial Sci 1:9-14.
34. de Onis M, Onyango AW, Van den Broeck J, Chumlea WC, Martorell R 2004 Measurement and standardization protocols for anthropometry used in the construction of a new international growth reference. Food Nutr Bull 25: S27-36.
35. World Health Organization. The WHO Child Growth Standards. Available at: www. who. int/childgrowth/standards/en/ (accessed January 22, 2018).
36. Dold S, Zimmermann MB, Aboussad A, Cherkaoui M, Jia Q, Jukic T, Kusic Z, Quirino A, Sang Z, San Luis TO, Vandea E, Andersson M 2017 Breast milk iodine concentration is a more accurate biomarker of iodine status than urinary iodine concentration in exclusively breastfeeding women. J Nutr 147:528-537.
37. Institute of Medicine, Academy of Sciences, USA 2001 Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. National Academies Press, Washington, DC.
38. Goellner MH, Ziegler EE, Fomon SJ 1981 Urination during the first three years of life. Nephron 28:174-178.
39. Dold S, Baumgartner J, Zeder C, Krzystek A, Osei J, Haldimann M, Zimmermann MB, Andersson M 2016 Optimization of a new mass spectrometry method for measurement of breast milk iodine concentrations and an assessment of the effect of analytic method and timing of within-feed sample collection on breast milk iodine concentrations. Thyroid 26:287-295.
40. The World Bank. Average preciptiation in depth (mm per year). Available at: https://data. worldbank. org/indicator/ AG. LND. PRCP. MMlocations=DJ (accessed February 23, 2018).
41. Dorey CM, Zimmermann MB 2008 Reference values for spot urinary iodine concentrations in iodine-sufficient newborns using a new pad collection method. Thyroid 18: 347-352.
42. Pino S, Fang SL, Braverman LE 1996 Ammonium persulfate: A safe alternative oxidizing reagent for measuring urinary iodine. Clin Chem 42:239-243.
43. Johnson CC 2003 The geochemistry of iodine and its application to environmental strategies for reducing the risks from iodine deficiency disorders. British Geological Survey Commissioned Report. Vol CR/03/057N. British Geological Survey, Keyworth, Nottingham, United Kingdom, 54.
44. Stinca S, Andersson M, Erhardt J, Zimmermann MB 2015 Development and validation of a new low-cost enzymelinked immunoassay for serum and dried blood spot thyroglobulin. Thyroid 25:1297-1305.
45. Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, Pessah-Pollack R, Singer PA, Woeber KA 2012 Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract 18:988-1028.
46. Mandel SJ, Spencer CA, Hollowell JG 2005 Are detection and treatment of thyroid insufficiency in pregnancy feasible Thyroid 15:44-53.
47. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, Nixon A, Pearce EN, Soldin OP, Sullivan S, Wiersinga W 2011 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid 21:1081-1125.
48. Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, Grobman WA, Laurberg P, Lazarus JH, Mandel SJ, Peeters RP, Sullivan S 2017 2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid 27:315-389.
49. University of Hamburg. GLIM-Global Lithological Map. Available at: https://www. geo. uni-hamburg. de/geologie/ forschung/geochemie/glim. html (accessed April 20, 2017).
50. Oyebode O, Oti S, Chen YF, Lilford RJ 2016 Salt intakes in sub-Saharan Africa: A systematic review andmeta-regression. Popul Health Metr 14:1.
51. Getachew A. Djibouti to drink Ethiopian water for free: Ambassador. Available at: https://aa. com. Tr/en/africa/djibouti-todrink-ethiopian-water-for-free-ambassador/989462 (accessed April 6, 2018).
52. Luo Y, Ishido Y, Hiroi N, Ishii N, Suzuki K 2014 The emerging roles of thyroglobulin. Adv Endocrinol 2014:1-7.
53. Sellitti DF, Suzuki K 2014 Intrinsic regulation of thyroid function by thyroglobulin. Thyroid 24:625-638.
54. Marino M, Pinchera A, McCluskey RT, Chiovato L 2001 Megalin in thyroid physiology and pathology. Thyroid 11: 47-56.
55. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, Braverman LE 2002 Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87:489-499.
56. Cooper DS, Biondi B 2012 Subclinical thyroid disease. Lancet 379:1142-1154.
57. Stanbury JB, Ermans AE, Bourdoux P, Todd C, Oken E, Tonglet R, Vidor G, Braverman LE, Medeiros-Neto G 1998 Iodine-induced hyperthyroidism: occurrence and epidemiology. Thyroid 8:83-100.
58. Delange F, de Benoist B, Alnwick D 1999 Risks of iodineinduced hyperthyroidism after correction of iodine deficiency by iodized salt. Thyroid 9:545-556.
59. Pedersen IB, Laurberg P, Knudsen N, Jørgensen T, Perrild H, Ovesen L, Rasmussen LB 2007 An increased incidence of overt hypothyroidism after iodine fortification of salt in Denmark: A prospective population study. J Clin Endocrinol Metabol 92:3122-3127.
60. De Groot L, Abalovich M, Alexander EK, Amino N, Barbour L, Cobin RH, Eastman CJ, Lazarus JH, Luton D, Mandel SJ, Mestman J, Rovet J, Sullivan S 2012 Management of thyroid dysfunction during pregnancy and postpartum: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 97:2543-2565.
61. Lee SY, Pearce EN 2015 Reproductive endocrinology: iodine intake in pregnancy-even a little excess is too much. Nat Rev Endocrinol 11:260-261.
62. Pearce EN, Lazarus JH, Moreno-Reyes R, Zimmermann MB 2016 Consequences of iodine deficiency and excess inpregnant women: An overview of current knowns and unknowns. Am J Clin Nutr 104:918S-923S.
63. Zoeller RT 2003 Transplacental thyroxine and fetal brain development. J Clin Invest 111:954-957.
64. Yarrington C, Pearce EN 2011 Iodine and pregnancy. J Thyroid Res 2011:934104.
65. Connelly KJ, Boston BA, Pearce EN, Sesser D, Snyder D, Braverman LE, Pino S, LaFranchi SH 2012 Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion. J Pediatr 161:760-762.
66. Korevaar TI, Schalekamp-Timmermans S, de Rijke YB, Visser WE, Visser W, de Muinck Keizer-Schrama SM, Hofman A, Ross HA, Hooijkaas H, Tiemeier H, Bongers-Schokking JJ, Jaddoe VW, Visser TJ, Steegers EA, Medici M, Peeters RP 2013 Hypothyroxinemia and TPO-antibody positivity are risk factors for premature delivery: The Generation R Study. J Clin Endocrinol Metab 98:4382-4390.
67. Henrichs J, Bongers-Schokking JJ, Schenk JJ, Ghassabian A, Schmidt HG, Visser TJ, Hooijkaas H, de Muinck Keizer-Schrama SM, Hofman A, Jaddoe VV, Visser W, Steegers EA, Verhulst FC, de Rijke YB, Tiemeier H 2010 Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: The Generation R Study. J Clin Endocrinol Metab 95:4227-4234.
68. Lavado-Autric R, AusóE, Garca-Velasco JV, del Carmen Arufe M, Escobar del Rey F, Berbel P, Morreale de Escobar G 2003 Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. J Clin Invest 111:1073-1082.
69. Yu X, Shan Z, Li C, Mao J, Wang W, Xie X, Liu A, Teng X, Zhou W, Li C, Xu B, Bi L, Meng T, Du J, Zhang S, Gao Z, Zhang X, Yang L, Fan C, Teng W 2015 Iron deficiency, an independent risk factor for isolated hypothyroxinemia in pregnant and nonpregnant women of childbearing age in China. J Clin Endocrinol Metab 100:1594-1601.
70. Morreale de Escobar G, Obregon MJ, Escobar del Rey F 2000 Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia J Clin Endocrinol Metab 85:3975-3987.
71. De Lima LF, Barbosa Júnior F, Navarro AM 2013 Excess iodinuria in infants and its relation to the iodine in maternal milk. J Trace Elem Med Biol 27:221-225.
72. Aakre I, Strand TA, Bjoro T, Norheim I, Barikmo I, Ares S, Alcorta MD, Henjum S 2016 Thyroid function among breastfed children with chronically excessive iodine intakes. Nutrients 8:398.
73. Aakre I, Strand TA, Moubarek K, Barikmo I, Henjum S 2017 Associations between thyroid dysfunction and developmental status in children with excessive iodine status. PLoS One 12:e0187241.
74. Pedersen IB, Knudsen N, Carle A, Vejbjerg P, Jorgensen T, Perrild H, Ovesen L, Rasmussen LB, Laurberg P 2011A cautious iodization programme bringing iodine intake to a low recommended level is associated with an increase in the prevalence of thyroid autoantibodies in the population. Clin Endocrinol 75:120-126.
75. Abizari AR, Dold S, Kupka R, Zimmermann MB 2017 More than two-thirds of dietary iodine in children in northern Ghana is obtained from bouillon cubes containing iodized salt. Public Health Nutr 20:1107-1113.