Central inhibition of granulocyte-macrophage colony-stimulating factor is analgesic in experimental neuropathic pain

Pain

Volumn 159, Issue 3, 2018, Pages 550-559

  Nicol, Louise S C ^a   Thornton, Peter ^b   Hatcher, Jon P ^b   Glover, Colin P ^a   Webster, Carl I ^a   Burrell, Matthew ^a   Hammett, Kessia ^c   Jones, Clare A ^a   Sleeman, Matthew A ^a   Billinton, Andrew ^b   Chessell, Iain ^b  

^a MEDIMMUNE LTD   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Astrocyte; Blood brain barrier; Cytokine; Granulocyte macrophage colony stimulating factor; Inflammation; Microglia; Neuropathic pain

Indexed keywords

CAM 3003; CAT 004; CYTOKINE; GLIAL FIBRILLARY ACIDIC PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; ANALGESIC AGENT; ANTIBODY; CALCIUM BINDING PROTEIN; CD11B ANTIGEN;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CELL FUNCTION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG PENETRATION; DRUG TARGETING; EXPERIMENTAL NEUROPATHIC PAIN; FEMALE; GENE DELETION; GLIA CELL; GLIOSIS; GM-CSF SIGNALING; HUMAN; INFLAMMATION; MECHANICAL HYPERALGESIA; MICROGLIA; MOUSE; NERVE INJURY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; UPREGULATION; ANIMAL; BRAIN; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; GLIA; IMMUNOLOGY; METABOLISM; NEURALGIA; PATHOLOGY; TRANSGENIC MOUSE;

ANALGESICS; ANIMALS; ANTIBODIES; BRAIN; CALCIUM-BINDING PROTEINS; CD11B ANTIGEN; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; NEURALGIA; NEUROGLIA; SIGNAL TRANSDUCTION;

EID: 85053289248     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1097/j.pain.0000000000001130     Document Type: Article

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