Association of schizophrenia polygenic risk score with manic and depressive psychosis in bipolar disorder

Translational Psychiatry

Volumn 8, Issue 1, 2018, Pages

  Markota, Matej ^a   Coombes, Brandon J ^a   Larrabee, Beth R ^a   McElroy, Susan L ^b   Bond, David J ^c   Veldic, Marin ^a   Colby, Colin L ^a   Chauhan, Mohit ^d   Cuellar Barboza, Alfredo B ^e   Fuentes, Manuel ^f   Kung, Simon ^a   Prieto, Miguel L ^g   Rummans, Teresa A ^a,b   Bobo, William V ^a   Frye, Mark A ^a   Biernacka, Joanna M ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d MAYO CLINIC   (United States)

^e UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

^f UNIVERSIDAD DEL DESARROLLO   (Chile)

^g UNIVERSIDAD DE LOS ANDES   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; ATYPICAL ANTIPSYCHOTIC AGENT;

ADULT; ARTICLE; BIPOLAR DISORDER; COMPARATIVE STUDY; CONTROLLED STUDY; DEPRESSIVE PSYCHOSIS; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MALE; MANIC PSYCHOSIS; PHENOTYPE; POLYGENIC RISK SCORE; RISK ASSESSMENT; SCHIZOPHRENIA; CASE CONTROL STUDY; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; PSYCHOLOGY; STATISTICAL MODEL;

ADULT; BIPOLAR DISORDER; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; PHENOTYPE; RISK ASSESSMENT; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 85053217636     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/s41398-018-0242-3     Document Type: Article

References (33)

1. Alda, M. The phenotypic spectra of bipolar disorder. Eur. Neuropsychopharmacol. 14(Suppl. 2), S94–S99 (2004)
2. Alda, M., Hajek, T., Calkin, C. & O'Donovan, C. Treatment of bipolar disorder: new perspectives. Ann. Med. 41, 186–196 (2009)
3. Winham, S. J. et al. Bipolar disorder with comorbid binge eating history: a genome-wide association study implicates APOB. J. Affect Disord. 165, 151–158 (2014)
4. Saunders, E. H., Scott, L. J., McInnis, M. G. & Burmeister, M. Familiality and diagnostic patterns of subphenotypes in the National Institutes of Mental Health bipolar sample. Am. J. Med. Genet. B 147B, 18–26 (2008)
5. Kraepelin, E., Barclay, R. M. & Robertson, G. M. Manic-Depressive Insanity and Paranoia. Ayer Co. Pub: Salem, NH, 1990
6. Anticevic, A. et al. Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biol. Psychiatry 73, 565–573 (2013)
7. Pantazopoulos, H. et al. Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala. Transl. Psychiatry 5, e496 (2015)
8. Clementz, B. A. et al. Identification of distinct psychosis biotypes using brain-based biomarkers. Am. J. Psychiatry 173, 373–384 (2016)
9. Ivleva, E. I. et al. Brain structure biomarkers in the psychosis biotypes: findings from the bipolar–schizophrenia network for intermediate phenotypes. Biol. Psychiatry 82, 26–39 (2017)
10. Pantazopoulos, H., Wiseman, J. T., Markota, M., Ehrenfeld, L. & Berretta, S. Decreased numbers of somatostatin-expressing neurons in the amygdala of subjects with bipolar disorder or schizophrenia: relationship to circadian rhythms. Biol. Psychiatry 81, 536–547 (2017)
11. Cross-Disorder Group of the Psychiatric Genomics C. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381, 1371–1379 (2013)
12. International Schizophrenia, C. et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460, 748–752 (2009)
13. Purcell, S. M. et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature 506, 185–190 (2014)
14. Craddock, N., O'Donovan, M. C. & Owen, M. J. Psychosis genetics: modeling the relationship between schizophrenia, bipolar disorder, and mixed (or "schizoaffective") psychoses. Schizophr. Bull. 35, 482–490 (2009)
15. Green, E. K. et al. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol. Psychiatry 15, 1016–1022 (2010)
16. Lichtenstein, P. et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 373, 234–239 (2009)
17. O'Donovan, M. C. et al. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat. Genet. 40, 1053–1055 (2008)
18. Ruderfer, D. M., Fanous, A. H., Ripke, S., McQuillin, A. & Amdur, R. L., Schizophrenia Working Group of the Psychiatric Genomics C. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. Mol. Psychiatry 19, 1017–1024 (2014)
19. Ruderfer, D., Sklar, P. & Kendler, K. Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes. Cell. 173, 1705–1715 (2018)
20. Hamshere, M. L. et al. Polygenic dissection of the bipolar phenotype. Br. J. Psychiatry 198, 284–288 (2011)
21. Allardyce, J. et al. Association between schizophrenia-related polygenic liability and the occurrence and level of mood-incongruent psychotic symptoms in bipolar disorder. JAMA Psychiatry 75, 28–35 (2018)
22. Hickie, I. B. Evidence for separate inheritance of mania and depression challenges current concepts of bipolar mood disorder. Mol. Psychiatry 19, 153–155 (2014)
23. Merikangas, K. R. et al. Mania with and without depression in a community sample of US adolescents. Arch. Gen. Psychiatry 69, 943–951 (2012)
24. Tohen, M. et al. The McLean-Harvard First-Episode Mania Study: prediction of recovery and first recurrence. Am. J. Psychiatry 160, 2099–2107 (2003)
25. Martinez-Aran, A. et al. Neurocognitive impairment in bipolar patients with and without history of psychosis. J. Clin. Psychiatry 69, 233–239 (2008)
26. Frye, M. A. et al. Development of a bipolar disorder biobank: differential phenotyping for subsequent biomarker analyses. Int. J. Bipolar Disord. 3, 30 (2015)
27. American Psychiatric Association. Task Force on DSM-IV. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR 4th edn, xxxvii, 943 (American Psychiatric Association, Washington, DC, 2000)
28. Olson, J. E. et al. The Mayo Clinic Biobank: a building block for individualized medicine. Mayo Clin. Proc. 88, 952–962 (2013)
29. Howie, B., Fuchsberger, C., Stephens, M., Marchini, J. & Abecasis, G. R. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat. Genet. 44, 955–959 (2012)
30. Euesden, J., Lewis, C. M. & O'Reilly, P. F. PRSice: Polygenic Risk Score software. Bioinformatics 31, 1466–1468 (2015)
31. Schizophrenia Working Group of the Psychiatric Genomics C. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427 (2014)
32. Chang, C. C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 4, 7 (2015)
33. Charney, A. W. et al. Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. Transl. Psychiatry 7, e993 (2017)