Isolation of pathology-associated intranuclear inclusions

Methods in Molecular Biology

Volumn 463, Issue , 2008, Pages 181-190

  Iwahashi, Christine ^a   Hagerman, Paul J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ataxia; Crystallin; Dementia; Flow cytometry; Fragile X syndrome; Fragile X associated tremor ataxia syndrome; FXTAS; Huntington; Immunochemistry; Parkinson; Ubiquitin

Indexed keywords

CRYSTALLIN; UBIQUITIN;

ATAXIA; CELL NUCLEUS; CELL NUCLEUS INCLUSION BODY; CHEMISTRY; DEGENERATIVE DISEASE; FLOW CYTOMETRY; FRAGILE X SYNDROME; HUMAN; HUNTINGTON CHOREA; METABOLISM; NERVE CELL; PARKINSON DISEASE; PATHOLOGY; PROCEDURES;

ATAXIA; CELL NUCLEUS; CRYSTALLINS; FLOW CYTOMETRY; FRAGILE X SYNDROME; HUMANS; HUNTINGTON DISEASE; INTRANUCLEAR INCLUSION BODIES; NEURODEGENERATIVE DISEASES; NEURONS; PARKINSON DISEASE; UBIQUITIN;

EID: 85052549673     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-406-3_13     Document Type: Article

References (9)

1. Ross, C. A. and Poirier, M. A. (2004) Protein aggregation, and neurodegenerative disease. Ato. Med. 10 Suppl, S 10-17.
2. Ozawa, T. (2006) Pathology and genetics of multiple system atrophy: an approach to determining genetic susceptibility spectrum. Acta Neuropathol. (Berl) 112, 531-538.
3. Olanow, C. W. and McNaught, K. S. (2006) Ubiquitin-proteasome system and Parkinson's disease. Mov. Disord. 21, 1806-1823.
4. Lee, H. G., Petersen, R. B., Zhu, X., Honda, K., Aliev, G., Smith, M. A., and Perry, G. (2003) Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases? Brain Pathol. 13, 630-638.
5. Slow, E. J., Graham, R. K., Osmand, A. P., Devon, R. S., Lu, G., Deng, Y. Pearson, J., Vaid, K., Bissada, N., Wetzel, R., Leavitt, B. R., and Haydeii, M. R. (2005) Absence of behavioral abnormalities and neurodegeneration in. vivo despite widespread neuronal huntingtin. inclusions. Proc. Natl, Acad. Sci. USA 102, 11402-11407.
6. Iwatsubo, T., Yamaguchi, H., Fujimuro, M., Yokosawa, H., Ihara, Y., Trojanowski, J. Q., and Lee, V. M. (1996) Lewy bodies: purification from diffuse Lewy body disease brains. Ann. NY. Acad. Sci. 786, 195-205.
7. Iwatsubo, T., Yamaguchi, H., Fujimuro, M., Yokosawa, H., Ihara, Y., Trojanowski, J. Q., and Lee, V. M. (1996) Purification and characterization of Lewy bodies from, the brains of patients with diffuse Lewy body disease. Am. J. Pathol. 148, 1517-1529.
8. Hazeki, N., Tsukamoto, T., Yazawa, I., Koyama, M., Hattori. S., Someki, I., Iwatsubo, T., Nakamura, K., Goto, J., and Kanazawa, I. (2002) Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine. Biochem. Biophys. Res. Commun. 294, 429-440.
9. Iwahashi, C. K., Yasui, D. H., An, H. J., Greco, C. M., Tassone, F., Nannen, K., Babineau, B., Lebrilla, C. B., Hagerman, R. J., and Hagerman, P. J. (2006) Protein composition of the intranuclear inclusions of PXTAS. Brain 129, 256-271.