Comparing molecular quantification of herpes simplex virus (HSV) in cerebrospinal fluid (CSF) with quantitative structural and functional disease severity in patients with HSV encephalitis (HSVE): Implications for improved therapeutic approaches

Journal of Clinical Virology

Volumn 107, Issue , 2018, Pages 29-37

  Ramirez, Kacy A ^a,b,c   Choudhri, Asim F ^a,b   Patel, Anami ^a,b   Lenny, Noel T ^a,b   Thompson, Rebecca E ^b   Berkelhammer Greenberg, Leslie ^a,b   Clanton Watson, Nancy ^a,b   Kocak, Mehmet ^b   DeVincenzo, John P ^a,b,d  

^a LE BONHEUR CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d LE BONHEUR CHILDREN'S MEDICAL CENTER   (United States)

Author keywords

Disease severity; Encephalitis; HSV; PCR; Viral load

Indexed keywords

ACICLOVIR; VIRUS DNA;

ADULT; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROSPINAL FLUID ANALYSIS; CHILD; CLINICAL ARTICLE; CLINICAL OUTCOME; DISEASE SEVERITY; DNA EXTRACTION; DRUG MEGADOSE; FEMALE; HERPES SIMPLEX ENCEPHALITIS; HERPES SIMPLEX VIRUS; HOSPITAL DISCHARGE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LESION VOLUME; MALE; MORBIDITY; NEWBORN; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; VERO CELL LINE; VIRAL CLEARANCE; VIRUS CULTURE; VIRUS LOAD; VIRUS REPLICATION; ADOLESCENT; BRAIN; CEREBROSPINAL FLUID; COMPARATIVE STUDY; GENETICS; HERPES SIMPLEX VIRUS 2; HUMAN ALPHAHERPESVIRUS 1; INFANT; ISOLATION AND PURIFICATION; PATHOLOGY; PRESCHOOL CHILD; PROCEDURES; SEVERITY OF ILLNESS INDEX; VIROLOGY; YOUNG ADULT;

ACYCLOVIR; ADOLESCENT; ADULT; BRAIN; CHILD; CHILD, PRESCHOOL; DNA, VIRAL; ENCEPHALITIS, HERPES SIMPLEX; FEMALE; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HUMANS; INFANT; INFANT, NEWBORN; MAGNETIC RESONANCE IMAGING; MALE; POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; VIRAL LOAD; YOUNG ADULT;

EID: 85052452771     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2018.08.005     Document Type: Article

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