메뉴 건너뛰기




Volumn 57, Issue 15, 2018, Pages 2105-2114

The anticipated renoprotective effects of sodium-glucose cotransporter 2 inhibitors

Author keywords

Diabetic kidney disease; Final common pathway; Sodium glucose cotransporter 2 (SGLT2) inhibitors; Tubuloglomerular feedback (TGF)

Indexed keywords

ALBUMIN; CANAGLIFLOZIN; CREATININE; DAPAGLIFLOZIN; EMPAGLIFLOZIN; GLUCOSE; HEMOGLOBIN A1C; INSULIN; KETONE BODY; OXYGEN; PLACEBO; SODIUM GLUCOSE COTRANSPORTER 2; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; URIC ACID; ANTIDIABETIC AGENT; SODIUM GLUCOSE COTRANSPORTER;

EID: 85051113901     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.9842-17     Document Type: Review
Times cited : (23)

References (29)
  • 1
    • 84918531200 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter-2 inhibition and the potential for renal protection in diabetic nephropathy
    • ŠkrtićM, Cherney DZI. Sodium-glucose cotransporter-2 inhibition and the potential for renal protection in diabetic nephropathy. Curr Opin Nephrol Hypertens 24: 96-103, 2015.
    • (2015) Curr Opin Nephrol Hypertens , vol.24 , pp. 96-103
    • Škrtićm, C.D.Z.I.1
  • 2
    • 79955771730 scopus 로고    scopus 로고
    • The proximal tubule in the pathophysiology of the diabetic kidney
    • Vallon V. The proximal tubule in the pathophysiology of the diabetic kidney. AJP Regul Integr Comp Physiol 300: R1009-R1022, 2011.
    • (2011) AJP Regul Integr Comp Physiol , vol.300 , pp. R1009-R1022
    • Vallon, V.1
  • 3
    • 84897394040 scopus 로고    scopus 로고
    • Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control
    • Kohan DE, Fioretto P, Tang W, List JF. Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int 85: 962-971, 2014.
    • (2014) Kidney Int , vol.85 , pp. 962-971
    • Kohan, D.E.1    Fioretto, P.2    Tang, W.3    List, J.F.4
  • 5
    • 84979895487 scopus 로고    scopus 로고
    • Empagliflozin and progression of kidney disease in type 2 diabetes
    • Wanner C, Inzucchi SE, Lachin JM, et al. Empagliflozin and progression of kidney disease in type 2 diabetes. N Engl J Med 375: 323-334, 2016.
    • (2016) N Engl J Med , vol.375 , pp. 323-334
    • Wanner, C.1    Inzucchi, S.E.2    Lachin, J.M.3
  • 6
    • 85034766786 scopus 로고    scopus 로고
    • Canagliflozin and cardiovascular and renal events in type 2 diabetes
    • Neal B, Perkovic V, Mahaffey KW, et al. Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med 377: 644-657, 2017.
    • (2017) N Engl J Med , vol.377 , pp. 644-657
    • Neal, B.1    Perkovic, V.2    Mahaffey, K.W.3
  • 7
    • 56149087069 scopus 로고    scopus 로고
    • Phlorizin prevents glomerular hyperfiltration but not hypertrophy in diabetic rats
    • Malatiali S, Francis I, Barac-Nieto M. Phlorizin prevents glomerular hyperfiltration but not hypertrophy in diabetic rats. Exp Diabetes Res 2008: 305403, 2008.
    • (2008) Exp Diabetes Res , vol.2008
    • Malatiali, S.1    Francis, I.2    Barac-Nieto, M.3
  • 8
    • 84892588641 scopus 로고    scopus 로고
    • SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice
    • Vallon V, Gerasimova M, Rose MA, et al. SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice. Am J Physiol Renal Physiol 306: F194-F204, 2014.
    • (2014) Am J Physiol Renal Physiol , vol.306 , pp. F194-F204
    • Vallon, V.1    Gerasimova, M.2    Rose, M.A.3
  • 9
    • 84873497173 scopus 로고    scopus 로고
    • Effects of SGLT2 inhibition in human kidney proximal tubular cells-renoprotection in diabetic nephropathy?
    • Panchapakesan U, Pegg K, Gross S, et al. Effects of SGLT2 inhibition in human kidney proximal tubular cells-renoprotection in diabetic nephropathy? PLoS One 8: e54442, 2013.
    • (2013) Plos One , vol.8
    • Panchapakesan, U.1    Pegg, K.2    Gross, S.3
  • 10
    • 33645452371 scopus 로고    scopus 로고
    • Chronic hypoxia and tubulointerstitial injury: A final common pathway to end-stage renal failure
    • Nangaku M. Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 17: 17-25, 2006.
    • (2006) J am Soc Nephrol , vol.17 , pp. 17-25
    • Nangaku, M.1
  • 11
    • 84975840750 scopus 로고    scopus 로고
    • Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis
    • Mudaliar S, Alloju S, Henry RR. Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis. Diabetes Care 39: 1115-1122, 2016.
    • (2016) Diabetes Care , vol.39 , pp. 1115-1122
    • Mudaliar, S.1    Alloju, S.2    Henry, R.R.3
  • 12
    • 84975853831 scopus 로고    scopus 로고
    • CV protection in the EMPA-REG OUTCOME trial: A “Thrifty Substrate” hypothesis
    • Ferrannini E, Mark M, Mayoux E. CV protection in the EMPA-REG OUTCOME trial: a “Thrifty Substrate” hypothesis. Diabetes Care 39: 1108-1114, 2016.
    • (2016) Diabetes Care , vol.39 , pp. 1108-1114
    • Ferrannini, E.1    Mark, M.2    Mayoux, E.3
  • 13
    • 84991106931 scopus 로고    scopus 로고
    • Empagliflozin’s fuel hypothesis: Not so soon
    • Lopaschuk GD, Verma S. Empagliflozin’s fuel hypothesis: not so soon. Cell Metab 24: 200-202, 2016.
    • (2016) Cell Metab , vol.24 , pp. 200-202
    • Lopaschuk, G.D.1    Verma, S.2
  • 14
    • 84893295683 scopus 로고    scopus 로고
    • Sodium glucose transport 2 (SGLT2) inhibition decreases glomerular hyperfiltration: Is there a role for SGLT2 inhibitors in diabetic kidney disease?
    • Stanton RC. Sodium glucose transport 2 (SGLT2) inhibition decreases glomerular hyperfiltration: is there a role for SGLT2 inhibitors in diabetic kidney disease? Circulation 129: 542-544, 2014.
    • (2014) Circulation , vol.129 , pp. 542-544
    • Stanton, R.C.1
  • 15
    • 84893214045 scopus 로고    scopus 로고
    • Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus
    • Cherney DZI, Perkins BA, Soleymanlou N, Maione M, Lai V, Lee A, et al. Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus. Circulation 129: 587-597, 2014.
    • (2014) Circulation , vol.129 , pp. 587-597
    • Cherney, D.Z.I.1    Perkins, B.A.2    Soleymanlou, N.3    Maione, M.4    Lai, V.5    Lee, A.6
  • 16
    • 0028216159 scopus 로고
    • Increased renal metabolism in diabetes. Mechanism and functional implications
    • Körner A, Eklöf AC, Celsi G, Aperia A. Increased renal metabolism in diabetes. Mechanism and functional implications. Diabetes 43: 629-633, 1994.
    • (1994) Diabetes , vol.43 , pp. 629-633
    • Körner, A.1    Eklöf, A.C.2    Celsi, G.3    Aperia, A.4
  • 18
    • 84984630329 scopus 로고    scopus 로고
    • Predicted consequences of diabetes and SGLT inhibition on transport and oxygen consumption along a rat nephron
    • Layton AT, Vallon V, Edwards A. Predicted consequences of diabetes and SGLT inhibition on transport and oxygen consumption along a rat nephron. Am J Physiol Renal Physiol 310: F1269-F1283, 2016.
    • (2016) Am J Physiol Renal Physiol , vol.310 , pp. F1269-F1283
    • Layton, A.T.1    Vallon, V.2    Edwards, A.3
  • 19
    • 84880850027 scopus 로고    scopus 로고
    • Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes
    • Lambers Heerspink HJ, de Zeeuw D, Wie L, Leslie B, List J. Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes Obes Metab 15: 853-862, 2013.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 853-862
    • Lambers Heerspink, H.J.1    de Zeeuw, D.2    Wie, L.3    Leslie, B.4    List, J.5
  • 20
    • 85019367291 scopus 로고    scopus 로고
    • Increased hematocrit during sodium-glucose cotransporter 2 inhibitor therapy indicates recovery of tubulointerstitial function in diabetic kidneys
    • Sano M, Takei M, Shiraishi Y, Suzuki Y. Increased hematocrit during sodium-glucose cotransporter 2 inhibitor therapy indicates recovery of tubulointerstitial function in diabetic kidneys. J Clin Med Res 8: 844-847, 2016.
    • (2016) J Clin Med Res , vol.8 , pp. 844-847
    • Sano, M.1    Takei, M.2    Shiraishi, Y.3    Suzuki, Y.4
  • 21
    • 84978743298 scopus 로고    scopus 로고
    • Dapagliflozin, SGLT2 inhibitor, attenuates renal ischemia-reperfusion injury
    • Chang Y-K, Choi H, Jeong JY, et al. Dapagliflozin, SGLT2 inhibitor, attenuates renal ischemia-reperfusion injury. PLoS One 11: e0158810, 2016.
    • (2016) Plos One , vol.11
    • Chang, Y.-K.1    Choi, H.2    Jeong, J.Y.3
  • 22
    • 79960959816 scopus 로고    scopus 로고
    • Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: Meta-analysis of randomised controlled trials
    • Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, et al. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ 343: d4169, 2011.
    • (2011) BMJ , vol.343 , pp. d4169
    • Boussageon, R.1    Bejan-Angoulvant, T.2    Saadatian-Elahi, M.3
  • 23
    • 84893827104 scopus 로고    scopus 로고
    • Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
    • Merovci A, Solis-Herrera C, Daniele G, et al. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J Clin Invest 124: 509-514, 2014.
    • (2014) J Clin Invest , vol.124 , pp. 509-514
    • Merovci, A.1    Solis-Herrera, C.2    Daniele, G.3
  • 24
    • 33750596002 scopus 로고    scopus 로고
    • Mechanisms of disease: Pathway-selective insulin resistance and microvascular complications of diabetes
    • Groop P-H, Forsblom C, Thomas MC. Mechanisms of disease: pathway-selective insulin resistance and microvascular complications of diabetes. Nat Clin Pract Endocrinol Metab 1: 100-110, 2005.
    • (2005) Nat Clin Pract Endocrinol Metab , vol.1 , pp. 100-110
    • Groop, P.-H.1    Forsblom, C.2    Thomas, M.C.3
  • 25
    • 69549084672 scopus 로고    scopus 로고
    • Solute carrier family 2, member 9 and uric acid homeostasis
    • Cheeseman C. Solute carrier family 2, member 9 and uric acid homeostasis. Curr Opin Nephrol Hypertens 18: 428-432, 2009.
    • (2009) Curr Opin Nephrol Hypertens , vol.18 , pp. 428-432
    • Cheeseman, C.1
  • 26
    • 84905996272 scopus 로고    scopus 로고
    • Renal effects of dapagliflozin in patients with type 2 diabetes
    • Thomas MC. Renal effects of dapagliflozin in patients with type 2 diabetes. Ther Adv Endocrinol Metab 5: 53-61, 2014.
    • (2014) Ther Adv Endocrinol Metab , vol.5 , pp. 53-61
    • Thomas, M.C.1
  • 27
    • 84951572386 scopus 로고    scopus 로고
    • Effect of sodium-glucose cotransport inhibition on polycystic kidney disease progression in PCK rats
    • Kapoor S, Rodriguez D, Riwanto M, et al. Effect of sodium-glucose cotransport inhibition on polycystic kidney disease progression in PCK rats. PLoS One 10: e0125603, 2015.
    • (2015) Plos One , vol.10
    • Kapoor, S.1    Rodriguez, D.2    Riwanto, M.3
  • 28
    • 84954514891 scopus 로고    scopus 로고
    • Effects of canagliflozin on fracture risk in patients with type 2 diabetes mellitus
    • Watts NB, Bilezikian JP, Usiskin K, et al. Effects of canagliflozin on fracture risk in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 101: 157-166, 2016.
    • (2016) J Clin Endocrinol Metab , vol.101 , pp. 157-166
    • Watts, N.B.1    Bilezikian, J.P.2    Usiskin, K.3
  • 29
    • 84954564720 scopus 로고    scopus 로고
    • Evaluation of bone mineral density and bone biomarkers in patients with type 2 diabetes treated with canagliflozin
    • Bilezikian JP, Watts NB, Usiskin K, et al. Evaluation of bone mineral density and bone biomarkers in patients with type 2 diabetes treated with canagliflozin. J Clin Endocrinol Metab 101: 44-51, 2016.
    • (2016) J Clin Endocrinol Metab , vol.101 , pp. 44-51
    • Bilezikian, J.P.1    Watts, N.B.2    Usiskin, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.