Clinical outcomes of minimized hydrocortisone dosage of 100mg/day on lower occurrence of hyperglycemia in septic shock patients

Shock

Volumn 50, Issue 3, 2018, Pages 280-285

  Ngaosuwan, Kanchana ^a,b   Ounchokdee, Kanit ^a   Chalermchai, Thep ^a  

^a SRINAKHARINWIROT UNIVERSITY   (Thailand)

^b CHULABHORN GRADUATE INSTITUTE   (Thailand)

Author keywords

Adverse effect; Critical illness; Hyperglycemia; Lower dosage; Sepsis; Steroid

Indexed keywords

DOPAMINE; EPINEPHRINE; GLUCOSE; HYDROCORTISONE SODIUM SUCCINATE; NORADRENALIN; HYDROCORTISONE;

ADULT; ARTICLE; CLINICAL OUTCOME; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG FATALITY; DRUG WITHDRAWAL; FEMALE; FLUID THERAPY; GASTROINTESTINAL HEMORRHAGE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; MAJOR CLINICAL STUDY; MALE; MORTALITY RATE; OUTCOME ASSESSMENT; PARALLEL DESIGN; RANDOMIZED CONTROLLED TRIAL; RECOMMENDED DRUG DOSE; SEPTIC SHOCK; SIMPLIFIED ACUTE PHYSIOLOGY SCORE; SUPERINFECTION; AGED; BLOOD; COMPLICATION; DISEASE FREE SURVIVAL; MIDDLE AGED; MORTALITY; SURVIVAL RATE; TIME FACTOR; VERY ELDERLY;

AGED; AGED, 80 AND OVER; DISEASE-FREE SURVIVAL; DOUBLE-BLIND METHOD; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMANS; HYDROCORTISONE; HYPERGLYCEMIA; MALE; MIDDLE AGED; SHOCK, SEPTIC; SURVIVAL RATE; TIME FACTORS;

EID: 85051031361     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000001061     Document Type: Article

References (16)

1. Marik PE, Pastores SM, Annane D, Meduri GU, Sprung CL, Arlt W, Keh D, Briegel J, Beishuizen A, Dimopoulou I, et al.: American College of Critical Care: recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 36(6):1937-1949, 2008.
2. Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troche G, et al.: Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288(7):862-871, 2002.
3. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, et al.: Hydrocortisone therapy for patients with septic shock. N Engl J Med 358(2):111-124, 2008.
4. Annane D, Bellissant E, Bollaert PE, Briegel J, Confalonieri M, De Gaudio R, Keh D, Kupfer Y, Oppert M, Meduri GU: Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review. JAMA 301(22): 2362-2375, 2009.
5. Patel GP, Balk RA: Systemic steroids in severe sepsis and septic shock. Am J Respir Crit Care Med 185(2):133-139, 2012.
6. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, et al.: Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41(2):580-637, 2013.
7. Egi M, Bellomo R, Stachowski E, French CJ, Hart GK, Hegarty C, Bailey M: Blood glucose concentration and outcome of critical illness: the impact of diabetes. Crit Care Med 36(8):2249-2255, 2008.
8. Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Henderson WR, et al.: The Nice-sugar study investigators: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360(13):1283-1297, 2009.
9. Kalil AC, Sun J: Low-dose steroids for septic shock and severe sepsis: the use of Bayesian statistics to resolve clinical trial controversies. Intensive Care Med 37(3):420-429, 2011.
10. Boonen E, Vervenne H, Meersseman P, Andrew R, Mortier L, Declercq PE, Vanwijngaerden YM, Spriet I, Wouters PJ, Vander Perre S, et al.: Reduced cortisol metabolism during critical illness. N Engl J Med 368(16):1477-1488, 2013.
11. Kerrigan JR, Veldhuis JD, Leyo SA, Iranmanesh A, Rogol AD: Estimation of daily cortisol production and clearance rates in normal pubertal males by deconvolution analysis. J Clin Endocrinol Metab 76(6):1505-1510, 1993.
12. Le Gall JR, Lemeshow S, Saulnier F: A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 270(24):2957-2963, 1993.
13. Jung Y, Lee MJ, Sin HY, Kim NH, Hwang JH, Park J, Choe PG, Park WB, Kim ES, Park SW, et al.: Differences in characteristics between healthcare-associated and community-acquired infection in community-onset Klebsiella pneumoniae bloodstream infection in Korea. BMC Infect Dis 12:239, 2012.
14. Colpan A, Akinci E, Erbay A, Balaban N, Bodur H: Evaluation of risk factors for mortality in intensive care units: a prospective study from a referral hospital in Turkey. Am J Infect Control 33(1):42-47, 2005.
15. Kavanagh BP, McCowen KC: Clinical practice. Glycemic control in the ICU. N Engl J Med 363(26):2540-2546, 2010.
16. Lv QQ, Gu XH, Chen QH, Yu JQ, Zheng RQ: Early initiation of low-dose hydrocortisone treatment for septic shock in adults: a randomized clinical trial. Am J Emerg Med 35(12):1810-1814, 2017.