BiP, an anti-inflammatory ER protein, is a potential new therapy for the treatment of rheumatoid arthritis

The Biology of Extracellular Molecular Chaperones

Volumn , Issue , 2008, Pages 212-220

  Panayi, Gabriel S ^a   Corrigall, Valerie M ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85050901103     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470754030.ch16     Document Type: Chapter

References (10)

1. Bodman-Smith M, Corrigall VM, Kemeny DM, Panayi GS 2003 BiP, a putative autoantigen in rheumatoid arthritis, stimulates IL-10-producing CD8 positive T cells from normal individ uals. Rheumatology (Oxford) 42:637-644
2. Brownlie RJ, Myers LK, Wooley PH et al 2006 Treatment of murine collagen-induced arthritis by the stress protein BiP via interleukin-4-producing regulatory T cells: a novel function for an ancient protein. Arthritis Rheum 54:854-863
3. Corrigall VM, Bodman-Smith MD, Fife MS et al 2001 The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induc tion of experimental arthritis. J Immunol 166:1492-1498
4. Corrigall VM, Bodman-Smith MD, Panayi GS 2003 The stress protein, immunoglobulin binding protein (BiP), has a specific cell surface receptor. Rheumatology (Oxford) 42 Suppl:43
5. Corrigall VM, Bodman-Smith MD, Brunst M, Cornell H, Panayi GS 2004 Inhibition of antigen-presenting cell function and stimulation of human peripheral blood mononuclear cells to express an antiinflammatory cytokine profile by the stress protein BiP: relevance to the treatment of inflammatory arthritis. Arthritis Rheum 50:1164-1171
6. Corrigall VM, Bodman-Smith M, Panayi GS 2005 BiP stimulation induces an anti-inflamma tory gene activation profile in monocytes. Rheumatology (Oxford) 44 Suppl:38
7. Gordon S 2003 Alternative activation of macrophages. Nat Rev Immunol 3:23-35
8. Matsuno H, Sawai T, Nezuka T et al 1998 Treatment of rheumatoid synovitis with anti-reshap ing human interleukin-6 receptor monoclonal antibody. Arthritis Rheum 41:2014-2021
9. Panayi GS, Corrigall VM, Henderson B 2004 Stress cytokines: pivotal proteins in immune regulatory networks; Opinion. Curr Opin Immunol 16:531-534
10. Macario AJL, Conway de Macario E 2007 Viral virulence and stress. In: Fink G (ed) The encyclopedia of stress second edition. Academic Press, Oxford, Vol 3, p 842-849