메뉴 건너뛰기




Volumn 27, Issue 7, 2018, Pages 595-599

Janus kinase inhibitors for the treatment of inflammatory bowel diseases: developments from phase I and phase II clinical trials

Author keywords

future perspectives; IBD; JAK inhibitors; phase I and II clinical trials

Indexed keywords

FILGOTINIB; JANUS KINASE INHIBITOR; PEFICITINIB; PF 06651600; TD 1473; UNCLASSIFIED DRUG; UPADACITINIB; GASTROINTESTINAL AGENT;

EID: 85050868087     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1080/13543784.2018.1492547     Document Type: Review
Times cited : (50)

References (21)
  • 1
    • 77957309991 scopus 로고    scopus 로고
    • Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects
    • Allez M, Karmiris K, Louis E, et al. Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects. J Crohn’s Colitis. 2010;4:355–366.
    • (2010) J Crohn’s Colitis , vol.4 , pp. 355-366
    • Allez, M.1    Karmiris, K.2    Louis, E.3
  • 2
    • 79953688705 scopus 로고    scopus 로고
    • Review article: loss of response to anti-TNF treatments in Crohn’s disease
    • Ben-Horin S, Chowers Y., Review article: loss of response to anti-TNF treatments in Crohn’s disease. Aliment Pharmacol Ther. 2011;33:987–995.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 987-995
    • Ben-Horin, S.1    Chowers, Y.2
  • 3
    • 85019631117 scopus 로고    scopus 로고
    • Advances in the development of Janus kinase inhibitors in inflammatory bowel disease: future prospects
    • Flamant M, Rigaill J, Paul S, et al. Advances in the development of Janus kinase inhibitors in inflammatory bowel disease: future prospects. Drugs. 2017;77:1057–1068.
    • (2017) Drugs , vol.77 , pp. 1057-1068
    • Flamant, M.1    Rigaill, J.2    Paul, S.3
  • 4
    • 85014062632 scopus 로고    scopus 로고
    • Signaling as a target for inflammatory and autoimmune diseases: current and future prospects
    • Apr
    • Banerjee S, Biehl A, Gadina M, et al. Signaling as a target for inflammatory and autoimmune diseases: current and future prospects. Drugs. 2017 Apr;77(5):521–546.
    • (2017) Drugs , vol.77 , Issue.5 , pp. 521-546
    • Banerjee, S.1    Biehl, A.2    Gadina, M.3
  • 5
    • 85052759725 scopus 로고    scopus 로고
    • Available from,. Access date: 25 May 2018
    • Medscape. FDA approves tofacitinib for rheumatoid arthritis. 2012. Access date: 25 May 2018. Available from http://www.medscape.com/viewarticle/774015
    • (2012) FDA approves tofacitinib for rheumatoid arthritis
  • 7
    • 85019133160 scopus 로고    scopus 로고
    • Tofacitinib as induction and maintenance therapy for ulcerative colitis
    • Sandborn WJ, Su C, Sands BE, et al. Tofacitinib as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2017;376:1723–1736.
    • (2017) N Engl J Med , vol.376 , pp. 1723-1736
    • Sandborn, W.J.1    Su, C.2    Sands, B.E.3
  • 8
    • 84906792069 scopus 로고    scopus 로고
    • A phase 2 study of tofacitinib, an oral Janus kinase inhibitor, in patients with Crohn’s disease
    • Sep,. doi:, Epub 2014 Jan 27
    • Sandborn WJ, Ghosh S, Panes J, et al. A phase 2 study of tofacitinib, an oral Janus kinase inhibitor, in patients with Crohn’s disease. Clin Gastroenterol Hepatol. 2014 Sep 12 (9):1485–1493.e2. doi:10.1016/j.cgh.2014.01.029 Epub 2014 Jan 27.
    • (2014) Clin Gastroenterol Hepatol , vol.9
    • Sandborn, W.J.1    Ghosh, S.2    Panes, J.3
  • 9
    • 84882433613 scopus 로고    scopus 로고
    • Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease
    • Oct
    • Coskun M, Salem M, Pedersen J, et al. Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease. Pharmacol Res. 2013 Oct;76:1–8.
    • (2013) Pharmacol Res , vol.76 , pp. 1-8
    • Coskun, M.1    Salem, M.2    Pedersen, J.3
  • 10
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and STATs: biological implications
    • Leonard WJ, O’Shea JJ., Jaks and STATs: biological implications. Annu Rev Immunol. 1998;16:293–322.
    • (1998) Annu Rev Immunol , vol.16 , pp. 293-322
    • Leonard, W.J.1    O’Shea, J.J.2
  • 12
    • 84956881232 scopus 로고    scopus 로고
    • JAK inhibition using tofacitinib for inflammatory bowel disease treatment: a hub for multiple inflammatory cytokines
    • Feb
    • Danese S, Grisham M, Hodge J, et al. JAK inhibition using tofacitinib for inflammatory bowel disease treatment: a hub for multiple inflammatory cytokines. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 1;310(3):G155–62.
    • (2016) Am J Physiol Gastrointest Liver Physiol , vol.310 , Issue.3 , pp. G155-G162
    • Danese, S.1    Grisham, M.2    Hodge, J.3
  • 13
    • 61849086101 scopus 로고    scopus 로고
    • Janus kinases in immune cell signaling
    • Mar
    • Ghoreschi K, Laurence A, O’Shea JJ. Janus kinases in immune cell signaling. Immunol Rev. 2009 Mar;228(1):273–287.
    • (2009) Immunol Rev , vol.228 , Issue.1 , pp. 273-287
    • Ghoreschi, K.1    Laurence, A.2    O’Shea, J.J.3
  • 14
    • 80054928002 scopus 로고    scopus 로고
    • Genomics and the multifactorial nature of human autoimmune disease
    • Oct
    • Cho JH, Gregersen PK. Genomics and the multifactorial nature of human autoimmune disease. N Engl J Med. 2011 Oct 27;365(17):1612–1623.
    • (2011) N Engl J Med , vol.365 , Issue.17 , pp. 1612-1623
    • Cho, J.H.1    Gregersen, P.K.2
  • 15
    • 84937967474 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacokinetic/pharmacodynamic modeling of filgotinib (GLPG0634), a selective JAK1 inhibitor, in support of phase IIB dose selection
    • Namour F, Diderichsen PM, Cox E, et al. Pharmacokinetics and pharmacokinetic/pharmacodynamic modeling of filgotinib (GLPG0634), a selective JAK1 inhibitor, in support of phase IIB dose selection. Clin. Pharmacokinet. 54, 859–874.
    • Clin. Pharmacokinet , vol.54 , pp. 859-874
    • Namour, F.1    Diderichsen, P.M.2    Cox, E.3
  • 17
    • 84904286774 scopus 로고    scopus 로고
    • JAK inhibitors in development for rheumatoid arthritis
    • Aug
    • Selective NP. JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067–1077.
    • (2014) Expert Opin Investig Drugs , vol.23 , Issue.8 , pp. 1067-1077
    • Selective, N.P.1
  • 18
    • 85021132123 scopus 로고    scopus 로고
    • Assessment of effect of CYP3A inhibition, CYP induction, OATP1B inhibition, and high-fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib
    • Mohamed MEF, Jungerwirth S, Asatryan A, et al.; Assessment of effect of CYP3A inhibition, CYP induction, OATP1B inhibition, and high-fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib; Br J Clin Pharmacol (2017) 83 2242–2248
    • (2017) Br J Clin Pharmacol , vol.83 , pp. 2242-2248
    • Mohamed, M.E.F.1    Jungerwirth, S.2    Asatryan, A.3
  • 21
    • 84953887794 scopus 로고    scopus 로고
    • Loss of response to anti-TNFs: definition, epidemiology, and management
    • Roda G, Jharap B, Neeraj N, et al. Loss of response to anti-TNFs: definition, epidemiology, and management. Clin Transl Gastroenterol. 2016;7:e135.
    • (2016) Clin Transl Gastroenterol , vol.7 , pp. e135
    • Roda, G.1    Jharap, B.2    Neeraj, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.