Association between the New York sepsis care mandate and in-hospital mortality for pediatric sepsis

JAMA - Journal of the American Medical Association

Volumn 320, Issue 4, 2018, Pages 358-367

  Evans, Idris V R ^a   Phillips, Gary S ^b   Alpern, Elizabeth R ^c   Angus, Derek C ^a   Friedrich, Marcus E ^d   Kissoon, Niranjan ^e   Lemeshow, Stanley ^f   Levy, Mitchell M ^g   Parker, Margaret M ^h   Terry, Kathleen M ^b   Scott Watson, R ⁱ   Weiss, Scott L ^j   Zimmerman, Jerry ⁱ   Seymour, Christopher W ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b IPRO Inc   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d NEW YORK STATE DEPARTMENT OF HEALTH   (United States)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f OHIO STATE UNIVERSITY   (United States)

^g BROWN UNIVERSITY   (United States)

^h STONY BROOK UNIVERSITY   (United States)

ⁱ SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^j UNIVERSITY OF PENNSYLVANIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT;

ADOLESCENT; ARTICLE; BLOOD CULTURE; CHILD; CHILD CARE; CLINICAL PROTOCOL; COHORT ANALYSIS; CONTROLLED STUDY; EMERGENCY WARD; FEMALE; HOSPITAL MORTALITY; HOSPITAL PATIENT; HUMAN; INFANT; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; NEW YORK; NEWBORN; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEPSIS; SEPTIC SHOCK; TREATMENT DURATION; CARE BUNDLE; EMERGENCY TREATMENT; HOSPITAL EMERGENCY SERVICE; MANDATORY PROGRAM; MORTALITY; ODDS RATIO; PRACTICE GUIDELINE; PRESCHOOL CHILD; PROTOCOL COMPLIANCE; RISK ASSESSMENT; TIME FACTOR;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; EMERGENCY SERVICE, HOSPITAL; EMERGENCY TREATMENT; FEMALE; GUIDELINE ADHERENCE; HOSPITAL MORTALITY; HUMANS; INFANT; INFANT, NEWBORN; MALE; MANDATORY PROGRAMS; NEW YORK; ODDS RATIO; PATIENT CARE BUNDLES; PRACTICE GUIDELINES AS TOPIC; RISK ADJUSTMENT; SEPSIS; TIME FACTORS;

EID: 85050801810     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2018.9071     Document Type: Article

References (26)

1. Balamuth F, Weiss SL, Neuman MI, et al. Pediatric severe sepsis in US children's hospitals. Pediatr Crit Care Med. 2014;15(9):798-805. doi:10.1097 /PCC.0000000000000225
2. Dellinger RP, Levy MM, Rhodes A, et al; Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39(2):165-228. doi:10.1007/s00134-012-2769-8
3. Cruz AT, Perry AM, Williams EA, Graf JM, Wuestner ER, Patel B. Implementation of goal-directed therapy for children with suspected sepsis in the emergency department. Pediatrics. 2011;127(3):e758-e766. doi:10.1542/peds.2010-2895
4. Larsen GY, Mecham N, Greenberg R. An emergency department septic shock protocol and care guideline for children initiated at triage. Pediatrics. 2011;127(6):e1585-e1592. doi:10.1542/peds .2010-3513
5. Dwyer J. An infection, unnoticed, turns unstoppable. The New York Times. https://www.nytimes.com/2012/07/12/nyregion/in-rory -stauntons-fight-for-his-life-signs-that-went -unheeded.html. Published July 11, 2012. Accessed July 20, 2017.
6. New York State Department of Health. New York State report on sepsis care improvement initiative: hospital quality performance. https://www. health .ny.gov/ press/ reports/ docs/2015_sepsis_care _improvement_initiative.pdf. Published March 2017. Accessed December 22, 2017.
7. Brierley J, Carcillo JA, Choong K, et al. Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine [published correction appears in Crit Care Med. 2009;37(4):1536]. Crit Care Med. 2009;37(2):666-688. doi:10.1097/CCM.0b013e31819323c6
8. Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6(1):2-8. doi:10.1097/01.PCC.0000149131 .72248.E6
9. Seymour CW, Gesten F, Prescott HC, et al. Time to treatment and mortality during mandated emergency care for sepsis. N Engl J Med. 2017;376 (23):2235-2244. doi:10.1056/NEJMoa1703058
10. Psaty BM, Koepsell TD, Lin D, et al. Assessment and control for confounding by indication in observational studies. J Am Geriatr Soc. 1999;47(6): 749-754. doi:10.1111/j.1532-5415.1999.tb01603.x
11. Odetola FO, Gebremariam A, Freed GL. Patient and hospital correlates of clinical outcomes and resource utilization in severe pediatric sepsis. Pediatrics. 2007;119(3):487-494. doi:10.1542/peds .2006-2353
12. Watson RS, Carcillo JA, Linde-Zwirble WT, Clermont G, Lidicker J, Angus DC. The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med. 2003;167(5):695-701. doi:10.1164/rccm.200207-682OC
13. Leclerc F, Leteurtre S, Duhamel A, et al. Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children. Am J Respir Crit Care Med. 2005;171(4):348-353. doi:10.1164/rccm.200405-630OC
14. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Occurrence and outcomes of sepsis: influence of race. Crit Care Med. 2007;35(3):763-768. doi:10.1097/01.CCM.0000256726.80998.BF
15. New York State Department of Health. Statewide Planning and Research Cooperative System (SPARCS). https://www.health.ny.gov/statistics/sparcs/. Accessed May 18, 2018.
16. New York State Department of Health. Health facility certification information. https://health.data.ny.gov/Health/Health-Facility-Certification -Information/2g9y-7kqm/data. Accessed January 4, 2018.
17. Rosenberg DI, Moss MM; American College of Critical Care Medicine of the Society of Critical Care Medicine. Guidelines and levels of care for pediatric intensive care units. Crit Care Med. 2004; 32(10):2117-2127. doi:10.1097/01.CCM.0000142704 .36378.E9
18. Royston P, Sauerbrei W. Building multivariable regression models with continuous covariates in clinical epidemiology: with an emphasis on fractional polynomials. Methods Inf Med. 2005;44 (4):561-571. doi:10.1055/s-0038-1634008
19. Dimick JB, Staiger DO, Birkmeyer JD. Ranking hospitals on surgical mortality: the importance of reliability adjustment. Health Serv Res. 2010;45(6, pt 1):1614-1629. doi:10.1111/j.1475-6773 .2010.01158.x
20. Czaja AS, Zimmerman JJ, Nathens AB. Readmission and late mortality after pediatric severe sepsis. Pediatrics. 2009;123(3):849-857. doi:10.1542/peds.2008-0856
21. Williams K, Thomson D, Seto I, et al; StaR Child Health Group. Standard 6: age groups for pediatric trials. Pediatrics. 2012;129(3)(suppl 3):S153-S160. doi:10.1542/peds.2012-0055I
22. Lash TL, Fox MP, Fink AK. Applying Quantitative Bias Analysis to Epidemiologic Data. New York, NY: Springer-Verlag; 2009.
23. Balamuth F, Weiss SL, Fitzgerald JC, et al. Protocolized treatment is associated with decreased organ dysfunction in pediatric severe sepsis. Pediatr Crit Care Med. 2016;17(9):817-822. doi:10.1097/PCC.0000000000000858
24. Davis AL, Carcillo JA, Aneja RK, et al. American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock. Crit Care Med. 2017;45 (6):1061-1093. doi:10.1097/CCM .0000000000002425
25. Kuhlmann S, Mason B, Ahlers-Schmidt CR. A quality improvement project to improve compliance with the joint commission children's asthma care-3 measure. Hosp Pediatr. 2013;3(1):45-51. doi:10.1542/hpeds.2012-0015
26. Seymour CW, Liu VX, Iwashyna TJ, et al. Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8): 762-774. doi:10.1001/jama.2016.0288