Does Akkermansia muciniphila play a role in type 1 diabetes?

Gut

Volumn 67, Issue 8, 2018, Pages 1373-1374

  Mithieux, Gilles ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ LYON 1   (France)

^c UNIVERSITÉ DE LYON   (France)

Author keywords

intestinal microbiology; intestinal transplantation; mucosal barrier; pancreatic disorders

Indexed keywords

INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

AKKERMANSIA MUCINIPHILA; BACTERIAL GENOME; BACTERIUM; BACTERIUM COLONY; DISEASE ASSOCIATION; ENDOTOXEMIA; HUMAN; IMMUNOREGULATION; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINE FLORA; INTESTINE MUCOSA PERMEABILITY; METABOLIC DISORDER; MICROBIAL DIVERSITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NOTE; OBESITY; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SYMBIONT; INTESTINE; VERRUCOMICROBIA;

DIABETES MELLITUS, TYPE 1; HUMANS; INTESTINES; VERRUCOMICROBIA;

EID: 85049172624     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2017-315732     Document Type: Note

References (14)

1. Turnbaugh PJ, Bäckhed F, Fulton L, et al. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 2008;3:213-23.
2. Everard A, Belzer C, Geurts L, et al. Cross-talk between akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A 2013;110:9066-71.
3. David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014;505:559-63.
4. Mithieux G. Gut microbiota and host metabolism: what relationship? Neuroendocrinology. In Press. 2017.
5. Rieder R, Wisniewski PJ, Alderman BL. Campbell SC: Microbes and mental health: A review. Brain Behav Immun. In Press. 2017.
6. Westfall S, Lomis N, Kahouli I, et al. Microbiome, probiotics and neurodegenerative diseases: Deciphering the gut brain axis. Cell Mol Life Sci. 2017;74:3769-87.
7. Levy M, Kolodziejczyk AA, Thaiss CA, et al. Dysbiosis and the immune system. Nat Rev Immunol 2017;17:219-32.
8. Yurkovetskiy LA, Pickard JM, Chervonsky AV. Microbiota and autoimmunity: Exploring new avenues. Cell Host Microbe 2015;17:548-52.
9. Hänninen A, Toivonen R, Pöysti S, et al. Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice. Gut 2018;67:1445-53.
10. Hansen CH, Krych L, Nielsen DS, et al. Early life treatment with vancomycin propagates akkermansia muciniphila and reduces diabetes incidence in the NOD mouse. Diabetologia 2012;55:2285-94.
11. Plovier H, Everard A, Druart C, et al. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nat Med 2017;23:107-13.
12. Sze MA, Schloss PD. Looking for a signal in the noise: Revisiting obesity and the microbiome. MBio 2016;7:e01018-16.
13. Lundberg R, Toft MF, August B, et al. Antibiotictreated versus germ-free rodents for microbiota transplantation studies. Gut Microbes 2016;7:68-74.
14. Quévrain E, Maubert MA, Michon C, et al. Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease. Gut 2016;65:415-25.