High prevalence of 16S rRNA methyltransferases among carbapenemase-producing Enterobacteriaceae in the UK and Ireland

International Journal of Antimicrobial Agents

Volumn 52, Issue 2, 2018, Pages 278-282

  Taylor, Emma ^a,b   Sriskandan, Shiranee ^a   Woodford, Neil ^a,b   Hopkins, Katie L ^a,b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

16S RMTase; Aminoglycoside resistance; blaNDM; Multiplex PCR

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE DERIVATIVE; GENTAMICIN; RIBOSOME RNA METHYLTRANSFERASE; RNA METHYLTRANSFERASE; TOBRAMYCIN; UNCLASSIFIED DRUG; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEMASE; METHYLTRANSFERASE; RNA 16S; RRNA (ADENOSINE-O-2'-)METHYLTRANSFERASE;

ANTIBIOTIC RESISTANCE; ARMA GENE; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIUM ISOLATE; BLA NDM GENE; CARBAPENEMASE PRODUCING ENTEROBACTERIACEAE; ESCHERICHIA COLI; GENE SEQUENCE; GENETIC ASSOCIATION; IRELAND; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; NONHUMAN; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; RMTB GENE; RMTC GENE; RMTF GENE; SCREENING; UNITED KINGDOM; CHEMISTRY; DRUG EFFECT; ESCHERICHIA COLI INFECTION; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; KLEBSIELLA INFECTION; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PLASMID; WHOLE GENOME SEQUENCING;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; IRELAND; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; PLASMIDS; PREVALENCE; RNA, RIBOSOMAL, 16S; UNITED KINGDOM; WHOLE GENOME SEQUENCING;

EID: 85049077140     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2018.03.016     Document Type: Article

References (19)

1. Doi, Y, Wachino, JI, Arakawa, Y, Aminoglycoside resistance: The emergence of acquired 16S ribosomal RNA methyltransferases. Infect Dis Clin North Am 30:2 (2016), 523–537.
2. Lee, H, Yong, D, Yum, JH, Roh, KH, Lee, K, Yamane, K, et al. Dissemination of 16s rRNA methylase-mediated highly amikacin-resistant isolates of Klebsiella pneumoniae and Acinetobacter baumannii in Korea. Diagn Microbiol Infect Dis 56:3 (2006), 305–312.
3. Bogaerts, P, Galimand, M, Bauraing, C, Deplano, A, Vanhoof, R, De Mendonca, R, et al. Emergence of ArmA and RmtB aminoglycoside resistance 16S rRNA methylases in Belgium. J Antimicrob Chemother 59 (2007), 459–464.
4. Wu, Q, Zhang, Y, Han, L, Sun, J, Ni, Y, Plasmid-mediated 16S rRNA methylases in aminoglycoside-resistant Enterobacteriaceae isolates in Shanghai, China. Antimicrob Agents Chemother 53 (2009), 271–272.
5. Doi, Y, Arakawa, Y, 16S ribosomal RNA methylation: Emerging resistance mechanism against aminoglycosides. Clin Infect Dis 45:1 (2007), 88–94.
6. Turton, JF, Perry, C, Elgohari, S, Hampton, CV, PCR characterization and typing of Klebsiella pneumoniae using capsular type-specific, variable number tandem repeat and virulence gene targets. J Med Microbiol, 2010, 541–547.
7. Woodford, N, Ward, ME, Kaufmann, ME, Turton, J, Fagan, EJ, James, D, et al. Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum β-lactamases in the UK. J Antimicrob Chemother, 2004, 735–743.
8. Doumith, M, Day, M, Ciesielczuk, H, Hope, R, Underwood, A, Reynolds, R, et al. Rapid identification of major E. coli sequence types causing urinary tract and bloodstream infections. J Clin Microbiol 53 (2015), 160–166.
9. Piekarska, K, Zacharczuk, K, Wołkowicz, T, Rzeczkowska, M, Bareja, E, Olak, M, et al. Distribution of 16S rRNA methylases among different species of aminoglycoside-resistant Enterobacteriaceae in a tertiary care hospital in Poland. Adv Clin Exp Med 25 (2016), 539–544.
10. Kang, HY, Kim, KY, Kim, J, Lee, JC, Lee, YC, Cho, DT, et al. Distribution of conjugative-plasmid-mediated 16S rRNA methylase genes among amikacin-resistant Enterobacteriaceae isolates collected in 1995 to 1998 and 2001 to 2006 at a university hospital in South Korea and identification of conjugative plasmids mediating dissemination of 16S rRNA methylase. J Clin Microbiol 46 (2008), 700–706.
11. Ho, PL, Lo, WU, Yeung, MK, Lin, CH, Chow, KH, Ang, I, et al. Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong. PLoS One, 6, 2011, e17989.
12. NDM-5 carried on an IncFII plasmid in an Escherichia coli isolate from a nontraveller patient in Spain. Antimicrob Agents Chemother 59 (2015), 659–662.
13. Gamal, D, Fernández-Martínez, M, Salem, D, El-Defrawy, I, Montes, LA, Ocampo-Sosa, A, et al. Carbapenem-resistant Klebsiella pneumoniae isolates from Egypt containing blaNDM-1 on IncR plasmids and its association with rmtF. Int J Infect Dis 43 (2016), 17–20.
14. Rojas, LJ, Hujer, AM, Rudin, SD, Wright, MS, Domitrovic, TN, Marshall, SH, et al. NDM-5 and OXA-181 beta-lactamases, a significant threat continues to spread in the Americas. Antimicrob Agents Chemother, 61, 2017 e00454-17.
15. D'Andrea, MM, Venturelli, C, Giani, T, Arena, F, Conte, V, Bresciani, P, et al. Persistent carriage and infection by multidrug-resistant Escherichia coli ST405 producing NDM-1 carbapenemase: report on the first Italian cases. J Clin Microbiol 49 (2011), 2755–2758.
16. Qin, S, Zhou, M, Zhang, Q, Tao, H, Ye, Y, Chen, H, et al. First identification of NDM-4-producing Escherichia coli ST410 in China. Emerg Microbes Infect, 5, 2016, e118.
17. Zhu, Y, Zhao, J, Xu, C, Zhao, H, Jia, N, Yan-nian, L, Identification of an NDM-5-producing Escherichia coli sequence type 167 in a neonatal patient in China. Sci Rep, 6, 2016, 29934.
18. NDM-1 in India, Sweden, and the United Kingdom. Antimicrob Agents Chemother 56 (2012), 2735–2738.
19. Wilson, ME, Chen, LH, NDM-1 and the Role of Travel in Its Dissemination. Curr Infect Dis Rep 14 (2012), 213–226.