The oral microbiota in colorectal cancer is distinctive and predictive

Gut

Volumn 67, Issue 8, 2018, Pages 1454-1463

  Flemer, Burkhardt ^a,b   Warren, Ryan D ^a   Barrett, Maurice P ^a,b   Cisek, Katryna ^c   Das, Anubhav ^c   Jeffery, Ian B ^a,b   Hurley, Eimear ^b   O'Riordain, Micheal ^b   Shanahan, Fergus ^a,b   O'Toole, Paul W ^a,b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c D Pharma Cork Ltd   (Ireland)

Author keywords

colonic bacteria; colorectal cancer; colorectal cancer screening; diet; tumour markers

Indexed keywords

TUMOR MARKER;

ADULT; AGED; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL OVERGROWTH; BACTERIUM DETECTION; BACTERIUM IDENTIFICATION; BIOFILM; CANCER CLASSIFICATION; CANCER DIAGNOSIS; CANCER RESISTANCE; CANCER SUSCEPTIBILITY; COLON MUCOSA; COLON TISSUE; COLORECTAL CANCER; COLORECTAL POLYP; CONTROLLED STUDY; CROHN DISEASE; DIAGNOSTIC TEST ACCURACY STUDY; DIET; DISEASE ASSOCIATION; EATING HABIT; FECES ANALYSIS; FEMALE; FUSOBACTERIUM; HUMAN; HUMAN TISSUE; INFECTIOUS AGENT; LACHNOSPIRACEAE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOUTH FLORA; ORAL BIOPSY; PARVIMONAS; PEPTOSTREPTOCOCCUS; POPULATION ABUNDANCE; PREDICTIVE VALUE; PREVOTELLA; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; STREPTOCOCCUS; CASE CONTROL STUDY; COLON POLYP; COLORECTAL TUMOR; FECES; MICROBIOLOGY; MICROFLORA; MOUTH; PATHOLOGY;

ADULT; AGED; CASE-CONTROL STUDIES; COLONIC POLYPS; COLORECTAL NEOPLASMS; FECES; FEMALE; HUMANS; MALE; MICROBIOTA; MIDDLE AGED; MOUTH; SENSITIVITY AND SPECIFICITY;

EID: 85048620328     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2017-314814     Document Type: Article

References (42)

1. Polk DB, Peek RM. Helicobacter pylori: Gastric cancer and beyond. Nat Rev Cancer 2010;10:403-14.
2. Mf G, Smoot DT, pylori H. gastric malt lymphoma, and adenocarcinoma of the stomach. Semin Gastrointest Dis 2000;11:134-41 https://www. ncbi. nlm. nih. gov/ pubmed/ 10950459
3. Flemer B, Lynch DB, Brown JM, et al. Tumour-associated and non-tumour-associated microbiota in colorectal cancer. Gut 2017;66:633-43.
4. Baxter NT, Ruffin MT, Rogers MA, et al. Microbiota-based model improves the sensitivity of fecal immunochemical test for detecting colonic lesions. Genome Med 2016;8:37.
5. Zeller G, Tap J, Voigt AY, et al. Potential of fecal microbiota for early-stage detection of colorectal cancer. Mol Syst Biol 2014;10:766.
6. Warren RL, Freeman DJ, Pleasance S, et al. Co-occurrence of anaerobic bacteria in colorectal carcinomas. Microbiome 2013;1:16.
7. Kostic AD, Gevers D, Pedamallu CS, et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res 2012;22:292-8.
8. Castellarin M, Warren RL, Freeman JD, et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res 2012;22:299-306.
9. Wu S, Rhee KJ, Albesiano E, et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med 2009;15:1016-22.
10. Arthur JC, Perez-Chanona E, Muhlbauer M, et al. Intestinal inflammation targets cancer-inducing activity of the microbiota. Science 2012;338:120-3.
11. Kostic AD, Chun E, Robertson L, et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 2013;14:207-15.
12. Rubinstein MR, Wang X, Liu W, et al. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. Cell Host Microbe 2013;14:195-206.
13. Nakatsu G, Li X, Zhou H, et al. Gut mucosal microbiome across stages of colorectal carcinogenesis. Nat Commun 2015;6:8727.
14. Liang Q, Chiu J, Chen Y, et al. Fecal bacteria act as novel biomarkers for noninvasive diagnosis of colorectal cancer. Clin Cancer Res 2017;23:2061-70.
15. Pushalkar S, Ji X, Li Y, et al. Comparison of oral microbiota in tumor and nontumor tissues of patients with oral squamous cell carcinoma. BMC Microbiol 2012;12:144.
16. Schmidt BL, Kuczynski J, Bhattacharya A, et al. Changes in abundance of oral microbiota associated with oral cancer. PLoS One 2014;9:e98741.
17. Chen X, Winckler B, Lu M, et al. Oral Microbiota and risk for esophageal squamous cell carcinoma in a high-risk area of china. PLoS One 2015;10:e0143603.
18. Farrell JJ, Zhang L, Zhou H, et al. Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer. Gut 2012;61:582-8.
19. Torres PJ, Fletcher EM, Gibbons SM, et al. Characterization of the salivary microbiome in patients with pancreatic cancer. PeerJ 2015;3:e1373.
20. Kato I, Vasquez AA, Moyerbrailean G, et al. Oral microbiome and history of smoking and colorectal cancer. J Epidemiol Res 2016;2:92-101.
21. Gevers D, Kugathasan S, Denson LA, et al. The treatment-naive microbiome in newonset Crohn's disease. Cell Host Microbe 2014;15:382-92.
22. Martin M. Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet.journal 2011;17:10-12.
23. Core Team R. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, 2016. https://www. R - project. org/
24. Urrea V, Calle M. AUCRF: Variable selection with random forest and the area under the curve, 2012. https:// CRAN. R- project. org/ package= AUCRF
25. Robin X, Turck N, Hainard A, et al. pROC: An open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics 2011;12:77.
26. Segata N, Haake SK, Mannon P, et al. Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples. Genome Biol 2012;13:R42.
27. Bassis CM, Erb-Downward JR, Dickson RP, et al. Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals. MBio 2015;6:e00037.
28. Hundt S, Haug U, Brenner H. Comparative evaluation of immunochemical fecal occult blood tests for colorectal adenoma detection. Ann Intern Med 2009;150:162-9 https://www. ncbi. nlm. nih. gov/ pubmed/ 19189905.
29. Flanagan L, Schmid J, Ebert M, et al. Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome. Eur J Clin Microbiol Infect Dis 2014;33:1381-90.
30. Arora N, Mishra A, Chugh S. Microbial role in periodontitis: Have we reached the top? some unsung bacteria other than red complex. J Indian Soc Periodontol 2014;18:9-13.
31. Jover-Diaz F, Cuadrado JM, Laveda R, et al. Porphyromonas asaccharolytica liver abscess. Anaerobe 2003;9:87-9.
32. Palmer RJ. Composition and development of oral bacterial communities. Periodontol 2000 2014;64:20-39.
33. Socransky SS, Haffajee AD, Cugini MA, et al. Microbial complexes in subgingival plaque. J Clin Periodontol 1998;25:134-44 https://www. ncbi. nlm. nih. gov/ pubmed/ 9495612
34. Heller D, Helmerhorst EJ, Gower AC, et al. Microbial Diversity in the Early In Vivo-Formed Dental Biofilm. Appl Environ Microbiol 2016;82:1881-8.
35. Tahara T, Yamamoto E, Suzuki H, et al. Fusobacterium in colonic flora and molecular features of colorectal carcinoma. Cancer Res 2014;74:1311-8.
36. Shah MS, DeSantis TZ, Weinmaier T, et al. Leveraging sequence-based faecal microbial community survey data to identify a composite biomarker for colorectal cancer. Gut 2017.
37. Marchesi JR, Dutilh BE, Hall N, et al. Towards the human colorectal cancer microbiome. PLoS One 2011;6:e20447.
38. Dejea CM, Wick EC, Hechenbleikner EM, et al. Microbiota organization is a distinct feature of proximal colorectal cancers. Proc Natl Acad Sci U S A 2014;111:18321-6.
39. Abed J, Emgard JE, Zamir G, et al. Fap2 mediates fusobacterium nucleatum colorectal adenocarcinoma enrichment by binding to tumor-expressed Gal-GalNAc. Cell Host Microbe 2016;20:215-25.
40. Tjalsma H, Boleij A, Marchesi JR, et al. A bacterial driver-passenger model for colorectal cancer: Beyond the usual suspects. Nat Rev Microbiol 2012;10:575-82.
41. Said IT, Shamsuddin AM, Sherief MA, et al. Comparison of different techniques for detection of Gal-GalNAc, an early marker of colonic neoplasia. Histol Histopathol 1999;14:351-7 https://www. ncbi. nlm. nih. gov/ pubmed/ 10212796
42. Zhang C, Derrien M, Levenez F, et al. Ecological robustness of the gut microbiota in response to ingestion of transient food-borne microbes. Isme J 2016;10:2235-45.