Clonal emergence of Klebsiella pneumoniae ST14 co-producing OXA-48-type and NDM carbapenemases with high rate of colistin resistance in Dubai, United Arab Emirates

International Journal of Antimicrobial Agents

Volumn 52, Issue 1, 2018, Pages 90-95

  Moubareck, Carole Ayoub ^a,b   Mouftah, Shaimaa F ^c   Pál, Tibor ^c   Ghazawi, Akela ^c   Halat, Dalal H ^a,d   Nabi, Anju ^e   AlSharhan, Mouza A ^e   AlDeesi, Zulfa O ^f   Peters, Christabel C ^g   Celiloglu, Handan ^h   Sannegowda, Manjunath ⁱ   Sarkis, Dolla K ^a,b   Sonnevend, Ágnes ^c  

^a SAINT JOSEPH UNIVERSITY   (Lebanon)

^b ZAYED UNIVERSITY   (United Arab Emirates)

^c UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^d LEBANESE INTERNATIONAL UNIVERSITY   (Lebanon)

^e DUBAI HOSPITAL   (United Arab Emirates)

^f RASHID HOSPITAL   (United Arab Emirates)

^g American Hospital Dubai   (United Arab Emirates)

^h Mediclinic City Hospital ^*  (United Arab Emirates)

ⁱ Welcare Hospital Dubai   (United Arab Emirates)

Author keywords

Carbapenemase producer Enterobacteriaceae; Colistin resistance; Dubai

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; AZTREONAM; CARBAPENEMASE; CARBAPENEMASE NDM; CARBAPENEMASE OX 48; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CHLORAMPHENICOL; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; ERTAPENEM; GENTAMICIN; IMIPENEM; MEROPENEM; NITROFURANTOIN; PIPERACILLIN PLUS TAZOBACTAM; TIGECYCLINE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; BETA LACTAMASE; OXACILLINASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; CLONAL EVOLUTION; DUBAI; EMIRATI; ENTEROBACTERIACEAE; ENZYME SYNTHESIS; ESCHERICHIA COLI; HUMAN; KLEBSIELLA PNEUMONIAE; NONHUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; DRUG EFFECT; ENTEROBACTERIACEAE INFECTION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; UNITED ARAB EMIRATES;

BACTERIAL PROTEINS; BETA-LACTAMASES; COLISTIN; DRUG RESISTANCE, BACTERIAL; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; HUMANS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; UNITED ARAB EMIRATES;

EID: 85048526051     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2018.03.003     Document Type: Article

References (19)

1. Iovleva, A, Doi, Y, Carbapenem-resistant Enterobacteriaceae. Clin Lab Med 37 (2017), 303–315.
2. Diene, SM, Rolain, JM, Carbapenemase genes and genetic platforms in Gram-negative bacilli: Enterobacteriaceae, Pseudomonas and Acinetobacter species. Clin Microbiol Infect 20 (2014), 831–838.
3. Giamarellou, H, Epidemiology of infections caused by polymyxin-resistant pathogens. Int J Antimicrob Agents 48 (2016), 614–621.
4. Kluytmans, J., Plasmid-encoded colistin resistance: mcr-one, two, three and counting. Euro Surveill, 2017, 22.
5. Zowawi, HM, Sartor, AL, Balkhy, HH, Walsh, TR, Al Johani, SM, AlJindan, RY, et al. Molecular characterization of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the countries of the Gulf cooperation council: dominance of OXA-48 and NDM producers. Antimicrob Agents Chemother 58 (2014), 3085–3090.
6. Sonnevend, A, Ghazawi, AA, Hashmey, R, Jamal, W, Rotimi, VO, Shibl, AM, et al. Characterization of carbapenem-resistant Enterobacteriaceae with high rate of autochthonous transmission in the Arabian Peninsula. PLoS One, 10, 2015, e0131372.
7. Hammoudi Halat, D, Moubareck, CA, Sarkis, DK, Heterogeneity of carbapenem resistance mechanisms among Gram-negative pathogens in Lebanon: results of the first cross-sectional countrywide study. Microb Drug Resist 23 (2017), 733–743.
8. Sonnevend, A, Ghazawi, A, Darwish, D, AlDeesi, Z, Kadhum, AF, Pal, T, Characterization of KPC-type carbapenemase-producing Klebsiella pneumoniae strains isolated in the Arabian Peninsula. J Antimicrob Chemother 70 (2015), 1592–1593.
9. CLSI. Performance Standard for Antimicrobial Susceptibility testing; M100-S24. 2014, Clinical and Laboratory Standard Institute, Wayne, PA, USA.
10. Nordmann, P, Poirel, L, Dortet, L, Rapid Detection of Carbapenemase-producing Enterobacteriaceae. Emerging Infectious Diseases 18 (2012), 1503–1507.
11. Liu, YY, Wang, Y, Walsh, TR, Yi, LX, Zhang, R, Spencer, J, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 16 (2016), 161–168.
12. Xavier, BB, Lammens, C, Ruhal, R, Kumar-Singh, S, Butaye, P, Goossens, H, et al. Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016. Euro Surveill., 2016, 21.
13. Yin, W, Li, H, Shen, Y, Liu, Z, Wang, S, Shen, Z, et al. Novel plasmid-mediated colistin resistance gene mcr-3 in Escherichia coli. MBio, 2017, 8.
14. Carattoli, A, Villa, L, Feudi, C, Curcio, L, Orsini, S, Luppi, A, et al. Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016. Euro Surveill, 2017, 22.
15. Jamal, WY, Albert, MJ, Rotimi, VO, High prevalence of New Delhi metallo-beta-lactamase-1 (NDM-1) producers among carbapenem-resistant Enterobacteriaceae in Kuwait. PLoS One, 11, 2016, e0152638.
16. Sonnevend, A, Ghazawi, A, Hashmey, R, Haidermota, A, Girgis, S, Alfaresi, M, et al. Multihospital occurrence of pan-resistant Klebsiella pneumoniae sequence type 147 with an ISEcp1-directed blaOXA-181 insertion in the mgrB gene in the United Arab Emirates. Antimicrob Agents Chemother, 2017, 61.
17. Giske, CG, Froding, I, Hasan, CM, Turlej-Rogacka, A, Toleman, M, Livermore, D, et al. Diverse sequence types of Klebsiella pneumoniae contribute to the dissemination of blaNDM-1 in India, Sweden, and the United Kingdom. Antimicrob Agents Chemother 56 (2012), 2735–2738.
18. Doi, Y, Hazen, TH, Boitano, M, Tsai, YC, Clark, TA, Korlach, J, et al. Whole-genome assembly of Klebsiella pneumoniae coproducing NDM-1 and OXA-232 carbapenemases using single-molecule, real-time sequencing. Antimicrob Agents Chemother 58 (2014), 5947–5953.
19. Sonnevend, A, Ghazawi, A, Alqahtani, M, Shibl, A, Jamal, W, Hashmey, R, et al. Plasmid-mediated colistin resistance in Escherichia coli from the Arabian Peninsula. Int J Infect Dis 50 (2016), 85–90.