Evaluation of whole-genome sequencing for mycobacterial species identification and drug susceptibility testing in a clinical setting: A large-scale prospective assessment of performance against line probe assays and phenotyping

Journal of Clinical Microbiology

Volumn 56, Issue 2, 2018, Pages

  Quan, T Phuong ^a,b   Bawa, Zharain ^c   Foster, Dona ^a,b   Walker, Tim ^b   del Ojo Elias, Carlos ^b   Rathod, Priti ^c   Iqbal, Zamin ^d   Bradley, Phelim ^d   Mowbray, Janet ^c   Walker, A Sarah ^a,b   Crook, Derrick W ^a,b,c   Wyllie, David H ^b   Peto, Timothy E A ^a,b   Smith, E Grace ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c PUBLIC HEALTH ENGLAND   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Line probe assay; Mycobacteria; Phenotype; WGS; Whole genome sequencing

Indexed keywords

ISONIAZID; RIFAMPICIN; TUBERCULOSTATIC AGENT;

ANTIBIOTIC RESISTANCE; BACTERIAL GENOME; COMPARATIVE STUDY; DRUG EFFECT; EVALUATION STUDY; GENETICS; HUMAN; ISOLATION AND PURIFICATION; MICROBIOLOGY; MOLECULAR TYPING; MYCOBACTERIUM TUBERCULOSIS; PROCEDURES; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; TIME FACTOR; TUBERCULOSIS;

ANTITUBERCULAR AGENTS; DRUG RESISTANCE, BACTERIAL; GENOME, BACTERIAL; HUMANS; ISONIAZID; MOLECULAR TYPING; MYCOBACTERIUM TUBERCULOSIS; PROSPECTIVE STUDIES; RIFAMPIN; SENSITIVITY AND SPECIFICITY; TIME FACTORS; TUBERCULOSIS;

EID: 85048164854     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.01480-17     Document Type: Article

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