-
1
-
-
84864092949
-
Pseudomonas aeruginosa outbreaks in the neonatal intensive care unit—a systematic review of risk factors and environmental sources
-
PID: 22683659
-
Jefferies JMC, Cooper T, Yam T, Clarke SC. Pseudomonas aeruginosa outbreaks in the neonatal intensive care unit—a systematic review of risk factors and environmental sources. J Med Microbiol. 2012;61:1052–61.
-
(2012)
J Med Microbiol
, vol.61
, pp. 1052-1061
-
-
Jefferies, J.M.C.1
Cooper, T.2
Yam, T.3
Clarke, S.C.4
-
2
-
-
84992361685
-
Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011–2014
-
PID: 27573805
-
Weiner LM, Webb AK, Limbago B, Dudeck MA, Patel J, Kallen AJ, et al. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011–2014. Infect Control Hosp Epidemiol. 2016;37:1288–301.
-
(2016)
Infect Control Hosp Epidemiol
, vol.37
, pp. 1288-1301
-
-
Weiner, L.M.1
Webb, A.K.2
Limbago, B.3
Dudeck, M.A.4
Patel, J.5
Kallen, A.J.6
Edwards, J.R.7
Sievert, D.M.8
-
3
-
-
85048178357
-
-
Accessed 13 Dec 2017. The CDC provides the current landscape of antimicrobial susceptibilities, showing the growing problem resistance
-
• National Healthcare Safety Network. NHSN antibiotic resistance data. CDC website. Available at: https://gis.cdc.gov/grasp/PSA/index.html. Accessed 13 Dec 2017. The CDC provides the current landscape of antimicrobial susceptibilities, showing the growing problem resistance.
-
NHSN Antibiotic Resistance Data
-
-
-
4
-
-
69049110965
-
Pseudomonas aeruginosa—a phenomenon of bacterial resistance
-
PID: 19528173
-
Strateva T, Yordanov D. Pseudomonas aeruginosa—a phenomenon of bacterial resistance. J Med Microbiol. 2009;58:1133–48.
-
(2009)
J Med Microbiol
, vol.58
, pp. 1133-1148
-
-
Strateva, T.1
Yordanov, D.2
-
5
-
-
84877930877
-
Mechanisms of β-lactam resistance among Pseudomonas aeruginosa
-
PID: 22894618
-
Wolter DJ, Lister PD. Mechanisms of β-lactam resistance among Pseudomonas aeruginosa. Curr Pharm Des. 2013;19:209–22.
-
(2013)
Curr Pharm Des
, vol.19
, pp. 209-222
-
-
Wolter, D.J.1
Lister, P.D.2
-
6
-
-
33646458074
-
Stepwise upregulation of the Pseudomonas aeruginosa chromosomal cephalosporinase conferring high-level β-lactam resistance involves three AmpD homologues
-
PID: 16641450, Illustrative in vitro study of the regulation of beta-lactamase expression inPseudomonasand consequences of stable derepression
-
• Juan C, Moyá B, Pérez JL, Oliver A. Stepwise upregulation of the Pseudomonas aeruginosa chromosomal cephalosporinase conferring high-level β-lactam resistance involves three AmpD homologues. Antimicrob Agents Chemother. 2006;50:1780–7. Illustrative in vitro study of the regulation of beta-lactamase expression in Pseudomonas and consequences of stable derepression.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 1780-1787
-
-
Juan, C.1
Moyá, B.2
Pérez, J.L.3
Oliver, A.4
-
7
-
-
85048207406
-
Pharmacology of drug resistance
-
Mayers DL, Lerner SA, Ouellette M, Sobel JD, (eds), Humana Press, Totowa
-
Drusano GL. Pharmacology of drug resistance. In: Mayers DL, Lerner SA, Ouellette M, Sobel JD, editors. Antimicrobial drug resistance. Totowa: Humana Press; 2009. p. 33–42.
-
(2009)
Antimicrobial drug resistance
, pp. 33-42
-
-
Drusano, G.L.1
-
8
-
-
0036403720
-
Function of Pseudomonas porins in uptake and efflux
-
PID: 12142471
-
Hancock REW, Brinkman FSL. Function of Pseudomonas porins in uptake and efflux. Annu Rev Microbiol. 2002;56:17–38.
-
(2002)
Annu Rev Microbiol
, vol.56
, pp. 17-38
-
-
Hancock, R.E.W.1
Brinkman, F.S.L.2
-
9
-
-
0035093095
-
Of Pseudomonas, porins, pumps and carbapenems
-
PID: 11222556
-
Livermore DM. Of Pseudomonas, porins, pumps and carbapenems. J Antimicrob Chemother. 2001;47:247–50.
-
(2001)
J Antimicrob Chemother
, vol.47
, pp. 247-250
-
-
Livermore, D.M.1
-
10
-
-
84876899005
-
Clinical and Laboratory Standards Institute
-
The current CLSI guidelines give context to the effectiveness of different antibiotics to Pseudomonas aeruginosa
-
• Patel JB, Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 2017. The current CLSI guidelines give context to the effectiveness of different antibiotics to Pseudomonas aeruginosa.
-
Performance Standards for Antimicrobial Susceptibility Testing; 2017
-
-
Patel, J.B.1
-
11
-
-
0024450329
-
Comparative activity of meropenem against Pseudomonas aeruginosa strains with well-characterized resistance mechanisms
-
PID: 2553657
-
Livermore DM, Yang YJ. Comparative activity of meropenem against Pseudomonas aeruginosa strains with well-characterized resistance mechanisms. J Antimicrob Chemother. 1989;24(Suppl A):149–59.
-
(1989)
J Antimicrob Chemother
, vol.24
, pp. 149-159
-
-
Livermore, D.M.1
Yang, Y.J.2
-
12
-
-
70449124604
-
Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms
-
PID: 19822890
-
Lister PD, Wolter DJ, Hanson ND. Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clin Microbiol Rev. 2009;22:582–610.
-
(2009)
Clin Microbiol Rev
, vol.22
, pp. 582-610
-
-
Lister, P.D.1
Wolter, D.J.2
Hanson, N.D.3
-
13
-
-
34250839342
-
16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides
-
PID: 17554708
-
Doi Y, Arakawa Y. 16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides. Clin Infect Dis. 2007;45:88–94.
-
(2007)
Clin Infect Dis
, vol.45
, pp. 88-94
-
-
Doi, Y.1
Arakawa, Y.2
-
14
-
-
0037405379
-
Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa
-
PID: 12727072
-
Higgins PG, Fluit AC, Milatovic D, Verhoef J, Schmitz F-J. Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa. Int J Antimicrob Agents. 2003;21:409–13.
-
(2003)
Int J Antimicrob Agents
, vol.21
, pp. 409-413
-
-
Higgins, P.G.1
Fluit, A.C.2
Milatovic, D.3
Verhoef, J.4
Schmitz, F.-J.5
-
15
-
-
78650417877
-
Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms
-
PID: 20974151
-
Sainsbury S, Bird L, Rao V, Shepherd SM, Stuart DI, Hunter WN, et al. Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms. J Mol Biol. 2011;405:173–84.
-
(2011)
J Mol Biol
, vol.405
, pp. 173-184
-
-
Sainsbury, S.1
Bird, L.2
Rao, V.3
Shepherd, S.M.4
Stuart, D.I.5
Hunter, W.N.6
Owens, R.J.7
Ren, J.8
-
16
-
-
84994762012
-
Spotlight on ceftazidime/avibactam: a new option for MDR Gram-negative infections
-
PID: 27432599
-
Falcone M, Paterson D. Spotlight on ceftazidime/avibactam: a new option for MDR Gram-negative infections. J Antimicrob Chemother. 2016;71:2713–22.
-
(2016)
J Antimicrob Chemother
, vol.71
, pp. 2713-2722
-
-
Falcone, M.1
Paterson, D.2
-
17
-
-
84963568986
-
In vitro activity of ceftazidime-avibactam against contemporary Pseudomonas aeruginosa isolates from U.S. medical centers by census region, 2014
-
PID: 26810650
-
Huband MD, Castanheira M, Flamm RK, Farrell DJ, Jones RN, Sader HS. In vitro activity of ceftazidime-avibactam against contemporary Pseudomonas aeruginosa isolates from U.S. medical centers by census region, 2014. Antimicrob Agents Chemother. 2016;60:2537–41.
-
(2016)
Antimicrob Agents Chemother
, vol.60
, pp. 2537-2541
-
-
Huband, M.D.1
Castanheira, M.2
Flamm, R.K.3
Farrell, D.J.4
Jones, R.N.5
Sader, H.S.6
-
18
-
-
84896833758
-
Antimicrobial activity of ceftazidime-avibactam against Gram-negative organisms collected from U.S. medical centers in 2012
-
PID: 24379201
-
Sader HS, Castanheira M, Flamm RK, Farrell DJ, Jones RN. Antimicrobial activity of ceftazidime-avibactam against Gram-negative organisms collected from U.S. medical centers in 2012. Antimicrob Agents Chemother. 2014;58:1684–92.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 1684-1692
-
-
Sader, H.S.1
Castanheira, M.2
Flamm, R.K.3
Farrell, D.J.4
Jones, R.N.5
-
19
-
-
84929583498
-
Ceftazidime-avibactam activity against multidrug-resistant Pseudomonas aeruginosa isolated in U.S. medical centers in 2012 and 2013
-
PID: 25845861
-
Sader HS, Castanheira M, Mendes RE, Flamm RK, Farrell DJ, Jones RN. Ceftazidime-avibactam activity against multidrug-resistant Pseudomonas aeruginosa isolated in U.S. medical centers in 2012 and 2013. Antimicrob Agents Chemother. 2015;59:3656–9.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 3656-3659
-
-
Sader, H.S.1
Castanheira, M.2
Mendes, R.E.3
Flamm, R.K.4
Farrell, D.J.5
Jones, R.N.6
-
20
-
-
84947026302
-
Ceftazidime-avibactam activity when tested against ceftazidime-nonsusceptible Citrobacter spp., Enterobacter spp., Serratia marcescens, and Pseudomonas aeruginosa from United States medical centers (2011–2014)
-
PID: 26162518
-
Sader HS, Castanheira M, Farrell DJ, Flamm RK, Jones RN. Ceftazidime-avibactam activity when tested against ceftazidime-nonsusceptible Citrobacter spp., Enterobacter spp., Serratia marcescens, and Pseudomonas aeruginosa from United States medical centers (2011–2014). Diagn Microbiol Infect Dis. 2015;83:389–94.
-
(2015)
Diagn Microbiol Infect Dis
, vol.83
, pp. 389-394
-
-
Sader, H.S.1
Castanheira, M.2
Farrell, D.J.3
Flamm, R.K.4
Jones, R.N.5
-
21
-
-
84937627900
-
Phase I study assessing the safety, tolerability, and pharmacokinetics of avibactam and ceftazidime-avibactam in healthy Japanese volunteers
-
PID: 26076867
-
Tominaga N, Edeki T, Li J, Learoyd M, Bouw MR, Das S. Phase I study assessing the safety, tolerability, and pharmacokinetics of avibactam and ceftazidime-avibactam in healthy Japanese volunteers. J Infect Chemother. 2015;21(8):551–8.
-
(2015)
J Infect Chemother
, vol.21
, Issue.8
, pp. 551-558
-
-
Tominaga, N.1
Edeki, T.2
Li, J.3
Learoyd, M.4
Bouw, M.R.5
Das, S.6
-
22
-
-
85048195111
-
-
Accessed 18 Nov 2017
-
US Food and Drug Administration Anti-Infective Drugs Advisory Committee. Cerexa, ceftazidime-avibactam for injection,2014. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/206494Orig1s000CllinPharmR.pdf. Accessed 18 Nov 2017.
-
Cerexa, ceftazidime-avibactam for injection,2014
-
-
-
23
-
-
84971578709
-
Efficacy and safety of ceftazidime-avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infection: results from a randomized, controlled, double-blind, phase 3 program
-
PID: 26962078
-
Mazuski JE, Gasink LB, Armstrong J, Broadhurst H, Stone GG, Rank D, et al. Efficacy and safety of ceftazidime-avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infection: results from a randomized, controlled, double-blind, phase 3 program. Clin Infect Dis. 2016;62:1380–9.
-
(2016)
Clin Infect Dis
, vol.62
, pp. 1380-1389
-
-
Mazuski, J.E.1
Gasink, L.B.2
Armstrong, J.3
Broadhurst, H.4
Stone, G.G.5
Rank, D.6
Llorens, L.7
Newell, P.8
Pachl, J.9
-
24
-
-
85017371968
-
A randomised, double-blind, phase 3 study comparing the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem for complicated intra-abdominal infections in hospitalised adults in Asia
-
PID: 28363526
-
Qin X, Tran BG, Kim MJ, Wang L, Nguyen DA, Chen Q, et al. A randomised, double-blind, phase 3 study comparing the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem for complicated intra-abdominal infections in hospitalised adults in Asia. Int J Antimicrob Agents. 2017;49:579–88.
-
(2017)
Int J Antimicrob Agents
, vol.49
, pp. 579-588
-
-
Qin, X.1
Tran, B.G.2
Kim, M.J.3
Wang, L.4
Nguyen, D.A.5
Chen, Q.6
Song, J.7
Laud, P.J.8
Stone, G.G.9
Chow, J.W.10
-
25
-
-
84995390345
-
Ceftazidime-avibactam versus doripenem for the treatment of complicated urinary tract infections, including acute pyelonephritis: RECAPTURE, a Phase 3 randomized trial program
-
PID: 27313268
-
Wagenlehner FM, Sobel JD, Newell P, Armstrong J, Huang X, Stone GG, et al. Ceftazidime-avibactam versus doripenem for the treatment of complicated urinary tract infections, including acute pyelonephritis: RECAPTURE, a Phase 3 randomized trial program. Clin Infect Dis. 2016;63:754–62.
-
(2016)
Clin Infect Dis
, vol.63
, pp. 754-762
-
-
Wagenlehner, F.M.1
Sobel, J.D.2
Newell, P.3
Armstrong, J.4
Huang, X.5
Stone, G.G.6
Yates, K.7
Gasink, L.B.8
-
26
-
-
84870399321
-
Efficacy and safety of ceftazidime–avibactam versus imipenem–cilastatin in the treatment of complicated urinary tract infections, including acute pyelonephritis, in hospitalized adults: results of a prospective, investigator-blinded, randomized study
-
PID: 23145859
-
Vazquez JA, Patzán LDG, Stricklin D, Duttaroy DD, Kreidly Z, Lipka J, et al. Efficacy and safety of ceftazidime–avibactam versus imipenem–cilastatin in the treatment of complicated urinary tract infections, including acute pyelonephritis, in hospitalized adults: results of a prospective, investigator-blinded, randomized study. Curr Med Res Opin. 2012;28:1921–31.
-
(2012)
Curr Med Res Opin
, vol.28
, pp. 1921-1931
-
-
Vazquez, J.A.1
Patzán, L.D.G.2
Stricklin, D.3
Duttaroy, D.D.4
Kreidly, Z.5
Lipka, J.6
-
27
-
-
84877123198
-
Comparative study of the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infections in hospitalized adults: results of a randomized, double-blind, Phase II trial
-
PID: 23391714
-
Lucasti C, Popescu I, Ramesh MK, Lipka J, Sable C. Comparative study of the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infections in hospitalized adults: results of a randomized, double-blind, Phase II trial. J Antimicrob Chemother. 2013;68:1183–92.
-
(2013)
J Antimicrob Chemother
, vol.68
, pp. 1183-1192
-
-
Lucasti, C.1
Popescu, I.2
Ramesh, M.K.3
Lipka, J.4
Sable, C.5
-
28
-
-
85048155716
-
-
CA, GlaxoSmithKline
-
Avycaz [package insert]. Irvine. GlaxoSmithKline: CA; 2015.
-
(2015)
Irvine
-
-
-
29
-
-
84963954564
-
Ceftazidime-avibactam or best available therapy in patients with ceftazidime-resistant Enterobacteriaceae and Pseudomonas aeruginosa complicated urinary tract infections or complicated intra-abdominal infections (REPRISE): a randomised, pathogen-directed, phase 3 study
-
PID: 27107460
-
Carmeli Y, Armstrong J, Laud PJ, Newell P, Stone G, Wardman A, et al. Ceftazidime-avibactam or best available therapy in patients with ceftazidime-resistant Enterobacteriaceae and Pseudomonas aeruginosa complicated urinary tract infections or complicated intra-abdominal infections (REPRISE): a randomised, pathogen-directed, phase 3 study. Lancet Infect Dis. 2016;16:661–73.
-
(2016)
Lancet Infect Dis
, vol.16
, pp. 661-673
-
-
Carmeli, Y.1
Armstrong, J.2
Laud, P.J.3
Newell, P.4
Stone, G.5
Wardman, A.6
Gasink, L.B.7
-
30
-
-
85039424423
-
Ceftazidime-avibactam versus meropenem in nosocomial pneumonia, including ventilator-associated pneumonia (REPROVE): A randomised, double-blind, phase 3 non-inferiority trial
-
This randomized controlled trial evaluates ceftazidime-avibactam as an alternative to meropenem in the treatment of nosocomial pneumonia caused by Gram-negative pathogens, including Pseudomonas aeruginosa
-
• Torres A, Zhong N, Pachl J, Timsit J-F, Kollef M, Chen Z, et al. Ceftazidime-avibactam versus meropenem in nosocomial pneumonia, including ventilator-associated pneumonia (REPROVE): a randomised, double-blind, phase 3 non-inferiority trial. Lancet Infect Dis. 2017; 10.1016/S1473-3099(17)30747-8. This randomized controlled trial evaluates ceftazidime-avibactam as an alternative to meropenem in the treatment of nosocomial pneumonia caused by Gram-negative pathogens, including Pseudomonas aeruginosa.
-
(2017)
Lancet Infect Dis
-
-
Torres, A.1
Zhong, N.2
Pachl, J.3
Timsit, J.-F.4
Kollef, M.5
Chen, Z.6
-
31
-
-
85009170434
-
Clinical experience with ceftazidime/avibactam in patients with severe infections, including meningitis and lung abscesses, caused by extensively drug-resistant Pseudomonas aeruginosa
-
PID: 27979500
-
Xipell M, Bodro M, Marco F, Losno RA, Cardozo C, Soriano A. Clinical experience with ceftazidime/avibactam in patients with severe infections, including meningitis and lung abscesses, caused by extensively drug-resistant Pseudomonas aeruginosa. Int J Antimicrob Agents. 2017;49:266–8.
-
(2017)
Int J Antimicrob Agents
, vol.49
, pp. 266-268
-
-
Xipell, M.1
Bodro, M.2
Marco, F.3
Losno, R.A.4
Cardozo, C.5
Soriano, A.6
-
32
-
-
85027156348
-
Activity of ceftolozane/tazobactam against surveillance and ‘problem’ Enterobacteriaceae, Pseudomonas aeruginosa and non-fermenters from the British Isles
-
PID: 28520867
-
Livermore DM, Mushtaq S, Meunier D, Hopkins KL, Hill R, Adkin R, et al. Activity of ceftolozane/tazobactam against surveillance and ‘problem’ Enterobacteriaceae, Pseudomonas aeruginosa and non-fermenters from the British Isles. J Antimicrob Chemother. 2017;72:2278–89.
-
(2017)
J Antimicrob Chemother
, vol.72
, pp. 2278-2289
-
-
Livermore, D.M.1
Mushtaq, S.2
Meunier, D.3
Hopkins, K.L.4
Hill, R.5
Adkin, R.6
Chaudhry, A.7
Pike, R.8
Staves, P.9
Woodford, N.10
-
33
-
-
84997002173
-
Ceftazidime/avibactam and ceftolozane/tazobactam: second-generation β-lactam/β-lactamase inhibitor combinations
-
PID: 27098166, This is a useful comparative review of the mechanism of action, spectrum of activity, and pharmacokinetics of ceftazidime-avibactam and ceftolozane-tazobactam
-
• van Duin D, Bonomo RA. Ceftazidime/avibactam and ceftolozane/tazobactam: second-generation β-lactam/β-lactamase inhibitor combinations. Clin Infect Dis. 2016;63:234–41. This is a useful comparative review of the mechanism of action, spectrum of activity, and pharmacokinetics of ceftazidime-avibactam and ceftolozane-tazobactam.
-
(2016)
Clin Infect Dis
, vol.63
, pp. 234-241
-
-
van Duin, D.1
Bonomo, R.A.2
-
34
-
-
77956123209
-
Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa
-
PID: 20547785
-
Moyá B, Zamorano L, Juan C, Ge Y, Oliver A. Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2010;54:3933–7.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 3933-3937
-
-
Moyá, B.1
Zamorano, L.2
Juan, C.3
Ge, Y.4
Oliver, A.5
-
35
-
-
84865413973
-
Pan-β-lactam resistance development in Pseudomonas aeruginosa clinical strains: molecular mechanisms, penicillin-binding protein profiles, and binding affinities
-
PID: 22733064
-
Moyá B, Beceiro A, Cabot G, Juan C, Zamorano L, Alberti S, et al. Pan-β-lactam resistance development in Pseudomonas aeruginosa clinical strains: molecular mechanisms, penicillin-binding protein profiles, and binding affinities. Antimicrob Agents Chemother. 2012;56:4771–8.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 4771-4778
-
-
Moyá, B.1
Beceiro, A.2
Cabot, G.3
Juan, C.4
Zamorano, L.5
Alberti, S.6
Oliver, A.7
-
36
-
-
84887449664
-
Antimicrobial activity of ceftolozane-tazobactam tested against Enterobacteriaceae and Pseudomonas aeruginosa with various resistance patterns isolated in U.S. hospitals (2011–2012)
-
PID: 24100499
-
Farrell DJ, Flamm RK, Sader HS, Jones RN. Antimicrobial activity of ceftolozane-tazobactam tested against Enterobacteriaceae and Pseudomonas aeruginosa with various resistance patterns isolated in U.S. hospitals (2011–2012). Antimicrob Agents Chemother. 2013;57:6305–10.
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 6305-6310
-
-
Farrell, D.J.1
Flamm, R.K.2
Sader, H.S.3
Jones, R.N.4
-
37
-
-
84957904467
-
-
Syracuse, NY: Merck & Co., Inc
-
Zerbaxa [package insert]. Syracuse, NY: Merck & Co., Inc; 2014.
-
(2014)
Zerbaxa [Package Insert]
-
-
-
38
-
-
84861121314
-
Pharmacokinetics and safety of intravenous ceftolozane-tazobactam in healthy adult subjects following single and multiple ascending doses
-
PID: 22450972
-
Miller B, Hershberger E, Benziger D, Trinh M, Friedland I. Pharmacokinetics and safety of intravenous ceftolozane-tazobactam in healthy adult subjects following single and multiple ascending doses. Antimicrob Agents Chemother. 2012;56:3086–91.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 3086-3091
-
-
Miller, B.1
Hershberger, E.2
Benziger, D.3
Trinh, M.4
Friedland, I.5
-
39
-
-
85030723349
-
Determination of alternative ceftolozane/tazobactam dosing regimens for patients with infections due to Pseudomonas aeruginosa with MIC values between 4 and 32 mg/L
-
PID: 29091209
-
Natesan S, Pai MP, Lodise TP. Determination of alternative ceftolozane/tazobactam dosing regimens for patients with infections due to Pseudomonas aeruginosa with MIC values between 4 and 32 mg/L. J Antimicrob Chemother. 2017;72:2813–6.
-
(2017)
J Antimicrob Chemother
, vol.72
, pp. 2813-2816
-
-
Natesan, S.1
Pai, M.P.2
Lodise, T.P.3
-
40
-
-
84929206762
-
Ceftolozane/tazobactam plus metronidazole for complicated intra-abdominal infections in an era of multidrug resistance: results from a randomized, double-blind, phase 3 trial (ASPECT-cIAI)
-
PID: 25670823
-
Solomkin J, Hershberger E, Miller B, Popejoy M, Friedland I, Steenbergen J, et al. Ceftolozane/tazobactam plus metronidazole for complicated intra-abdominal infections in an era of multidrug resistance: results from a randomized, double-blind, phase 3 trial (ASPECT-cIAI). Clin Infect Dis. 2015;60:1462–71.
-
(2015)
Clin Infect Dis
, vol.60
, pp. 1462-1471
-
-
Solomkin, J.1
Hershberger, E.2
Miller, B.3
Popejoy, M.4
Friedland, I.5
Steenbergen, J.6
Yoon, M.7
Collins, S.8
Yuan, G.9
Barie, P.S.10
Eckmann, C.11
-
41
-
-
84929606496
-
Ceftolozane-tazobactam compared with levofloxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI)
-
PID: 25931244
-
Wagenlehner FM, Umeh O, Steenbergen J, Yuan G, Darouiche RO. Ceftolozane-tazobactam compared with levofloxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI). Lancet. 2015;385:1949–56.
-
(2015)
Lancet
, vol.385
, pp. 1949-1956
-
-
Wagenlehner, F.M.1
Umeh, O.2
Steenbergen, J.3
Yuan, G.4
Darouiche, R.O.5
-
42
-
-
85021827336
-
Ceftolozane-tazobactam for the treatment of multidrug-resistant Pseudomonas aeruginosa infections: clinical effectiveness and evolution of resistance
-
PID: 29017262
-
Haidar G, Philips NJ, Shields RK, Snyder D, Cheng S, Potoski BA, et al. Ceftolozane-tazobactam for the treatment of multidrug-resistant Pseudomonas aeruginosa infections: clinical effectiveness and evolution of resistance. Clin Infect Dis. 2017;65:110–20.
-
(2017)
Clin Infect Dis
, vol.65
, pp. 110-120
-
-
Haidar, G.1
Philips, N.J.2
Shields, R.K.3
Snyder, D.4
Cheng, S.5
Potoski, B.A.6
Doi, Y.7
Hao, B.8
Press, E.G.9
Cooper, V.S.10
Clancy, C.J.11
Nguyen, M.H.12
-
43
-
-
85014124690
-
Salvage therapy with ceftolozane-tazobactam for multidrug-resistant pseudomonas aeruginosa infections
-
PID: 27956431
-
Castón JJ, la TÁD, Ruiz-Camps I, Sorlí ML, Torres V, Torre-Cisneros J. Salvage therapy with ceftolozane-tazobactam for multidrug-resistant pseudomonas aeruginosa infections. Antimicrob Agents Chemother. 2017;61:e02136–16.
-
(2017)
Antimicrob Agents Chemother
, vol.61
, pp. e2116-e02136
-
-
Castón, J.J.1
la, T.Á.D.2
Ruiz-Camps, I.3
Sorlí, M.L.4
Torres, V.5
Torre-Cisneros, J.6
-
44
-
-
84942018581
-
Ceftolozane/tazobactam therapy of respiratory infections due to multidrug-resistant Pseudomonas aeruginosa
-
PID: 26021991
-
Gelfand MS, Cleveland KO. Ceftolozane/tazobactam therapy of respiratory infections due to multidrug-resistant Pseudomonas aeruginosa. Clin Infect Dis. 2015;61:853–5.
-
(2015)
Clin Infect Dis
, vol.61
, pp. 853-855
-
-
Gelfand, M.S.1
Cleveland, K.O.2
-
45
-
-
84977091066
-
Successful treatment of multi-drug resistant Pseudomonas aeruginosa bacteremia with the recommended renally adjusted ceftolozane/tazobactam regimen
-
PID: 26935574
-
Patel UC, Nicolau DP, Sabzwari RK. Successful treatment of multi-drug resistant Pseudomonas aeruginosa bacteremia with the recommended renally adjusted ceftolozane/tazobactam regimen. Infect Dis Ther. 2016;5:73–9.
-
(2016)
Infect Dis Ther
, vol.5
, pp. 73-79
-
-
Patel, U.C.1
Nicolau, D.P.2
Sabzwari, R.K.3
-
46
-
-
84991338328
-
Successful treatment of multidrug-resistant Pseudomonas aeruginosa breakthrough bacteremia with ceftolozane/tazobactam
-
PID: 27670678
-
Hernández-Tejedor A, Merino-Vega CD, Martín-Vivas A, de L-GRR, Delgado-Iribarren A, Gabán-Díez Á, et al. Successful treatment of multidrug-resistant Pseudomonas aeruginosa breakthrough bacteremia with ceftolozane/tazobactam. Infection. 2017;45:115–7.
-
(2017)
Infection
, vol.45
, pp. 115-117
-
-
Hernández-Tejedor, A.1
Merino-Vega, C.D.2
Martín-Vivas, A.3
de, L.-G.R.R.4
Delgado-Iribarren, A.5
Gabán-Díez, Á.6
-
47
-
-
85018289904
-
Successful treatment of MDR Pseudomonas aeruginosa skin and soft-tissue infection with ceftolozane/tazobactam
-
PID: 27999042
-
Sousa Dominguez A, Perez-Rodríguez MT, Nodar A, Martinez-Lamas L, Perez-Landeiro A, Crespo Casal M. Successful treatment of MDR Pseudomonas aeruginosa skin and soft-tissue infection with ceftolozane/tazobactam. J Antimicrob Chemother. 2017;72:1262–3.
-
(2017)
J Antimicrob Chemother
, vol.72
, pp. 1262-1263
-
-
Sousa Dominguez, A.1
Perez-Rodríguez, M.T.2
Nodar, A.3
Martinez-Lamas, L.4
Perez-Landeiro, A.5
Crespo Casal, M.6
-
48
-
-
85019134830
-
Multidrug-resistant Pseudomonas aeruginosa skin and soft-tissue infection successfully treated with ceftolozane/tazobactam
-
PID: 28495526
-
Castaldo N, Givone F, Peghin M, Righi E, Sartor A, Bassetti M. Multidrug-resistant Pseudomonas aeruginosa skin and soft-tissue infection successfully treated with ceftolozane/tazobactam. J Glob Antimicrob Resist. 2017;9:100–2.
-
(2017)
J Glob Antimicrob Resist
, vol.9
, pp. 100-102
-
-
Castaldo, N.1
Givone, F.2
Peghin, M.3
Righi, E.4
Sartor, A.5
Bassetti, M.6
-
49
-
-
85031015450
-
Successful treatment of post-surgical osteomyelitis caused by XDR Pseudomonas aeruginosa with ceftolozane/tazobactam monotherapy
-
PID: 28575437
-
Gentile I, Buonomo AR, Maraolo AE, Scotto R, De Zottis F, Di Renzo G, et al. Successful treatment of post-surgical osteomyelitis caused by XDR Pseudomonas aeruginosa with ceftolozane/tazobactam monotherapy. J Antimicrob Chemother. 2017;72(9):2678–9.
-
(2017)
J Antimicrob Chemother
, vol.72
, Issue.9
, pp. 2678-2679
-
-
Gentile, I.1
Buonomo, A.R.2
Maraolo, A.E.3
Scotto, R.4
De Zottis, F.5
Di Renzo, G.6
-
50
-
-
85048184078
-
Multidrug resistant Pseudomonas mycotic pseudoaneurysm following cardiac transplant bridged by ventricular assistant device
-
Aye C, Williams M, Horvath R. Multidrug resistant Pseudomonas mycotic pseudoaneurysm following cardiac transplant bridged by ventricular assistant device. Case Rep Infect Dis. 2017;2017:1–4. 10.1155/2017/1402320.
-
(2017)
Case Rep Infect Dis
, vol.2017
, pp. 1-4
-
-
Aye, C.1
Williams, M.2
Horvath, R.3
-
51
-
-
85048180578
-
Ceftolozane/tazobactam for the treatment of MDR Pseudomonas aeruginosa left ventricular assist device infection as a bridge to heart transplant
-
Peghin M, Maiani M, Castaldo N, Givone F, Righi E, Lechiancole A, et al. Ceftolozane/tazobactam for the treatment of MDR Pseudomonas aeruginosa left ventricular assist device infection as a bridge to heart transplant. Infection. 2017:1–3.
-
(2017)
Infection
, pp. 1-3
-
-
Peghin, M.1
Maiani, M.2
Castaldo, N.3
Givone, F.4
Righi, E.5
Lechiancole, A.6
-
52
-
-
84990849773
-
Successful use of ceftolozane-tazobactam to treat a pulmonary exacerbation of cystic fibrosis caused by multidrug-resistant Pseudomonas aeruginosa
-
PID: 27522066
-
Vickery SB, McClain D, Wargo KA. Successful use of ceftolozane-tazobactam to treat a pulmonary exacerbation of cystic fibrosis caused by multidrug-resistant Pseudomonas aeruginosa. Pharmacotherapy. 2016;36:e154–9.
-
(2016)
Pharmacotherapy
, vol.36
, pp. e154-e159
-
-
Vickery, S.B.1
McClain, D.2
Wargo, K.A.3
-
53
-
-
84964939441
-
Evaluation of the in vitro activity of ceftazidime-avibactam and ceftolozane-tazobactam against meropenem-resistant Pseudomonas aeruginosa isolates
-
PID: 26976862
-
Buehrle DJ, Shields RK, Chen L, Hao B, Press EG, Alkrouk A, et al. Evaluation of the in vitro activity of ceftazidime-avibactam and ceftolozane-tazobactam against meropenem-resistant Pseudomonas aeruginosa isolates. Antimicrob Agents Chemother. 2016;60:3227–31.
-
(2016)
Antimicrob Agents Chemother
, vol.60
, pp. 3227-3231
-
-
Buehrle, D.J.1
Shields, R.K.2
Chen, L.3
Hao, B.4
Press, E.G.5
Alkrouk, A.6
Potoski, B.A.7
Kreiswirth, B.N.8
Clancy, C.J.9
Nguyen, M.H.10
-
54
-
-
85029744649
-
Multicenter evaluation of ceftazidime-avibactam and ceftolozane-tazobactam inhibitory activity against meropenem-nonsusceptible Pseudomonas aeruginosa from blood, respiratory tract, and wounds
-
PID: 28739780
-
Grupper M, Sutherland C, Nicolau DP. Multicenter evaluation of ceftazidime-avibactam and ceftolozane-tazobactam inhibitory activity against meropenem-nonsusceptible Pseudomonas aeruginosa from blood, respiratory tract, and wounds. Antimicrob Agents Chemother. 2017;61:e00875–17.
-
(2017)
Antimicrob Agents Chemother
, vol.61
, pp. e817-e00875
-
-
Grupper, M.1
Sutherland, C.2
Nicolau, D.P.3
-
55
-
-
85034985921
-
Activity of ceftolozane-tazobactam and ceftazidime-avibactam against beta-lactam resistant Pseudomonas aeruginosa isolates
-
AAC.01858–17
-
Humphries RM, Hindler JA, Wong-Beringer A, Miller SA. Activity of ceftolozane-tazobactam and ceftazidime-avibactam against beta-lactam resistant Pseudomonas aeruginosa isolates. Antimicrob Agents Chemother. 2017;AAC.01858–17.
-
(2017)
Antimicrob Agents Chemother
-
-
Humphries, R.M.1
Hindler, J.A.2
Wong-Beringer, A.3
Miller, S.A.4
-
56
-
-
84872850695
-
Siderophore conjugates
-
PID: 23346861
-
Page MGP. Siderophore conjugates. Ann N Y Acad Sci. 2013;1277:115–26.
-
(2013)
Ann N Y Acad Sci
, vol.1277
, pp. 115-126
-
-
Page, M.G.P.1
-
57
-
-
85039799071
-
In vitro antibacterial properties of cefiderocol, a novel siderophore cephalosporin, against gram-negative bacteria
-
Ito A, Sato T, Ota M, Takemura M, Nishikawa T, Toba S, et al. In vitro antibacterial properties of cefiderocol, a novel siderophore cephalosporin, against gram-negative bacteria. Antimicrob Agents Chemother. 2018;62:e01454–17. 10.1128/AAC.01454-17.
-
(2018)
Antimicrob Agents Chemother
, vol.62
, pp. e01454-e1417
-
-
Ito, A.1
Sato, T.2
Ota, M.3
Takemura, M.4
Nishikawa, T.5
Toba, S.6
-
58
-
-
85028361727
-
In vitro activity of the siderophore cephalosporin, cefiderocol, against a recent collection of clinically relevant Gram-negative bacilli from North America and Europe, including carbapenem-nonsusceptible isolates (SIDERO-WT-2014 Study)
-
Hackel MA, Tsuji M, Yamano Y, Echols R, Karlowsky JA, Sahm DF. In vitro activity of the siderophore cephalosporin, cefiderocol, against a recent collection of clinically relevant Gram-negative bacilli from North America and Europe, including carbapenem-nonsusceptible isolates (SIDERO-WT-2014 Study). Antimicrob Agents Chemother. 2017;61:e00093–17. 10.1128/AAC.00093-17.
-
(2017)
Antimicrob Agents Chemother
, vol.61
, pp. e00093-e17
-
-
Hackel, M.A.1
Tsuji, M.2
Yamano, Y.3
Echols, R.4
Karlowsky, J.A.5
Sahm, D.F.6
-
59
-
-
85040962574
-
In vitro activity of the siderophore cephalosporin, cefiderocol, against carbapenem-nonsusceptible and multidrug-resistant isolates of gram-negative bacilli collected worldwide in 2014 to 2016
-
PID: 29158270, This study describes the in vitro activity of cefiderocol against multidrug-resistant Gram-negative clinical isolates alongside comparator antimicrobials
-
• Hackel MA, Tsuji M, Yamano Y, Echols R, Karlowsky JA, Sahm DF. In vitro activity of the siderophore cephalosporin, cefiderocol, against carbapenem-nonsusceptible and multidrug-resistant isolates of gram-negative bacilli collected worldwide in 2014 to 2016. Antimicrob Agents Chemother. 2018;62:e01968–17. This study describes the in vitro activity of cefiderocol against multidrug-resistant Gram-negative clinical isolates alongside comparator antimicrobials.
-
(2018)
Antimicrob Agents Chemother
, vol.62
, pp. e01968-e1917
-
-
Hackel, M.A.1
Tsuji, M.2
Yamano, Y.3
Echols, R.4
Karlowsky, J.A.5
Sahm, D.F.6
-
60
-
-
85019660287
-
In vitro activity of imipenem-relebactam against Gram-negative ESKAPE pathogens isolated by clinical laboratories in the United States in 2015 (results from the SMART Global Surveillance Program)
-
Lob SH, Hackel MA, Kazmierczak KM, Young K, Motyl MR, Karlowsky JA, et al. In vitro activity of imipenem-relebactam against Gram-negative ESKAPE pathogens isolated by clinical laboratories in the United States in 2015 (results from the SMART Global Surveillance Program). Antimicrob Agents Chemother. 2017;61:e02209–16. 10.1128/AAC.02209-16.
-
(2017)
Antimicrob Agents Chemother
, vol.61
, pp. e02209-e02216
-
-
Lob, S.H.1
Hackel, M.A.2
Kazmierczak, K.M.3
Young, K.4
Motyl, M.R.5
Karlowsky, J.A.6
Sahm, D.F.7
-
61
-
-
85009274824
-
Pharmacokinetic/pharmacodynamic modeling and simulation of cefiderocol, a parenteral siderophore cephalosporin, for dose adjustment based on renal function
-
Katsube T, Wajima T, Ishibashi T, Arjona Ferreira JC, Echols R. Pharmacokinetic/pharmacodynamic modeling and simulation of cefiderocol, a parenteral siderophore cephalosporin, for dose adjustment based on renal function. Antimicrob Agents Chemother. 2016;61:e01381–16. 10.1128/AAC.01381-16.
-
(2016)
Antimicrob Agents Chemother
, vol.61
, pp. e1316-e01381
-
-
Katsube, T.1
Wajima, T.2
Ishibashi, T.3
Arjona Ferreira, J.C.4
Echols, R.5
-
62
-
-
84996478385
-
Siderophore cephalosporin cefiderocol utilizes ferric iron transporter systems for antibacterial activity against Pseudomonas aeruginosa
-
PID: 27736756
-
Ito A, Nishikawa T, Matsumoto S, Yoshizawa H, Sato T, Nakamura R, et al. Siderophore cephalosporin cefiderocol utilizes ferric iron transporter systems for antibacterial activity against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2016;60:7396–401.
-
(2016)
Antimicrob Agents Chemother
, vol.60
, pp. 7396-7401
-
-
Ito, A.1
Nishikawa, T.2
Matsumoto, S.3
Yoshizawa, H.4
Sato, T.5
Nakamura, R.6
Tsuji, M.7
Yamano, Y.8
-
63
-
-
84960837126
-
In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria
-
PID: 26645269
-
Ito A, Kohira N, Bouchillon SK, West J, Rittenhouse S, Sader HS, et al. In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria. J Antimicrob Chemother. 2016;71:670–7.
-
(2016)
J Antimicrob Chemother
, vol.71
, pp. 670-677
-
-
Ito, A.1
Kohira, N.2
Bouchillon, S.K.3
West, J.4
Rittenhouse, S.5
Sader, H.S.6
Rhomberg, P.R.7
Jones, R.N.8
Yoshizawa, H.9
Nakamura, R.10
Tsuji, M.11
Yamano, Y.12
-
64
-
-
85026916641
-
Activity of the novel siderophore cephalosporin cefiderocol against multidrug-resistant Gram-negative pathogens
-
PID: 28748397
-
Dobias J, Dénervaud-Tendon V, Poirel L, Nordmann P. Activity of the novel siderophore cephalosporin cefiderocol against multidrug-resistant Gram-negative pathogens. Eur J Clin Microbiol Infect Dis. 2017;36:2319–27.
-
(2017)
Eur J Clin Microbiol Infect Dis
, vol.36
, pp. 2319-2327
-
-
Dobias, J.1
Dénervaud-Tendon, V.2
Poirel, L.3
Nordmann, P.4
-
65
-
-
85032468440
-
Efficacy of humanized exposures of cefiderocol (s-649266) against a diverse population of gram-negative bacteria in a murine thigh infection model
-
PID: 28848004
-
Monogue ML, Tsuji M, Yamano Y, Echols R, Nicolau DP. Efficacy of humanized exposures of cefiderocol (s-649266) against a diverse population of gram-negative bacteria in a murine thigh infection model. Antimicrob Agents Chemother. 2017;61:e01022–17.
-
(2017)
Antimicrob Agents Chemother
, vol.61
, pp. e1017-e01022
-
-
Monogue, M.L.1
Tsuji, M.2
Yamano, Y.3
Echols, R.4
Nicolau, D.P.5
-
66
-
-
85048156170
-
-
San Diego, CA
-
Portsmouth S, Van Veenhuyzen D, Echols R, et al. (2017). Poster 1869: Clinical response of cefiderocol compared with imipenem/cilastatin in the treatment of adults with complicated urinary tract infections with or without pyelonephritis or acute uncomplicated pyelonephritis: results from a multicenter, double-blind, randomized study (APEKS-cUTI). IDWeek 2017, San Diego, CA.
-
(2017)
Poster 1869: Clinical Response of Cefiderocol Compared with Imipenem/Cilastatin in the Treatment of Adults with Complicated Urinary Tract Infections with Or without Pyelonephritis Or Acute Uncomplicated Pyelonephritis: Results from a Multicenter, Double-Blind, Randomized Study (Apeks-Cuti). Idweek
, pp. 2017
-
-
Portsmouth, S.1
van Veenhuyzen, D.2
Echols, R.3
-
67
-
-
84893699884
-
Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®
-
PID: 24433862
-
Blizzard TA, Chen H, Kim S, Wu J, Bodner R, Gude C, et al. Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®. Bioorg Med Chem Lett. 2014;24:780–5.
-
(2014)
Bioorg Med Chem Lett
, vol.24
, pp. 780-785
-
-
Blizzard, T.A.1
Chen, H.2
Kim, S.3
Wu, J.4
Bodner, R.5
Gude, C.6
Imbriglio, J.7
Young, K.8
Park, Y.W.9
Ogawa, A.10
Raghoobar, S.11
Hairston, N.12
Painter, R.E.13
Wisniewski, D.14
Scapin, G.15
Fitzgerald, P.16
Sharma, N.17
Lu, J.18
Ha, S.19
Hermes, J.20
Hammond, M.L.21
more..
-
68
-
-
85042199196
-
AmpC β-lactamase induction by avibactam and relebactam
-
PID: 28962008
-
Livermore DM, Jamrozy D, Mushtaq S, Nichols WW, Young K, Woodford N. AmpC β-lactamase induction by avibactam and relebactam. J Antimicrob Chemother. 2017;72:3342–8.
-
(2017)
J Antimicrob Chemother
, vol.72
, pp. 3342-3348
-
-
Livermore, D.M.1
Jamrozy, D.2
Mushtaq, S.3
Nichols, W.W.4
Young, K.5
Woodford, N.6
-
69
-
-
84888787952
-
Activity of MK-7655 combined with imipenem against Enterobacteriaceae and Pseudomonas aeruginosa
-
PID: 23696619
-
Livermore DM, Warner M, Mushtaq S. Activity of MK-7655 combined with imipenem against Enterobacteriaceae and Pseudomonas aeruginosa. J Antimicrob Chemother. 2013;68:2286–90.
-
(2013)
J Antimicrob Chemother
, vol.68
, pp. 2286-2290
-
-
Livermore, D.M.1
Warner, M.2
Mushtaq, S.3
-
70
-
-
84862573378
-
In vitro activity of mk-7655, a novel β-lactamase inhibitor, in combination with imipenem against carbapenem-resistant Gram-negative bacteria
-
PID: 22526311
-
Hirsch EB, Ledesma KR, Chang K-T, Schwartz MS, Motyl MR, Tam VH. In vitro activity of mk-7655, a novel β-lactamase inhibitor, in combination with imipenem against carbapenem-resistant Gram-negative bacteria. Antimicrob Agents Chemother. 2012;56(7):3753–7.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, Issue.7
, pp. 3753-3757
-
-
Hirsch, E.B.1
Ledesma, K.R.2
Chang, K.-T.3
Schwartz, M.S.4
Motyl, M.R.5
Tam, V.H.6
-
71
-
-
84939785073
-
Activity of imipenem with relebactam against gram-negative pathogens from New York City
-
PID: 26014931
-
Lapuebla A, Abdallah M, Olafisoye O, Cortes C, Urban C, Landman D, et al. Activity of imipenem with relebactam against gram-negative pathogens from New York City. Antimicrob Agents Chemother. 2015;59:5029–31.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 5029-5031
-
-
Lapuebla, A.1
Abdallah, M.2
Olafisoye, O.3
Cortes, C.4
Urban, C.5
Landman, D.6
Quale, J.7
-
72
-
-
81155162497
-
Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors
-
PID: 21840248
-
Coleman K. Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors. Curr Opin Microbiol. 2011;14(5):550–5.
-
(2011)
Curr Opin Microbiol
, vol.14
, Issue.5
, pp. 550-555
-
-
Coleman, K.1
-
73
-
-
84992360092
-
Phase 2, dose-ranging study of relebactam with imipenem-cilastatin in subjects with complicated intra-abdominal infection
-
PID: 27503659, This prospective phase II randomized controlled trial determined that imipenem-cilastatin/relebactam was non-inferior to imipenem-cilastatin plus placebo for the treatment of complicated intra-abdominal infections
-
• Lucasti C, Vasile L, Sandesc D, Venskutonis D, McLeroth P, Lala M, et al. Phase 2, dose-ranging study of relebactam with imipenem-cilastatin in subjects with complicated intra-abdominal infection. Antimicrob Agents Chemother. 2016;60:6234–43. This prospective phase II randomized controlled trial determined that imipenem-cilastatin/relebactam was non-inferior to imipenem-cilastatin plus placebo for the treatment of complicated intra-abdominal infections.
-
(2016)
Antimicrob Agents Chemother
, vol.60
, pp. 6234-6243
-
-
Lucasti, C.1
Vasile, L.2
Sandesc, D.3
Venskutonis, D.4
McLeroth, P.5
Lala, M.6
-
74
-
-
85040143612
-
Prospective, randomized, double-blind, Phase 2 dose-ranging study comparing efficacy and safety of imipenem/cilastatin plus relebactam with imipenem/cilastatin alone in patients with complicated urinary tract infections
-
PID: 28575389
-
Sims M, Mariyanovski V, McLeroth P, Akers W, Lee Y-C, Brown ML, et al. Prospective, randomized, double-blind, Phase 2 dose-ranging study comparing efficacy and safety of imipenem/cilastatin plus relebactam with imipenem/cilastatin alone in patients with complicated urinary tract infections. J Antimicrob Chemother. 2017;72:2616–26.
-
(2017)
J Antimicrob Chemother
, vol.72
, pp. 2616-2626
-
-
Sims, M.1
Mariyanovski, V.2
McLeroth, P.3
Akers, W.4
Lee, Y.-C.5
Brown, M.L.6
du, J.7
Pedley, A.8
Kartsonis, N.A.9
Paschke, A.10
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