Influence of PEGylation on Domain Dynamics of Phosphoglycerate Kinase: PEG Acts Like Entropic Spring for the Protein

Bioconjugate Chemistry

Volumn 29, Issue 6, 2018, Pages 1950-1960

  Ciepluch, Karol ^a,c   Radulescu, Aurel ^a   Hoffmann, Ingo ^b   Raba, Andreas ^a   Allgaier, Jürgen ^a   Richter, Dieter ^a   Biehl, Ralf ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b INSTITUT LAUE LANGEVIN   (France)

^c JAN KOCHANOWSKI UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; BROWNIAN MOVEMENT; DYNAMICS; ENZYMES; FUNCTIONAL POLYMERS; LIGANDS; NEUTRON SCATTERING;

ANTIGENICITY; DOMAIN DYNAMICS; HALF LIVES; IMMUNOGENICITY; PEGYLATION; PHARMACOKINETIC PROPERTIES; PHOSPHOGLYCERATE KINASE; PROTEIN POLYMERS; PROTEIN THERAPEUTICS; WATER SOLUBILITIES;

POLYETHYLENE GLYCOLS;

ADENOSINE TRIPHOSPHATE; MACROGOL; PHOSPHOGLYCERATE KINASE;

ALPHA HELIX; ARTICLE; BINDING SITE; CHEMICAL MODIFICATION; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONJUGATION; ELECTRIC POTENTIAL; ELECTRON SPIN RESONANCE; ENTROPY; ENZYMATIC ASSAY; ENZYME ACTIVITY; GLUCONEOGENESIS; LIGAND BINDING; MOLECULAR WEIGHT; NEUTRON SCATTERING; NONHUMAN; PHOSPHATE TRANSPORT; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; SMALL ANGLE SCATTERING; CHEMISTRY; ENZYME STABILITY; ENZYMOLOGY; METABOLISM; MOLECULAR DYNAMICS; SACCHAROMYCES CEREVISIAE;

ENTROPY; ENZYME STABILITY; MOLECULAR DYNAMICS SIMULATION; PHOSPHOGLYCERATE KINASE; POLYETHYLENE GLYCOLS; PROTEIN DOMAINS; PROTEIN STRUCTURE, SECONDARY; SACCHAROMYCES CEREVISIAE;

EID: 85047966377     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/acs.bioconjchem.8b00203     Document Type: Article

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