Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI)

European Journal of Human Genetics

Volumn 10, Issue 1, 2002, Pages 36-43

  Bardien Kruger, Soraya ^a,c   Wulff, Heike ^b   Arieff, Zainu ^a,c   Brink, Paul ^a   Chandy, K George ^b   Corfield, Valerie ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF THE WESTERN CAPE   (South Africa)

Author keywords

Inherited cardiac conduction disorders; KCNA7; kcna7; Kv1.7; lKur; PFHB1; Potassium channels

Indexed keywords

4 AMINOPYRIDINE; AMINO ACID; AMIODARONE; CHARYBDOTOXIN; FLECAINIDE; ION CHANNEL; MARGATOXIN; MESSENGER RNA; POTASSIUM CHANNEL; SOTALOL; TETRYLAMMONIUM CHLORIDE; VERAPAMIL;

ADULT; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CHROMOSOME 19Q; CONTROLLED STUDY; EXON; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENETIC CODE; HEART BLOCK; HEART DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; INHERITANCE; INTRON; MOUSE; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; COS CELLS; DNA; HEART BLOCK; HEART DISEASES; HUMANS; MICE; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; TRINUCLEOTIDE REPEATS;

ANIMALIA;

EID: 85047699794     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5200739     Document Type: Article

References (17)

1. Molecular biology of arrhythmic syndromes
2. Cardiac conduction defects associate with mutations in SCN5A
3. A sodium-channel mutation causes isolated cardiac conduction disease
4. Gene for progressive familial heart block type I maps to chromosome 19q13
5. Progressive familial heart block - Two types
6. An isolated cardiac conduction disease maps to chromosome 19q
7. Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7
8. + channel genes. Ligand and voltage-gated ion channels
9. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
10. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
11. + channel genes with intronless coding regions
12. Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila
13. + channel current
14. Ultrarapid delayed rectifier current inactivation in human atrial myocytes: Properties and consequences
15. + channel cloned from the human heart
16. + currents in cultured adult human atrial myocytes
17. Human genetics: Breaking the rule of three