High expression of transgenes mediated by hybrid retroviral vectors in hepatocytes: Comparison of promoters from murine retroviruses in vitro and in vivo

Gene Therapy

Volumn 9, Issue 4, 2002, Pages 303-306

  Ohnishi, N ^a,b   Itoh, K ^a   Itoh, Y ^b   Baum, C ^c   Higashitsuji, H ^a   Yamaguchi, K ^a   Tsuji, T ^a   Okanoue, T ^b   Fujita, J ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cis activity; FMEV type; Hepatocyte; Retrovirus; SFFVp

Indexed keywords

RETROVIRUS VECTOR; SIGNAL PEPTIDE;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; GENE EXPRESSION; GENE REPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; HYBRID; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER CELL CARCINOMA; LONG TERMINAL REPEAT; MOLONEY LEUKEMIA ONCOVIRUS; POLYCYTHEMIA; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RETROVIRUS; SPLEEN FOCUS FORMING VIRUS; TRANSGENE; TUMOR DIFFERENTIATION;

ANIMALS; GENE EXPRESSION; GENES, REPORTER; GENETIC VECTORS; HEPATOCYTES; HUMANS; MICE; MINK CELL FOCUS-INDUCING VIRUSES; MOLONEY MURINE LEUKEMIA VIRUS; RETROVIRIDAE; SPLEEN FOCUS-FORMING VIRUSES; TERMINAL REPEAT SEQUENCES; TRANSGENES; TUMOR CELLS, CULTURED;

MOLONEY MURINE LEUKEMIA VIRUS; MURINAE; MURINE LEUKEMIA VIRUS; ONCOVIRINAE; SPLEEN FOCUS-FORMING VIRUS; UNIDENTIFIED RETROVIRUS;

EID: 85047699090     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301655     Document Type: Article

References (26)

1. The basic science of gene therapy
2. In vivo gene therapy of hemophilia B: Sustained partial correction in factor IX-deficient dogs
3. Liver-directed gene therapy: Molecular tools and current preclinical and clinical studies
4. Comparison of the expression of a mutant dihydrofolate reductase under control of different internal promoters in retroviral vectors
5. Liver-directed gene therapy: Quantitative evaluation of promoter elements by using in vivo retroviral transduction
6. Quantitative evaluation of liver-specific promoters from retroviral vectors after in vivo transduction of hepatocytes
7. Transforming genes and target cells of murine spleen focus-forming viruses
8. Long -terminal repeat sequences impart hematopoietic transformation properties to the myeloproliferative sarcoma virus
9. Embryonic stem cell virus, a recombinant murine retrovirus with expression in embryonic stem cells
10. Growth of human hepatoma cells lines with differentiated functions in chemically defined medium
11. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen
12. Establishment and some characteristics of human hepatoma cell lines
13. Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line
14. A new human cholangiocellular carcinoma cell line (KMC-1)
15. Establishment and characterization of a human combined hepatocholangiocarcinoma cell line and its heterologous transplantation in nude mice
16. The potent enhancer activity of the polycytemic strain of spleen focus-forming virus in hematopoietic cell is governed by a binding site for Sp1 in the upstream control region and by a unique enhancer core exclusive target for PEBP/CBF
17. Efficient gene transfer by hybrid retroviral vectors to murine spermatogenic cells
18. Contribution of the retroviral leader to gene transfer and expression in packaging cells and myeloid stem and progenitor cells
19. Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells
20. Activity of Friend mink cell focus-forming retrovirus during myelo-erythroid hematopoiesis
21. Retroviral vector-mediated gene expression in human CD34+CD38- cells expanded in vitro: Cis elements of FMEV are superior to those of Mo-MuLV
22. Functional analysis of a retroviral host-range mutant: Altered long terminal repeat sequences allow expression in embryonal carcinoma cells
23. Calcium phosphate transfection
24. Detection of activity of P-glycoprotein in human tumor samples using rhodamine 123
25. Experimental pathology of the liver. I. Restoration of the liver of white rat following partial surgical removal
26. Real-time quantitative PCR