Immunohistochemically Demonstrated Lymph Node Micrometastasis and Prognosis in Patients with Otherwise Node-Negative Hilar Cholangiocarcinoma

Annals of Surgery

Volumn 237, Issue 2, 2003, Pages 201-207

  Tojima, Yuichiro ^a   Nagino, Masato ^a   Ebata, Tomoki ^a   Uesaka, Katsuhiko ^a   Kamiya, Junichi ^a   Nimura, Yuji ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 18; CYTOKERATIN 8; KERATIN; MONOCLONAL ANTIBODY;

ADULT; AGED; ANTIBODY DETECTION; ARTICLE; BILE DUCT CARCINOMA; CANCER GRADING; CANCER INVASION; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CELL DIFFERENTIATION; CLINICAL ARTICLE; COX PROPORTIONAL HAZARDS MODEL; DISEASE ASSOCIATION; EVALUATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH NODE MICROMETASTASIS; MALE; MICROSCOPIC ANATOMY; PRIORITY JOURNAL; PROGNOSIS; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE; BILE DUCT TUMOR; INTRAHEPATIC BILE DUCT; LYMPH NODE; METABOLISM; MIDDLE AGED; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; SURVIVAL;

ADULT; AGED; ANTIBODIES, MONOCLONAL; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CHOLANGIOCARCINOMA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; SURVIVAL ANALYSIS;

EID: 85047694512     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.SLA.0000048446.18118.FC     Document Type: Article

References (38)

1. Tompkins RK, Saunders K, Roslyn JJ, et al. Changing patterns in diagnosis and management of bile duct cancer. Ann Surg 1990; 211: 614-621.
2. Schoenthaler R, Phillips TL, Castro J, et al. Carcinoma of the extrahepatic bile ducts: The University of California at San Francisco experience. Ann Surg 1994; 219:267-274.
3. Nakeeb A, Pitt HA, Sohn T, et al. Cholangiocarcinoma: A spectrum of intrahepatic, perihilar, and distal tumors. Ann Surg 1996; 224:463-475.
4. Pichlmayr R, Weimann A, Klempnauer J, et al. Surgical treatment in proximal bile duct cancer: A single-center experience. Ann Surg 1996; 224:628-638.
5. Ogura Y, Kawarada Y. Surgical strategies for carcinoma of the hepatic duct confluence. Br J Surg 1998; 85:20-24.
6. Ishiyama S, Fuse A, Kuzu H, et al. Results of surgical treatment and prognostic factors for hepatic hilar bile duct cancer. J Hepatobiliary Pancreat Surg 1998; 5:429-436.
7. Miyazaki M, Ito H, Nakagawa K, et al. Parenchyma-preserving hepatectomy in the surgical treatment of hilar cholangiocarcinoma. J Am Coll Surg 1999; 189:575-583.
8. Kosuge T, Yamamoto J, Shimada K, et al. Improved surgical results for hilar cholangiocarcinoma with procedures including major hepatic resection. Ann Surg 1999; 230:663-671.
9. Neuhaus P, Jonas S, Bechstein WO, et al. Extended resections for hilar cholangiocarcinoma. Ann Surg 1999; 230:808-819.
10. Todoroki T, Kawamoto T, Koike N, et al. Radical resection of hilar bile duct carcinoma and predictors of survival. Br J Surg 2000; 87: 306-313.
11. Tsao J, Nimura Y, Kamiya J, et al. Management of hilar cholangiocarcinoma: comparison of an American and a Japanese experience. Ann Surg 2000; 232:166-174.
12. Nimura Y, Kamiya J, Kondo S, et al. Aggressive preoperative management and extended surgery for hilar cholangiocarcinoma. J Hepatobiliary Pancreat Surg 2000; 7:155-162.
13. Bhuiya MR, Nimura Y, Kamiya J, et al. Clinicopathologic factors influencing survival of patients with bile duct carcinoma: Multivariate statistical analysis. World J Surg 1993; 17:653-657.
14. Kitagawa Y, Nagino M, Kamiya J, et al. Lymph node metastasis from hilar cholangiocarcinoma: Audit of 110 patients who underwent regional and paraaortic node dissection. Ann Surg 2001; 233:385-392.
15. McGuckin MA, Cummings MC, Walsh MD, et al. Occult axillary node metastases in breast cancer: their detection and prognostic significance. Br J Cancer 1996; 73:88-95.
16. Clare SE, Sever SF, Wilkens W, et al. Prognostic significance of occult lymph node metastases in node-negative breast cancer. Ann Surg Oncol 1997; 4:447-451.
17. Goldstein NS, Mani A, Chmielewski G, et al. Immunohistochemically detected micrometastases in peribronchial and mediastinal lymph nodes from patients with T1, N0, M0 pulmonary adenocarcinoma. Am J Surg Pathol 2000; 24:274-279.
18. Ohta Y, Oda M, Wu J, et al. Can tumor size be a guide for limited surgical intervention in patients with peripheral non-small cell lung cancer? Assessment from the point of view of nodal micrometastasis. J Thorac Cardiovasc Surg 2001; 122:900-906.
19. Izbicki JR, Hosch SB, Pichlmeier U, et al. Prognostic value of immunohistochemically identifiable tumor cells in lymph nodes of patients with completely resected esophageal cancer. N Engl J Med 1997; 337:1188-1194.
20. Glickman JN, Torres C, Wang HH, et al. The prognostic significance of lymph node micrometastasis in patients with esophageal carcinoma. Cancer 1999; 85:769-778.
21. Sato F, Shimada Y, Li Z, et al. Lymph node micrometastasis and prognosis in patients with oesophageal squamous cell carcinoma. Br J Surg 2001; 88:426-432.
22. Maehara Y, Oshiro T, Endo K, et al. Clinical significance of occult micrometastasis in lymph nodes from patients with early gastric cancer who died of recurrence. Surgery 1996; 119:397-402.
23. Cai J, Ikeguchi M, Maeta M, et al. Micrometastasis in lymph nodes and microinvasion of the muscularis propria in primary lesions of submucosal gastric cancer. Surgery 1999; 126:32-39.
24. Jeffers MD, O'Dowd GM, Mulcahy H, et al. The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma. J Pathol 1994; 172:183-187.
25. Oberg A, Stenling R, Tavelin B, et al. Are lymph node micrometastases of any clinical significance in Dukes' stages A and B colorectal cancer? Dis Colon Rectum 1998; 41:1244-1249.
26. Yokoyama N, Shirai Y, Hatakeyama K. Immunohistochemical detection of lymph node micrometastases from gallbladder carcinoma using monoclonal anticytokeratin antibody. Cancer 1999; 85:1465-1469.
27. Nagakura S, Shirai Y, Yokoyama N, et al. Clinical significance of lymph node micrometastasis in gallbladder carcinoma. Surgery 2001; 129:704-713.
28. Tajima Y, Tomioka T, Ikematsu Y, et al. Immunohistochemical demonstration of cytokeratin is useful for detecting micrometastatic foci from gall bladder carcinoma in regional lymph nodes. Jpn J Clin Oncol 1999; 29:425-428.
29. International Union Against Cancer (UICC). TNM classification of malignant tumors, 5th ed. New York: Wiley-Liss, 1997.
30. Japanese Society of Biliary Surgery. General rules for surgical and pathological studies on cancer of biliary tract, 4th ed. Tokyo: Kanehara, 1997.
31. Sasaki M, Watanabe H, Jass JR, et al. Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras. Histopathology 1998; 32:199-208.
32. Wong JH, Severino R, Honnebier MB, et al. Number of nodes examined and staging accuracy in colorectal carcinoma. J Clin Oncol 1999; 17:2896-2900.
33. Natsugoe S, Mueller J, Stein HJ, et al. Micrometastasis and tumor cell microinvolvement of lymph nodes from esophageal squamous cell carcinoma: frequency, associated tumor characteristics, and impact on prognosis. Cancer 1998; 83:858-866.
34. Komukai S, Nishimaki T, Watanabe H, et al. Significance of immunohistochemically demonstrated micrometastases to lymph nodes in esophageal cancer with histologically negative nodes. Surgery 2000; 127:40-46.
35. Kell MR, Winter DC, O'Sullivan GC, et al. Biological behavior and clinical implications of micrometastases. Br J Surg 2000; 87:1629-1639.
36. Tsukada K, Kurosaki I, Uchida K, et al. Lymph node spread from carcinoma of the gallbladder. Cancer 1997; 80:661-667.
37. Kondo S, Nimura Y, Hayakawa N, et al. Regional and paraaortic lymphadenectomy in radical surgery for advanced gallbladder carcinoma. Br J Surg 2000; 87:418-422.
38. Boniest S, Panis Y, Fagniez P. Long-term results after curative resection for carcinoma of the gallbladder. Am J Surg 1998; 175: 118-122.