α2-adrenoceptors do not mediate reflex mydriasis in rabbits

Journal of Ocular Pharmacology and Therapeutics

Volumn 20, Issue 6, 2004, Pages 479-488

  Yu, Yongxin ^a   Koss, Michael C ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12 ETHYLSULFONYL 5,8,8A,9,10,11,12,12A,13,13A DECAHYDRO 3 METHOXY 6H ISOQUINO[2,1 G][1,6]NAPHTHYRIDINE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; DOPAMINE; DOPAMINE RECEPTOR BLOCKING AGENT; HALOPERIDOL; PHENOXYBENZAMINE; UNCLASSIFIED DRUG; DOPAMINE RECEPTOR; ISOQUINOLINE DERIVATIVE; NAPHTHYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOPAMINE RECEPTOR BLOCKING; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ELECTROSTIMULATION; MYDRIASIS; NERVE STIMULATION; NONHUMAN; PARASYMPATHETIC INNERVATION; PUPIL REFLEX; RABBIT; SCIATIC NERVE; SYMPATHECTOMY; SYMPATHETIC INNERVATION; ANESTHESIA; ANIMAL; BIOLOGICAL MODEL; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENTIATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADRENERGIC ALPHA-ANTAGONISTS; ANESTHESIA; ANIMALS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ELECTRIC STIMULATION; HALOPERIDOL; INJECTIONS, INTRAVENOUS; ISOQUINOLINES; MALE; MODELS, NEUROLOGICAL; MYDRIASIS; NAPHTHYRIDINES; PHENOXYBENZAMINE; RABBITS; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, DOPAMINE; REFLEX, PUPILLARY; SCIATIC NERVE; SYMPATHECTOMY;

EID: 85047691768     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2004.20.479     Document Type: Article

References (36)

1. Koss, M.C., and San, L.C. Analysis of clonidine-induced mydriasis. Invest. Ophthalmol. 15:566-570, 1976.
2. Gherezghiher, T., and Koss, M.C. Clonidine mydriasis in the rat. Eur. J. Pharmacol. 57:263-266, 1979.
3. 2-Adrenoceptor agonists induce mydriasis in the rat by an action within the central nervous system. Br. J. Pharmacol. 78:507-515, 1983.
4. 2-adrenoceptor activation. J. Pharmacol. Methods 15:1-19, 1986.
5. 2-adrenoceptors in the brain. Eur. J. Pharmacol. 170:19-28, 1989.
6. Koss, M.C., and Christensen, H.D. Evidence for a central postsynaptic action of clonidine. Naunyn-Schmiedeberg's Arch. Pharmacol. 307:45-50, 1979.
7. Koss, M.C. Clonidine mydriasis in the cat: Further evidence for a CNS postsynaptic action. Naunyn-Schmiedeberg's Arch. Pharmacol. 309:235-239, 1979.
8. Koss, M.C., Gherezghiher, T., and Nomura, A. CNS adrenergic inhibition of parasympathetic oculomotor tone. J. Auton. Ner. Syst. 10:55-68, 1984.
9. Hey, J.A., Gherezghiher, T., and Koss, M.C. Analysis of clonidine-induced mydriasis in rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 328:258-263, 1985.
10. 2-adrenoceptors. J. Psychopharmacol. 10:6-18, 1996.
11. Allen, R.C., and Langham, M.E. The intraocular pressure response of conscious rabbits to clonidine. Invest. Ophthalmol. 15:815-823, 1976.
12. Sharpe, L.G., and Pickworth, W.B. Opposite pupillary size effects in the cat and dog after microinjections of morphine, normorphine, and clonidine in the Edinger-Westphal nucleus. Brain Res. Bull. 15:329-333, 1985.
13. 2-adrenoreceptor antagonist RX 781094. Br. J. Clin. Pharmacol. 14:99-101, 1982.
14. Murray, R.B., Adler, M.W., and Korczyn, A.D. The pupillary effects of opioids. Life Sci. 33:495-509, 1983.
15. 2-adrenoceptor agonist, on human pupillary reflexes during general anesthesia. Br. J. Clin. Pharmacol. 51:27-33, 2001.
16. Larson, M.D. The effect of antiemetics on pupillary reflex dilation during epidural/general anesthesia. Anesth. Analg. 97:1652-1656, 2003.
17. Morgan, W.W., Morlan, S.L., Krupp, J.H., and Rosenkrantz, J.G. Pentobarbital anesthesia in the rabbit. Am. J. Vet. Res. 27:1133-1134, 1966.
18. Loewenfeld, I.E. Reflex dilation. In: Loewenfeld, I.E., ed. The pupil: Anatomy, physiology, and clinical applications. Detroit, MI: Wayne State University Press, 1993:318-394.
19. Blier, Z.A. Reciprocal inhibition during one type of pupillary dilatation. Proc. Soc. Exp. Biol. Med. 26:461-462, 1928.
20. Ury, B., and Gellhorn, E. Influence of oxygen deficiency on reflex dilatation of the pupil. Proc. Soc. Exp. Bio. Med. 38:426-427, 1938.
21. Anderson, H.K. Reflex pupil dilatation by way of the cervical sympathetic nerve. J. Physiol. 30:15-24, 1904.
22. Oono, S. Pharmacological studies of pupillary reflex dilation. Jpn. J. Pharmacol. 15:95-112, 1965.
23. Larson, M.D., Tayefeh, F., Sessler, D.I., Daniel, M., and Noorani, M. Sympathetic nervous system does not mediate reflex pupillary dilation during desflurane anesthesia. Anesthesiology 85:748-754, 1996.
24. Ohsawa, H., Yamaguchi, S., Ishimaru, H., Shimura, M., and Sato, Y. Neural mechanism of pupillary dilation elicited by electro-acupuncture stimulation in anesthetized rats. J. Auton. Nerv. Syst. 64:101-106, 1997.
25. Weinstein, E.A., and Bender, M.B. Pupillodilator reactions to sciatic and diencephalic stimulation: A comparative study in cat and monkey. J. Neurophysiol. 4:44-50, 1941.
26. Shoumura, K., Kimura, S., and Kaneko, M. Properties of the pupillary dilation produced by the humoral factor in the pupillary reflex dilation: An experimental study in the cat. Jpn. J. Ophthalmol. 33:490-500, 1989.
27. 2-adrenoreceptor antagonists produce opposing mydriatic effects by a central action. J. Auton. Pharmacol. 8:229-239, 1988.
28. Yu, Y., and Koss, M.C. Studies of α-adrenoceptor antagonists on sympathetic mydriasis in rabbits. J. Ocular Pharmacol. Ther. 19:255-263, 2003.
29. 2-adrenoceptor subtypes. Ann. N. Y. Acad. Sci. 812:176-177, 1997.
30. Yu, Y., Ramage, A.G., and Koss, M.C. Pharmacological studies of 8-OH-DPAT-induced pupillary dilation in anesthetized rats. Eur. J. Pharmacol. 489:207-213, 2004.
31. Bogdanski, D.F., Sulser, F., and Brodie, B.B. Comparative action of reserpine, tetrabenazine, and chlorpromazine on central parasympathetic activity: Effects on pupillary size and lacrimation in rabbit and on salivation in dog. J. Pharmacol. Exp. Ther. 132:176-182, 1961.
32. Bo, P., Patrucco, M., Savoldi, F., Formigli, L., and Manzo, L. Behavioral and eegraphic changes induced by dopaminergic antidepressants in rabbits. Farmaco [Sci] 40:608-616, 1985.
33. Yamasaki, T, Kojima, H., Tanaka, M., Aibara, S., Hirohashi, M., Kasai, Y., Tsubokawa, M., Watanabe, K., and Akashi, A. Pharmacological studies on timiperone, a new neuroleptic drug. Arzneimittelforschung 31:707-715, 1981.
34. Preston, K.L., Sullivan, J.T., Strain, E.C., Bigelow, G.E. Effects of cocaine alone and in combination with bromocriptine in human cocaine abusers. J. Pharmacol. Exp. Ther. 262:279-291, 1992.
35. Bachtell, R.K., Tsivkovskaia, N.O., and Ryabinin, A.E. Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: Pharmacological and signal transduction mechanisms. J. Pharmacol. Exp. Ther. 302:516-524, 2002.
36. Yamamoto, H., Maeda, T., Fujimura, M., and Fujimiya, M. Urocortin-like immunoreactivity in the substantia nigra, ventral tegmental area, and Edinger-Westphal nucleus of rat. Neurosci. Lett. 243:21-24, 1998.