Intravenous pentamidine is safe and effective as primary Pneumocystis pneumonia prophylaxis in children and adolescents undergoing hematopoietic stem cell transplantation

Pediatric Infectious Disease Journal

Volumn 32, Issue 9, 2013, Pages 933-936

  Demasi, James M ^a   Cox, Jennifer A ^b   Leonard, David ^c   Koh, Andrew Y ^a,c   Aquino, Victor M ^a,c  

^a CHILDREN S MEDICAL CENTER   (United States)

^b HUNTSVILLE HOSPITAL   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Bone marrow transplantation; Oncology; Pediatrics; Pentamidine; Pneumocystis jiroveci

Indexed keywords

ADRENALIN; ANTIEMETIC AGENT; COTRIMOXAZOLE; IMMUNOSUPPRESSIVE AGENT; PENTAMIDINE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANAPHYLAXIS; ARTICLE; CHEMOPROPHYLAXIS; CHILD; CHILDHOOD LEUKEMIA; COHORT ANALYSIS; DRUG EFFICACY; DRUG INFUSION; DRUG MEGADOSE; DRUG SAFETY; DRUG WITHDRAWAL; ENGRAFTMENT; FEMALE; GRAFT VERSUS HOST REACTION; HOSPITALIZED CHILD; HUMAN; HYPOTENSION; IMMUNOSUPPRESSIVE TREATMENT; INFECTION PREVENTION; INTENSIVE CARE UNIT; KIDNEY DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; METABOLIC DISORDER; MYELOABLATIVE CONDITIONING; NAUSEA AND VOMITING; NEUROBLASTOMA; NEUTROPHIL COUNT; PANCREATITIS; PNEUMOCYSTIS PNEUMONIA; PRIMARY PREVENTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD;

ADMINISTRATION, INTRAVENOUS; ADOLESCENT; ANTIFUNGAL AGENTS; CHEMOPREVENTION; CHILD; CHILD, PRESCHOOL; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOCOMPROMISED HOST; MALE; PENTAMIDINE; PNEUMOCYSTIS CARINII; PNEUMONIA, PNEUMOCYSTIS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 85047688864     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e318292f560     Document Type: Article

References (23)

1. Calderón EJ, Gutierréz-Rivero S, Durand-Joly I, et al. Pneumocystis infection in humans: diagnosis and treatment. Expert Rev Anti Infect Ther. 2010;8:683-701.
2. Gilroy SA, Bennett NX Pneumocystis pneumonia. Semin Respir Crit Care Med. 2011;32:775-782.
3. Kovacs JA, Masur H. Evolving health effects of Pneumocystis: one hundred years of progress in diagnosis and treatment. JAMA. 2009;301:2578-2585.
4. Sepkowitz KA. Opportunistic infections in patients with and patients without Acquired Immunodeficiency Syndrome. Clin Infect Dis. 2002;34:1098-1107.
5. Tuan IZ, Dennison D, Weisdorf DJ. Pneumocystis carinii pneumonitis following bone marrow transplantation. Bone Marrow Transplant. 1992;10:267-272.
6. De Castro N, Neuville S, Sarfati C, et al. Occurrence of Pneumocystis jiroveci pneumonia after allogeneic stem cell transplantation: a 6-year retrospective study. Bone Marrow Transplant. 2005;36:879-883.
7. Kim SY, Dabb AA, Glenn DJ, et al. Intravenous pentamidine is effective as second line Pneumocystis pneumonia prophylaxis in pediatric oncology patients. Pediatr Blood Cancer. 2008;50:779-783.
8. Lindemulder S, Albano E. Successful intermittent prophylaxis with trimethoprim/sulfamethoxazole 2 days per week for Pneumocystis carinii (jiroveci) pneumonia in pediatric oncology patients. Pediatrics. 2007;120:e47-e51.
9. Jules-Elysee KM, Stover DE, Zaman MB, et al. Aerosolized pentamidine: effect on diagnosis and presentation of Pneumocystis carinii pneumonia. Ann Intern Med. 1990;112:750-757.
10. Milstone AM, Balakrishnan SL, Foster CB, et al. Failure of intravenous pentamidine prophylaxis to prevent Pneumocystis pneumonia in a pediatric hematopoietic stem cell transplant (HSCT) patient. Pediatr Blood Cancer. 2006;47:859-860.
11. Ulm K. A simple method to calculate the confidence interval of a standardized mortality ratio (SMR). Am J Epidemiol. 1990;131:373-375.
12. Dykewicz CA; Centers for Disease Control and Prevention (U. S.); Infectious Diseases Society of America; American Society of Blood and Marrow Transplantation. Summary of the guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. Clin Infect Dis. 2001;33:139-144.
13. Link H, Vohringer HF, Wingen F, et al. Pentamidine aerosol for prophylaxis of Pneumocystis carinii pneumonia after BMT. Bone Marrow Transplant. 1993;11:403-406.
14. Hughes WT, Rivera GK, Schell MJ, et al. Successful intermittent chemoprophylaxis for Pneumocystis carinii pneumonitis. N Engl J Med. 1987;316:1627-1632.
15. Marras TK, Sanders K, Lipton JH, et al. Aerosolized pentamidine prophylaxis for Pneumocystis carinii pneumonia after allogeneic marrow transplantation. Transpl Infect Dis. 2002;4:66-74.
16. Vasconcelles MJ, Bernardo MV, King C, et al. Aerosolized pentamidine as Pneumocystis prophylaxis after bone marrow transplantation is inferior to other regimens and is associated with decreased survival and an increased risk of other infections. Biol Blood Marrow Transplant. 2000;6:35-43.
17. Mustafa MM, Pappo A, Cash J, et al. Aerosolized pentamidine for the prevention of Pneumocystis carinii pneumonia in children with cancer intolerant or allergic to trimethoprim/sulfamethoxazole. J Clin Oncol. 1994;12:258-261.
18. O'Sullivan BP, Spaulding R. The use of aerosolized pentamidine for prophylaxis of Pneumocystis carinii pneumonia in children with leukemia. Pediatr Pulmonol. 1994;18:228-231.
19. Weinthal J, Frost JD, Briones G, et al. Successful Pneumocystis carinii pneumonia prophylaxis using aerosolized pentamidine in children with acute leukemia. J Clin Oncol. 1994;12:136-140.
20. Girard PM, Landman R, Guadebout C, et al. Dapsone-pyrimethamine compared with aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia and toxoplasmosis in HIV infection. N Engl J Med. 1993;328:1514-1520.
21. Souza JP, Boeckh M, Gooley TA, et al. High rates of Pneumocystis carinii pneumonia in allogeneic blood and marrow transplant recipients receiving dapsone prophylaxis. Clin Infect Dis. 1999;29:1467-1471.
22. Chan C, Montaner J, Lefebvre EA, et al. Atovaquone suspension compared with aerosolized pentamidine for prevention of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected subjects intolerant of trimethoprim or sulfonamides. J Infect Dis. 1999;180:369-376.
23. Colby C, McAfee S, Sackstein R, et al. A prospective randomized trial comparing the toxicity and safety of atovaquone with trimethoprim/ sulfamethoxazole as Pneumocystis carinii pneumonia prophylaxis following autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 1999;24:897-902.