Aerosolized Pentamidine as Pneumocystis Prophylaxis After Bone Marrow Transplantation Is Inferior to Other Regimens and Is Associated with Decreased Survival and an Increased Risk of Other Infections

Biology of Blood and Marrow Transplantation

Volumn 6, Issue 1, 2000, Pages 35-43

  Vasconcelles, M J ^a,b   Bernardo, M V P ^a   King, C ^a   Weller, E A ^a   Antin, J H ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Bone marrow transplantation; Pneumocystis carinii pneumonia; Prophylaxis

Indexed keywords

ANTIFUNGAL AGENT; DAPSONE; PENTAMIDINE; PROPELLANT; SULFAMETHOXAZOLE; TRIMETHOPRIM;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD DISEASE; BONE MARROW TRANSPLANTATION; CLINICAL TRIAL; COHORT ANALYSIS; COMPARATIVE STUDY; DRUG SCREENING; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; INFECTION; INHALATIONAL DRUG ADMINISTRATION; MALE; METHODOLOGY; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PNEUMOCYSTOSIS; RETROSPECTIVE STUDY; SURVIVAL RATE;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; AEROSOL PROPELLANTS; AGED; ANTIFUNGAL AGENTS; BONE MARROW TRANSPLANTATION; COHORT STUDIES; COMBINED MODALITY THERAPY; DAPSONE; DRUG EVALUATION; FEMALE; GRAFT VS HOST DISEASE; HEMATOLOGIC NEOPLASMS; HUMANS; INFECTION; MALE; MIDDLE AGED; PENTAMIDINE; PNEUMOCYSTIS INFECTIONS; RETROSPECTIVE STUDIES; SULFAMETHOXAZOLE; SURVIVAL RATE; TRIMETHOPRIM;

EID: 0033631194     PISSN: 10838791     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1083-8791(00)70050-4     Document Type: Article

References (36)

1. Krowka M, Rosenow E, Hoagland H. Pulmonary complications of bone marrow transplantation. Chest. 1985;87:237.
2. Link H, Vohringer H-F, Wingen F, et al. Pentamidine aerosol for prophylaxis of Pneumocystis carinii pneumonia after BMT. Bone Marrow Transplant. 1993;11:403.
3. Hughes W, Kuhn S, Chaudhary S, et al. Successful chemoprophylaxis for Pneumocystis carinii pneumonitis. N Engl J Med. 1977;297:1419.
4. Olsen S, Renlund D, O'Connell J, et al. Prevention of Pneumocystis carinii pneumonia in cardiac transplant recipients by trimethoprim sulfamethoxazole. Transplantation. 1993;56:359.
5. Kramer M, Stoehr C, Lewiston N, et al. Trimethoprim-sulfamethoxazole prophylaxis for Pneumocystis carinii infections in heart-lung and lung transplantation - how effective and for how long? Transplantation. 1992;53:586.
6. Higgins R, Bloom S, Hopkin J, et al. The risks and benefits of low-dose cotrimoxazole prophylaxis for Pneumocystis pneumonia in renal transplantation. Transplantation. 1988;47:558.
7. Nachman S, Mueller B, Mirochnick M, et al. High failure rate of dapsone and pentamidine as Pneumocystis carinii pneumonia prophylaxis in Human Immunodeficiency Virus-infected children. Pediatr Infect Dis J. 1994;13:1004.
8. Schneider M, Hoepelman A, Schattenkerk J, et al. A controlled trial of aerosolized pentamidine or trimethoprim-sulfamethoxazole as primary prophylaxis against Pneumocystis carinii pneumonia in patients with Human Immunodeficiency Virus infection. N Engl J Med. 1992;327:1836.
9. U.S. Public Health Service Task Force on Antipneumocystis Prophylaxis in Patients with Human Immunodeficiency Virus Infection: Recommendations for prophylaxis against Pneumocystis carinii pneumonia for persons infected with Human Immunodeficiency Virus. J Acquir Immune Defic Synd. 1993;6:46.
10. Pretet S, Salmon D, Rousseau F, et al. Long-term results of monthly inhaled pentamidine as primary prophylaxis of Pneumocystis carinii pneumonia in HTV-infected patients. Am J Med. 1993;94:35.
11. Imrie KR, Prince HM, Couture F, et al. Effect of antimicrobial prophylaxis on hematopoietic recovery following autologous bone marrow transplantation: ciprofloxacin versus co-trimoxazole. Bone Marrow Transplant.1995;15:267.
12. Lew MA, Kehoe K, Ritz J, et al. Ciprofloxacin versus trimethoprim/sulfamethoxazole for prophylaxis of bacterial infections in bone marrow transplant recipients: a randomized, controlled trial. J Clin Oncol. 1995;13:239.
13. Woods WG, Daigle AE, Hutchinson RJ, et al. Myelosuppression associated with co-trimoxazole as a prophylactic antibiotic in the maintenance phase of childhood acute lymphocytic leukemia. J Pediatrics. 1984;105:639.
14. Fahy J, Chin D, Schnapp L, et al. Effect of aerosolized pentamidine prophylaxis on the clinical severity and diagnosis of Pneumocystis carinii pneumonia. Am Rev Respir Dis. 1992;146:844.
15. Woolson RF: Statistical Methods for the Analysis of Biomedical Data. New York: John Wiley and Sons, 1987.
16. Hosmer DW, Lemeshow ST: Applied Logistic Regression. New-York: John Wiley and Sons, 1989.
17. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457.
18. Antin JH, Bierer BR, Smith BR, et al. Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies. Blood. 1991;78:2139.
19. Ballen KK, Gilliland DG, Guinan EC, et al. Bone marrow transplantation for therapy-related myelodysplasia: comparison with primary myelodysplasia. Bone Marrow Transplant. 1997;20:737.
20. Fay JW, Wingard JR, Antin JH, et al. FK506 (Tacrolimus) monotherapy for prevention of graft-versus-host disease after histocompatible sibling allogeneic bone marrow transplantation. Blood. 1996;87:3514.
21. Wheeler C, Eickhoff C, Elias A, et al. High-dose cyclophosphamide, carmustine, and etoposide with autologous transplantation in Hodgkin's disease: a prognostic model for treatment outcomes. Biol Blood Marrow Transplant. 1997;3:98.
22. Kovatch A, Wald E, Albo V, et al. Oral trimethoprim/sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children. Pediatrics. 1985;76:754.
23. Gualtieri R, Donowitz G, Kaiser D, et al. Double-blind randomized study of prophylactic trimethoprim/sulfamethoxazole in granulocytopenic patients with hematologic malignancies. Am J Med. 1983;74:934.
24. Kauffman C, Liepman M, Bergman A, et al. Trimethoprim/sulfamethoxazole prophylaxis in neutropenic patients. Am J Med. 1983;74:599.
25. de Jongh C, Wade J, Finley R, et al. Trimethoprim/sulfamethoxazole versus placebo: A double-blind comparison of infection prophylaxis in patients with small cell carcinoma of the lung. J Clin Oncol. 1983;1:302.
26. May T, Beuscart C, Reynes J, et al. Trimethoprim-sulfamethoxazole versus aerosolized pentamidine for primary prophylaxis of Pneumocystis carinii pneumonia: a prospective, randomized, controlled clinical trial. J Acquir Immune Defic Syndr. 1994;7:457.
27. Mallolas J, Zamora L, Gatell J, et al. Primary prophylaxis for Pneumocystis carinii pneumonia: a randomized trial comparing cotrimoxazole, aerosolized pentamidine and dapsone plus pyrimethamine. AIDS. 1993;7:59.
28. Antinori A, Murri R, Ammassari A, et al. Aerosolized pentamidine, cotrimoxazole and dapsone-pyrimethamine for primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis. AIDS. 1995;9:1343.
29. Rizzardi G, Lazzarin A, Musicco M, et al. Risks and benefits of aerosolized pentamidine and cotrimoxazole in primary prophylaxis of Pneumocystis carinii pneumonia in HIV-1 infected patients: a two year Italian multicentric randomized controlled trial. J Infect. 1996;32:123.
30. Mahon F, Sadoun A, Benz-Lemoine E, et al. Possible prevention of Pneumocystis carinii pneumonia by pentamidine aerosol after bone marrow transplantation. Bone Marrow Transplant. 1991;9:64.
31. Machado CM, Macedo MCA, Medeiros RSS, et al. Primary Pneumocystis carinii prophylaxis with aerosolized pentamidine after bone marrow transplantation. Acta Haem. 1998;99:54.
32. Winston D, Ho W, Gale R, et al. Prophylaxis of infection in bone marrow transplants. Eur J Cancer Clin Oncol. 1988;24(suppl 1):S15.
33. Tuan IZ, Dennison D, Weisdorf DJ: Pneumocystis carinii pneumonitis following bone marrow transplantation. Bone Marrow Transplant. 1992;10:267.
34. Meyers J, Flournoy N, Thomas E: Nonbacterial pneumonia after allogeneic marrow transplantation: a review of ten years' experience. Rev Infect Dis. 1982;4:1119.
35. Lyytikainen O, Ruutu T, Volin L, et al. Late onset Pneumocystis carinii pneumonia following allogeneic bone marrow transplantation. Bone Marrow Transplant. 1996;17:1057.
36. El-Sadr WM, Murphy RL, Yurik TM, et al. Atovaquone compared with dapsone for the prevention of Pneumocystis carinii pneumonia in patients with HIV infection who cannot tolerate trimethoprim, sulfonamides, or both: community Program for Clinical Research on AIDS and the AIDS Clinical Trials Group. N Engl J Med. 1998;339:1889.