Steroids fail to down-regulate respiratory syncytial virus-induced IL-8 secretion in infants

Pediatric Research

Volumn 52, Issue 3, 2002, Pages 368-372

  Thomas, Lynette H ^a   Sharland, Mike ^a   Friedland, Jon S ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; CHEMOKINE; DEXAMETHASONE; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 8; STEROID; GLUCOCORTICOID;

ADULT; ARTICLE; BRONCHIOLITIS; CHILD; CLINICAL ARTICLE; CYTOKINE RELEASE; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HOST RESISTANCE; HUMAN; INFANT; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RNA VIRUS INFECTION; TH2 CELL; CELL CULTURE; CELL LINE; DRUG EFFECT; IMMUNOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; SECRETION; VIROLOGY;

ADULT; CELL LINE; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; DEXAMETHASONE; DOWN-REGULATION; FEMALE; GLUCOCORTICOIDS; HUMANS; INFANT; INTERLEUKIN-10; INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKIN-8; LEUKOCYTES, MONONUCLEAR; MALE; RESPIRATORY SYNCYTIAL VIRUSES;

EID: 85047684267     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200209000-00010     Document Type: Article

References (43)

1. Prospects for a respiratory syncytial virus vaccine
2. Respiratory syncytial virus pneumonia in the hospital setting: Length of stay, charges, and mortality
3. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years
4. Respiratory syncytial virus disease in infants despite prior administration of an antigenic inactivated vaccine
5. Pathological changes in virus infections of the lower respiratory tract in children
6. Analysis of cells obtained by bronchial lavage of infants with respiratory syncitial virus infection
7. Nasal cytokine production in viral acute upper respiratory infection of childhood
8. Elevated plasma interleukin-8 in respiratory syncytial virus bronchiolitis
9. Peripheral blood cytokine responses and disease severity in respiratoy syncytial virus bronchiolitis
10. Cytokine (tumour necrosis factor, IL-6 and IL-8) production by respiratory syncytial virus-infected human alveolar macrophages
11. Cytokine (IL-8, IL-6, TNF-α) and soluble TNF receptor-I release from human peripheral blood mononuclear cells after respiratory syncytial virus infection
12. Mechanism of RSV-induced IL-8 gene expression in A549 cells before viral replication
13. Inducible translational regulation of the NF-IL6 transcription factor by respiratory syncytial virus infection in pulmonary epithelial cells
14. Cell-specific expression of RANTES, MCP-1, and MIP-1 alpha by lower airway epithelial cells and eosinophils infected with respiratory syncytial virus
15. Activator protein-1 is the preferred transcription factor for cooperative interaction with nuclear factor kappaB in respiratory syncytial virus-induced interleukin-8 gene expression in airway epithelium
16. High level interleukin-12 production, but diminished interferon-γ production, by cord blood mononuclear cells
17. Characteristics of IL-6 and TNF-γ production by respiratory syncytial virus-infected macrophages in the neonate
18. Decreased interleukin-12 levels in umbilical cord blood in children who developed acute bronchiolitis
19. Cytokine response to respiratory syncytial virus stimulation of human peripheral blood mononuclear cells
20. Phenotypic and functional characterization of T cell lines specific for individual respiratory syncytial virus proteins
21. Microplaque immunoperoxidase detection of infectious respiratory syncytial virus in the lungs of infected mice
22. Synergistic upregulation of IL-8 secretion from pulmonary epithelial cells by direct and monocyte-dependent effects of respiratory syncytial virus infection
23. Transcriptional activation of the interleukin-8 gene by respiratory syncytial virus infection in alveolar epithelial cells: Nuclear translocation of the RelA transcription factor as a mechanism producing airway mucosal inflammation
24. Health effects of passive smoking I. Parental smoking and lower respiratory illness in infancy and early childhood
25. Breast feeding and lower respiratory tract illness in the first year of life
26. Fetal mononuclear cells show a comparable capacity with maternal mononuclear cells to produce IL-8 in response to lipopolysaccharide in chorioaminionitis
27. Decreased interleukin-15 from activated cord versus adult peripheral blood mononuclear cells and the effect of interleukin-15 in upregulating antitumor immune activity and cytokine production in cord blood
28. Development of in vitro correlates of cell-mediated immunity to respiratory syncytial virus infection in humans
29. Development of cell-mediated cytotoxic immunity to respiratory syncytial virus in human infants following naturally-acquired infection
30. Respiratory syncytial virus-induced cytokine production by neonatal macrophages
31. Respiratory syncytial virus infection of human mononuclear leukocytes in vitro and in vivo
32. Respiratory syncytial virus RNA in cells from the peripheral blood during acute infection
33. Respiratory syncytial virus infection of human cord and adult blood monocytes and alveolar macrophages
34. Respiratory syncytial virus bronchiolitis: A double blind dexamethasone efficacy study
35. Dexamethasone in bronchiolitis: A randomised controlled trial
36. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of monocytes. Comparison with IL-4 and modulation by interferon-gamma or IL-10
37. Interleukin (IL)-10 inhibits nuclear factor κB (NFKB) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms
38. Overexpression of interleukin-4 delays virus clearance in mice infected with respiratory sycytial virus
39. Critical roles for interleukin-4 and interleukin-5 during respiratory sycytial virus infection in the development of airway hyperresponsiveness after airway sensitization
40. Elevated cytokine concentrations in the nasopharyngeal and tracheal secretions of children with respiratory syncytial virus disease
41. Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a one-year follow-up study
42. Monocyte interleukin-12 production is inversely related to duration of respiratory failure in respiratory syncytial virus bronchiolitis
43. Respiratory syncytial virus predisposes mice to augmented allergic airway responses via IL-13-mediated mechanisms