-
1
-
-
84959423289
-
Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology
-
Zhang D, Xu C, Manwani D, Frenette PS. Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology. Blood. 2016;127(7):801-809.
-
(2016)
Blood
, vol.127
, Issue.7
, pp. 801-809
-
-
Zhang, D.1
Xu, C.2
Manwani, D.3
Frenette, P.S.4
-
2
-
-
69549107429
-
Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions
-
Kato GJ, Hebbel RP, Steinberg MH, Gladwin MT. Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions. Am J Hematol. 2009;84(9):618-625.
-
(2009)
Am J Hematol
, vol.84
, Issue.9
, pp. 618-625
-
-
Kato, G.J.1
Hebbel, R.P.2
Steinberg, M.H.3
Gladwin, M.T.4
-
3
-
-
84866046917
-
Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases
-
Larsen R, Gouveia Z, Soares MP, Gozzelino R. Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases. Front Pharmacol. 2012;3:77.
-
(2012)
Front Pharmacol
, vol.3
, pp. 77
-
-
Larsen, R.1
Gouveia, Z.2
Soares, M.P.3
Gozzelino, R.4
-
4
-
-
77949496427
-
Heme degradation and vascular injury
-
Belcher JD, Beckman JD, Balla G, Balla J, Vercellotti G. Heme degradation and vascular injury. Antioxid Redox Signal. 2010;12(2):233-248.
-
(2010)
Antioxid Redox Signal
, vol.12
, Issue.2
, pp. 233-248
-
-
Belcher, J.D.1
Beckman, J.D.2
Balla, G.3
Balla, J.4
Vercellotti, G.5
-
5
-
-
84975044348
-
Cardiovascular complications and risk of death in sickle-cell disease
-
Gladwin MT. Cardiovascular complications and risk of death in sickle-cell disease. Lancet. 2016;387(10037):2565-2574.
-
(2016)
Lancet
, vol.387
, Issue.10037
, pp. 2565-2574
-
-
Gladwin, M.T.1
-
6
-
-
84908373728
-
Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development
-
Schaer DJ, Vinchi F, Ingoglia G, Tolosano E, Buehler PW. Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development. Front Physiol. 2014;5:415.
-
(2014)
Front Physiol
, vol.5
, pp. 415
-
-
Schaer, D.J.1
Vinchi, F.2
Ingoglia, G.3
Tolosano, E.4
Buehler, P.W.5
-
7
-
-
0014360531
-
Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases
-
Muller-Eberhard U, Javid J, Liem HH, Hanstein A, Hanna M. Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases. Blood. 1968;32(5): 811-815.
-
(1968)
Blood
, vol.32
, Issue.5
, pp. 811-815
-
-
Muller-Eberhard, U.1
Javid, J.2
Liem, H.H.3
Hanstein, A.4
Hanna, M.5
-
8
-
-
0027358877
-
Endothelial-cell heme uptake from heme proteins: Induction of sensitization and desensitization to oxidant damage
-
Balla J, Jacob HS, Balla G, Nath K, Eaton JW, Vercellotti GM. Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc Natl Acad Sci USA. 1993;90(20):9285-9289.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, Issue.20
, pp. 9285-9289
-
-
Balla, J.1
Jacob, H.S.2
Balla, G.3
Nath, K.4
Eaton, J.W.5
Vercellotti, G.M.6
-
9
-
-
84931271446
-
Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease
-
Camus SM, De Moraes JA, Bonnin P, et al. Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease. Blood. 2015;125(24):3805-3814.
-
(2015)
Blood
, vol.125
, Issue.24
, pp. 3805-3814
-
-
Camus, S.M.1
De Moraes, J.A.2
Bonnin, P.3
-
10
-
-
85015958869
-
Intravascular hemolysis and the pathophysiology of sickle cell disease
-
Kato GJ, Steinberg MH, Gladwin MT. Intravascular hemolysis and the pathophysiology of sickle cell disease. J Clin Invest. 2017; 127(3):750-760.
-
(2017)
J Clin Invest
, vol.127
, Issue.3
, pp. 750-760
-
-
Kato, G.J.1
Steinberg, M.H.2
Gladwin, M.T.3
-
11
-
-
84894567032
-
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
-
Belcher JD, Chen C, Nguyen J, et al. Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood. 2014;123(3): 377-390.
-
(2014)
Blood
, vol.123
, Issue.3
, pp. 377-390
-
-
Belcher, J.D.1
Chen, C.2
Nguyen, J.3
-
13
-
-
80051962945
-
A central role of heme oxygenase-1 in cardiovascular protection
-
Wu ML, Ho YC, Yet SF. A central role of heme oxygenase-1 in cardiovascular protection. Antioxid Redox Signal. 2011;15(7): 1835-1846.
-
(2011)
Antioxid Redox Signal
, vol.15
, Issue.7
, pp. 1835-1846
-
-
Wu, M.L.1
Ho, Y.C.2
Yet, S.F.3
-
14
-
-
33644649611
-
Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice
-
Belcher JD, Mahaseth H, Welch TE, Otterbein LE, Hebbel RP, Vercellotti GM. Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice. J Clin Invest. 2006;116(3):808-816.
-
(2006)
J Clin Invest
, vol.116
, Issue.3
, pp. 808-816
-
-
Belcher, J.D.1
Mahaseth, H.2
Welch, T.E.3
Otterbein, L.E.4
Hebbel, R.P.5
Vercellotti, G.M.6
-
15
-
-
78649477021
-
Heme oxygenase in the regulation of vascular biology: From molecular mechanisms to therapeutic opportunities
-
Kim YM, Pae HO, Park JE, et al. Heme oxygenase in the regulation of vascular biology: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2011; 14(1):137-167.
-
(2011)
Antioxid Redox Signal
, vol.14
, Issue.1
, pp. 137-167
-
-
Kim, Y.M.1
Pae, H.O.2
Park, J.E.3
-
16
-
-
84903637752
-
Hemin controls T cell polarization in sickle cell alloimmunization
-
Zhong H, Bao W, Friedman D, Yazdanbakhsh K. Hemin controls T cell polarization in sickle cell alloimmunization. J Immunol. 2014; 193(1):102-110.
-
(2014)
J Immunol
, vol.193
, Issue.1
, pp. 102-110
-
-
Zhong, H.1
Bao, W.2
Friedman, D.3
Yazdanbakhsh, K.4
-
17
-
-
28344437694
-
Selective expansion of CD16highCCR2- Subpopulation of circulating monocytes with preferential production of haem oxygenase (HO)-1 in response to acute inflammation
-
Mizuno K, Toma T, Tsukiji H, et al. Selective expansion of CD16highCCR2- subpopulation of circulating monocytes with preferential production of haem oxygenase (HO)-1 in response to acute inflammation. Clin Exp Immunol. 2005;142(3):461-470.
-
(2005)
Clin Exp Immunol
, vol.142
, Issue.3
, pp. 461-470
-
-
Mizuno, K.1
Toma, T.2
Tsukiji, H.3
-
18
-
-
84876207357
-
Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal
-
Carlin LM, Stamatiades EG, Auffray C, et al. Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal. Cell. 2013;153(2):362-375.
-
(2013)
Cell
, vol.153
, Issue.2
, pp. 362-375
-
-
Carlin, L.M.1
Stamatiades, E.G.2
Auffray, C.3
-
19
-
-
85015778827
-
Endothelial protective monocyte patrolling in large arteries intensified by western diet and atherosclerosis
-
Quintar A, McArdle S, Wolf D, et al. Endothelial protective monocyte patrolling in large arteries intensified by western diet and atherosclerosis. Circ Res. 2017;120(11):1789-1799.
-
(2017)
Circ Res
, vol.120
, Issue.11
, pp. 1789-1799
-
-
Quintar, A.1
McArdle, S.2
Wolf, D.3
-
20
-
-
84887611153
-
Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta
-
Michaud JP, Bellavance MA, Préfontaine P, Rivest S. Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta. Cell Reports. 2013;5(3):646-653.
-
(2013)
Cell Reports
, vol.5
, Issue.3
, pp. 646-653
-
-
Michaud, J.P.1
Bellavance, M.A.2
Préfontaine, P.3
Rivest, S.4
-
21
-
-
0035885926
-
Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase
-
Wagener FA, Eggert A, Boerman OC, et al. Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase. Blood. 2001;98(6):1802-1811.
-
(2001)
Blood
, vol.98
, Issue.6
, pp. 1802-1811
-
-
Wagener, F.A.1
Eggert, A.2
Boerman, O.C.3
-
22
-
-
34547120742
-
Characterization of heme as activator of Toll-like receptor 4
-
Figueiredo RT, Fernandez PL, Mourao-Sa DS, et al. Characterization of heme as activator of Toll-like receptor 4. J Biol Chem. 2007; 282(28):20221-20229.
-
(2007)
J Biol Chem
, vol.282
, Issue.28
, pp. 20221-20229
-
-
Figueiredo, R.T.1
Fernandez, P.L.2
Mourao-Sa, D.S.3
-
23
-
-
84891121208
-
Vaso-occlusion in sickle cell disease: Pathophysiology and novel targeted therapies
-
Manwani D, Frenette PS. Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies. Blood. 2013;122(24):3892-3898.
-
(2013)
Blood
, vol.122
, Issue.24
, pp. 3892-3898
-
-
Manwani, D.1
Frenette, P.S.2
-
24
-
-
0005991370
-
Enhanced levels of soluble VCAM-1 in sickle cell patients and their specific increment during vasoocclusive crisis
-
Duits AJ, Pieters RC, Saleh AW, et al. Enhanced levels of soluble VCAM-1 in sickle cell patients and their specific increment during vasoocclusive crisis. Clin Immunol Immunopathol. 1996;81(1):96-98.
-
(1996)
Clin Immunol Immunopathol
, vol.81
, Issue.1
, pp. 96-98
-
-
Duits, A.J.1
Pieters, R.C.2
Saleh, A.W.3
-
25
-
-
80051959957
-
The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- Monocytes
-
Hanna RN, Carlin LM, Hubbeling HG, et al. The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes. Nat Immunol. 2011;12(8):778-785.
-
(2011)
Nat Immunol
, vol.12
, Issue.8
, pp. 778-785
-
-
Hanna, R.N.1
Carlin, L.M.2
Hubbeling, H.G.3
-
26
-
-
0030703240
-
Circulating activated endothelial cells in sickle cell anemia
-
Solovey A, Lin Y, Browne P, Choong S, Wayner E, Hebbel RP. Circulating activated endothelial cells in sickle cell anemia. N Engl J Med. 1997;337(22):1584-1590.
-
(1997)
N Engl J Med
, vol.337
, Issue.22
, pp. 1584-1590
-
-
Solovey, A.1
Lin, Y.2
Browne, P.3
Choong, S.4
Wayner, E.5
Hebbel, R.P.6
-
27
-
-
0033152361
-
Sickle cell anemia as a possible state of enhanced anti-apoptotic tone: Survival effect of vascular endothelial growth factor on circulating and unanchored endothelial cells
-
Solovey A, Gui L, Ramakrishnan S, Steinberg MH, Hebbel RP. Sickle cell anemia as a possible state of enhanced anti-apoptotic tone: survival effect of vascular endothelial growth factor on circulating and unanchored endothelial cells. Blood. 1999;93(11):3824-3830.
-
(1999)
Blood
, vol.93
, Issue.11
, pp. 3824-3830
-
-
Solovey, A.1
Gui, L.2
Ramakrishnan, S.3
Steinberg, M.H.4
Hebbel, R.P.5
-
28
-
-
0033558798
-
VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling
-
Gupta K, Kshirsagar S, Li W, et al. VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp Cell Res. 1999;247(2):495-504.
-
(1999)
Exp Cell Res
, vol.247
, Issue.2
, pp. 495-504
-
-
Gupta, K.1
Kshirsagar, S.2
Li, W.3
-
29
-
-
84933035566
-
Nonclassical patrolling monocyte function in the vasculature
-
Thomas G, Tacke R, Hedrick CC, Hanna RN. Nonclassical patrolling monocyte function in the vasculature. Arterioscler Thromb Vasc Biol. 2015;35(6):1306-1316.
-
(2015)
Arterioscler Thromb Vasc Biol
, vol.35
, Issue.6
, pp. 1306-1316
-
-
Thomas, G.1
Tacke, R.2
Hedrick, C.C.3
Hanna, R.N.4
-
30
-
-
34249979533
-
Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer
-
Venneri MA, De Palma M, Ponzoni M, et al. Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer. Blood. 2007; 109(12):5276-5285.
-
(2007)
Blood
, vol.109
, Issue.12
, pp. 5276-5285
-
-
Venneri, M.A.1
De Palma, M.2
Ponzoni, M.3
-
31
-
-
65649095964
-
Circulating monocytes expressing CD31: Implications for acute and chronic angiogenesis
-
Kim SJ, Kim JS, Papadopoulos J, et al. Circulating monocytes expressing CD31: implications for acute and chronic angiogenesis. Am J Pathol. 2009;174(5):1972-1980.
-
(2009)
Am J Pathol
, vol.174
, Issue.5
, pp. 1972-1980
-
-
Kim, S.J.1
Kim, J.S.2
Papadopoulos, J.3
-
32
-
-
84871527696
-
Highly angiogenic CXCR4(1)CD31(1) monocyte subset derived from 3D culture of human peripheral blood
-
Hur J, Choi JI, Yun JY, et al. Highly angiogenic CXCR4(1)CD31(1) monocyte subset derived from 3D culture of human peripheral blood. Biomaterials. 2013;34(8):1929-1941.
-
(2013)
Biomaterials
, vol.34
, Issue.8
, pp. 1929-1941
-
-
Hur, J.1
Choi, J.I.2
Yun, J.Y.3
-
33
-
-
84878739686
-
TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb
-
Patel AS, Smith A, Nucera S, et al. TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb. EMBO Mol Med. 2013;5(6):858-869.
-
(2013)
EMBO Mol Med
, vol.5
, Issue.6
, pp. 858-869
-
-
Patel, A.S.1
Smith, A.2
Nucera, S.3
-
34
-
-
84880099479
-
The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage
-
Hanafy KA. The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage. J Neuroinflammation. 2013;10(1):83.
-
(2013)
J Neuroinflammation
, vol.10
, Issue.1
, pp. 83
-
-
Hanafy, K.A.1
-
35
-
-
84862820762
-
Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage
-
Lin S, Yin Q, Zhong Q, et al. Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage. J Neuroinflammation. 2012;9(1):46.
-
(2012)
J Neuroinflammation
, vol.9
, Issue.1
, pp. 46
-
-
Lin, S.1
Yin, Q.2
Zhong, Q.3
-
36
-
-
84982113745
-
CCN1/ CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation
-
Imhof BA, Jemelin S, Ballet R, et al. CCN1/ CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation. Proc Natl Acad Sci USA. 2016; 113(33):E4847-E4856.
-
(2016)
Proc Natl Acad Sci USA
, vol.113
, Issue.33
, pp. E4847-E4856
-
-
Imhof, B.A.1
Jemelin, S.2
Ballet, R.3
-
37
-
-
84887457415
-
Extracellular hemin crisis triggers acute chest syndrome in sickle mice
-
Ghosh S, Adisa OA, Chappa P, et al. Extracellular hemin crisis triggers acute chest syndrome in sickle mice. J Clin Invest. 2013; 123(11):4809-4820.
-
(2013)
J Clin Invest
, vol.123
, Issue.11
, pp. 4809-4820
-
-
Ghosh, S.1
Adisa, O.A.2
Chappa, P.3
-
38
-
-
42049112071
-
Inducers of heme oxygenase-1
-
Ferrándiz ML, Devesa I. Inducers of heme oxygenase-1. Curr Pharm Des. 2008;14(5): 473-486.
-
(2008)
Curr Pharm Des
, vol.14
, Issue.5
, pp. 473-486
-
-
Ferrándiz, M.L.1
Devesa, I.2
-
39
-
-
84871713925
-
The social network of carbon monoxide in medicine
-
Wegiel B, Hanto DW, Otterbein LE. The social network of carbon monoxide in medicine. Trends Mol Med. 2013;19(1):3-11.
-
(2013)
Trends Mol Med
, vol.19
, Issue.1
, pp. 3-11
-
-
Wegiel, B.1
Hanto, D.W.2
Otterbein, L.E.3
-
40
-
-
84865998135
-
Bile pigments in pulmonary and vascular disease
-
Ryter SW. Bile pigments in pulmonary and vascular disease. Front Pharmacol. 2012;3:39.
-
(2012)
Front Pharmacol
, vol.3
, pp. 39
-
-
Ryter, S.W.1
-
41
-
-
84888260688
-
MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice
-
Belcher JD, Young M, Chen C, et al. MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice. Blood. 2013;122(15):2757-2764.
-
(2013)
Blood
, vol.122
, Issue.15
, pp. 2757-2764
-
-
Belcher, J.D.1
Young, M.2
Chen, C.3
-
42
-
-
85029371570
-
Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury
-
Rossi M, Thierry A, Delbauve S, et al. Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury. Sci Rep. 2017;7(1):197.
-
(2017)
Sci Rep
, vol.7
, Issue.1
, pp. 197
-
-
Rossi, M.1
Thierry, A.2
Delbauve, S.3
-
43
-
-
58149181985
-
Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes
-
Rushworth SA, MacEwan DJ, O’Connell MA. Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes. J Immunol. 2008;181(10):6730-6737.
-
(2008)
J Immunol
, vol.181
, Issue.10
, pp. 6730-6737
-
-
Rushworth, S.A.1
MacEwan, D.J.2
O’Connell, M.A.3
-
44
-
-
84959872829
-
IRG1 induced by heme oxygenase-1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production
-
Jamal Uddin M, Joe Y, Kim SK, et al. IRG1 induced by heme oxygenase-1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production. Cell Mol Immunol. 2016;13(2):170-179.
-
(2016)
Cell Mol Immunol
, vol.13
, Issue.2
, pp. 170-179
-
-
Jamal Uddin, M.1
Joe, Y.2
Kim, S.K.3
-
45
-
-
70349934860
-
Distinct roles of TLR4 and CD14 in LPS-induced inflammatory responses of neonates
-
Levy E, Xanthou G, Petrakou E, et al. Distinct roles of TLR4 and CD14 in LPS-induced inflammatory responses of neonates. Pediatr Res. 2009;66(2):179-184.
-
(2009)
Pediatr Res
, vol.66
, Issue.2
, pp. 179-184
-
-
Levy, E.1
Xanthou, G.2
Petrakou, E.3
-
46
-
-
49949089858
-
Cytosporone B is an agonist for nuclear orphan receptor Nur77
-
Zhan Y, Du X, Chen H, et al. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat Chem Biol. 2008;4(9): 548-556.
-
(2008)
Nat Chem Biol
, vol.4
, Issue.9
, pp. 548-556
-
-
Zhan, Y.1
Du, X.2
Chen, H.3
|