Investigating the genetic underpinnings of early-life irritability

Translational Psychiatry

Volumn 7, Issue 9, 2017, Pages

  Riglin, L ^a   Eyre, O ^a   Cooper, M ^a   Collishaw, S ^a   Martin, J ^a,b   Langley, K ^a,c   Leibenluft, E ^d   Stringaris, A ^d   Thapar, A K ^a   Maughan, B ^e   O'donovan M C ^a   Thapar, A ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b KAROLINSKA INSTITUTE   (Sweden)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ATTENTION DEFICIT DISORDER; CHILD; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HUMAN; IRRITABILITY; LONGITUDINAL STUDY; MAJOR DEPRESSION; MALE; MULTIFACTORIAL INHERITANCE;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; IRRITABLE MOOD; LONGITUDINAL STUDIES; MALE; MULTIFACTORIAL INHERITANCE;

EID: 85047303287     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/TP.2017.212     Document Type: Article

References (59)

1. Shaw P, Stringaris A, Nigg J, Leibenluft E. Emotion dysregulation in attention deficit hyperactivity disorder. Am J Psychiat 2014; 171: 276–293.
2. Leibenluft E. Irritability in children: what we know and what we need to learn. World Psychitary 2017; 16: 100–101.
3. Stringaris A, Goodman R. Longitudinal outcome of youth oppositionality: irritable, headstrong, and hurtful behaviors have distinctive predictions. J Am Acad Child Adolesc Psychiatry 2009; 48: 404–412.
4. Eyre O, Langley K, Stringaris A, Leibenluft E, Collishaw S, Thapar A. Irritability in ADHD: associations with depression liability. J Affect Disord 2017; 215: 281–287.
5. Dalsgaard S, Østergaard SD, Leckman JF, Mortensen PB, Pedersen MG. Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study. Lancet 2015; 385: 2190–2196.
6. Ellen Leibenluft. Severe mood dysregulation, irritability, and the diagnostic boundaries of bipolar disorder in youths. Am J Psychiat 2011; 168: 129–142.
7. Wiggins JL, Mitchell C, Stringaris A, Leibenluft E. Developmental trajectories of irritability and bidirectional associations with maternal depression. J Am Acad Child Adolesc Psychiatry 2014; 53: 1191–1205.e1194.
8. Copeland WE, Brotman MA, Costello EJ. Normative irritability in youth: developmental findings from the Great Smoky Mountains Study. J Am Acad Child Adolesc Psychiatry 2015; 54: 635–642.
9. Brotman MA, Kircanski K, Stringaris A, Pine DS, Leibenluft E. Irritability in youths: a translational model. Am J Psychiat 2017; 174: 520–532.
10. Vidal-Ribas P, Brotman MA, Valdivieso I, Leibenluft E, Stringaris A. The status of irritability in psychiatry: a conceptual and quantitative review. J Am Acad Child Adolesc Psychiatry 2016; 55: 556–570.
11. Merwood A, Chen W, Rijsdijk F, Skirrow C, Larsson H, Thapar A et al. Genetic associations between the symptoms of attention-deficit/hyperactivity disorder and emotional lability in child and adolescent twins. J Am Acad Child Adolesc Psychiatry 2014; 53: 209–220.e204.
12. Epstein JN, Conners CK, Erhardt D, Arnold LE, Hechtman L, Hinshaw SP et al. Familial aggregation of ADHD characteristics. J Abnorm Child Psychol 2000; 28: 585–594.
13. Surman CB, Biederman J, Spencer T, Yorks D, Miller CA, Petty CR et al. Deficient emotional self-regulation and adult attention deficit hyperactivity disorder: a family risk analysis. Am J Psychiat 2011; 168: 617–623.
14. Stringaris A, Zavos H, Leibenluft E, Maughan B, Eley TC. Adolescent irritability: phenotypic associations and genetic links with depressed mood. Am J Psychiat 2012; 169: 47–54.
15. Wray NR, Lee SH, Mehta D, Vinkhuyzen AA, Dudbridge F, Middeldorp CM. Research review: polygenic methods and their application to psychiatric traits. J Child Psychol Psychiatry 2014; 55: 1068–1087.
16. Boyd A, Golding J, Macleod J, Lawlor DA, Fraser A, Henderson J et al. Cohort Profile: The 'Children of the 90s'-the index offspring of the Avon Longitudinal Study of Parents and Children. Int J Epidemiol 2013; 42: 111–127.
17. Fraser A, Macdonald-Wallis C, Tilling K, Boyd A, Golding J, Davey Smith G et al. Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort. Int J Epidemiol 2013; 42: 97–110.
18. Power C, Elliott J. Cohort profile: 1958 british birth cohort (national child development study). Int J Epidemiol 2006; 35: 34–41.
19. Langley K, Martin J, Agha SS, Davies C, Stergiakouli E, Holmans P et al. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. Br J Psychiatry 2011; 199: 398–403.
20. Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 2013; 381: 1371–1379.
21. Cross-Disorder Group of the Psychiatric Genomics C. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013; 45: 984–994.
22. Neale BM, Medland SE, Ripke S, Asherson P, Franke B, Lesch K-P et al. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2010; 49: 884–897.
23. Yang L, Neale BM, Liu L, Lee SH, Wray NR, Ji N et al. Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome‐wide association study of both common and rare variants. Am J Med Genet Part B: Neuropsychiatric Genet 2013; 162: 419–430.
24. Ripke S, Wray NR, Lewis CM, Hamilton SP, Weissman MM, Breen G et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatr 2013; 18: 497–511.
25. Riglin L, Collishaw S, Thapar AK, Dalsgaard S, Langley K, Smith GD et al. Association of genetic risk variants with attention-deficit/hyperactivity disorder trajectories in the general population. JAMA Psychiatry 2016; 73: 1285–1292.
26. Stringaris A, Goodman R. Three dimensions of oppositionality in youth. J Child Psychol Psychiatry 2009; 50: 216–223.
27. Burke JD, Boylan K, Rowe R, Duku E, Stepp SD, Hipwell AE et al. Identifying the irritability dimension of ODD: application of a modified bifactor model across five large community samples of children. J Abnorm Psychol 2014; 123: 841–851.
28. Rowe R, Costello EJ, Angold A, Copeland WE, Maughan B. Developmental path-ways in oppositional defiant disorder and conduct disorder. J Abnorm Psychol 2010; 119: 726.
29. Goodman R, Ford T, Richards H, Gatward R, Meltzer H. The development and well-being assessment: description and initial validation of an integrated assessment of child and adolescent psychopathology. J Child Psychol Psychiatry 2000; 41: 645–655.
30. Rutter M, Tizard J, Whitmore K. Education, Health and Behaviour. Longman Pub-lishing Group: London, UK, 1970.
31. Angold A, Costello EJ. The child and adolescent psychiatric assessment (CAPA). J Am Acad Child Adolesc Psychiatry 2000; 39: 39–48.
32. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association: Washington, D.C, 2013.
33. Thapar A, Rutter M. Neurodevelopmental disorders. In: Thapar A, Pine DS, Leck-man JF, Scott S, Snowling MJ, Taylor E (eds). Rutter's Child and Adolescent Psy-chiatry. Sixth edn., Wiley Press: Oxford, 2015.
34. Fernández de la Cruz L, Simonoff E, McGough JJ, Halperin JM, Arnold LE, Stringaris A. Treatment of children with attention-deficit/hyperactivity disorder (ADHD) and irritability: results from the Multimodal Treatment Study of Children with ADHD (MTA). J Am Acad Child Adolesc Psychiatry 2015; 54: 62–70. e63.
35. Hamshere ML, Langley K, Martin J, Agha SS, Stergiakouli E, Anney RJ et al. High loading of polygenic risk for ADHD in children with comorbid aggression. Am J Psychiat 2013; 170: 909–916.
36. Martin J, Hamshere ML, Stergiakouli E, O'Donovan MC, Thapar A. Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder. J Child Psychol Psychiatry 2015; 56: 648–656.
37. Martin J, Hamshere ML, Stergiakouli E, O’Donovan MC, Thapar A. Genetic risk for attention-deficit/hyperactivity disorder contributes to neurodevelopmental traits in the general population. Biol Psychiat 2014; 76: 664–671.
38. Groen-Blokhuis MM, Middeldorp CM, Kan K-J, Abdellaoui A, van Beijsterveldt CE, Ehli EA et al. Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children. J Am Acad Child Adolesc Psychiatry 2014; 53: 1123–1129. e1126.
39. Lahey BB, Van Hulle CA, Singh AL, Waldman ID, Rathouz PJ. Higher-order genetic and environmental structure of prevalent forms of child and adolescent psy-chopathology. Arch Gen Psychiatry 2011; 68: 181–189.
40. Savage J, Verhulst B, Copeland W, Althoff RR, Lichtenstein P, Roberson-Nay R. A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms. J Am Acad Child Adolesc Psychiatry 54: 377–384.
41. Roberson-Nay R, Leibenluft E, Brotman MA, Myers J, Larsson H, Lichtenstein P et al. Longitudinal stability of genetic and environmental influences on irritability: from childhood to young adulthood. Am J Psychiat 2015; 172: 657–664.
42. Dougherty L, Smith V, Bufferd S, Carlson G, Stringaris A, Leibenluft E et al. DSM-5 disruptive mood dysregulation disorder: correlates and predictors in young children. Psychol Med 2014; 44: 2339–2350.
43. Copeland WE, Angold A, Costello EJ, Egger H. Prevalence, comorbidity, and correlates of DSM-5 proposed disruptive mood dysregulation disorder. Am J Psychiat 2013; 170: 173–179.
44. Axelson D, Findling RL, Fristad MA, Kowatch RA, Youngstrom EA, Horwitz SM et al. Examining the proposed disruptive mood dysregulation disorder diagnosis in children in the Longitudinal Assessment of Manic Symptoms study. J Clin Psychiatry 2012; 73: 1342–1350.
45. Ambrosini PJ, Bennett DS, Elia J. Attention deficit hyperactivity disorder char-acteristics: II. Clinical correlates of irritable mood. J Affect Disord 2013; 145: 70–76.
46. Cuthbert BN, Insel TR. Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Med 2013; 11: 126.
47. Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS. Research Domain Criteria (RDoC): toward a new classification framework for Re. Am J Psychiatry 2010; 167: 7.
48. Power RA, Tansey KE, Buttenschøn HN, Cohen-Woods S, Bigdeli T, Hall LS et al. Genome-wide association for major depression through age at onset stratifica-tion. Biol Psychiat 2017; 81: 325–335.
49. Anttila V, Bulik-Sullivan B, Finucane HK, Bras J, Duncan L, Escott-Price V et al. Analysis of shared heritability in common disorders of the brain. bioRxiv 2016; 048991.
50. Bulik-Sullivan B, Finucane HK, Anttila V, Gusev A, Day FR, Loh P-R et al. An atlas of genetic correlations across human diseases and traits. Nat Genet 2015; 47: 1236–1241.
51. Consortium C-DGotPG Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013; 45: 984–994.
52. Spencer T, Biederman J, Wilens T. Attention-deficit/hyperactivity disorder and comorbidity. Pediatr Clin North Am 1999; 46: 915–927.
53. Seymour KE, Chronis-Tuscano A, Halldorsdottir T, Stupica B, Owens K, Sacks T. Emotion regulation mediates the relationship between ADHD and depressive symptoms in youth. J Abnorm Child Psychol 2012; 40: 595–606.
54. Krieger FV, Polanczyk GV, Goodman R, Rohde LA, Graeff-Martins AS, Salum G et al. Dimensions of oppositionality in a Brazilian community sample: testing the DSM-5 proposal and etiological links. J Am Acad Child Adolesc Psychiatry 2013; 52: 389–400. e381.
55. Whelan YM, Stringaris A, Maughan B, Barker ED. Developmental continuity of oppositional defiant disorder subdimensions at ages 8, 10, and 13 years and their distinct psychiatric outcomes at age 16 years. J Am Acad Child Adolesc Psychiatry 2013; 52: 961–969.
56. Martin J, Tilling K, Hubbard L, Stergiakouli E, Thapar A, Smith GD et al. Association of genetic risk for schizophrenia with nonparticipation over time in a population-based cohort study. Am J Epidemiol 2016; 183: 1149–1158.
57. Wolke D, Waylen A, Samara M, Steer C, Goodman R, Ford T et al. Selective drop-out in longitudinal studies and non-biased prediction of behaviour disorders. Br J Psychiatry 2009; 195: 249–256.
58. Dudbridge F. Power and predictive accuracy of polygenic risk scores. PLoS Genet 2013; 9: e1003348.
59. Jones HJ, Stergiakouli E, Tansey KE, Hubbard L, Heron J, Cannon M et al. Phenotypic manifestation of genetic risk for schizophrenia during adolescence in the general population. JAMA Psychiatry 2016; 73: 221–228.