Global Analysis of the E. coli Toxin MazF Reveals Widespread Cleavage of mRNA and the Inhibition of rRNA Maturation and Ribosome Biogenesis

Molecular Cell

Volumn 70, Issue 5, 2018, Pages 868-880.e10

  Culviner, Peter H ^a   Laub, Michael T ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

endoribonucleases; ribosome profiling; rRNA maturation; toxin antitoxin systems; translational control

Indexed keywords

BACTERIAL TOXIN; MESSENGER RNA; PROTEIN MAZF; RIBONUCLEASE; RIBOSOME PROTEIN; RIBOSOME RNA; RNA 16S; UNCLASSIFIED DRUG; BACTERIAL RNA; DNA BINDING PROTEIN; ESCHERICHIA COLI PROTEIN; MAZF PROTEIN, E COLI;

ARTICLE; BIOGENESIS; CELL GROWTH; CONTROLLED STUDY; ESCHERICHIA COLI; GENE MAPPING; HIGH THROUGHPUT SEQUENCING; NONHUMAN; QUANTITATIVE ANALYSIS; RIBOSOME; RNA CLEAVAGE; RNA RECOGNITION MOTIF; RNA SEQUENCE; RNA TRANSCRIPTION; TOXIN-ANTITOXIN SYSTEM; 5' UNTRANSLATED REGION; BIOSYNTHESIS; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROTEIN SYNTHESIS; RNA PROCESSING; RNA STABILITY; SEQUENCE ANALYSIS;

5' UNTRANSLATED REGIONS; DNA-BINDING PROTEINS; ENDORIBONUCLEASES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; PROTEIN BIOSYNTHESIS; RIBOSOMAL PROTEINS; RIBOSOMES; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA STABILITY; RNA, BACTERIAL; RNA, MESSENGER; RNA, RIBOSOMAL; SEQUENCE ANALYSIS, RNA;

EID: 85047193200     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2018.04.026     Document Type: Article

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