A Trojan-Horse Strategy Including a Bacterial Suicide Action for the Efficient Use of a Specific Gram-Positive Antibiotic on Gram-Negative Bacteria

Journal of Medicinal Chemistry

Volumn 61, Issue 9, 2018, Pages 3842-3844

  Schalk, Isabelle J ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CARBAPENEM DERIVATIVE; CEPHALOSPORIN; CEPHALOSPORIN DERIVATIVE; CEPHAMYCIN DERIVATIVE; PENICILLIN DERIVATIVE; SIDEROPHORE; ANTIINFECTIVE AGENT;

ACINETOBACTER; ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ENTEROBACTERIACEAE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INNER MEMBRANE; MICROBIAL ACTIVITY; NONHUMAN; OUTER MEMBRANE; PERIPLASM; PSEUDOMONAS; REVIEW; WORLD HEALTH ORGANIZATION; DRUG DEVELOPMENT; DRUG EFFECT;

ANTI-BACTERIAL AGENTS; DRUG DISCOVERY; DRUG RESISTANCE, BACTERIAL; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA;

EID: 85046725151     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.8b00522     Document Type: Review

References (11)

1. J. Med. Chem. 2018, DOI: 10.1021/acs.jmedchem.8b00218
2. Liu, L. R.; Miller, P. A.; Vakulenko, S. B.; Stewart, N. K.; Boggess, W. C.; Miller, M. J. A Synthetic Dual Drug Sideromycin Induces Gram-Negative Bacteria To Commit Suicide with a Gram-Positive Antibiotic. J. Med. Chem. 2018, DOI: 10.1021/acs.jmedchem.8b00218.
3. Mislin, G. L.; Schalk, I. J. Siderophore-Dependent Iron Uptake Systems as Gates for Antibiotic Trojan Horse Strategies against Pseudomonas Aeruginosa. Metallomics: integrated biometal science 2014, 6 (3), 408-420, 10.1039/C3MT00359K
4. Górska, A.; Sloderbach, A.; Marszał ł, M. P. Siderophore-Drug Complexes: Potential Medicinal Applications of the "Trojan Horse" Strategy. Trends Pharmacol. Sci. 2014, 35 (9), 442-449, 10.1016/j.tips.2014.06.007
5. Pagès, J.-M.; James, C. E.; Winterhalter, M. The Porin and the Permeating Antibiotic: A Selective Diffusion Barrier in Gram-Negative Bacteria. Nat. Rev. Microbiol. 2008, 6 (12), 893-903, 10.1038/nrmicro1994
6. Hider, R. Siderophore Mediated Absorption of Iron. Struct. Bonding (Berlin) 1984, 58, 25, 10.1007/BFb0111310
7. Schalk, I. J.; Mislin, G. L.; Brillet, K. Structure, Function and Binding Selectivity and Stereoselectivity of Siderophore-Iron Outer Membrane Transporters. Curr. Top. Membr. 2012, 69, 37-66, 10.1016/B978-0-12-394390-3.00002-1
8. Cornelis, P.; Dingemans, J. Pseudomonas aeruginosa Adapts Its Iron Uptake Strategies in Function of the Type of Infections. Front. Cell. Infect. Microbiol. 2013, 3, 75, 10.3389/fcimb.2013.00075
9. Rebuffat, S. Microcins in Action: Amazing Defence Strategies of Enterobacteria. Biochem. Soc. Trans. 2012, 40 (6), 1456-1462, 10.1042/BST20120183
10. Gasser, V.; Baco, E.; Cunrath, O.; August, P. S.; Perraud, Q.; Zill, N.; Schleberger, C.; Schmidt, A.; Paulen, A.; Bumann, D.; Mislin, G. L.; Schalk, I. J. Catechol Siderophores Repress the Pyochelin Pathway and Activate the Enterobactin Pathway in Pseudomonas Aeruginosa: An Opportunity for Siderophore-Antibiotic Conjugates Development. Environ. Microbiol. 2016, 18 (3), 819-832, 10.1111/1462-2920.13199
11. Schalk, I. J.; Guillon, L. Fate of Ferrisiderophores after Import across Bacterial Outer Membranes: Different Iron Release Strategies Are Observed in the Cytoplasm or Periplasm Depending on the Siderophore Pathways. Amino Acids 2013, 44 (5), 1267-1277, 10.1007/s00726-013-1468-2