A snapshot of translational research funded by the National Institutes of Health (NIH): A case study using behavioral and social science research awards and clinical and translational science awards funded publications

PLoS ONE

Volumn 13, Issue 5, 2018, Pages

  Han, Xueying ^a   Williams, Sharon R ^a   Zuckerman, Brian L ^a  

^a Science and Technology Policy Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APPLIED RESEARCH; ARTICLE; AWARDS AND PRIZES; BASIC RESEARCH; HUMAN; NATIONAL HEALTH ORGANIZATION; PUBLICATION; SOCIOLOGY; TRANSLATIONAL RESEARCH; MEDICAL RESEARCH; ORGANIZATION; PUBLISHING; UNITED STATES;

ACADEMIES AND INSTITUTES; AWARDS AND PRIZES; BIOMEDICAL RESEARCH; HUMANS; NATIONAL INSTITUTES OF HEALTH (U.S.); PUBLICATIONS; PUBLISHING; TRANSLATIONAL MEDICAL RESEARCH; UNITED STATES;

EID: 85046724712     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0196545     Document Type: Article

References (35)

1. Sung NS, Crowley WF Jr, Genel M, Salber P, Sandy L, Sherwood LM, et al. Central challenges facing the national clinical research enterprise. Jama 2003; 289(10): 1278–1287. PMID: 12633190
2. Khoury MJ, Gwinn M, Yoon PW, Dowling N, Moore CA, Bradley L. The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genetics in Medicine 2007; 9: 655–675. https://doi.org/10.1097/GIM.0b013e31815699d0
3. Westfall JM, Mold J, Fagnan L. Practice-based research—“Blue Highways” on the NIH Roadmap. Jama 2007; 297(4): 403–406. https://doi.org/10.1001/jama.297.4.403 PMID: 17244837
4. Dougherty D, Conway PH. The ‘3T’s’ road map to transform US health care: the ‘how’ of high-quality care. Jama 2008; 299(19): 2319–2321. https://doi.org/10.1001/jama.299.19.2319 PMID: 18492974
5. Woolf SH. The meaning of translational research and why it matters. Jama 2008; 299: 211–213. https://doi.org/10.1001/jama.2007.26 PMID: 18182604
6. Waldman SA, Terzic A. Clinical and translational science: from bench-bedside to global village. Clinical and Translational Science 2010; 3(5): 254–257. https://doi.org/10.1111/j.1752-8062.2010.00227.xPMID: 20973923
7. Callard F, Rose D, Wykes T. Close to the bench as well as at the bedside: involving service users in all phases of translational research. Health Expectations 2011; 15: 389–400. https://doi.org/10.1111/j.1369-7625.2011.00681.x PMID: 21615638
8. Drolet BC, Lorenzi NM. Translational research: understanding the continuum from bench to bedside. Translational Research 2011; 157(1): 1–5. https://doi.org/10.1016/j.trsl.2010.10.002 PMID: 21146144
9. National Center for Advancing Translational Sciences. Translational science spectrum. 2017 [cited 25 August 2017]. https://ncats.nih.gov/translation/spectrum.
10. Weber GM. Identifying translational science within the triangle of biomedicine. Journal of Translational Medicine 2013; 11:126. https://doi.org/10.1186/1479-5876-11-126 PMID: 23705970
11. Surkis A, Hogle JA, DiazGranados D, Hunt JD, Mazmanian PE, Connors E, et al. Classifying publications from the clinical and translational science award program along the translational research spectrum: a machine learning approach. Journal of Translational Medicine 2016; 14: 235. https://doi.org/10.1186/s12967-016-0992-8 PMID: 27492440
12. Kempner J. The chilling effect: how do researchers react to controversy? PLoS Med 2008; 5(11): 3222. https://doi.org/10.1371/journal.pmed.0050222 PMID: 19018657
13. Fang FC, Casadevall A. Lost in translation—basic science in the era of translational research. Infection and Immunity 2010; 78(2): 563–566. https://doi.org/10.1128/IAI.01318-09 PMID: 20038540
14. Flake J. Twenty questions: government studies that will leave you scratching your head. 10 May 2016 [cited 24 August 2017]. In: Jeff Flake U.S. Senator ~ Arizona [Internet]. https://www.flake.senate.gov/public/_cache/files/ef6fcd58-c537-491f-aa06-6f7a81038d0e/sen.-jeff-flake-s-twenty-questions—report.pdf.
15. Butler D. Translational research: crossing the valley of death. Nature 2008; 453: 840–842 https://doi.org/10.1038/453840a PMID: 18548043
16. Zerhouni E. The NIH Roadmap. Science 2003; 302: 63–64, 72. https://doi.org/10.1126/science. 1091867 PMID: 14526066
17. National Institutes of Health. A decade of discovery: the NIH Roadmap and Common Fund. 2014 [cited 24 August 2017]. http://commonfund.nih.gov/sites/default/files/ADecadeofDiscoveryNIHRoadmapCF.pdf.
18. National Center for Advancing Translational Sciences. About the CTSA Program. 2017 [cited 24 August 2017]. https://ncats.nih.gov/ctsa/about.
19. National Center for Advancing Translational Sciences. Funded activities under the NCATS Clinical and Translational Science Awards (CTSA) Program. 2017 [cited 25 August 2017]. https://ncats.nih.gov/files/ctsa-funding-information.pdf.
20. Rosas SR, Schouten JT, Cope MT, Kagan JM. Modeling the dissemination and uptake of clinical trials results. Research Evaluation 2013; 22: 179–186. https://doi.org/10.1093/reseval/rvt005 PMID: 24808630
21. Schneider M, Kane CM, Rainwater J, Guerrero L, Tong G, Desai SR, et al. Feasibility of common biblio-metrics in evaluating translational science. Journal of Clinical and Translational Science 2017; 1: 45–52. https://doi.org/10.1017/cts.2016.8 PMID: 28480055
22. NIH Office of Behavioral and Social Sciences Research. BSSR definition. 2018 [cited 13 March 2018]. https://obssr.od.nih.gov/about-us/bssr-definition/.
23. NIH RePORT. Estimates of funding for various research, condition, and disease categories (RCDC). 2017 [cited 30 August 2017]. https://report.nih.gov/categorical_spending.aspx.
24. National Institutes of Health. Types of applications. 2017 [cited 30 August 2017]. https://grants.nih.gov/grants/how-to-apply-application-guide/prepare-to-apply-and-register/type-of-applications.htm.
25. Winter D, Chamberlain S, Gaungchun H. rentrez: Entrez in R. 2017 [cited 30 August 2017]. https://cran.r-project.org/web/packages/rentrez/index.html.
26. U.S. National Library of Medicine. Publication characteristics (publication types) with Scope notes: 2017 MeSH edition. 2017 [cited 31 August 2017]. https://www.nlm.nih.gov/mesh/pubtypes.html.
27. Hutchins BI, Yuan X, Anderson JM, Santangelo GM. Relative Citation Ratio (RCR): a new metric that uses citation rates to measure influence at the article level. PLoS Biol 2016; 14(9): e1002541. https://doi.org/10.1371/journal.pbio.1002541 PMID: 27599104
28. Bates D, Maechler M, Bolker B, Walker S, Christensen RHB, Singmann H, et al. Package ‘lme4’. 2017 [cited 30 August 2017]. https://cran.r-project.org/web/packages/lme4/lme4.pdf.
29. Kloke JD, McKean JW. Rfit: rank-based estimation for linear models. The R Journal 2012; 4(2): 57–64.
30. Riveros C, Dechartres A, Perrodeau E, Haneef R, Boutron I, Ravaud P. Timing and completeness of trial results posted at ClinicalTrials.gov and published in journals. PLoS Med 10(12): e1001566. https://doi.org/10.1371/journal.pmed.1001566 PMID: 24311990
31. Easterbrook PJ, Berlin JA, Gopalan R, Matthew DR. Publication bias in clinical research. The Lancet 1991; 337(8746): 867–872.
32. Stern JM, Simes RJ. Publication bias: evidence of delayed publication in a cohort study of clinical research projects. BMJ 1997; 315(7109): 640–645. PMID: 9310565
33. Ioannidis JPA. Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials. Jama 1998; 279(4): 281–286. https://doi.org/10.1001/jama.279.4.281PMID: 9450711
34. Decullier E, Lheritier V, Chapuis F. Fate of biomedical research protocols and publication bias in France: retrospective cohort study. BMJ 2005; 331(7507): 19. https://doi.org/10.1136/bmj.38488.385995.8F PMID: 15967761
35. Hopewell S, Clarke MJ, Stewart L, Tierney J. Time to publication for results of clinical results. Cochrane Database of Systematic Reviews 2008; 2: MR000011. https://doi.org/10.1002/14651858.MR000011. pub2 PMID: 17443632