A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action

Neuron

Volumn 98, Issue 5, 2018, Pages 963-976.e5

  Stoeber, Miriam ^a   Jullié, Damien ^a   Lobingier, Braden T ^a   Laeremans, Toon ^b   Steyaert, Jan ^b,c   Schiller, Peter W ^d   Manglik, Aashish ^a,e   von Zastrow, Mark ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

biosensor; endosome; Golgi; GPCR; ligand bias; ligand induced activation; opioid drug; opioid receptor; signaling; subcellular location

Indexed keywords

OPIATE RECEPTOR; ENKEPHALIN[2 ALANINE 5 LEUCINE]; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; MORPHINE; NALOXONE; NARCOTIC ANALGESIC AGENT; NARCOTIC ANTAGONIST; PEPTIDE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONFORMATION; CONTROLLED STUDY; ENDOSOME; ENZYME ACTIVATION; GENETIC CODE; GOLGI COMPLEX; HUMAN; HUMAN CELL; INTERNALIZATION; MOLECULAR IMAGING; MOLECULAR PROBE; NERVE CELL; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; ANIMAL; DENDRITE; FLUORESCENCE MICROSCOPY; GENETIC PROCEDURES; HEK293 CELL LINE; HELA CELL LINE; INTRACELLULAR SPACE; METABOLISM; SPATIOTEMPORAL ANALYSIS;

ANALGESICS, OPIOID; ANIMALS; BIOSENSING TECHNIQUES; CELL MEMBRANE; DENDRITES; ENDOSOMES; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALIN, LEUCINE-2-ALANINE; GOLGI APPARATUS; HEK293 CELLS; HELA CELLS; HUMANS; INTRACELLULAR SPACE; MICROSCOPY, FLUORESCENCE; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; NEURONS; PEPTIDES; RATS; RECEPTORS, OPIOID; SPATIO-TEMPORAL ANALYSIS;

EID: 85046722934     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2018.04.021     Document Type: Article

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