Fasting versus nonfasting and low- density lipoprotein cholesterol accuracy

Circulation

Volumn 137, Issue 1, 2018, Pages 10-19

  Sathiyakumar, Vasanth ^a   Park, Jihwan ^b   Golozar, Asieh ^b,c   Lazo, Mariana ^b   Quispe, Renato ^a,c   Guallar, Eliseo ^b,c   Blumenthal, Roger S ^a   Jones, Steven R ^a   Martin, Seth S ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Cholesterol; Data accuracy; Fasting; LDL

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; INFORMED CONSENT; LIMIT OF QUANTITATION; MAJOR CLINICAL STUDY; MALE; MEASUREMENT ACCURACY; POPULATION RESEARCH; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; ULTRACENTRIFUGATION; BLOOD; BLOOD ANALYSIS; COMPARATIVE STUDY; DIET RESTRICTION; FACTUAL DATABASE; MIDDLE AGED; PREDICTIVE VALUE; PROCEDURES; SPECIMEN HANDLING; VALIDATION STUDY;

ADULT; AGED; BIOMARKERS; BLOOD CHEMICAL ANALYSIS; CHOLESTEROL, LDL; CROSS-SECTIONAL STUDIES; DATA ACCURACY; DATABASES, FACTUAL; FASTING; FEMALE; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; SPECIMEN HANDLING; TRIGLYCERIDES; ULTRACENTRIFUGATION;

EID: 85046573893     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.117.030677     Document Type: Article

References (40)

1. Nordestgaard BG, Langsted A, Mora S, Kolovou G, Baum H, Bruckert E, Watts GF, Sypniewska G, Wiklund O, Borén J, Chapman MJ, Cobbaert C, Descamps OS, von Eckardstein A, Kamstrup PR, Pulkki K, Kronenberg F, Remaley AT, Rifai N, Ros E, Langlois M; European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Joint Consensus Initiative. Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points: a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine. Eur Heart J. 2016;37:1944-1958. doi: 10.1093/eurheartj/ehw152.
2. Jacobson TA, Ito MK, Maki KC, Orringer CE, Bays HE, Jones PH, McKenney JM, Grundy SM, Gill EA, Wild RA, Wilson DP, Brown WV. National lipid association recommendations for patient-centered management of dyslipidemia, part 1: full report. J Clin Lipidol. 2015;9:129-169. doi: 10.1016/j.jacl.2015.02.003.
3. Langsted A, Nordestgaard BG. Nonfasting lipid profiles: the way of the future. Clin Chem. 2015;61:1123-1125. doi: 10.1373/clinchem.2015.243139.
4. Mora S. Nonfasting for routine lipid testing: from evidence to action. JAMA Intern Med. 2016;176:1005-1006. doi: 10.1001/jamainternmed.2016.1979.
5. Gaziano JM. Should we fast before we measure our lipids? Arch Intern Med. 2012;172:1705-1706. doi: 10.1001/jamainternmed.2013.1771.
6. Eckel RH. LDL cholesterol as a predictor of mortality, and beyond: to fast or not to fast, that is the question? Circulation. 2014;130:528-529. doi: 10.1161/CIRCULATIONAHA.114.011512.
7. Mora S, Rifai N, Buring JE, Ridker PM. Fasting compared with nonfasting lipids and apolipoproteins for predicting incident cardiovascular events. Circulation. 2008;118:993-1001. doi: 10.1161/CIRCULATIONAHA. 108.777334.
8. Ridker PM, Rifai N, Cook NR, Bradwin G, Buring JE. Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA. 2005;294:326-333. doi: 10.1001/jama.294.3.326.
9. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007;298:299-308. doi: 10.1001/jama.298.3.299.
10. Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA. 2007;298:309-316. doi: 10.1001/jama.298.3.309.
11. van Deventer HE, Miller WG, Myers GL, Sakurabayashi I, Bachmann LM, Caudill SP, Dziekonski A, Edwards S, Kimberly MM, Korzun WJ, Leary ET, Nakajima K, Nakamura M, Shamburek RD, Vetrovec GW, Warnick GR, Remaley AT. Non-HDL cholesterol shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL cholesterol in a dyslipidemic population. Clin Chem. 2011;57:490-501. doi: 10.1373/clinchem.2010.154773.
12. Sidhu D, Naugler C. Fasting time and lipid levels in a community-based population: a cross-sectional study. Arch Intern Med. 2012;172:1707-1710. doi: 10.1001/archinternmed.2012.3708.
13. Brenner H, Heiss G. The intraindividual variability of fasting triglyceride: a challenge for further standardization. Eur Heart J. 1990;11:1054-1058.
14. Driver SL, Martin SS, Gluckman TJ, Clary JM, Blumenthal RS, Stone NJ. Fasting or nonfasting lipid measurements: it depends on the question. J Am Coll Cardiol. 2016;67:1227-1234. doi: 10.1016/j.jacc.2015.12.047.
15. Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, Goldberg AC, Gordon D, Levy D, Lloyd-Jones DM, McBride P, Schwartz JS, Shero ST, Smith SC Jr, Watson K, Wilson PW, Eddleman KM, Jarrett NM, LaBresh K, Nevo L, Wnek J, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK, Smith SC Jr, Tomaselli GF; American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(suppl 2):S1-S45. doi: 10.1161/01.cir.0000437738.63853.7a.
16. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502.
17. Scharnagl H, Nauck M, Wieland H, März W. The Friedewald formula underestimates LDL cholesterol at low concentrations. Clin Chem Lab Med. 2001;39:426-431. doi: 10.1515/CCLM.2001.068.
18. Jun KR, Park HI, Chun S, Park H, Min WK. Effects of total cholesterol and triglyceride on the percentage difference between the low-density lipoprotein cholesterol concentration measured directly and calculated using the Friedewald formula. Clin Chem Lab Med. 2008;46:371-375. doi: 10.1515/CCLM.2008.064.
19. Lindsey CC, Graham MR, Johnston TP, Kiroff CG, Freshley A. A clinical comparison of calculated versus direct measurement of low-density lipoprotein cholesterol level. Pharmacotherapy. 2004;24:167-172.
20. Martin SS, Blaha MJ, Elshazly MB, Toth PP, Kwiterovich PO, Blumenthal RS, Jones SR. Comparison of a novel method vs the Friedewald equation for estimating low-density lipoprotein cholesterol levels from the standard lipid profile. JAMA. 2013;310:2061-2068. doi: 10.1001/jama.2013.280532.
21. Ruge T, Svensson M, Eriksson JW, Olivecrona G. Tissue-specific regulation of lipoprotein lipase in humans: effects of fasting. Eur J Clin Invest. 2005;35:194-200. doi: 10.1111/j.1365-2362.2005.01470.x.
22. Ladu MJ, Kapsas H, Palmer WK. Regulation of lipoprotein lipase in adipose and muscle tissues during fasting. Am J Physiol. 1991;260(pt 2):R953-R959.
23. Miller WG, Waymack PP, Anderson FP, Ethridge SF, Jayne EC. Performance of four homogeneous direct methods for LDL-cholesterol. Clin Chem. 2002;48:489-498.
24. Mora S, Rifai N, Buring JE, Ridker PM. Comparison of LDL cholesterol concentrations by Friedewald calculation and direct measurement in relation to cardiovascular events in 27, 331 women. Clin Chem. 2009;55:888-894. doi: 10.1373/clinchem.2008.117929.
25. HPS3/TIMI55-REVEAL Collaborative Group. Effects of anacetrapib in patients with atherosclerotic cardiovascular disease. N Engl J Med. 2017;377:1217-1227.
26. Ferreira CEDS, Scartezini M, França CN. Lipid profile, the world needs to change. J Clin Lipidol. 2017;11:769-770. doi: 10.1016/j.jacl.2017.01.019.
27. Scartezini M, Ferreira CEDS, Izar MCO, Bertoluci M, Vencio S, Campana GA, Sumita NM, Barcelos LF, Faludi AA, Santos RD, Malachias MVB, Aquino JL, Galoro CAO, Sabino C, Gurgel MHC, Turatti LAA, Hohl A, Martinez TLDR. Positioning about the flexibility of fasting for lipid profiling. Arq Bras Cardiol. 2017;108:195-197. doi: 10.5935/abc.20170039.
28. Catapano AL, Graham I, De Backer G, Wiklund O, Chapman MJ, Drexel H, Hoes AW, Jennings CS, Landmesser U, Pedersen TR, Reiner Ž, Riccardi G, Taskinen MR, Tokgozoglu L, Verschuren WM, Vlachopoulos C, Wood DA, Zamorano JL. 2016 ESC/EAS guidelines for the management of dyslipidaemias. Eur Heart J. 2016;37:2999-3058. doi: 10.1093/eurheartj/ehw272.
29. Lloyd-Jones DM, Morris PB, Ballantyne CM, Birtcher KK, Daly DD Jr, De- Palma SM, Minissian MB, Orringer CE, Smith SC Jr. 2016 ACC expert consensus decision pathway on the role of non-statin therapies for LDLcholesterol lowering in the management of atherosclerotic cardiovascular disease risk: a report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol. 2016;68:92-125.
30. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143-3421.
31. ClinicalTrials.gov. The Very Large Database of Lipids (VLDL). ClinicalTrials. gov identifier: NCT01698489. Accessed June 1, 2017.
32. Martin SS, Blaha MJ, Toth PP, Joshi PH, McEvoy JW, Ahmed HM, Elshazly MB, Swiger KJ, Michos ED, Kwiterovich PO, Kulkarni KR, Chimera J, Cannon CP, Blumenthal RS, Jones SR. Very Large Database of Lipids: rationale and design. Clin Cardiol. 2013;36:641-648.
33. Khera AV, Mora S. Fasting for lipid testing: is it worth the trouble? Arch Intern Med. 2012;172:1710-1712.
34. Langsted A, Freiberg JJ, Nordestgaard BG. Fasting and nonfasting lipid levels: influence of normal food intake on lipids, lipoproteins, apolipoproteins, and cardiovascular risk prediction. Circulation. 2008;118:2047-2056. doi: 10.1161/CIRCULATIONAHA.108.804146.
35. Steiner MJ, Skinner AC, Perrin EM. Fasting might not be necessary before lipid screening: a nationally representative cross-sectional study. Pediatrics. 2011;128:463-470. doi: 10.1542/peds.2011-0844.
36. Langsted A, Nordestgaard BG. Nonfasting lipids, lipoproteins, and apolipoproteins in individuals with and without diabetes: 58 434 individuals from the Copenhagen General Population Study. Clin Chem. 2011;57:482-489. doi: 10.1373/clinchem.2010.157164.
37. Li C, Balluz LS, Okoro CA, Strine TW, Lin JM, Town M, Garvin W, Murphy W, Bartoli W, Valluru B; Centers for Disease Control and Prevention (CDC). Surveillance of certain health behaviors and conditions among states and selected local areas: Behavioral Risk Factor Surveillance System, United States, 2009. MMWR Surveill Summ. 2011;60:1-250.
38. Miller M, Stone NJ, Ballantyne C, Bittner V, Criqui MH, Ginsberg HN, Goldberg AC, Howard WJ, Jacobson MS, Kris-Etherton PM, Lennie TA, Levi M, Mazzone T, Pennathur S; American Heart Association Clinical Lipidology, Thrombosis, and Prevention Committee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular Nursing; Council on the Kidney in Cardiovascular Disease. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2011;123:2292-2333. doi: 10.1161/CIR.0b013e3182160726.
39. Langsted A, Kamstrup PR, Nordestgaard BG. Lipoprotein(a): fasting and nonfasting levels, inflammation, and cardiovascular risk. Atherosclerosis. 2014;234:95-101. doi: 10.1016/j.atherosclerosis.2014.01.049.
40. Ridker PM. Fasting versus nonfasting triglycerides and the prediction of cardiovascular risk: do we need to revisit the oral triglyceride tolerance test? Clin Chem. 2008;54:11-13. doi: 10.1373/clinchem.2007.097907.