Effects of total cholesterol and triglyceride on the percentage difference between the low-density lipoprotein cholesterol concentration measured directly and calculated using the Friedewald formula

Clinical Chemistry and Laboratory Medicine

Volumn 46, Issue 3, 2008, Pages 371-375

  Ran Jun, Kyung ^a   Park, Hae Il ^b   Chun, Sail ^a   Park, Hyosoon ^c   Min, Won Ki ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Cholesterol; Friedewald formula; Homogeneous method; Koreans; Low density lipoprotein cholesterol

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; AGED; ANALYTIC METHOD; ARTICLE; ASSAY; CALCULATION; CARDIOVASCULAR RISK; CHILD; CHOLESTEROL BLOOD LEVEL; FEMALE; FRIEDEWALD; HUMAN; HYPERLIPIDEMIA; ISCHEMIC HEART DISEASE; KOREA; MALE; MEASUREMENT; POPULATION; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FEMALE; HUMANS; MALE; MIDDLE AGED; TRIGLYCERIDES;

EID: 39849090352     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2008.064     Document Type: Article

References (18)

1. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002;360:7-22.
2. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). J Am Med Assoc 2001;285:2486-97.
3. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
4. Nauck M, Warnick GR, Rifai N. Methods for measurement of LDL-cholesterol: a critical assessment of direct measurement by homogeneous assays versus calculation. Clin Chem 2002;48:236-54.
5. Bachorik PS, Ross JW. National Cholesterol Education Program recommendations for measurement of low-density lipoprotein cholesterol: executive summary. The National Cholesterol Education Program Working Group on Lipoprotein Measurement. Clin Chem 1995;41:1414-20.
6. Wang TY, Haddad M, Wang TS. Low triglyceride levels affect calculation of low-density lipoprotein cholesterol values. Arch Pathol Lab Med 2001;125:404-5.
7. Tighe DA, Ockene IS, Reed G, Nicolosi R. Calculated low density lipoprotein cholesterol levels frequently underestimate directly measured low density lipoprotein cholesterol determinations in patients with serum triglyceride levels < or =4.52 mmol/l: an analysis comparing the LipiDirect magnetic LDL assay with the Friedewald calculation. Clin Chim Acta 2006;365:236-42.
8. Scharnagl H, Nauck M, Wieland H, Marz W. The Friedewald formula underestimates LDL cholesterol at low concentrations. Clin Chem Lab Med 2001;39:426-31.
9. Sniderman AD, Blank D, Zakarian R, Bergeron J, Frohlich J. Triglycerides and small dense LDL: the twin Achilles heels of the Friedewald formula. Clin Biochem 2003;36: 499-504.
10. Tremblay AJ, Morrissette H, Gagne JM, Bergeron J, Gagne C, Couture P. Validation of the Friedewald formula for the determination of low-density lipoprotein cholesterol compared with beta-quantification in a large population. Clin Biochem 2004;37:785-90.
11. Cordova CM, Schneider CR, Juttel ID, Cordova MM. Comparison of LDL-cholesterol direct measurement with the estimate using the Friedewald formula in a sample of 10,664 patients. Arq Bras Cardiol 2004;83:482-7; 76-81.
12. Hur M, Kim C, Park M, Kwak I, Lee K. Analysis of low-density lipoprotein cholesterol by homogeneous assay in comparison with Friedewald formula. Korean J Lab Med 2003;23:104-8.
13. Lee YW, Min WK, Lee W, Chun S, Park H, Lee DH, et al. Risk analysis of coronary heart diseases in Korean adults by using the National Cholesterol Education Program Adult Treatment Panel III. J Clin Lab Anal 2007;21: 178-82.
14. Chun S, Min WK, Park H, Song J, Kim JQ, Min YI, et al. The risk groups for coronary heart disease in Koreans. Assessment by distribution of serum lipid concentrations. Clin Chem Lab Med 1999;37:969-74.
15. Nauck M, Graziani MS, Bruton D, Cobbaert C, Cole TG, Lefevre F, et al. Analytical and clinical performance of a detergent-based homogeneous LDL-cholesterol assay: a multicenter evaluation. Clin Chem 2000;46:506-14.
16. Bairaktari ET, Seferiadis KI, Elisaf MS. Evaluation of methods for the measurement of low-density lipoprotein cholesterol. J Cardiovasc Pharmacol Therapeut 2005;10: 45-54.
17. Esteban-Salan M, Guimon-Bardesi A, de La Viuda-Unzueta JM, Azcarate-Ania MN, Pascual-Usandizaga P, Amoroto-Del-Rio E. Analytical and clinical evaluation of two homogeneous assays for LDL-cholesterol in hyperlipidemic patients. Clin Chem 2000;46:1121-31.
18. Warnick GR, Myers GL, Cooper GR, Rifai N. Impact of the Third Cholesterol Report from the Adult Treatment Panel of the National Cholesterol Education Program on the Clinical Laboratory. Clin Chem 2002;48:11-7.