The ethics of experimenting with human brain tissue comment

Nature

Volumn 556, Issue 7702, 2018, Pages 429-432

  Farahany, Nita A ^a   Greely, Henry T ^b   Hyman, Steven ^c   Koch, Christof ^c   Grady, Christine ^c   Pasca, Sergiu P ^c   Sestan, Nenad ^c   Arlotta, Paola ^c   Bernat, James L ^c   Ting, Jonathan ^c   Lunshof, Jeantine E ^c   Iyer, Eswar P R ^c   Hyun, Insoo ^c   Capestany, Beatrice H ^c   Church, George M ^c   Huang, Hao ^c   Song, Hongjun ^c  

^a DUKE UNIVERSITY   (United States)

^b STANFORD LAW SCHOOL   (United States)

^c NONE

Author keywords

Diseases; Neuroscience

Indexed keywords

BRAIN; DISEASE; ETHICS; EXPERIMENTAL STUDY; LIFE SCIENCE; NEUROLOGY; NUMERICAL MODEL;

BRAIN TISSUE; CHIMERA; DATA PROCESSING; DEATH; ELECTROENCEPHALOGRAPHY; EX VIVO STUDY; HUMAN; INFORMED CONSENT; MEDICAL ETHICS; NONHUMAN; ORGANIZATION AND MANAGEMENT; ORGANOID; PRIORITY JOURNAL; REVIEW; SPECIMEN HANDLING; WELFARE; ANIMAL; BIOLOGICAL MODEL; BRAIN; CONSCIOUSNESS; CYTOLOGY; ETHICS; GROWTH, DEVELOPMENT AND AGING; HUMAN EXPERIMENT; IN VITRO STUDY; MAMMALIAN EMBRYO; MOUSE; NEUROSCIENCE; PHYSIOLOGY; PIG; RAT; XENOGRAFT;

ANIMALS; BRAIN; CHIMERA; CONSCIOUSNESS; DEATH; EMBRYO, MAMMALIAN; HETEROGRAFTS; HUMAN EXPERIMENTATION; HUMANS; IN VITRO TECHNIQUES; INFORMED CONSENT; MICE; MODELS, BIOLOGICAL; NEUROSCIENCES; ORGANOIDS; OWNERSHIP; RATS; SWINE;

EID: 85045987496     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/d41586-018-04813-x     Document Type: Review

References (19)

1. Quadrato, G., Brown, J. & Arlotta, P. Nature Med. 22, 1220-1228 (2016).
2. Pasca, S. P. Nature 553, 437-445 (2018).
3. Arlotta, P. Nature Meth. 15, 27-29 (2018).
4. Eisenstein, M. Nature Meth. 15, 19-22 (2018).
5. Lancaster, M. A. & Knoblich, J. A. Nature Protoc. 9, 2329-2340 (2014).
6. Qian, X. et al. Cell 165, 1238-1254 (2016).
7. Kadoshima, T. et al. Proc. Natl Acad. Sci. USA 110, 20284-20289 (2013).
8. Birey, F. et al. Nature 545, 54-59 (2017).
9. Sloan, S. A. et al. Neuron 95, 779-790 (2017).
10. Mariani, J. et al. Cell 162, 375-390 (2015).
11. Ye, F. et al. Neuron 96, 1041-1054 (2017).
12. Qian, X., Nguyen, H. N., Jacob, F., Song, H. & Ming, G. L. Development 144, 952-957 (2017).
13. Quadrato, G. et al. Nature 545, 48-53 (2017).
14. Mansour, A. A. et al. Nature Biotechnol. https://doi.org/10.1038/nbt.4127 (2018).
15. Koch, C., Massimini, M., Boly, M. & Tononi, G. Nature Rev. Neurosci. 17, 307-321 (2016).
16. Bourret, R. et al. Stem Cell. Res. Ther. 7, 87 (2016).
17. Greely, H. T., Ramos, K. M. & Grady, C. Neuron 92, 637-641 (2016).
18. Gray Matters: Integrative Approaches for Neuroscience, Ethics, and Society (Presidential Commission for the Study of Bioethical Issues, 2014); available at https://go.nature.com/2qvm83f
19. Gray Matters: Topics at the Intersection of Neuroscience, Ethics, and Society (Presidential Commission for the Study of Bioethical Issues, 2015); available at https://go.nature.com/2vdqx5j