Comparative hypoglycemic potentials and phytochemical profiles of 12 common leafy culinary vegetables consumed in Nsukka, Southeastern Nigeria

Journal of Basic and Clinical Physiology and Pharmacology

Volumn 29, Issue 4, 2018, Pages 313-320

  Aba, Patrick Emeka ^a   Udechukwu, Ifeanyi Ronald ^a  

^a UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

culinary vegetable; diabetes; phytochemical; rat; Southeastern Nigeria

Indexed keywords

ANTIDIABETIC AGENT; PHYTOCHEMICAL; PLANT EXTRACT;

ANIMAL; CHEMISTRY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; MALE; NIGERIA; PHYTOTHERAPY; PLANT LEAF; PROCEDURES; RAT; VEGETABLE; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; MALE; NIGERIA; PHYTOCHEMICALS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; VEGETABLES;

EID: 85045931614     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/jbcpp-2017-0134     Document Type: Article

References (39)

1. WHO. Definition diagnosis and classification of diabetes mellitus and its complications. Switzerland: A Report of WHO consultation Department of Non-communicable disease surveillance Geneva, 1999.
2. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: Prevalence, numerical estimates and projections. Diabetes Care 1998;21:1414-31.
3. Aba PE, Okenwa-Ani CP. Biochemical effects of methanolic extracts of Vernonia amygdalina and Gongronema latifolium on alloxan-induced diabetic rats. Br J Pharm Res 2015;9:1-10.
4. Eze CC, Ugwu GZ. Geoelectrical sounding for estimating ground water and potential in Nsukka LGA, Enugu state, Nigeria. Int J Phy Sci 2010;5:415-20.
5. Mepha HD, Eboh L, Banigbo DE. Effects of processing treatments on the nutritive composition and consumer acceptance of some Nigeria edible vegetables. Africa J Food Agric Nutri Dev 2007;7:1-8.
6. Iweala EJ, Osundiya AO. Biochemical, haematological and histological effects of dietary supplementation with leaves of Gnetum africanum Welw on paracetamol-induced hepatotoxicity in rats. Int J Pharm 2010;6:872-9.
7. Ali MA, Chanu KH, Devi LI. Antioxidant capacities of vegetables consumed in Northeast India assessed by three different in vitro assays. Int J Res Pharma Sci 2011;2:118-23.
8. Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: An overview. Sci World J 2013;2013:1-16.
9. Edet EE, Akpanabiatu MI, Eno AE, Umoh IB, Ham EH. Effects of Gongronema latifolium crude leaf extract on some cardiac enzymes of alloxan-induced diabetic rats. Afr J Biochem Res 2009;3:366-9.
10. Morebise O. A review on Gongronema latifolium, an extremely useful plant with great prospects. Eur J Med Plants 2015;10:1-9.
11. Prabhu KS, Lobo R, Shirwaikar AA, Shirwaikar A. Ocimum gratissimum: A review of its chemical, pharmacological and ethnomedicinal properties. Open Compl Med J 2009;1:1-5.
12. Mohammed A, Tanko Y, Okasha MA, Magaji RA, Yaro AH. Effects of aqueous leaves extract of Ocimum gratissimum on blood glucose levels of streptozotocin-induced diabetic Wistar rats. Int J Aromather 2007;14:119-28.
13. Shulz V, Rudef H, Mark B. Medicinal plants phytoremedies and phytotherapy. A physician's guide to herbal medicine, 4th ed. Berlin, New York: Springer Publisher, 2001:1-39.
14. Okwu DE, Ekeke T. Phytochemical screening and the medicinal composition of chewing stick in southeastern Nigeria. Global J Pure Appl Sci 2003;9:235-8.
15. Usunomena U, Igwe VC. Phytochemical screening, mineral composition and in vitro antioxidant activities of Pterocarpus mildbraedii leaves. Int J Sci World 2016;4:23-6.
16. Mensah JK, Okoli RI, Ohaju-Obodo K, Fifediyi K. Phytochemical, nutritional, and medicinal properties of some leafy vegetables consumed by Edo people of Nigeria. Afr J Biotech 2008;7:1-7.
17. Oboh G, Ekperigin MM, Kazeem MI. Nutritional and hemolytic properties of egg plants (Solanum macrocarpon) leaves. J Food Compos Anal 2005;18:153-60.
18. Opeyemi CE, Shalom NC. Effect of Solanum aethiopicum and Solanum macrocarpon fruits on weight gain, blood glucose and liver glycogen of wistar rats. World J Nutri Health 2016;4:1-4.
19. Ezekwe MO, Besong SA, Igbokwe PE. Beneficial influence of purslane and water leaf supplement to human. FASEB J 2001;16:636-9.
20. Sudha RJ. Ameliorative potential of aqueous extract of Talinum triangulare on diabetes associated metabolic alterations. Indian J Med Healthcare 2012;1:2278-966.
21. Eseyin OA, Igboasoiyi AC, Aforah E, Nkop N, Agboke A. Hypoglycemic activity of Telfaria occidentalis in rats. J Pharm Bioresour 2005;2:36-42.
22. Akah PA, Okafor CI. Blood sugar lowering effect of Vernonia amygdalina Del.in experimental rabbit model. Phytother Res 1992;6:171-3.
23. Nwogo AO, Kalu MK, Uchechukwu O, Glory O. Hypoglycemic effects of aqueous and methanolic extracts of Vitex doniana on alloxan-induced diabetic rats. J Med Sci 2013;13:700-7.
24. Venugopal PM, Prince PS, Pari L. Hypoglycemic activities of Syzigium cumini seeds effect on lipid peroxidation in alloxan diabetic rats. J Ethnopharmacol 1998;61:1-7.
25. Trease GE, Evans WC. Textbook of pharmacognosy, 14th ed. London: W. B Saunders, 1998:40-7.
26. Sylvester EG, Israel EU, Olajumoke AD. The effect of Gongronema latifolium extract on blood biochemical assay in diabetic rats. J Sci Res Rep 2005;6:514-22.
27. Ugochukwu NH, Babady NE. Antihyperglycemic effect of aqueous and ethanolic extracts of Gongronema latifolium leaves on glucose and glycogen metabolism in livers of normal and streptozotocin-induced diabetic rats. Life Sci 2003;73: 1925-38.
28. Okwuosa CN, Unekwe PC, AchukwuPU, Udeani TK, Ogidi UH. Glucose and triglyceride lowering activity of Pterocarpus santalinoides leaf extract against dexamethasone induced hyperlipidemia and insulin resistance in rats. Afr J Biotech 2011;10:9415-20.
29. Offor CE, Aloke C, Ominyi MC, Edwin N, Ugwu OP, Nwobasi CS, et al. Evaluation of antidiabetic effect of ethanol leaf extract of Pterocarpus santalinoides in alloxan-induced diabetic albino rats. IDOSR J Appl Sci 2017;2:114-22.
30. Mohammed A, Tanko Y, Okasha MA, Magaji RA, Yaro AH. Effects of aqueous leaves extract of Ocimum gratissimum on blood glucose levels of streptozotocin-induced diabetic wistar rats. Afr J Biotech 2007;6:2087-90.
31. Ezekwesili CN, Adegbite AV, Okani OC. Effects of aqueous and ethanolic leaf extracts of Pterocarpus mildbraedii on renal and heart functions of albino rats. Animal Res Int 2016;13:2446-53.
32. Taiwo IA, Odeigah PG, Ogunkanmi LA. The glycaemic effects of Vernonia amygdalina and Vernonia tenoreana with tolbutamide in rats and the implications for the treatment of diabetes mellitus. J Sci Res Dev 2009;11:122-30.
33. Gayatri N, Mruntyanjay S, Rahani KS. Antioxidant potentials and nutritional values of vegetables: A review. Res J Med Plants 2014;8:50-81.
34. Campanero MA, Escolar M, Perez G, Garcia-Quetglas E, Sadaba B, Azanza JR. Simultaneous determination of diosmin and diosmetin in human plasma by ion trap liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: Application to a clinical pharmacokinetic study. J Pharm Biomed Analy 2010;51:875-81.
35. Kunyanga CN, Imungi JK, Okoth M, Momanyi C, Biesalski HK, Vadivel V. Antioxidant and antidiabetic properties of condensed tannins in acetonic extract of selected raw and processed indigenous food ingredients from Kenya. J Food Sci 2011;76:560-7.
36. Metwally NS, Mohamed AM, EL Sharabasy FS. Chemical constituents of the Egyptian Plant Anabasis articulata (Forssk) Moq and its antidiabetic effects on rats with streptozotocin-induced diabetic hepatopathy. J Appl Pharm Sci 2012;2:54-65.
37. Maulidiani SK, Paetz C, Stanslas J, Abas F, Lajis NH. Naturally occurring labdane diterpene and benzofuran from Globba pendula. Nat Prod Comm 2009;4:1031-6.
38. Sharma B, Salunke R, Balomajumder C, Daniel S, Roy P. Antidiabetic potential of alkaloid-rich fraction from Capparis deciduas on diabetic mice. J Ethnopharmacol 2009;127:457-62.
39. Verma N, Shakya VK, Saxena RC. Antidiabetic activity of glycoside isolated from Gymnema sylvestre in streptozotocin induced diabetic rats. Asian J Chem 2008;20:5033-6.