Function and specificity of human natural killer cell receptors

European Journal of Immunogenetics

Volumn 24, Issue 6, 1997, Pages 455-468

  Moretta, A ^a,c   Parolini, S ^a   Castriconi, R ^c   Bottino, C ^b   Vitale, M ^b   Sivori, S ^c   Millo, R ^c  

^a UNIVERSITY OF BRESCIA   (Italy)

^b CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD94 ANTIGEN; COMPLEMENTARY DNA; HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN; LYMPHOCYTE RECEPTOR; MEMBRANE PROTEIN; IMMUNOGLOBULIN RECEPTOR;

ALLELE; ANTIGEN RECOGNITION; CELL SURFACE; CYTOLYSIS; HUMAN; LYMPHOCYTE SUBPOPULATION; MOLECULAR WEIGHT; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; CYTOTOXICITY; IMMUNOLOGY;

CYTOTOXICITY, IMMUNOLOGIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; KILLER CELLS, NATURAL; RECEPTORS, IMMUNOLOGIC;

EID: 85045589345     PISSN: 09607420     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2370.1997.d01-117.x     Document Type: Review

References (81)

1. ARAMBURU, J., BALBOA, M.A., RAMIREZ, A., SILVA, A., ACEVEDO, A., SÀNCHEZ-MADRID, F., DE LANDÀZURI, M.O. & LOPEZ-BOTET, M. (1990) A novel functional cell surface dimer (Kp43) expressed by natural killer cells and T-cell receptor-γ/δ+ T lymphocytes. Inhibition of IL-2 dependent proliferation by anti-Kp43 monoclonal antibody. Journal of Immunology, 44, 3238.
2. BIASSONI, R., CANTONI, C., FALCO, M., VERDIANI, S., BOTTINO, C., VITALE, M., CONTE, R., POGGI, A., MORETTA, A. & MORETTA, L. (1996) The human leukocyte antigen (HLA)-C-specific 'activatory' or 'inhibitory' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. Journal of Experimental Medicine, 183, 645.
3. BIASSONI, R., FALCO, M., CAMBIAGGI, A., COSTA, P., VERDIANI, S., PENDE, D., CONTE, R., DI DONATO, C., PARHAM, P. & MORETTA, L. (1995) Amino acid substitutions can influence the natural killer (NK) -mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cell protection from lysis mediated by 'Group 2' or 'Group 1' NK clones. Journal of Experimental Medicine, 182, 605.
4. BIASSONI, R., PESSINO, A., MALASPINA, A., CANTONI, C., SIVORI, S., MORETTA, L. & MORETTA, A. (1997) Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA-Cw4 molecules. European Journal of Immunology, in press.
5. BINSTADT, B.A., BRUMBAUGH, K.M., DICK, C.J., SCHARENBERG, A.M., WILLIAMS, B.L., COLONNA, M., LANIER, L.L., KINET, J.P., ABRAHAM, R.T. & LEIBSON, P.J. (1996) Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity, 5, 629.
6. BOLHUIS, R.L.H., VAN ROOZEMOND, R.C. & DE GRIEND, R.J. (1986) Induction and blocking of cytolysis in CD2+, CD3- NK and CD2+, CD3+ cytotoxic T lymphocytes via CD2, 50 kD sheep erythrocyte receptor. Journal of Immunology, 136, 3939.
7. BOTTINO, C., SIVORI, S., VITALE, M., CANTONI, C., FALCO, M., PENDE, D., MORELLI, L., AUGUGLIARO, R., SEMENZATO, G.P., BIASSONI, R., MORETTA, L. & MORETTA, A. (1996) A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation. European Journal of Immunology, 26, 1816.
8. lck kinase. European Journal of Immunology, 24, 2527.
9. BURSHTYN, D.N., SHARENBERG, A.M., WAGTMANN, N., RAJAGOPALAN, S., BERRULA, K., YI, T., KINET, J.-P. & LONG, E.O. (1996) Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. Immunity, 4, 77.
10. CAMPBELL, K.S., DESSING, M., LOPEZ-BOTET, M., CELLA, M. & COLONNA, M. (1996) Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein phosphatase 1C. Journal of Experimental Medicine, 184, 93.
11. CANTONI, C., BIASSONI, R., PENDE, D., SIVORI, S., ACCAME, L., MORETTA, L., MORETTA, A. & BOTTINO, C. (1997) The activating form of CD94 receptor complex. The CD94-associated Kp39 protein represents the product of the NKG2-C gene. European Journal of Immunology, in press.
12. CANTONI, C., VERDIANI, S., FALCO, M., CONTE, R. & BIASSONI, R. (1996) Molecular structures of HLA-specific human NK cell receptors. Chemical Immunology, 64, 88.
13. CARRETERO, M., CANTONI, C., BELLONI, C., BOTTINO, C., BIASSONI, R., RODRIGUEZ, A., PÉREZ-VILLAR, J.J., MORETTA, L., MORETTA, A. & LOPEZ-BOTET, M. (1997) The CD94 and NKG2A C-type lectins covalently assemble to form a NK cell inhibitory receptor for HLA class I molecules. European Journal of Immunology, 27, 563.
14. CHANG, C., RODRIGUEZ, A., CARRETERO, M., LLRRETBOTET, M., PHILLIPS, J.H. & LANIER, L.L. (1995) Molecular characterization of human CD94: a type II membrane glycoprotein related to the C type lectin superfamily. European Journal of Immunology, 25, 2433.
15. CICCONE, E., PENDE, D., VIALE, O., DI DONATO, C., TRIPODI, G., ORENGO, A.M., GUARDIOLA, J., MORETTA, A. & MORETTA, L. (1992) Evidence of a natural killer (NK) cell repertoire for (allo)antigen recognition: definition of five distinct NK-determined allospecificities in humans. Journal of Experimental Medicine, 175, 709.
16. CICCONE, E., PENDE, D., VITALE, M., NANNI, L., DI DONATO, C., BOTTINO, C., MORELLI, L., VIALE, O., AMOROSO, A., MORETTA, A. & MORETTA, L. (1994) Self class I molecules protect normal cells from lysis mediated by autologous natural killer cells. European Journal of Immunology, 24, 1003.
17. COLONNA, M. & SAMARIDIS, J. (1995) Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science, 268, 405.
18. COLONNA, M., BORSELLINO, G., FALCO, M., FERRARA, G.B. & STROMINGER, J.L. (1993) HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells. Proceedings of the National Academy of Sciences, 90, 12000.
19. D'ANDREA, A., CHANG, C., FRANZ-BACON, K., MCCLANAHAN, T., PHILLIPS, J.H. & LANIER, L.L. (1995) Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. Journal of Immunology, 155, 2306.
20. DOHRING, C., SCHEIDEGGER, D., SAMARIDIS, J., CELLA, M. & COLONNA, M. (1996) A human killer inhibitory receptor specific for HLA-A. Journal of Immunology, 156, 3098.
21. FRY, A.M., LANIER, L.L. & WEISS, A. (1996) Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signalling and for association with protein tyrosine phosphatase 1C. Journal of Experimental Medicine, 184, 295.
22. GARRIDO, F., CABRERA, T., LOPEZ NEVOT, M.A. & RUIZ-CABELLO, F. (1995) HLA class I antigens in human tumours. Advances in Cancer Research, 67, 155.
23. GARRIDO, F., RUIZ-CABELLO, F., CABRERA, T., PÉREZ-VILLAR, J.J., LOPEZ-BOTET, M., DUGGAN-KEEN, M. & STERN, P.L. (1997) Implications for immunosurveillance of altered HLA class I phenotypes in human tumours. Immunology Today, 18, 89.
24. GERAGHTY, D.E., KOLLER, B.H. & ORR, H.T. (1987) A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment. Proceedings of the National Academy of Sciences, 84, 9145.
25. GUMPERZ, J.E., LITWIN, V., PHILLIPS, J.H., LANIER, L.L. & PARHAM, P. (1995) The Bw4- public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor. Journal of Experimental Medicine, 181, 1113.
26. GUMPERZ, J.E. & PARHAM, P. (1995) The enigma of the natural killer cell. Nature, 378, 245.
27. HERBERMAN, R.B., NUNN, M.E. & LAVRIN, D.H. (1975) Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumours. I. Distribution of reactivity and specificity. International Journal of Cancer, 16, 216.
28. HOUCHINS, J.P., YABE, T., MCSHERRY, C. & BACH, F.H. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. Journal of Experimental Medicine, 173, 1017.
29. IKEDA, H., LETHÉ, B., LEHMANN, F., VAN BAREN, N., BAURAIN, J.F., DE SMET, C., CHAMBOST, H., VITALE, M., MORETTA, A., BOON, T. & COULIE, P. (1997) Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. Immunity, 6, 199.
30. KÄRRE, K. (1992) An unexpected petition for pardon. Current Biology, 11, 613.
31. KIESSLING, R., KLEIN, E. & WIGZELL, H. (1975) 'Natural killer' cells in the mouse I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. European Journal of Immunology, 5, 112.
32. KING, A., LOKE, Y.W. & CHAOUAT, G. (1997) NK cells and reproduction. Immunology Today, 18, 64.
33. LANIER, L.L., CORLISS, B. & PHILLIPS, J.H. (1997) Arousal and inhibition of human NK cells. Immunological Reviews, 155, 145.
34. LANIER, L.L., PHILLIPS, J., HACKETT, J., TUTT, M. & KUMAR, V. (1986) Natural killer cells: definition of a cell type rather than a function. Journal of Immunology, 137, 2375.
35. LANIER, L.L., RUITENBERG, J.J. & PHILLIPS, J.H. (1988) Functional and biochemical analysis of CD16 antigen on natural killer cells and granulocytes. Journal of Immunology, 141, 3478.
36. LAZETIC, S., CHANG, C., HOUCHINS, J.P., LANIER, L.L. & PHILLIPS, J.H. (1996) Human natural killer cell receptors involved in MHC class I recognition are disulphide-linked heterodimers of CD94 and NKG2 subunits. Journal of Immunology, 157, 4741.
37. LITWIN, V., GUMPERZ, J.E., PARHAM, P., PHILLIPS, J.H. & LANIER, L.L. (1994) NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules. Journal of Experimental Medicine, 180, 537.
38. LJUNGGREN, H.-G. & KÄRRE, K. (1990) In search of the 'missing self'. MHC molecules and NK cell recognition. Immunology Today, 11, 237.
39. MADDEN, D.R., GORGA, J.C., STROMINGER, J.L. & WILEY, D.C. (1992) The three-dimensional structure of HLA-B27 at 2.1 Å resolution suggests a general mechanism for tight peptide binding to MHC. Cell, 70, 1035.
40. MALNATI, M.S., PERUZZI, M., PARKER, K.C., BIDDISON, W.E., CICCONE, E., MORETTA, A. & LONG, E.O. (1995) Peptide specificity in the recognition of MHC class I by natural killer cell clones. Science, 267, 1016.
41. MASON, L.H., ORTALDO, J.R., YOUNG, H.A., KUMAR, V., BENNET, M. & ANDERSON, S.K. (1995) Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the ly 49 gene family (Ly-49G2). Journal of Experimental Medicine, 182, 293.
42. MORETTA, A. (1997) Molecular mechanisms in cell-mediated cytotoxicity. Cell, 90, 13.
43. MORETTA, A., BIASSONI, R., BOTTINO, C., PENDE, D., VITALE, M., POGGI, A., MINGARI, M.C. & MORETTA, L. (1997) Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunological Review, 155, 105.
44. MORETTA, A., BOTTINO, C., PENDE, D., TRIPODI, G., TAMBUSSI, G., VIALE, O., ORENGO, A., BARBARESI, M., MERLI, A., CICCONE, E. & MORETTA, L. (1990b) Identification of four subsets of human CD3-CD16+ NK cells by the expression of clonally distributed functional surface molecules. Correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition. Journal of Experimental Medicine, 172, 1589.
45. MORETTA, A., BOTTINO, C., TRIPODI, G., VITALE, M., PENDE, D., MORELLI, L., AUGUGLIARO, R., BARBARESI, M., CICCONE, E., MILLO, R. & MORETTA, L. (1992) Novel surface molecules involved in human NK cell activation and triggering of the lytic machinery. International Journal of Cancer, Suppl. 7, 6.
46. MORETTA, A., BOTTINO, C., VITALE, M., PENDE, D., BIASSONI, R., MINGARI, M.C. & MORETTA, L. (1996) Receptors for HLA class I-molecules in human natural killer cells. Annual Review of Immunology, 14, 619.
47. MORETTA, A., POGGI, A., PENDE, D., TRIPODI, G., ORENGO, A.M., PELLA, N., AUGUGLIARO, R., BOTTINO, C., CICCONE, E. & MORETTA, L. (1991) CD69-mediated pathway of lymphocyte activation. Anti-CD69 mAbs trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing TCRα/β. Journal of Experimental Medicine, 174, 1393.
48. MORETTA, A., SIVORI, S., VITALE, M., PENDE, D., MORELLI, L., AUGUGLIARO, R., BOTTINO, C. & MORETTA, L. (1995) Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells. Journal of Experimental Medicine, 182, 875.
49. MORETTA, A., TAMBUSSI, G., BOTTINO, C., TRIPODI, G., MERLI, A., CICCONE, E., PANTALEO, G. & MORETTA, L. (1990b) A novel surface antigen expressed by a subset of human CD3-CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function. Journal of Experimental Medicine, 171, 695.
50. MORETTA, A., TAMBUSSI, G., CICCONE, E., PENDE, D., MELIOLI, G. & MORETTA, L. (1989) CD16 Surface molecules regulate the cytolytic function of CD3-CD16+ human 'natural killer' cells. International Journal of Cancer, 44, 727.
51. MORETTA, A., VITALE, M., BOTTINO, C., ORENGO, A.M., MORELLI, L., AUGUGLIARO, R., BARBARESI, M., CICCONE, E. & MORETTA, L. (1993) P58 molecules as putative receptors for MHC class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. Journal of Experimental Medicine, 178, 597.
52. MORETTA, A., VITALE, M., SIVORI, S., BOTTINO, C., MORELLI, L., AUGUGLIARO, R., BARBARESI, M., PENDE, D., CICCONE, E., LOPEZ-BOTET, M. & MORETTA, L. (1994) Human natural killer cell receptors for HLA class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles. Journal of Experimental Medicine, 180, 545.
53. MORETTA, L., CICCONE, E., MINGARI, M.C., BIASSONI, R. & MORETTA, A. (1994) Human NK cells: origin, clonality, specificity and receptors. Advances in Immunology, 55, 341.
54. MORETTA, L., CICCONE, E., MORETTA, A., HÖGLUND, P., OHLEN, C. & KÄRRE, K. (1992) Allorecognition by NK cells: nonself or no self? Immunology Today, 13, 300.
55. MUNZ, C., HOLMES, N., KING, A., LOKE, Y.W., COLONNA, M., SCHILD, H. & RAMMENSEE, H.G. (1997) Human histocompatibility leukocyte antigen (HLA-G) molecules inhibit NKAT3 expressing natural killer cells. Journal of Experimental Medicine, 185, 385.
56. OLCESE, L., CAMBIAGGI, A., SEMENZATO, G., BOTTINO, C., MORETTA, A. & VIVIER, E. (1997) Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells. Journal of Immunology, 158, 5083.
57. OLCESE, L., LANG, P., VÉLY, F., CAMBIAGGI, A., MARGUET, D., BLÉRY, M., HIPPEN, K.L., BIASSONI, R., MORETTA, A., MORETTA, L., CAMBIERI, J.C. & VIVIER, E. (1996) Human and mouse natural killer cell inhibitory receptors recruit the PTP1C and PTP1D protein tyrosine phosphatases. Journal of Immunology, 156, 4531.
58. PAZMANY, L., MANDELBOIM, O., VALÉS-GOMEZ, M., DAVIS, D.M., REYBURN, H.T. & STROMINGER, J.L. (1996) Protection from natural killer cells-mediated lysis by HLA-G expression on target cells. Science, 274, 792.
59. PENDE, D., BIASSONI, R., CANTONI, C., VERDIANI, S., FALCO, M., DI DONATO, C., ACCAME, L., BOTTINO, C., MORETTA, A. & MORETTA, L. (1996) The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140 kD disulphide-linked dimer. Journal of Experimental Medicine, 184, 505.
60. PENDE, D., SIVORI, S., ACCAME, L., PARETI, L., FALCO, M., GERAGHTY, D., LE BOUTEILLER, P., MORETTA, L. & MORETTA, A. (1997) HLA-G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and as activating receptor complex. European Journal of Immunology, 27, 1875.
61. PÉREZ-VILLAR, J.J., CARRETERO, M., NAVARRO, F., MELERO, I., RODRIGUEZ, A., BOTTINO, C., MORETTA, A. & LOPEZ-BOTET, M. (1996) Biochemical and serological evidence for the existence of functionally distinct isoforms of the CD94 NK-cell receptor. Journal of Immunology, 157, 5367.
62. PÉREZ-VILLAR, J.J., MELERO, I., NAVARRO, F., CARRETERO, M., BELLON, T., LLANO, M., COLONNA, M., GERAGHTY, D.E. & LOPEZ-BOTET, M. (1997) The CD94/NKG2A inhibitory receptor complex is involved in the natural killer cell-mediated recognition of cells expressing HLA-G1. Journal of Immunology, 158, 5736.
63. PÉREZ-VILLAR, J.J., MELERO, I., RODRIGUEZ, A., CARRETERO, M., ARAMBURU, J., SIVORI, S., ORENGO, A.M., MORETTA, A. & LOPEZ-BOTET, M. (1995) Functional ambivalence of the Kp43 (CD94) NK cell-associated surface antigen. Journal of Immunology, 154, 5779.
64. PERUZZI, M., PARKER, K.C., LONG, E.O. & MALNATI, M.S. (1996) Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells. Journal of Immunology, 157, 3350.
65. PHILLIPS, J.H., CHANG, C., MATTSON, J., GUMPERZ, J.E., PARHAM, P. & LANIER, L.L. (1996) CD94 and a novel associated protein (94AP) form an NK cell receptor involved in the recognition of HLA-A, -B, -C allotypes. Immunity, 5, 163.
66. RAJAGOPALAN, S. & LONG, E.O. (1997) The direct binding of a p58 killer cell inhibitory receptor to human histocompatibility leukocyte antigen (HLA)-Cw4 exhibits peptide selectivity. Journal of Experimental Medicine, 185, 1523.
67. SÖDERSTROM, K., CORLISS, B., LANIER, L.L. & PHILLIPS, J.H. (1997) CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells. Journal of Immunology, 159, 1071.
68. SIVORI, S., VITALE, M., BOTTINO, C., MARCENARO, E., SANSEVERINO, L., PAROLINI, S., MORETTA, L. & MORETTA, A. (1996) CD94 functions as a natural killer cell inhibitory receptor for different HLA CLASS-I alleles. Identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies. European Journal of Immunology, 26, 2487.
69. SIVORI, S., VITALE, M., MORELLI, L., SANSEVERINO, L., AUGUGLIARO, R., BOTTINO, C., MORETTA, L. & MORETTA, A. (1997) p46, a novel natural killer cell-specific surface molecule that mediates cell activation. Journal of Experimental Medicine, in press.
70. STONEMAN, E.R., BENNET, M., AN, J., CHESNUT, K.A., WAKELAND, E.K. & SCHEERER, J.B. (1995) Cloning and characterization of 5E6 (Ly-49C), a receptor molecule expressed on a subset of murine natural killer cells. Journal of Experimental Medicine, 182, 305.
71. STORKUS, W.J., HOWELL, D.N., SALTERN, R.D., DAWSON, J.R. & CRESSWELL, P. (1987) NK susceptibility varies inversely with target cell class I HLA antigen expression. Journal of Immunology, 138, 1657.
72. TRINCHIERI, G. (1989) Biology of natural killer cells. Advances in Immunology, 47, 187.
73. VALIANTE, N.M., LIENERT, K., SHILLING, H.G., SMITS, B.J. & PARHAM, P. (1997) Killer cell receptors: keeping pace with MHC class I evolution. Immunological Review, 155, 155.
74. VÉLY, F., OLIVERO, S., OLCESE, L., MORETTA, A., DAMEN, J.E., LIU, L., KRYSTAL, G., CAMBIER, J.C., DAERON, M. & VIVIER, E. (1997) Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs. European Journal of Immunology, 27, 1994.
75. VITALE, M., SIVORI, S., PENDE, D., AUGUGLIARO, R., DI DONATO, C., AMOROSO, A., MALNATI, M., BOTTINO, C., MORETTA, L. & MORETTA, A. (1996) Physical and functional independency of p70 and p58 cell receptors for HLA class I. Their role in the definition of different groups of alloreactive NK cell clones. Proceedings of the National Academy of Sciences, 93, 1453.
76. VITALE, M., SIVORI, S., PENDE, D., MORETTA, L. & MORETTA, A. (1995) The co-expression of two functionally independent p58 inhibitory receptors in human NK cell clones results in the inability to kill all normal allogeneic target cells. Proceedings of the National Academy of Sciences, 92, 3536.
77. WAGTMANN, N., BIASSONI, R., CANTONI, C., VERDIANI, S., MALNATI, M.S., VITALE, M., BOTTINO, C., MORETTA, L., MORETTA, A. & LONG, E.O. (1995) Molecular clones of the p58 NK cell receptor reveal immunoglobulin related molecules with diversity in both the extra- and intracellular domains. Immunity, 2, 439.
78. WONG, S., FREEMAN, J.D., KELLEHER, C., MAGER, D. & TAKEI, F. (1991) Ly-49 multigene family. New members of a superfamily of type II membrane proteins with lectin-like domains. Journal of Immunology, 147, 1417.
79. YOKOYAMA, W.M. & SEAMAN, W.E. (1993) The Ly49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annual Review of Immunology, 11, 613.
80. YOKOYAMA, W.M., DANIELS, B.F., SEAMAN, W.E., HUNZIKER, R., MARGULIES, D.H. & SMITH, H.R. (1995) A family of murine NK cell receptors specific for target cell MHC class I molecules. Seminars in Immunology, 7, 89.
81. ZAPPACOSTA, F., BORREGO, F., BROOKS, A.G., PARKER, K.C. & COLIGAN, J.E. (1997) Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis. Proceedings of the National Academy of Sciences, 94, 6313.