Hemodynamic mechanisms underlying elevated oxygen extraction fraction (OEF) in moyamoya and sickle cell anemia patients

Journal of Cerebral Blood Flow and Metabolism

Volumn 38, Issue 9, 2018, Pages 1618-1630

  Watchmaker, Jennifer M ^a   Juttukonda, Meher R ^a   Davis, Larry T ^a   Scott, Allison O ^a   Faraco, Carlos C ^a   Gindville, Melissa C ^b   Jordan, Lori C ^b   Cogswell, Petrice M ^a   Jefferson, Angela L ^b   Kirshner, Howard S ^b   Donahue, Manus J ^a,b  

^a Department of Orthopaedic Surgery ^*  (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

moyamoya; MRI; neurophysiology; Oxygen extraction fraction; stroke

Indexed keywords

HEMOGLOBIN S; HYDROXYUREA; OXYGEN;

ADULT; ARTICLE; BRAIN BLOOD FLOW; CLINICAL ARTICLE; CONTROLLED STUDY; DIGITAL SUBTRACTION ANGIOGRAPHY; DISEASE SEVERITY; END TIDAL CARBON DIOXIDE TENSION; FEMALE; FOLLOW UP; HEMATOCRIT; HIGH RISK PATIENT; HUMAN; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MODIFIED SUZUKI SCORE; MOYAMOYA DISEASE; OXYGEN EXTRACTION FRACTION; OXYGEN SATURATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCORING SYSTEM; SICKLE CELL ANEMIA; VASCULAR DISEASE; AGED; BRAIN CIRCULATION; HEMODYNAMICS; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES;

ADULT; AGED; ANEMIA, SICKLE CELL; CEREBROVASCULAR CIRCULATION; FEMALE; HEMODYNAMICS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MOYAMOYA DISEASE; OXYGEN; OXYGEN CONSUMPTION;

EID: 85045107894     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1177/0271678X16682509     Document Type: Article

References (45)

1. Scott RM, Smith ER. Moyamoya disease and moyamoya syndrome. New Engl J Med 2009; 360: 1226–1237
2. Hallemeier CL, Rich KM, Grubb RL, Jr. Clinical features and outcome in North American adults with moyamoya phenomenon. Stroke 2006; 37: 1490–1496
3. Arias EJ, Derdeyn CP, Dacey RG, Jr. Advances and surgical considerations in the treatment of moyamoya disease. Neurosurgery 2014; 74(Suppl 1): S116–S125
4. Liebeskind DS, Cotsonis GA, Saver JL, Collaterals dramatically alter stroke risk in intracranial atherosclerosis. Ann Neurol 2011; 69: 963–974
5. Strother MK, Anderson MD, Singer RJ, Cerebrovascular collaterals correlate with disease severity in adult North American patients with Moyamoya disease. AJNR Am J Neuroradiol 2014; 35: 1318–1324
6. Ostergaard L, Smith DF, Vestergaard-Poulsen P, Absolute cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking: comparison with positron emission tomography values. J Cereb Blood Flow Metab 1998; 18: 425–432
7. Derdeyn CP, Videen TO, Yundt KD, Variability of cerebral blood volume and oxygen extraction: stages of cerebral haemodynamic impairment revisited. Brain: J Neurol 2002; 125: 595–607
8. Donahue MJ, Sideso E, MacIntosh BJ, Absolute arterial cerebral blood volume quantification using inflow vascular-space-occupancy with dynamic subtraction magnetic resonance imaging. J Cereb Blood Flow Metab 2010; 30: 1329–1342
9. Leng X, Wong KS, Liebeskind DS. Evaluating intracranial atherosclerosis rather than intracranial stenosis. Stroke 2014; 45: 645–651
10. Jordan LC, Gindville MC, Scott AO, Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia. Brain 2016; 139: 738–750
11. Yamauchi H, Fukuyama H, Nagahama Y, Evidence of misery perfusion and risk for recurrent stroke in major cerebral arterial occlusive diseases from PET. J Neurol Neurosurg Psychiatry 1996; 61: 18–25
12. Derdeyn CP, Yundt KD, Videen TO, Increased oxygen extraction fraction is associated with prior ischemic events in patients with carotid occlusion. Stroke 1998; 29: 754–758
13. Iwama T, Akiyama Y, Morimoto M, Comparison of positron emission tomography study results of cerebral hemodynamics in patients with bleeding- and ischemic-type moyamoya disease. Neurosurg Focus 1998; 5: e3
14. Lu H, Xu F, Rodrigue KM, Alterations in cerebral metabolic rate and blood supply across the adult lifespan. Cereb Cortex 2011; 21: 1426–1434
15. Zheng G, Wen J, Lu H, Elevated global cerebral blood flow, oxygen extraction fraction and unchanged metabolic rate of oxygen in young adults with end-stage renal disease: an MRI study. Eur Radiol 2015; 26: 1732–1741
16. Sheng M, Lu H, Liu P, Cerebral perfusion differences in women currently with and recovered from anorexia nervosa. Psychiatry Res 2015; 232: 175–183
17. Liu P, Huang H, Rollins N, Quantitative assessment of global cerebral metabolic rate of oxygen (CMRO2) in neonates using MRI. NMR Biomed 2014; 27: 332–340
18. Schubert GA, Czabanka M, Seiz M, Perfusion characteristics of Moyamoya disease: an anatomically and clinically oriented analysis and comparison. Stroke 2014; 45: 101–106
19. Ogasawara K, Ogawa A, Yoshimoto T. Cerebrovascular reactivity to acetazolamide and outcome in patients with symptomatic internal carotid or middle cerebral artery occlusion: a xenon-133 single-photon emission computed tomography study. Stroke 2002; 33: 1857–1862
20. Ikezaki K, Matsushima T, Kuwabara Y, Cerebral circulation and oxygen metabolism in childhood moyamoya disease: a perioperative positron emission tomography study. J Neurosurg 1994; 81: 843–850
21. Yamauchi H, Okazawa H, Kishibe Y, Oxygen extraction fraction and acetazolamide reactivity in symptomatic carotid artery disease. J Neurol Neurosurg Psychiatry 2004; 75: 33–37
22. Donahue MJ, Ayad M, Moore R, Relationships between hypercarbic reactivity, cerebral blood flow, and arterial circulation times in patients with moyamoya disease. J Magn Reson Imag 2013; 38: 1129–1139
23. Donahue MJ, Dethrage LM, Faraco CC, Routine clinical evaluation of cerebrovascular reserve capacity using carbogen in patients with intracranial stenosis. Stroke 2014; 45: 2335–2341
24. Donahue MJ, Faraco CC, Strother MK, Bolus arrival time and cerebral blood flow responses to hypercarbia. J Cerebral Blood Flow Metab 2014; 34: 1243–1252
25. Wu B, Lou X, Wu X, Intra- and interscanner reliability and reproducibility of 3D whole-brain pseudo-continuous arterial spin-labeling MR perfusion at 3T. J Magn Reson Imag 2014; 39: 402–409
26. Meher R, Juttukonda MR, Jordan LC, Gindville MC, et al. Cerebral hemodynamics and pseudo-continuous arterial spin labeling considerations in adults with sickle cell anemia. NMR in Biomed. Epub ahead of print 12 November 2016
27. Lu H, Ge Y. Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRI. Magn Reson Med 2008; 60: 357–363
28. Lu H, Xu F, Grgac K, Calibration and validation of TRUST MRI for the estimation of cerebral blood oxygenation. Magn Reson Med 2012; 67: 42–49
29. Mugikura S, Takahashi S, Higano S, Predominant involvement of ipsilateral anterior and posterior circulations in moyamoya disease. Stroke 2002; 33: 1497–1500
30. Alsop DC, Detre JA, Golay X, Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med 2015; 73: spcone
31. Smith SM, Jenkinson M, Woolrich MW, Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 2004; 23(Suppl 1): S208–S219
32. Jenkinson M, Smith S. A global optimisation method for robust affine registration of brain images. Med Image Anal 2001; 5: 143–156
33. Lu H, Clingman C, Golay X, Determining the longitudinal relaxation time (T1) of blood at 3.0 Tesla. Magn Reson Med 2004; 52: 679–682
34. Leenders KL, Perani D, Lammertsma AA, Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age. Brain 1990; 113(Pt 1): 27–47
35. Herold S, Brozovic M, Gibbs J, Measurement of regional cerebral blood flow, blood volume and oxygen metabolism in patients with sickle cell disease using positron emission tomography. Stroke 1986; 17: 692–698
36. Bulte DP, Kelly M, Germuska M, Quantitative measurement of cerebral physiology using respiratory-calibrated MRI. Neuroimage 2012; 60: 582–591
37. Yun TJ, Paeng JC, Sohn CH, Monitoring cerebrovascular reactivity through the use of arterial spin labeling in patients with moyamoya disease. Radiology 2016; 278: 205–213
38. Zaharchuk G, Do HM, Marks MP, Arterial spin-labeling MRI can identify the presence and intensity of collateral perfusion in patients with moyamoya disease. Stroke 2011; 42: 2485–2491
39. Roach BA, Donahue MJ, Davis LT, Interrogating the functional correlates of collateralization in patients with intracranial stenosis using multimodal hemodynamic imaging. AJNR Am J Neuroradiol 2016; 37: 1132–1138
40. Ni WW, Christen T, Rosenberg J, Imaging of cerebrovascular reserve and oxygenation in Moyamoya disease. J Cereb Blood Flow Metab. Epub ahead of print 20 May 2016. DOI: 10.1177/0271678X16651088
41. Heyn C, Poublanc J, Crawley A, Quantification of cerebrovascular reactivity by blood oxygen level-dependent MR imaging and correlation with conventional angiography in patients with Moyamoya disease. AJNR Am J Neuroradiol 2010; 31: 862–867
42. Han JS, Mikulis DJ, Mardimae A, Measurement of cerebrovascular reactivity in pediatric patients with cerebral vasculopathy using blood oxygen level-dependent MRI. Stroke 2011; 42: 1261–1269
43. Vaclavu L, Mutsaerts H, Ooij PV, et al. Arterial spin labeling MRI evaluation of cerebrovascular reserve with acetazolamide in patients with sickle cell disease. In: ISMRM 24th annual meeting & exhibition, Singapore, 2016
44. Krishnamurthy LC, Liu P, Ge Y, Vessel-specific quantification of blood oxygenation with T2-relaxation-under-phase-contrast MRI. Magn Reson Med 2014; 71: 978–989
45. Wise RG, Harris AD, Stone AJ, Measurement of OEF and absolute CMRO2: MRI-based methods using interleaved and combined hypercapnia and hyperoxia. Neuroimage 2013; 83: 135–147