SERCA2b Cycles Its Way to UCP1-Independent Thermogenesis in Beige Fat

Cell Metabolism

Volumn 27, Issue 1, 2018, Pages 7-9

  Mottillo, Emilio P ^a   Ramseyer, Vanesa D ^a   Granneman, James G ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CREATINE KINASE; CREATINE PHOSPHATE; FATTY ACID; GLUCOSE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2B; TRIACYLGLYCEROL; TRICARBOXYLIC ACID; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1;

BEIGE ADIPOCYTE; BROWN ADIPOCYTE; BROWN ADIPOSE TISSUE; CALCIUM HOMEOSTASIS; CITRIC ACID CYCLE; COLD STRESS; COLD TOLERANCE; ENERGY BALANCE; ENERGY EXPENDITURE; FATTY ACID SYNTHESIS; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; GLYCOLYSIS; HUMAN; METABOLISM; MITOCHONDRION; MUSCLE CONTRACTION; NONHUMAN; NONSHIVERING THERMOGENESIS; PRIORITY JOURNAL; RESTING ENERGY EXPENDITURE; SHORT SURVEY; THERMOGENESIS; WHITE ADIPOCYTE; BEIGE ADIPOSE TISSUE; HOMEOSTASIS;

ADIPOSE TISSUE, BEIGE; CALCIUM; GLUCOSE; HOMEOSTASIS; THERMOGENESIS; UNCOUPLING PROTEIN 1;

EID: 85044786227     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2017.12.015     Document Type: Short Survey

References (10)

1. Anunciado-Koza, R., Ukropec, J., Koza, R.A., Kozak, L.P., Inactivation of UCP1 and the glycerol phosphate cycle synergistically increases energy expenditure to resist diet-induced obesity. J. Biol. Chem. 283 (2008), 27688–27697.
2. Cannon, B., Nedergaard, J., Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans). Int. J. Obes. 34:Suppl 1 (2010), S7–S16.
3. Foster, D.O., Frydman, M.L., Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline. Can. J. Physiol. Pharmacol. 56 (1978), 110–122.
4. Hull, D., Segall, M.M., The contribution of brown adipose tissue to heat production in the new-born rabbit. J. Physiol. 181 (1965), 449–457.
5. Ikeda, K., Kang, Q., Yoneshiro, T., Camporez, J.P., Maki, H., Homma, M., Shinoda, K., Chen, Y., Lu, X., Maretich, P., et al. UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nat. Med. 23 (2017), 1454–1465.
6. Kazak, L., Chouchani, E.T., Jedrychowski, M.P., Erickson, B.K., Shinoda, K., Cohen, P., Vetrivelan, R., Lu, G.Z., Laznik-Bogoslavski, D., Hasenfuss, S.C., et al. A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell 163 (2015), 643–655.
7. Nowack, J., Giroud, S., Arnold, W., Ruf, T., Muscle non-shivering thermogenesis and its role in the evolution of endothermy. Front. Physiol., 8, 2017, 889.
8. Pant, M., Bal, N.C., Periasamy, M., Sarcolipin: a key thermogenic and metabolic regulator in skeletal muscle. Trends Endocrinol. Metab. 27 (2016), 881–892.
9. Ramseyer, V.D., Granneman, J.G., Adrenergic regulation of cellular plasticity in brown, beige/brite and white adipose tissues. Adipocyte 5 (2016), 119–129.
10. Rowland, L.A., Bal, N.C., Periasamy, M., The role of skeletal-muscle-based thermogenic mechanisms in vertebrate endothermy. Biol. Rev. Camb. Philos. Soc. 90 (2015), 1279–1297.